• The Journal of Pediatrics of Korean Medicine
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• v.32 no.3
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• pp.1-15
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• 2018

Objectives Alismatis Rhizoma has been known to suppress inflammation and allergic reaction. However, the cellular target of Alismatis Rhizoma and its mechanism of action remain unclear. This study was designed to examine the effect of Alismatis Rhizoma extract (ALC) on the RBL-2H3 mast cells in vitro and on the OVA/alum sensitized mice ex vivo. Methods In the study, RBL-2H3 mast cells were cultured in minimal essential medium (MEM) for 24 hours, and treated separately with cyclosporin A and varying doses of ALC, and then stimulated with Phorbol 12-myristate 13-acetate (PMA) (50 ng/ml) and Ionomycin ($0.5{\mu}M$). The levels of IL-13, IL-4 were measured by ELISA analysis. The mRNA levels of IL-4, IL-5, IL-6, IL-13, GM-CSF, $TNF-{\alpha}$ were analyzed with Real-time PCR. Also, manifestations of MAPKs transcription factors and $NF-{\kappa}B$ p65 translocation were analyzed by western blotting in vitro. Subsequently, for ex vivo experiment, we induced allergic inflammation on Balb/c mice by OVA/alum and administered ALC orally. And we measured serum OVA-specific IgE level and IL-4, IL-13 in the splenocyte culture supernatant by ELISA analysis. Results ALC was shown to suppress mRNA expression of IL-4, IL-5, IL-6, IL-13, GM-CSF, $TNF-{\alpha}$, and to inhibit the IL-13, IL-4 production. Also ALC reduced an activation of mast cells specific signal MAPKs transcription factors and $NF-{\kappa}B$ p65 from the western blot analysis in in vitro experiment. In ex vivo, ALC oral adminstration decreased the level of OVA-specific IgE in serum, and IL-4, IL-13 in the splenocyte culture supernatant. Conclusions ALC is shown to reduce inflammation and allergic response by suppressing Th2 cytokines through the regulation of transcription factors MAPKs and $NF-{\kappa}B$ p65 in mast cells. Administration of ALC suppressed OVA-specific IgE in ovalbumin allergy model through the inhibition of Th2 cytokine. In conclusion, ALC can be considered as an effective treatment for allergic diseases such as atopic dermatitis.

• The Journal of Internal Korean Medicine
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• v.37 no.1
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• pp.135-142
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• 2016

Objectives: To introduce the effect of traditional Korean medicine (TKM) treatment with Injinoryeong-san on alcoholic liver cirrhosis (ALC).Methods: A 37-year-old man with a history of alcohol ingestion for the past five years was diagnosed with ALC based upon his clinical symptoms, sonogram results, and laboratory studies. The patient received TKM treatment with acupuncture, moxibustion, and Injinoryeong-san in parallel to Western medicine for two weeks. The clinical assessment was monitored based upon changes in the Child-Pugh score and ultrasonography, body weight, and abdominal circumference for measuring the amount of ascites.Results: The patient’s clinical symptoms improved with decreases in abdominal circumference and body weight. Ultrasound revealed a regression of the amount of ascites in the abdominal cavity. Laboratory results also improved significantly, and the Child-Pugh score increased from class B to A.Conclusions: This case report showed a significant improvement of ALC with relatively simple treatment for only a short period and therefore supported the potential of TKM treatment in ALC.

• Nutrition Research and Practice
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• v.7 no.2
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• pp.109-114
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• 2013

We compared the preventive capacity of high intakes of vitamin C (VC) and vitamin E (VE) on oxidative stress and liver toxicity in rats fed a low-fat ethanol diet. Thirty-two Wistar rats received the low fat (10% of total calories) Lieber-DeCarli liquid diet as follows: either ethanol alone (Alc group, 36% of total calories) or ethanol in combination with VC (Alc + VC group, 40 mg VC/100 g body weight) or VE (Alc + VE group, 0.8 mg VE/100 g body weight). Control rats were pair-fed a liquid diet with the Alc group. Ethanol administration induced a modest increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), conjugated dienes (CD), and triglycerides but decreased total radical-trapping antioxidant potential (TRAP) in plasma. VE supplementation to alcohol-fed rats restored the plasma levels of AST, CD, and TRAP to control levels. However, VC supplementation did not significantly influence plasma ALT, AST, or CD. In addition, a significant increase in plasma aminothiols such as homocysteine and cysteine was observed in the Alc group, but cysteinylglycine and glutathione (GSH) did not change by ethanol feeding. Supplementing alcohol-fed rats with VC increased plasma GSH and hepatic S-adenosylmethionine, but plasma levels of aminothiols, except GSH, were not influenced by either VC or VE supplementation in ethanol-fed rats. These results indicate that a low-fat ethanol diet induces oxidative stress and consequent liver toxicity similar to a high-fat ethanol diet and that VE supplementation has a protective effect on ethanol-induced oxidative stress and liver toxicity.

• Journal of The Korean Digital Architecture Interior Association
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• v.13 no.4
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• pp.25-32
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• 2013

The green building is one of biggest factors to go the goal of energy saving and environmental conservation, reduction of energy consumption, friendly energy technology, recycling of resource, and environmental pollution reduction technology. The purpose of these green buildings realized by the energy-saving technology such as the exterior materials or curtain wall system. The curtain wall system is a element that come to insulated portions of building envelope that results in heat loss. The purpose of this paper is to carried out mock-up tests for exterior wall used in autoclaved lightweight concrete panels in green building practices. Mock-up test execute a mixed process between standard test procedure and complex test procedure based on AAMA 501(American Society for Testing and Materials) and ASTM 283, ASTM 330(American Society for Testing and Materials). In results, tests meet the requirements that grant values in steps of procedures provided on ASTM and AAMA. ALC panel is suitable for a exterior wall product to be gratified thermal cycling performance and structural capacity, deflection(H/200) and lateral displacement(H/50), for curtain walls.

• Advances in concrete construction
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• v.7 no.2
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• pp.107-115
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• 2019

The possibility of using a combination of mineral admixtures as a replacement for cement may reduce the $CO_2$ emission which causes global warming and climatic changes on the environment. By using the combination of different byproducts from various industries, for replacing cement in concrete leads to saving in energy and natural resources. In this article, an attempt has been made to study the mechanical and water absorption properties of concrete incorporated with combination of Fly ash (FA), Alccofine (ALC) and Collodial Nano Silica (CNS) at 7, 28 and 56 days curing period. Cement has been partially replaced by combination of FA at 25%, ALC at 10% and CNS at 0.5%, 1%, 2% and 3% with water cement ratio of 0.43. The result indicates that the incorporation of combination of FA, ALC and CNS can be very effective in improvement of mechanical and water absorption properties of concrete. The Mix with a combination of 25% FA, 10% ALC and 1% CNS is most effective in improvement of mechanical and water absorption properties as compared with all other mixes.

• 한국ITS학회:학술대회논문집
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• 2008.11a
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• pp.169-172
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• 2008

• Asian-Australasian Journal of Animal Sciences
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• v.5 no.2
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• pp.341-347
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• 1992

Eggs used in this study were obtained from Saudi Arabian Baladi laying hens which were divided into four experimental groups and subjected to the following treatments: Commercial laying ration (17% CP, 3.6% Ca and 0.343%, available P) fed ad libitum as a control (C); Conventional force molting, feed removal for 10 days followed by 18 days full-feed of cracked corn (F); 15 days ad libitum intake of the control ration supplemented, to initiate forced-molt, with 0.35% aluminum as the sulfate (ALS) or the chloride (ALC). The hens were in production for 52 weeks and 17 months of age at the start of the trial and the post-treatment period lasted 36 weeks. During the treatment period F and AL treated groups had similar egg and shell weight, egg surface area, shell thickness and shell weight per unit of surface area but significantly (p<0.05) lower than the control. F had significantly (p<0.05) the highest and the control the lowest Haugh unit values whereas AL fed groups had significantly (p<0.05) lower meat spot incidence compared with the control which tended to have higher value than F group. ALC and F had significantly (p<0.05) the lowest yolk color grade whereas ALC had significantly (p<0.05) lower egg index than ALS and the control. During the post-treatment period the control had significantly (p<0.05) the highest egg index and blood spots incidence and ALS the lowest shell diensity compared with other groups. ALS had significantly (p<0.05) lower shell weight than ALC and the control whereas F and AL treated hens had significantly (p<0.05) the highest Haugh unit values and yolk color grades respectively. F had significantly (p<0.05) lower meat spots incidence than ALC and the control. The same results were observed for ALS compared with the control.

• Journal of Home Health Care Nursing
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• v.23 no.2
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• pp.139-146
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• 2016

Purpose: This research seeks to identify differences between general characteristics, disease-related characteristics, glycated hemoglobin (HbAlc) levels, and aspects of chronic complications of diabetes mellitus in type 2 diabetes. Methods: This research was conducted from the 1st to the 15th of February in 2016, on 263 in patients. Patients' electronic medical records were used to identify their general characteristics, disease-related characteristics, HbAlc, and chronic diabetic complications. Chi-square test, ANOVA, ANCOVA, and the Cochran-Mantel-Haenszel test were used for data analysis. Results: Statistical significance was observed for general characteristics, based on smoking status, such as age, and education level; disease-related characteristics differed according to the duration of diabetes. Smoking status did not differ according to HbAlc level. In term of chronic diabetic complications, statistically significance was observed for diabetic nephropathy, based on smoking status. Conclusion: Patients who had a history of smoking, but were not currently smoking, were likely to display higher HbAlc levels and diabetic nephropathy. Therefore, there is need for regular checkups for diabetic complications among patients with a history of smoking and it is important to emphasize smoking cessation.

• Journal of Institute of Control, Robotics and Systems
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• v.9 no.6
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• pp.448-455
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• 2003

A system design technique of automatic thickness measurement and defect inspection system, which measures the thickness of the ALC(Autoclaved Lightweight Concrete) block and inspects the defect on a realtime basis is proposed. The image processing system was established with a CCD camera, an image grabber, and a personal computer without using assembled measurement equipment. The image obtained by this system was analyzed by a devised algorithm, specially designed for the enhanced measurement accuracy. For the realization of the proposed algorithm, the preprocessing method that can be applied to overcome uneven lighting environment, an enhanced edge decision method using 8 edge-pairs with irregular and rough surface, the unit length decision method in uneven condition with rocking objects, and the curvature calibration method of camera using a constructed grid are developed. The experimental results, show that the required measurement accuracy specification is sufficiently satisfied using our proposed method.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.6
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• pp.494-500
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• 2004

This paper presents a machine vision system, which inspects the measurement of the ALC block on a real-time basis in the production process. The automatic measurement system was established with a CCD camera, an image grabber, and a personal computer without using assembled measurement equipment. Images obtained by this system was processed by an algorithm, specially designed for an enhanced measurement accuracy. For the realization of the proposed algorithm, a preprocessing method that can be applied to overcome uneven lighting environment, boundary decision method, unit length decision method in uneven condition with rocking objects, and a projection of region using pixel summation are developed. From our experimental results, we could find that the required measurement accuracy specification is sufficiently satisfied by using the proposed method.