• Advances in Traditional Medicine
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• 제7권2호
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• pp.133-140
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• 2007

Anti-tumor activity of Euphorbia hirta (50 mg/kg and 100 mg/kg) has been evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice. Intraperitoneal (i.p) administration of Euphorbia hirta was effective in reducing solid tumor mass development induced by EAC cells. It exhibited significant anti-tumor activity in mice, when used at the dose of 100 mg/kg/day i.p., for 14days. The administration of Euphorbia hirta (100 mg/kg/day i.p.) resulted in an increase (P<0.001) of the life span (59.9%) of ascites tumor bearing mice as compared to the control group. After 14 days, on developed tumor masses, Euphorbia hirta administration brought about significant reduction in tumor volume and it reverse the changes in the hematological parameters, responding to tumor inoculation. The results are indicative of the anti-tumor activity of Euphorbia hirta against EAC induced tumor in a dose dependent manner.

• Advances in Traditional Medicine
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• 제7권2호
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• pp.197-204
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• 2007

The present study focused on the establishment of micropropagation protocol for the high value Pluchea (P.) indica (L.) Less., genotype, an important medicinal plant and evaluation of the diuretic activity of the leaf extract of the tissue cultured plant. Leaf explants, nodal segments and shoot tips were cultured in MS medium supplemented with auxin and cytokinin and their combinations. With the objective of inducing callus giving rise to new adult plants, naphthalene acetic acid was found to be most effective for (80%) for callus induction. The methanolic extract of leaves of the micropropagated P. indica was investigated for its diuretic activity in Wistar albino rats. Urinary excretion parameters were studied for evaluation of diuretic activity using Frusemide (20 mg/kg, p.o.) as standard. The extract showed significant diuretic activity at the doses of 100, 200 and 300 mg/kg. p.o. An oral acute toxicity study for the extract was carried out and the $LD_{50}$ value was found to be 2,825 mg/kg body weight.

• 한국식품과학회지
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• 제3권2호
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• pp.110-116
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• 1971

50 및 100 Krad의 감마선을 조사한 미곡의 안전성을 실험할 목적으로 400 마리의 실험백쥐를 사용해서, 이 실험동물의 사료를 방사선 처리 사료구(LLTG, HLTG)와 비 방사선 처리 사료구(NCG, PCG)로 구분하고 7개월간 사육시키면서 이를 사료종류에 따르는 사료 섭취량 증체량, 사료효율 및 성장도를 측정하였다. 그 결과는 각 시험구(NCG, PCG, LLTG, HLTG)간에 있어서, 백쥐의 사료 섭취량, 증체량, 사료 효율 및 성장도의 변화가 통계적으로 유의차가 없었다.

• Advances in Traditional Medicine
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• 제7권4호
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• pp.418-425
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• 2007

The study was to evaluate the antihyperglycemic activity of Biophytum sensitivum (L.) DC in different extracts. Albino Wistar rats with alloxan hydrate induced diabetes were divided into 7 groups of 6 each. Both aqueous and methanolic extract of Biophytum sensitivum were prepared and given individually at different doses to different batches of rats (both normal and diabetic rats) after an overnight fast. Methanolic extract at the dose of 200 mg/kg body weight showed maximum blood glucose lowering effect in diabetic rats. The same dosages did not produce any hypoglycemic activity in normal rats. The antihyperglycemic activity of Biophytum sensitivum was compared with a standard drug Glibenclamide, an oral hypoglycemic agent. The above results suggest that maximum hypoglycemic effect was found only with a dose of up to 200 mg/kg b.w. of methanolic extract which is therefore the optimum dose for hypoglycemia and was used in all the experiments of the present study.

• Advances in Traditional Medicine
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• 제7권3호
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• pp.297-303
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• 2007

The ethyl acetate fraction (EAF) and n-butanol fraction (NBF) of ethanolic extract of Bacopa monnieri aerial parts were screened for hepatoprotective activity and in vivo antioxidant activity on ethanol-induced hepatotoxic rats. Ethyl acetate fraction was found to be more potent even though both the fractions were endowed with significant hepatoprotective activity. EAF and NBF were investigated for hepatoprotective activity in albino rats at 300 mg/kg, p.o. dose and compared with standard drug Silymarin (25 mg/kg, p.o.). Results show that both the fractions were effective in blunting ethanol-induced enhanced activities of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, level of serum bilirubin (both total and direct), liver weight loss and was also effective in reducing ethanol-induced lipid peroxidation both in vitro and in vivo. Furthermore, the fractions could also enhance ethanol-induced suppressed activities of superoxide dismutase, catalase and decreased level of reduced glutathione. Results of hepatocellular damage caused by ethanol and its recovery by EAF and NBF, suggest that they might be considered as a potential source of natural hepatoprotective agents, which could be related to the free radical scavenging properties of saponins present in high concentration in the fractions.

• 대한방사선기술학회지:방사선기술과학
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• 제8권2호
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• pp.65-69
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• 1985

In order to investigate the effects of sulfamonomethoxine (SMM) on thyroid glands in short term administration as medical dose, a total of twenty albino rabbits (mean body weight 1,750g) were selected at random and allotted to control and experimental group. Rabbits in experiment were administered SMM of 50 mg/kg/day for 30 days, and histopathological changes of thyroid glands and the blood levels for T4 and T3 were observed every 5 days. The Results obtained were summarized as follows: 1. The thyroid follicles were decreased or obliterated by highly hypertrophic and hyperplastic epithelial cells and the newly formed small follicles contained scanty colloidal materials. These changes revealed increasing tendency in accordance with the experimental days. 2. The blood levels for T4 and T3 of experimental group manifested significantly decreased values than those of control through the experimental term consistently. Finally, above observations suggest that administration of SMM to animals leads thyroid glands to typical hypofunctional hyperplastic goiter.

• 대한방사선기술학회지:방사선기술과학
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• 제20권1호
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• pp.91-96
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• 1997

Male rats of Albino strain were divided into four groups. The radioprotective effect of treatment with S-2(3-aminopropylamino)ethylphosphorothioic acid(WR-2721) using the dose of 200 mg/kg by intraperitonial injection on rats for 20 min prior to whole body x-ray irradiation (8 Gy) was studied. The harzardous effects of x-ray irradiation were greatly corrected In the treated group. The concentrations of total serum cholesterol, HDL-cholesterol, triglyceride, and phospholipid were greatly affected, showing insignificant changes in the treated group of animals. The drastic hyperglycemic effect of x-ray irradiation in the untreated group decreased to a normal level. These results show the potentiality of WR-2721 as a radioprotective agent.

• 한국식품영양과학회지
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• 제16권1호
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• pp.42-47
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• 1987

The present studies were undertaken to prepare calcium acetate from sea-mussel shell and then, to investigate the calcium absorption ratio for calcium acetate by using young albino rate male. Purities such as chloride, nitrate, nitrate, sulfate, phosphate and heavy metal passed to test as reagent grade and calcium acetate assay was 99.0%. No significant differences in the body weight gain between calcium acetate group, calcium gluconate group and calcium carbonate group were not recognized. Diet consumptions of calcium acetate group was almost similar with calcium gluconate group and calcium carbonate group. It was found that absorption rate of calcium acetate was $57.68{\pm}0.83%,\;58.08{\pm}0.94%$ and was $2.0{\sim}3.0%$ high than calcium gluconate and calcium carbonate group.

• 한국식품과학회지
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• 제10권2호
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• pp.105-108
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• 1978

This experiment was designed to observe some influence on the serum components in rats by feeding basal diet (Protein contents: 20.0%; lipid contents: 3.5%) with soft water (Water, Carbonated cider, Cola and Fanta). Fourty male Albino rats were used as the experimental animals and the subjects were devided into four feeding group and each group was fed on the corresponding diet for six weeks. The contents of protein, lipid and cholesterol were determined in their serum. The obtained results are summarized as follows. 1) The protein contents in the serum was decreased by the feeding of the Carbonated cider, Cola and Fanta compared with Water experimental group. 2) The lipid contents in the serum was similar to each feeding experimental group. 3) The total cholesterol and ester form cholesterol in the serum were decreased by the feeding of the Carbonated cider compared with Water, but were similar to the feeding of the Cola and Fanta.

• 한국응용과학기술학회지
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• 제2권2호
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• pp.55-61
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• 1985

Our country has been produced much amounts of panax ginseng roots which has a stimulating effects on the metabolism of protein, lipid and nucleic acids in the body. And the leaf trunk of panax ginseng were also produced a considerable amounts as the by - products. Therefore, this study was devised to observe the nutritional effect to rats feeding of rice diet supplemented with by - products of panax ginseng, male Albino rats of pure strain weighing 73.8 ${\pm}$ 0.7 g were used as experimental animal to investigate the changes of cholesterol in heart and testis. The animals were divided into sixteen diet group, they were the protein contents of 9%, 12%, 15% and 18% supplemented with 2% panax ginseng roots and its by - products respectively. The group without the supplements were used as the control. The diet group were again divided into 2 groups according to the feeding terms, 4 weeks and 8 weeks. It is concluded that the free from cholesterol and total cholesterol contents in the heart and testis with the supplements of panax ginseng roots and its by - products showed significant difference compared to the control group.