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http://dx.doi.org/10.5762/KAIS.2017.18.2.218

Effects of Cudrania Tricuspidata Root Extract (CTE) on Ethanol-Induced Hangover via Modulating Alcohol Metabolizing Enzyme Activities and Blood Gas Levels in Rats  

Choi, Na-Eun (Department of Biomedical Laboratory Science, Konyang University)
Ro, Ju-Ye (Department of Biomedical Laboratory Science, Konyang University)
Lee, Ju-Yeong (Department of Biomedical Laboratory Science, Konyang University)
Ryu, Jin-Hyeob (Department of Biomedical Laboratory Science, Konyang University)
Cho, Hyun-Jeong (Department of Biomedical Laboratory Science, Konyang University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.18, no.2, 2017 , pp. 218-225 More about this Journal
Abstract
To investigate the anti-hangover effects of Cudrania tricuspidata root extract (CTE), the blood alcohol metabolism and blood gas imbalance of CTE in rats treated with 10 ml/kg alcohol were examined. CTE (500 mg/kg and 750 mg/kg) was administrated after 30 minutes of alcohol consumption (10 ml/kg). Blood collection was implemented from the tails of the animals after 1, 3, and 5 hours post alcohol consumption. The Condition drink (a commercial anti-hangover beverage) was used as a positive control. Single administration by the oral route was performed. The consumption of CTE (500 mg/kg and 750 mg/kg) decreased the serum alcohol concentration by increasing and maintaining both the alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) enzyme activity levels in the blood and liver. In addition, CTE led to recovery from the imbalances in the blood gas levels, including carbon dioxide ($CO_2$) and changes in pH, bicarbonate ($HCO_3{^-}$) and lactic acid levels due to alcohol ingestion. In conclusion, CTE exerted a more pronounced anti-hangover effect than a commercial anti-hangover drink. Therefore, CTE can be a novel and safe anti-hangover natural product agent for the prevention or treatment of symptoms caused by excessive alcohol consumption.
Keywords
Acetaldehyde dehydrogenase; Alcohol dehydrogenase; Blood gas; Cudrania tricuspidata; Anti-hangover;
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