• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4785-4790
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• 2013

Background and Objectives: Evidence for associations between alcohol consumption with breast cancer survival are conflicting, so we conducted the present meta-analysis. Methods: Comprehensive searches were conducted to find cohort studies that evaluated the relationship between alcohol consumption with breast cancer survival. Data were analyzed with meta-analysis software. Results: We included 25 cohort studies. The meta-analysis results showed that alcohol consumption was not associated with increased breast cancer mortality and recurrence after pooling all data from highest versus lowest comparisons. Subgroup analyses showed that pre-diagnostic or post-diagnostic consumpotion, and ER status did not affect the relationship with breast cancer mortality and recurrence. Although the relationships of different alcohol consumption with breast cancer mortality and recurrence were not significant, there seemed to be a dose-response relationship of alcohol consumption with breast cancer mortality and recurrence. Only alcohol consumption of >20 g/d was associated with increased breast cancer mortality, but not with increased breast cancer recurrence. Conclusion: Although our meta-analysis showed alcohol drinking was not associated with increased breast cancer mortality and recurrence, there seemed to be a dose-response relationship of alcohol consumption with breast cancer mortality and recurrence and alcohol consumption of >20 g/d was associated with increased breast cancer mortality.

• 지역사회간호학회지
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• 제14권1호
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• pp.55-65
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• 2003

Purpose: The purpose was to investigate the factors influencing the alcohol consumption behavior of adolescents to provide basic data for a nursing intervention program to improve health management and prohibit alcohol consumption. Method: The subjects were 306 university students, living in K city in Chungnam province from April 1 to 20th, 2002. The instruments used were the alcohol consumption behavior scale, that is the drinking intensity score, and developed by Shin(1998)'s scale of drinking problem, refusal self-efficacy scale by Aas et. al.(1995), alcohol expectancy by Goldman et. al. (1989), TPQ scale by Cloninger(1991), depression scale by Zung(1974), family cohesion scale by Olson et. al. (1983). The data were analyzed using descriptive statistics, Pearson correlation coefficient, t-test, ANOVA, and stepwise multiple regression by using SPSS & SAS program. Results: The multiple regression analysis revealed that the most powerful predictor of alcohol consumption behavior was the influence of friends (drinking everyday) (17.0%). A combination of alcohol expectancy (8.0%), influence of friends (4.0%), father's influence (2.0%), depression(2.0%), refusal self-efficacy (1.0%), personality of harm avoidance(1.0%), and monthly pocket money (2.0%) accounted for 38.6% of the variance in alcohol consumption behavior. Conclusion: From the results, we recommend to use the database that develops nursing intervention program for decreasing the alcohol consumption behavior including the influencing factors in university students.

• 보건교육건강증진학회지
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• 제30권1호
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• pp.83-93
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• 2013

Objectives: The objective of this study was to assess the gender differences in the relationship between alcohol use behaviors and the risk of metabolic syndrome among Korean adult population. Methods: Data from the Korean National Health and Nutrition Examination Survey (5th, 2010) was analyzed. Using the Alcohol Use Disorders Identification Test, subjects were classified into 4 groups including non-drinking, low-risk drinking, medium-level alcohol problem, and high-level alcohol problem group. Metabolic syndrome and its components were compared among the alcohol behavior groups by gender. Results: The odds ratio vs. non-drinking group for metabolic syndrome was significantly higher in male medium and high-level alcohol problem group. In female, high-level alcohol problem group showed significantly higher odds ratio for metabolic syndrome. Blood pressure and HDL-cholesterol were likely to be higher with the excessive drinking behaviors in both men and woman. Triglyceride level in men was significantly higher in the medium and high-level alcohol problem group than non-drinking group. Although fasting glucose level did not show differences among drinking groups, the odd ratios vs. non-drinking group for the hyperglycemia (${\geq}$ 100mg/dl) were significantly higher in female drinking groups. Conclusions: Problematic alcohol drinking is likely to increase the risk of metabolic syndrome in Korean adults.

• 사회복지연구
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• 제44권3호
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• pp.113-145
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• 2013

본 연구는 여성의 생애맥락적 관점을 유지한 채 이들이 알코올 의존에 이르게 되는 과정에 대하여 알아보고자 한 현상학적 사례연구이다. 참여자들의 생애맥락에서 가장 먼저 드러나는 현상은 '불완전한 관계'라는 현상이었고 이는 알코올 의존 현상을 추동하고 있었다. 특히 본 연구자들은 참여자들의 생애 첫 음주를 주목하였는데, 이들에게 생애 첫 음주는 '고유한 상징체계'로서 독특한 의미가 부여되고 있었다. 참여자들이 술을 선택하는 과정에서 드러난 현상은 일상 사건의 연장이라는 '일상성'의 현상이었다. 참여자들의 일상성의 맥락에서 본 알코올 의존 현상은 '침습' 혹은 '침투'라는 과정을 거치게 된다. 이러한 과정을 거쳐 여성들의 알코올 의존 체험은 '현실의 무성화'와 '현실의 신기루화'로 나타났다. 이러한 연구결과를 바탕으로 여성 알코올 의존자들에 대한 개입을 위한 실천적 함의를 도출하였다.

• Nutrition Research and Practice
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• 제13권5호
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• pp.425-433
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• 2019

BACKGROUND/OBJECTIVES: The International Agency for Research on Cancer defined alcohol beverages and acetaldehyde derived from alcoholic beverages as a Group 1 carcinogen to humans. However, the association between alcohol consumption and gastric cancer risk has been controversial in Korean. We assessed the relationship between alcohol consumption and gastric cancer risk in Korea through a case-control study. SUBJECTS/METHODS: From 2 hospitals, a total of 316 cases with gastric cancer (208 men, 108 women) were selected and matched to 316 controls by sex and age (${\pm}5years$) during the same duration. The current status, frequency, and amount of alcohol consumption for a year three years ago were assessed by trained interviewers. RESULTS: Alcohol consumption status and frequency did not show any significant association with gastric cancer risk. However, high alcohol consumption (${\geq}20g/day$ for women or ${\geq}40g/day$ for men) significantly increased the risk of gastric cancer (odds ratio (OR) 1.73; 95% confidence interval (CI) 1.05-2.85). Gastric cancer risk was strongly positively associated with alcohol consumption of ${\geq}20g/day$, especially in women (OR 5.62; 95% CI 1.32-23.81). CONCLUSION: The results from this study suggest that excessive alcohol consumption rather than the current status or frequency of alcohol consumption contributes to the increased risk of gastric cancer, especially in women.

• 대한한방내과학회지
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• 제43권4호
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• pp.738-750
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• 2022

Objective: Alcohol is known to cause inflammation in the stomach by decreasing the protective substances of the gastric mucosa and increasing oxidative stress. The purpose of this study was to investigate the anti-inflammatory effect of Artemisiae Argyi Folium extract (AF) on alcohol-induced gastritis. Methods: The total polyphenol and flavonoid contents of AF were confirmed through an in vitro experiment. Radical scavenging activities were confirmed using DPPH and ABTS assays. In vivo experiments were conducted on mice divided into 5 groups (n=8): a normal group (Nor), an alcohol-induced gastritis group (Con), an alcohol-induced gastritis group administered 10 mg/kg sucralfate (SC), an alcohol-induced gastritis group administered 100 mg/kg AF (AFL), and an alcohol-induced gastritis group administered 200 mg/kg AF(AFH). The serum levels of reactive oxygen species (ROS) were determined, and protein expressions were confirmed in gastric tissues. Results: In alcohol-induced gastritis, AF alleviated damage to the gastric mucosa caused by alcohol. AF also decreased the serum ROS levels. Western blots showed that AF decreased the expression of NADPH oxidase and decreased the expression of the NF-κB pathway associated with inflammation. AF also decreased the expression of adhesion molecules and chemokine proteins, and increased the expression of anti-inflammatory proteins. Conclusions: AF not only reduced oxidative stress in alcohol-induced gastritis, but it also relieved gastric mucosal inflammation by regulating the expression of the NF-κB pathway.

• 대한본초학회지
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• 제34권1호
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• pp.67-74
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• 2019

Objectives : Alcohol hangover is a common phenomenon which basically occurs after heavy drinking. Moreover, heavy alcohol consumption leads to acute and chronic diseases. We investigated the effect of herbal mixture (SJ) on alcohol metabolism in serum or/and liver. Methods : 5W-old Sprague Dawley rats were used for the study. To overnight fasted rats, 0.9% saline or SJ extract was administrated per os before alcohol treatment. Then, 40% alcohol was orally administrated to all rats in 30 mins. Ethanol, acetaldehyde concentrations, alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH) activities were measured by assay kits. Aspartate aminotransferase (AST) and alanine transaminase (ALT) were measured by analyzer. Results : Ethanol and acetaldehyde concentrations lowered in SJ groups compared with CON group. Especially, acetaldehyde concentration significantly decreased in SJ groups compared with CON group. AST and ALT levels tended to increase in SJ groups compared with CON group but there was no significant difference between CON group and SJ groups. ADH activity in serum was higher in SJ groups than CON group but no significant difference in liver. ALDH activity in both serum and liver showed significantly increased in SJ groups compared with CON group. Conclusions : Treatment of SJ extract showed not only reducing concentration of alcohol and acetaldehyde but also increasing activities of ADH and ALDH. These results suggest SJ may influence in alcohol metabolism via control of metabolic enzyme activities and metabolite. Therefore, SJ, herbal mixture, might have a function of preventing hangover after drinking alcohol.

• 한국식생활문화학회지
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• 제5권2호
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• pp.259-263
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• 1990

To assess the effects of water extracts in fruits of Omija (Schizandra chinensis Baillon) on alcohol metabolism, rats were orally administrated with alcohol (25% alcohol, 0.75g/200g B.W., 40% alcohol, 0.8g/200g B.W.). The level of metabolites and enzyme activities of the serum and liver were unchanged by the 25% ethanol or 40% ethanol treatment with acute orally administration. Blood alcohol level was markdely decreased by the treatment with water extracts in fruits of Omija. The serum level of Urea nitrogen, Free fatty acid, GPT and LDH were tended to decreased, level of GOT was unchanged. Contents of hepatic microsomal protein, glycogen, pyruvate in the liver were increased by water extracts in fruits of Omija. In conclusion, the present study clearly demonstrates that water extract in fruits of Omija promotes the overall metabolism and detoxication of alcohol.

• 동아시아식생활학회지
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• 제1권3호
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• pp.299-304
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• 1991

In this study the effects of water extracts of endocarps and seeds of omija(Schizandra chinensis Baillon)on alcohol metabolism in rats were investigated. 25% alcoholic solution(v/v,0.75g/200g B.W.)and 40% alcoholic solution(v/v,0.80g/200g B.W.)were orally administered to rats for 2 hours. The levels of metabolites and enzyme activities both on serum and liver were not changed by acute oral adminiatration of 25% and 40% alcoholic solution. Blood alcohol levels were significantly lowered by treatment of water extracts of endocarps and seeds of omija in rats administered with 25% and 40% alcohol. In 25% alcohol treated group, serum GPT level was decreased but hepatic G-6-P DH and pyruvate levels were increased. In 40% alcohol treated group, water extracts of endocarps and seeds of omija resulted in a significant decreased in serum levels of FFA, GPT but increased in serum glucose level. Hepatic levels of cytosolic protein, glycogen and pyruvate were increased by water extracts of omija parts in 40% alcohol treated group.

• 대한한방내과학회지
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• 제18권1호
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• pp.15-25
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• 1997

Chunggansan was tested for the effects on detoxication mechanism of alcohol. Chunggansan was treated firstly into samples, and then ethanol intoxicated animal models were set with them. The administration of Chunggansan to the rats increased proportionally in alcohol dehydrogenase activities in liver in relation to the level of concentration and days of treatment. Especially, the alcohol dehydrogenase was the most active when the concentration of extract was 200mg/kg and it was 7th day. The enzyme activities of alcohol dehydrogenase and aldehyde dehydrogenase in liver highly increased in Chunggansan pre-medicating group compared to that of ethanol treated group. Also, the blood ethanol concentration in rats was considerably decreased. In conclusion, Chunggansan recovers the damage of liver due to acute alcohol intoxication by the increased enzyme activities of alcohol dehydrogenase and aldehyde dehydrogenase.