• BMB Reports
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• 제54권10호
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• pp.522-527
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• 2021

Lysine-specific demethylase 1 (LSD1) is an epigenetic regulator that modulates the chromatin status, contributing to gene activation or repression. The post-translational modification of LSD1 is critical for the regulation of many of its biological processes. Phosphorylation of serine 112 of LSD1 by protein kinase C alpha (PKCα) is crucial for regulating inflammation, but its physiological significance is not fully understood. This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1^SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1^SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112A. Similar results were obtained from the mouse embryonic fibroblasts exposed to a PKCα inhibitor, Go6976. Thus, the lack of LSD1 phosphorylation exacerbates CSE/LPS-induced COPD by elevating inflammation and oxidative stress.

• Journal of Information Processing Systems
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• 제17권2호
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• pp.337-351
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• 2021

Automatically recognizing facial expressions in video sequences is a challenging task because there is little direct correlation between facial features and subjective emotions in video. To overcome the problem, a video facial expression recognition method using spatiotemporal recurrent neural network and feature fusion is proposed. Firstly, the video is preprocessed. Then, the double-layer cascade structure is used to detect a face in a video image. In addition, two deep convolutional neural networks are used to extract the time-domain and airspace facial features in the video. The spatial convolutional neural network is used to extract the spatial information features from each frame of the static expression images in the video. The temporal convolutional neural network is used to extract the dynamic information features from the optical flow information from multiple frames of expression images in the video. A multiplication fusion is performed with the spatiotemporal features learned by the two deep convolutional neural networks. Finally, the fused features are input to the support vector machine to realize the facial expression classification task. The experimental results on cNTERFACE, RML, and AFEW6.0 datasets show that the recognition rates obtained by the proposed method are as high as 88.67%, 70.32%, and 63.84%, respectively. Comparative experiments show that the proposed method obtains higher recognition accuracy than other recently reported methods.

• 한국기계가공학회지
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• 제19권10호
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• pp.68-73
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• 2020

The proportion of airline accidents caused by human factors is steadily increasing. The aviation industry has made considerable progress in reducing the accident rate; however, since the early 1980s, the accident rate has remained constant. Due to airspace congestion, the safety margins of these existing safety promotion methods are gradually decreasing; thus, new methods to prevent accidents and quasi-accidents must be devised. Causative factors of aviation accidents include increased air traffic due to increased air demand, increased cumulative working hours due to long-distance flights, and complicated flight environments. Accidents often occur when several small errors accumulate in the normal course of operation, rather than after a single error. Accordingly, in this study, the impacts on air navigation due to human error by aviation maintenance personnel and varying international standards (i.e., KOCA vs. F.A.A vs. EASA) analyzed, and the relationship between human decision-making and behavior was investigated. The resulting safety analysis and alternatives were presented to prevent aviation maintenance accidents and cognitive ergonomics errors.

• 한국항행학회논문지
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• 제24권6호
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• pp.508-514
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• 2020

지형적 경계 (geofence)란 무인기가 침범하거나 또는 벗어나지 말아야 할 영역을 설정해 놓은 가상의 경계로서, 저고도 무인기 교통관리체계(UAS traffic management)의 필수적인 구성요소 중 하나이다. 본 연구에서는 perpendicular 알고리즘을 개선하여 지형적 경계를 단순화하는 기법을 제안한다. 제안된 기법을 실제 건물을 측정하여 얻은 데이터에 적용하여 성능을 평가하였으며, 제안된 방법이 기존 방법에 비해 공간적 낭비를 최소화하면서도 꼭짓점의 개수를 효과적으로 줄임을 확인하였다.

• 항공우주시스템공학회지
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• 제15권4호
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• pp.64-74
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• 2021

Unmanned Aircraft Systems (UAS) are rapidly emerging not only as a key military power, such as surveillance and reconnaissance for military purposes but also as a new air transportation means in the form of Urban Air Mobility (UAM). Currently, airworthiness certification is carried out focused on the verification of technical standards for flight safety suitability of aircraft design in accordance with the Military Aircraft Flight Safety Certification Act and does not employ the model for operational risk assessment for mission areas and airspace. In this study, in order to evaluate the risk of the mission area from the perspective of the UAS operator, a risk assessment simulation has been conducted by applying the Specific Operations Risk Assessment (SORA) model to the operating environment of the Korean military UAS. Also, the validity of the SORA model has been verified through the analysis of simulation results, and a new application plan for airworthiness certification of the military unmanned aerial system has been presented.

• 한국항공운항학회지
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• 제29권4호
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• pp.166-172
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• 2021

Obstacle Limitation Surfaces (OLS) are set to protect a certain amount of airspace to limit objects, such as building, other structures, penetrating OLS for safety and regularity of aircraft operations in the vicinity of aerodromes. However, many civil petitions have been raising for effective utilization of lands and permission of building construction which penetrating OLS. While Republic of Korea are limiting installation of penetrating objects based on the National law of airport facilities, such objects are possibly permitted, only if, the possible risks coming from objects are acceptable or negligible in terms of safety and regularity in aircraft operations through the evaluation process, called as an aeronautical study. However, many countries are currently applying their own criteria, processes resulting in failing secure reliable results in aeronautical study. This research aims to establish the framework on criteria, process, and methodologies how the aeronautical study works including work flows between many stakeholder and responsibilities to be specified in national regulation system.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권9호
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• pp.3152-3171
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• 2022

This work investigates the physical layer secrecy of a multi-antenna hybrid satellite-terrestrial relay networks (HSTRN) with jamming, in which a satellite aims to make communication with a destination user by means of a relay, along with spatially random eavesdroppers. In order to weaken the signals of eavesdroppers, the conventional relay can also generate intentional interference, besides forwarding the received signal. Shadowed-Rician fading is adopted in satellite link, while Rayleigh fading is adopted in terrestrial link, eavesdropper link and jamming link. The analytical and asymptotic formulas for the system secrecy outage probability (SOP) are characterized. Practical insights on the diversity order of the network are revealed according to the asymptotic behavior of SOP at high signal-to-noise ratio (SNR) regime. Then, analysis of the system throughput is examined to assess the secrecy performance. In the end, numerical simulation results are presented to validate the theoretical analysis and point out: (1) The secrecy performance of the considered network is affected by the channel fading scenario, the system configuration; (2) Decrease of the relay coverage airspace can provide better SOP performance; (3) Jamming from the relay can improve secrecy performance without additional network resources.

• 한국항공운항학회지
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• 제31권3호
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• pp.71-78
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• 2023

To minimize the occurrence of aviation accidents in the post-COVID, continuous flight training is crucial. However, the current infrastructure of domestic airports and airfields is insufficient to prepare for and respond to accidents, and there is a need for sufficient facility capacity. Therefore, this study examines the construction of a regional airport to minimize aviation accidents and selects factors necessary for determining the site location. Among the 11 selected factors, six were considered the most important site selection factors, including noise issues, weather conditions, obstacle limitations, environmental issues, airspace conditions, and facility usability. Applying these factors, an analysis was conducted on the Songpo area of Sacheon City, Gyeongsangnam-do. Based on a comprehensive review, it can be concluded that the Songpo area is a suitable choice for a regional airport due to its excellent transportation environment, consideration of noise and environmental issues with the residential population, and other factors. Furthermore, the development of the aviation industry is expected to bring about an increase in tourism and economic benefits, and it is anticipated to make a significant contribution to the domestic aviation industry along with the construction of the currently under-construction Ulleung Airport.

• Steel and Composite Structures
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• 제21권2호
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• pp.249-266
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• 2016

The interest of this article lies in the proposition of using bionic method to develop a new sound absorber and analyze the efficient of this absorber in a ski cabin. Inspired by the coupling absorption structure of the skin and feather of a typical silent flying bird - owl, a bionic coupling multi-layer structure model is developed, which is composed of a micro-silt plate, porous fibrous material and a flexible micro-perforated membrane backed with airspace. The finite element simulation method with ACTRAN is applied to calculate the acoustic performance of the multi-layer absorber, the vibration modal of the ski cabin and the sound pressure level (SPL) near the skier's ears before and after pasting the absorber at the flour carpet and seats in the cabin. As expected, the SPL near the ears was significantly reduced after adding sound-absorbing material. Among them, the model 2 and model 5 showed the best sound absorption efficiency and the SPL almost reduced 5 dB. Moreover, it was most effctive for the SPL reduction with full admittance configuration at both the carpet and the seats, and the carpet contribution seems to be predominant.

• 한국항행학회논문지
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• 제20권4호
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• pp.292-297
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• 2016

항공안전 및 공역활용도를 높임과 동시에 항공기 소음, 조종사 관제사간의 교신, 연료소모 및 배기가스 등을 효과적으로 줄일수 있는 연속강하접근절차는 세계적으로 큰 기대를 모으며 확대 적용되고 있으며 한국에서도 많이 적용되어 환경적, 경제적 차원에서 많은 도움이 될 것으로 예상된다. 그러나 인천국제공항의 표준접근절차들을 면밀히 살펴본 결과 접근절차 중 일부절차의 최초접근지점에서의 고도제한이 다른 절차들에 비해 상대적으로 높아 조종사들이 연속강하접근절차의 목적에 역행하여 불필요한 항력장치를 사용하여야하는 경우가 종종 발생한다. 따라서 일부절차상의 문제점을 검토하여 연속강하접근절차의 취지에 맞도록 절차변경을 함으로써 안전하고 효율적이며 친환경적인 항공운항에 이바지하려한다.