• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.2
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• pp.251-258
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• 2019

Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Inflammation and oxidative stress are associated with COPD. The aim of this study was to evaluate the relationship among inflammation, oxidative stress, and airflow limitation severity in retired miners with COPD. Methods: The levels of serum high-sensitivity C-reactive protein(hsCRP) as a biomarker for inflammation, degree of reactive oxygen metabolites(dROMs) and biological antioxidants potential(BAP) in plasma as biomarkers for oxidative stress were measured in 211 male subjects with COPD. Degree of airflow limitation severity as determined by spirometry was divided into three grades grouped according to the classification of the Global Initiatives for Obstructive Lung Disease(GOLD)(1, mild; 2, moderate; $3{\leq}$, severe or more) using a fixed ratio, post- bronchodilator $FEV_1/FVC$ < 0.7. Results: Mean levels of dROMs significantly increased in relation to airflow limitation severity(GOLD 1, 317.8 U.CARR vs. GOLD 2, 320.3 U.CARR vs. GOLD $3{\leq}$, 350.9 U.CARR, p=0.047) and dROMs levels were correlated with serum hsCRP levels(r=0.514, p<0.001). Mean levels of hsCRP were higher in current smokers(non-smoker, 1.47 mg/L vs. smoker, 2.34 mg/L, p=0.006), and tended to increase with degree of airflow limitation severity(p=0.071). Mean levels of BAP were lower in current smokers(non-smoker, $1873{\mu}mol/L$ vs. smoker, $1754{\mu}mol/L$, p=0.006). Conclusions: These results suggest that inflammation and oxidative stress are related to airflow limitation severity in retired miners with COPD, and there was a correlation between inflammation and oxidative stress.

• Journal of Korean Tunnelling and Underground Space Association
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• v.12 no.1
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• pp.43-49
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• 2010

The escape connecting gallery in a tunnel on a road is one of emergency equipment to ensure safety for passer in the tunnel against the tunnel fire. Government stipulate over 500m tunnel has the cross passage at intervals of less then 250 m. However, this lump estimated interval is generated the concerns of exaggeration and under construction because peculiarity of the tunnel ex. The velocity of the tunnel airflow, an incline, degree of a fire, and innering area are not considered. The study indicate the way to estimate of the cross passage considered an incline and the velocity of the tunnel airflow for efficient application of cross passage on the tunnel design. As a result, in 0.0 m/s and 1.0 m/s of the velocity of the tunnel airflow case, the movement of smoke is influenced by the incline however, in 20 m/s case, it isn't influenced by incline much. According to the velocity of tunnel airflow and the incline, optimum interval of cross passage is not corresponded. Therefore established lump estimate that has 250 m intervals would be changed to estimate of optimum interval of cross passage that considered about the properties of tunnel, the velocity of the tunnel airflow, incline, degree of a fire and innering area of the tunnel.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.6
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• pp.460-464
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• 2000

Extracellular polymeric substances (EPS) are believed to play a role in the binding and formation of microbial flocs. However, the precise role is not well known. Sludge settling characteristics and the carbohydrate to protein ratio in EPS were tested with various airflow rates in this study. Sludge was collected from three modified sequencing batch reactors (SBRs), which were operated at 16$\^{C}$ with an airflow rate of 0.8L/min, 3L/min and 6L/min, respectively. During the operation, the reactor operated at an airflow rate of 0.8L/min showed sludge volume index (SVI) of 80 to 90ml/g and a constant ratio of carbohydrate to protein in the EPS, while a significant increase in the SVI was seen in the other reactors. Sludge bulking increased the amount of carbohydrate in the EPS, while kept protein almost constant in the airflow rate of 3L/min ad 6L/min. Surface charge also increased with increases in the carbohydrate to protein ratio in the EPS, which weakens the attraction between the EPS and multivalent cations. The ratio of carbohydrate to protein in the EPS was tween the EPS and multivalent cations. The ratio of carbohydrate to protein in the EPS was inferred to be essential for bioflocculation.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.31 no.7 s.262
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• pp.611-619
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• 2007

In this study, the droplet size distribution of a slit injector at different surrounding conditions, such as air flow and fuel temperature, were investigated. Phase Doppler anemometry (PDA) was utilized to investigate the initial droplet size distribution and the effect of fuel temperature and air flow on droplet size distribution. The entrained air motion was also evaluated by the temporal velocity profile of droplets. When the air flow velocity increased, the small droplets were more entrained to the upper and central parts of the spray and this tendency was confirmed by plotting the temporal velocity profile of droplets. This entrainment of small droplets at high airflow velocities caused relatively small mean droplet size at upper and central parts of the spray and the large mean droplet size at downstream and edge of the spray, compared to that of low airflow velocities. The total mean droplet size, obtained by averaging the size of all droplets measured at all test locations, decreased when the high airflow velocities were applied. The increased fuel temperature, with an airflow velocity of 10m/s, caused reduced droplet size at all test locations. However, the decreased value of mean droplet size at high fuel temperatures was relatively higher at upper parts of the spray, compared to downstream, as a result of enhanced entrainment of small droplets to upper parts of the spray.

• Wind and Structures
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• v.5 no.2_3_4
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• pp.115-126
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• 2002

A mesoscale meteorological model is applied to simulate turbulent airflow and eddy shedding over the Isle of Arran, SW Scotland, UK. Under conditions of NW flow, the mountain ridge of Kintyre, located upwind of Arran, induces gravity waves that also affect the airflow over the island. The possibility to nest domains allows description of the airflow over Arran with a very high resolution grid, while also including the effects of the surrounding mainland of Scotland, in particular of the mountain ridge of Kintyre. Initialised with a stably stratified NW flow, the mesoscale model simulates quasi-stationary gravity waves over the island induced by Kintyre. Embedded in the larger scale wave trains there is continuous development of small-scale transient eddies, created at the Arran hill tops, that move downstream through the stationary wave field. Although the transient eddies are more frequently simulated on the northern island where the terrain is more pronounced, they are also produced over Tighvein, a hill of 458 m on the southern island where measurements of surface pressure and 2 m meteorological variables have been recorded at intermittent intervals between 1996 and 2000. Comparison between early observations and simulations so far show qualitatively good agreement. Overall the computations demonstrate that turbulent flow can be modelled with a horizontal resolution of 70 m, and describe turbulent eddy structure on wavelength of only a few hundred metres.

• Tuberculosis and Respiratory Diseases
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• v.59 no.1
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• pp.5-13
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• 2005

Chronic obstructive pulmonary disease (COPD) is a chronic progressive disease, characterized by irreversible airflow limitation, with a partially reversible component. The pathological abnormalities of COPD are associated with lung inflammation, imbalances of proteinase and antiproteinase, and oxidative stress, which are induced by noxious particles and gases in susceptible individuals. The physiological changes of COPD are mucus hypersecretion, ciliary dysfunction, airflow limitation, pulmonary hyperinflation, gas exchange abnormalities, pulmonary hypertension, cor pulmonale and systemic effects. The airflow limitation principally results from an increase in the resistance of the small conducting airways and a decrease in pulmonary elastic recoil due to emphysematous lung destruction. This article provides a general overview of the pathophysiology of COPD.

• Research in Community and Public Health Nursing
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• v.29 no.3
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• pp.290-299
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• 2018

Purpose: The purpose of the present study is to examine risk factors for unawareness of obstructive airflow limitation among adults with chronic obstructive pulmonary disease. Methods: Secondary data analysis was performed with the data from the 6th Korea National Health and Nutrition Examination Survey (KNHANES; 2013-2014). The data were analyzed with the IBM SPSS 22.0 version using frequency, percentage, odds ratio, and logistic regression. Results: Ninety-eight percent of subject with a pulmonary function test score of $FEV_1/FVC$<0.7 (N=833) did not recognize that their lung function was impaired. The heavy drink, absence of tuberculosis or asthma diagnosis, and no symptom of expelling phlegm were identified as major risk factors for unawareness of airflow limitation. Conclusion: In order to increase awareness of airflow limitation and to prevent the worsening of the condition, the pulmonary function screening test should be provided to community residents including those who do not show symptoms of respiratory illness.

• Biomedical Science Letters
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• v.20 no.1
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• pp.8-13
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• 2014

Occupational long-term exposure to inorganic dusts may cause a variety of lung diseases such as pneumoconiosis and chronic obstructive pulmonary disease (COPD). Diagnosis of pneumoconiosis and COPD, however, is currently dependent on radiological findings and pulmonary test, which are both late diagnostic tools. Therefore, there is a need to identify novel biomarkers in pneumoconiosis and COPD. Hence, in this current study we investigated the serum concentrations of YKL-40, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-${\alpha}$) as biomarkers for pneumoconiosis and COPD in 161 retired male workers exposed to inorganic dusts. The serum concentration of YKL-40 was significantly increased with age, pneumoconiosis, and airflow limitation. The serum concentration of IL-6 was significantly higher in airflow limitation. These results suggest that serum concentration of YKL-40 is associated with age, pneumoconiosis, and airflow limitation. Also, serum concentration of IL-6 is associated with airflow limitation.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.31 no.5
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• pp.457-466
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• 2007

A numerical and experimental study on the evaluation and the prediction of cleanliness level in the mini-environment system was carried out. Using the concept of local mean air-age (LMA) and effective flow rate, the new direct method for estimating the mini-environment was developed and compared with the previous performance index of airflow pattern characteristics. It was found out that the airflow pattern analysis is a restricted method to estimate the real performance of the mini-environment. The reason is that the airflow pattern cannot predict the effect of the increment of the ventilation rate on the cleanliness level in the mini-environment. While LMA is capable of showing the effects of the contaminant accumulation caused by turbulent intensity, eddy, and the increment of the effective flow rate. This result showed that LMA is more exact and effective performance index than the previous one like the airflow pattern characteristics.

• The korean journal of orthodontics
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• v.22 no.1
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• pp.31-42
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• 1992

This study was designed to analyze normal nasal respiratory resistance in prepubertal children. The subjects consisted of 30 prepubertal children (male: 15, female: 15). The mean age was 11.4 years in male children and 11.5 years in female children. The results were as follows: I. The normal nasal respiratory patency was lower than the normal values from RION corp. 2. The normal nasal respiratory airflow rates showed no sexual differences. And there were no differences between inspiration and expiration. 3. Before and after use of nasal decongestants, there were no significant differences of normal nasal respiratory airflow rates and after the administration of nasal decongestants, nasal respiratory patency manifested lower variability. 4. The normal nasal respiratory resistance without nasal decongestants at 150 Pascal in inspiration was $0.30Pa/cm^3/sec({\pm}0.07)$ and peak nasal inspiratory airflow rate was $1016.83cm^3/sec({\pm}223.89)$. 5. The normal nasal respiratory resistance with nasal decongestant at 150 Pascal in inspiration was $0.25Pa/cm^3/sec({\pm}0.05)$ and peak nasal inspiratory airflow rate was $1148.33cm^3/sec({\pm}234.29)$.