• Biomolecules & Therapeutics
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• 제13권1호
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• pp.41-47
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• 2005

The study was conducted to determine whether oak wood vinegar extract influences blood alcohol concentration and hangover syndrome in healthy volunteers. 2% wood vinegar extract was effective to inhibit increase of blood alcohol concentration after alcohol intake and showed significantly different (P<0.1) compared to placebo. By result of questionnaire of volunteers, wood vinegar extract showed effects improving hangover syndrome. In comparative study about blood alcohol concentration and hangover syndrome of wood vinegar extract and other extract that hangover improvement effect was reported, average maximum blood alcohol concentration was lowered in those taking wood vinegar extract than those taking other extract. At drinking completion 210minutes (T210), blood alcohol concentration of those taking wood vinegar extract was the lowest by 0.063% compared with other extract but was not significantly different between in those taking wood vinegar extract and in those taking other extract. However, wood vinegar extract's experimental group was the highest by 0.462 in decrement rate of blood alcohol concentration and, when did P<0.1 by significance level, indicated difference that mean statistically compared to placebo group uniquely. At those taking wood vinegar extract, the improvement rate and the aggravation rate of hangover syndrome was each 87%, 2%. Thus it was concluded that wood vinegar extract showed excellent alcohol oxidation and was effective in hangover improvement.

• 대한한방내과학회지
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• 제38권1호
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• pp.20-31
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• 2017

Objectives: This study investigated the effect of SM-2015 on blood alcohol clearance and hangover. We undertook this study to test whether SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Methods: Twenty healthy volunteers participated in this randomized crossover study. All participants were classified between an SM-2015 intake group (test group) and a non-intake group (control group). The primary outcome measure was the difference in blood alcohol concentration and hangover severity scores between the test and control groups. The secondary outcome measure was the difference in a liver function test (LFT) between the test and control groups. Results: After alcohol exposure, the sensitivity scores of blood alcohol concentration and hangover symptoms (sleepiness, dizziness, nausea, weakness, stomach pain, diarrhea, and concentration disorder) were significantly decreased in the SM-2015 intake group compared with the non-intake group. There were no differences in the LFT results between the SM-2015 intake group and the non-intake group. Conclusions: SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.

• 한국자기공명학회논문지
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• 제22권4호
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• pp.82-90
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• 2018

The term "hangover" refers to symptoms such as headache, heartburn, nausea, and dizziness caused by acetaldehyde created through alcohol decomposition in the body after alcohol intake. Many scientists have conducted research on diverse drugs, foods, and medicinal herbs aimed at eliminating hangovers. However, research on metabolism to objectively verify or measure their effects on hangover symptoms has been lacking. Accordingly, in this study, deep sea water minerals were administered orally at varying concentrations to rats that consumed alcohol, and changes in the levels of amino acids in their bodies were measured using nuclear magnetic resonance spectroscopy to gauge the minerals' effects on hangover symptoms. Thus far, biochemical research on hangover cures has been confined to basic research measuring changes in the levels of alcohol dehydrogenase and acetaldehyde dehydrogenase as well as in the concentrations of ethanol, acetaldehyde, and acetate using spectroscopes such as enzyme-linked immunosorbent assay kits or gas chromatography-mass spectrometers. In comparison, this study presents pharmacokinetic research that simultaneously tracked biomaterials including amino acids and organic acids, metabolites associated with hangover, to clarify hangover mechanisms more specifically. In addition, this study examined hangover mechanisms without an external supply of tracked materials not overlapping with alcohol metabolism-related materials, such as external amino acids and sugars.

• 한국환경보건학회지
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• 제49권2호
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• pp.99-107
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• 2023

Background: Excessive alcohol consumption is at the root of serious social problems such as hangovers, liver dysfunction, and alcoholism. Objectives: This study was carried out to determine the hangover ameliorating effect of fermented rice extract and a combination of yeast-fermented powder and lysate containing aldehyde dehydrogenase (ALDH) (improved new ingredients) in an ethanol-induced rat study. Methods: The concentrations of alcohol, acetaldehyde, and malondialdehye in serum were evaluated to assess the anti-alcohol and anti-aldehyde hangover effect in two experiments, one with fermented rice extract) and a second with yeast-fermented powder and lysate, using animal studies. Results: Experiment 2 with yeast-fermented powder and lysate containing ALDH showed similar and higher activity, respectively, in reducing ethanol and acetaldehyde concentration compared with Experiment 1 with fermented rice extract. Experiment 2 also significantly reduced malondialdehyde, a type of lipid peroxide. The ALDH-related compound (ARC) lysate showed better hangover relief effect than ARC powder. Conclusions: These results indicate that ALDH-related compounds exhibit a hangover relief effect, and fermented lysate is considered to be a better candidate for hangover relief.

• Preventive Nutrition and Food Science
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• 제21권1호
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• pp.9-13
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• 2016

The present study was conducted to investigate the effects of beverages containing fermented Akebia quinata extracts on alcoholic hangover. For this study, 25 healthy young men were recruited. All participants consumed 100 mL of water (placebo), commercial hangover beverage A or B, fermented A. quinata leaf (AQL) or fruit (AQF) extract before alcohol consumption. After 1 h, all participants consumed a bottle of Soju, Korean distilled liquor (360 mL), containing 20% alcohol. Blood was collected at 0 h, 1 h, 3 h, and 5 h after alcohol consumption. The plasma alanine transaminase (ALT) activity was highest in the placebo group. Compared with the control group, the AQL and AQF groups showed decreased ALT activity at 5 h after alcohol consumption. Plasma ethanol concentration was increased after alcohol intake and peaked at 3 h after alcohol consumption. Compared with the control group, the A group showed a higher plasma ethanol concentration at 1 h (P<0.05). At 3 h after alcohol consumption, the AQF group showed the lowest mean plasma ethanol concentration compared to the other groups; however, there were no statistical differences. After 5 h of alcohol consumption, the AQL and AQF groups showed lower plasma ethanol concentrations compared with the B group. The sensory evaluation score for the fermented A. quinata fruit extract was lower than for the commercial hangover beverages. In conclusion, the present intervention study results suggest that fermented A. quinata extracts alleviate alcoholic hangover and reduce plasma ethanol concentrations.

• 대한한방내과학회지
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• 제33권4호
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• pp.511-519
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• 2012

Objectives : This study investigated the effect of Sinseonbulchuidan (SBD-1) on hangover syndrome. We undertook this study to test whether SBD-1 is effective in preventing the signs and symptoms of alcohol-induced hangover. Methods : Fifteen healthy volunteers participated in this double-blind randomized crossover study. All participants received either SBD-1 or indistinguishable placebo capsules before alcohol consumption. The primary outcome measure was the difference in hangover severity scores between SBD-1 and placebo intervention. Secondary outcome measure was the difference in profile of mood states (POMS) between SBD-1 and placebo intervention. Results : After alcohol exposure, the overall symptom scores were significantly decreased in the SBD-1 group compared with those given a placebo. The mean scores for the hangover symptoms were high in the placebo group, and statistical significance was observed in 4 symptom scores (loss of appetite, stomachache, nausea, and total score). There were no differences in the POMS and cognitive performance test results between SBD-1 and placebo intervention. Conclusions : We conclude that the SBD-1 is effective in preventing the signs and symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.

• 한국식생활문화학회지
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• 제36권6호
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• pp.563-570
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• 2021

The fruit stalk of Hovenia dulcis (H.dulcis) is traditionally used to relieve hangovers in Korea. Theracurmin is a highly absorbable curcumin preparation which increases the bioavailability of curcumin. Curcumin is known for its antioxidant and anti-inflammatory effects. However, the role of this combination in lowering alcohol levels in the body, thereby alleviating the severity of alcohol-induced hangover has not been investigated. Therefore, we conducted a study to investigate the eliminatory effects of a health drink containing the extract of the H. dulcis fruit stalk and theracurmin (theracurmin drink) on ethanol-induced hangover in rats. The theracurmin drink delivered orally to rats 30 mins before the administration of 40% ethanol (5 g/kg body weight), lowered the concentration of ethanol and acetaldehyde in the blood samples collected 1, 3, and 5 h after ethanol administration. Furthermore, the theracurmin drink increased the activities of alcohol dehydrogenase and aldehyde dehydrogenase enzymes. The effectiveness of the theracurmin drink was thus superior to that of other health drink products, suggesting that its consumption may alleviate or prevent an alcohol-induced hangover.

• 생명과학회지
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• 제32권2호
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• pp.79-85
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• 2022

최근 알코올성 간손상이나 간건강에 효과가 있는 천연물 원료를 포함하는 숙취해소제들이 시판되고 있다. 하지만 간손상이나 간건강에 대한 기능성은 숙취해소와는 다르기 때문에 숙취해소제들의 숙취해소 효능 검증이 필요하다. 본 연구는 국내의 4가지 숙취해소제의 효능을 알코올에 의한 숙취유도 흰쥐 모델에서 비교 조사하고자 하였다. 4가지 샘플들은 각각 C, M, R, S로 명명되었다. 동물실험에서 숙취 완화 효능은 혈중 알코올 및 아세탈데히드 농도로 평가되기 때문에 각 샘플들의 효과를 혈중 알코올과 아세탈데히드의 농도와 AUC (Area Under the Curve)로 평가하였다. 알코올 투여는 유의적으로 흰쥐의 혈중 알코올과 아세탈데히드 농도를 증가시켰다. 샘플 C, M, R, S순으로 에탄올의 Cmax와 AUC 감소율은 각각 5.9%, 3.1%, 8.4%, 11.7%와 8.9%, 2.2%, 12.1%, 19.6%였다. 아세탈데히드의 경우, 같은 샘플 순서로 Cmax는 14.2%, 15.2%, 28.2%, 35.0% 감소하였으며, AUC는 21.6%, 7.5%, 22.4%, 29.9%의 감소율을 보였다. 결론적으로, 샘플 S, R, C, M순으로 4개의 샘플 모두 EtOH군에 대비하여 숙취가 해소되는 경향을 보였으나, 샘플 S만이 에탄올과 아세탈데히드의 혈중 농도와 AUC 모두에서 통계적으로 유의적인 감소율을 보였다. 따라서 이러한 실험결과는 시중에 판매되는 숙취해소제의 객관적인 효능 검증이 부족하다는 것을 시사한다.

• 한국임상약학회지
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• 제20권1호
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• pp.1-8
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• 2010

We conducted a single blind, randomized and crossover clinical trial in order to test the effect of curcuma longa herbal mixture on blood alcohol level and alcohol hangover in 19 healthy volunteers. The herbal mixture did not show a statistical significance in $C_{max}$, $T_{max}$ and AUC in alcohol disposition. The herbal mixture did not also ameliorate blood laboratory result after alcohol consumption. In contrast, the herbal mixture is shown effective on alcohol hangover. In behavior tests, the fewer subjects in the herbal mixture group were impaired with alcohol than in reference group. Moreover, the symptom severity score in the herbal mixture was lower than that in reference group. The symptom severity score was statistically especially in stomach pain, diarrhea, concentration disorder, memory and bad breath at drinking day and one day after drinking. These results indicate that the general symptoms seemed to be recovered as time goes on. From these results, it was suggested that the herbal mixture have a beneficial effect on modulating alcohol hangover.

• 한국산학기술학회논문지
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• 제18권2호
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• pp.218-225
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• 2017

본 연구에서는 알코올을 섭취한 흰쥐에서 알코올 대사와 혈액가스 불균형에 대한 꾸지뽕 나무 뿌리 추출물 (이하 CTE)의 효과를 확인하고자 하였다. 알코올을 10 ml/kg의 농도로 흰쥐에게 경구 투여하였고, 섭취 30분 후 CTE를 500 mg/kg 및 750 mg/kg의 농도로 투여하였다. 혈액은 알코올 섭취 1시간, 3시간, 5시간 후 꼬리 정맥을 통하여 채취하였다. 양성 대조군은 시판되고 있는 숙취해소 음료 (컨디션)를 사용하였다. 약물 처리는 모두 단회 경구 투여로 진행되었다. CTE의 섭취는 흰쥐의 혈액과 간 조직 내 알코올 대사 효소인 알코올 분해효소 (alcohol dehydrogenase)와 아세트알데히드 분해효소(acetaldehyde dehydrogenase)를 증가 또는 유지시킴으로써 혈중 알코올 농도를 감소시켰다. 또한, CTE는 알코올섭취에 의한 혈액가스 (pH, $CO_2$, $HCO_3{^-}$, lactic acid)의 불균형을 회복시켰다. 결론적으로, CTE는 현재 시판되고 있는 숙취해소음료 보다 우수한 숙취 해소 효과를 나타내었다. 따라서 본 연구자는 CTE를 숙취 해소 및 예방을 위한 천연물 유래의 안전하고 새로운 물질로써 제시하는 바이다.