Browse > Article

The Serum Concentrations of YKL-40, IL-6, and TNF-${\alpha}$ in Retired Workers Exposed to Inorganic Dusts  

Lee, Kyung Myung (Forensic DNA Division, National Forensic Service)
Shin, Jae Hoon (Occupational Lung Diseases Institute, KCOMWEL)
Hwang, JooHwan (Occupational Lung Diseases Institute, KCOMWEL)
Lee, Jong Seong (Occupational Lung Diseases Institute, KCOMWEL)
Choi, Byung-Soon (Occupational Lung Diseases Institute, KCOMWEL)
Kim, In Sik (Graduate School of Health Science, Eulji University)
Publication Information
Biomedical Science Letters / v.20, no.1, 2014 , pp. 8-13 More about this Journal
Abstract
Occupational long-term exposure to inorganic dusts may cause a variety of lung diseases such as pneumoconiosis and chronic obstructive pulmonary disease (COPD). Diagnosis of pneumoconiosis and COPD, however, is currently dependent on radiological findings and pulmonary test, which are both late diagnostic tools. Therefore, there is a need to identify novel biomarkers in pneumoconiosis and COPD. Hence, in this current study we investigated the serum concentrations of YKL-40, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-${\alpha}$) as biomarkers for pneumoconiosis and COPD in 161 retired male workers exposed to inorganic dusts. The serum concentration of YKL-40 was significantly increased with age, pneumoconiosis, and airflow limitation. The serum concentration of IL-6 was significantly higher in airflow limitation. These results suggest that serum concentration of YKL-40 is associated with age, pneumoconiosis, and airflow limitation. Also, serum concentration of IL-6 is associated with airflow limitation.
Keywords
YKL-40; IL-6; TNF-${\alpha}$; COPD; Pneumoconiosis;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Vanhee D, Gosset P, Boitelle A, Wallaert B, Tonnel AB. Cytokines and cytokine network in silicosis and coal workers' pneumoconiosis. Eur Respir J. 1995. 8: 834-842.
2 Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, Stockley RA, Sin DD, Rodriguez-Roisin R. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013. 187: 347-365.   DOI   ScienceOn
3 Wouters EF, Groenewegen KH, Dentener MA, Vernooy JH. Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations. Proc Am Thorac Soc. 2007. 4: 626-634.   DOI   ScienceOn
4 Yende S, Waterer GW, Tolley EA, Newman AB, Bauer DC, Taaffe DR, Jensen R, Crapo R, Rubin S, Nevitt M, Simonsick EM, Satterfield S, Harris T, Kritchevsky SB. Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax. 2006. 61: 10-16.
5 Zhai R, Liu G, Ge X, Bao W, Wu C, Yang C, Liang D. Serum levels of tumor necrosis factor-alpha (TNF-$\alpha$), interleukin-6 (IL-6), and their soluble receptors in coal workers pneumoconiosis. Respir Med. 2002. 96: 829-834.   DOI   ScienceOn
6 Razzaque MS, Taguchi T. Pulmonary fibrosis: cellular and molecular events. Pathol Int. 2003. 53: 133-145.   DOI   ScienceOn
7 Letuve S, Kozhich A, Arouche N, Grandsaigne M, Reed J, Dombret MC, Kiener PA, Aubier M, Coyle AJ, Pretolani M. YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages. J Immunol. 2008. 181: 5167-5173.   DOI
8 Nielsen AR, Plomgaard P, Krabbe KS, Johansen JS, Pedersen BK. IL-6, but not TNF-alpha, increases plasma YKL-40 in human subjects. Cytokine. 2011. 55: 152-155.   DOI   ScienceOn
9 Nishikawa KC, Millis AJT. gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Exp Cell Res. 2003. 287: 79-87.   DOI   ScienceOn
10 Renkema GH, Boot RG, Au FL, Donker-Koopman WE, Strijland A, Muijsers AO, Hrebicek M, Aerts JM. Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. Eur J Biochem. 1998. 251: 504-509.   DOI   ScienceOn
11 Reuben JS, Guo RF, Ward PA. Oxygen/Nitrogen radicals-Lung injury and disease: Mediators of lung inflammation-Role of reactive oxygen and nitrogen species (Vallyathan et al., Ed.). 2004. Marcel Deckker, NewYork, pp. 91-110.
12 Sakazaki Y, Hoshino T, Takei S, Sawada M, Oda H, Takenaka S, Imaoka H, Matsunaga K, Ota T, Abe Y, Miki I, Fujimoto K, Kawayama T, Kato S, Aizawa H. Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD. PLoS One. 2011. 6: e24177.   DOI
13 Schins RP, Borm PJ. Mechanisms and mediators in coal dust induced toxicity: a review. Ann Occup Hyg. 1999. 43: 7-33.
14 Vallyathan V, Goins M, Lapp LN, Pack D, Leonard S, Shi X, Castranova V. Changes in bronchoalveolar lavage indices associated with radiographic classification in coal miners. Am J Respir Crit Care Med. 2000. 162: 958-965.   DOI   ScienceOn
15 Lasky JA, Ortiz LA, Brody AR. Lung injury-mechanisms, pathophysiology, and therapy: Mediators and mechanisms in chronic lung injury and fibrosis (Notter, RH., et al. Eds). 2005. Taylor & Francis Group, FL, pp. 175-226.
16 Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA. Role of breast regression protein 39 (BRP-39)/chitinase 3- like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med. 2009. 206: 1149-1166.   DOI   ScienceOn
17 Johansen JS, Bojesen SE, Mylin AK, Frikke-Schmidt R, Price PA, Nordestgaard BG. Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population. J Clin Oncol. 2009. 27: 572-578.   DOI
18 Korthagen NM, van Moorsel CH, Barlo NP, Ruven HJ, Kruit A, Heron M, van den Bosch JM, Grutters JC. Serum and BALF YKL-40 levels are predictors of survival in idiopathic pulmonary fibrosis. Respir Med. 2011. 105: 106-113.   DOI   ScienceOn
19 Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. Role of chitin and chitinase/ chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol. 2011. 73: 479-501.   DOI   ScienceOn
20 Lee JS, Shin JH, Lee JO, Lee WJ, Hwang JH, Kim JH, Choi BS. Blood levels of IL-1$\beta$, IL-8, TNF-$\alpha$, and MCP-1 in pneumoconiosis patients exposed to inorganic dusts. Toxicol Res. 2009. 25: 217-224.   DOI   ScienceOn
21 Lee JS, Shin JH, Lee JO, Lee KM, Kim JH, Choi BS. Serum levels of interleukin-8 and tumor necrosis factor-alpha in coal workers' pneumoconiosis: One-year follow-up study. Safety and health at Work. 2010. 1: 69-79.   DOI   ScienceOn
22 Johansen JS. Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Dan Med Bull. 2006. 53: 172-209.
23 Hashimoto S, Suzuki T, Dong H-Y, Yamazaki N, matsushima K. Serial analysis of gene expression in human monocytes and macrophages. Blood. 1999. 94: 837-844.
24 Holmgaard DB, Mygind LH, Titlestad IL, Madsen H, Pedersen SS, Johansen JS, Pedersen C. Plasma YKL-40 and all-cause mortality in patients with chronic obstructive pulmonary disease. BMC Pulm Med. 2013. 13: 77.   DOI   ScienceOn
25 Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, Cullen M, Grandsaigne M, Dombret MC, Aubier M, Pretolani M, Elias JA. A chitinaselike protein in the lung and circulation of patients with severe asthma. N Engl J Med. 2007. 357: 2016-2027.   DOI   ScienceOn
26 ILO. Guidelines for the use of the ILO international classification of radiographs of pneumoconiosis. 2002. Geneva, International labor Organization.
27 Johansen JS, Jensen BV, Roslind A, Nielsen D, Price PA. Serum YKL-40, a new prognostic biomarker in cancer patients? Rev Cancer Epidemiol Biomarkers Prev. 2006. 15:194-202.   DOI   ScienceOn
28 Ferrari R, Tanni SE, Caram LM, Correa C, Correa CR, Godoy I. Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease. Respir Res. 2013. 20: 14-24.
29 Di Francia M, Barbier D, Mege JL, Orehek J. Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1994. 150: 1453-1455.   DOI   ScienceOn
30 Elias JA, Zitnik RJ. Cytokine-cytokine interactions in the context of cytokine networking. Am J Respir Cell Mol Biol. 1992. 7: 365-367.   DOI   ScienceOn
31 Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax. 2004. 59: 574-580.   DOI   ScienceOn
32 Gosset P, Lassale P, Vanhee D, Wallaert C, Aerts C, Voisin C, Tonne AB. Production of tumor necrosis factor alpha and interleukin-6 by human macrophages exposed in vitro to coal mine dust. Am J Resp Cell Mol Biol. 1991. 5: 431-436.   DOI   ScienceOn
33 Guerra S, Halonen M, Sherrill DL, Venker C, Spangenberg A, Carsin AE, Tarès L, Lavi I, Barreiro E, Martinez-Moratalla J, Urrutia I, Sunyer J, Antó JM, Martinez FD. The relation of circulating YKL-40 to levels and decline of lung function in adult life. Respir Med. 2013. 107: 1923-1930.   DOI   ScienceOn
34 Brusasco V, Crapo R, Viegi G. Series "ATS/ERS Task Force: Standardisation of lung function testing. Eur Respir J. 2005. 26: 319-338.   DOI   ScienceOn
35 Gulumian M, Borm PJ, Vallyathan V, Castranova V, Donaldson K, Nelson G, Murray J. Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: a comprehensive review. J Toxicol Environ Health B Crit Rev. 2006. 9: 357-395.   DOI   ScienceOn
36 Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J. 2009. 33: 1165-1185.   DOI   ScienceOn
37 Brochner CB, Johansen JS, Larsen LA, Bak M, Mikkelsen HB, Byskov AG, Andersen CY, Mollgard K. YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers. J Histochem Cytochem. 2012. 60: 188-204.   DOI
38 Agusti AG, Noguera A, Sauleda J, Sala E, Pons J, Busquets X. Systemic effects of chronic obstructive pulmonary disease. Eur Respir J. 2003. 21: 347-360.   DOI   ScienceOn
39 Kawada M, Seno H, Kanda K, Nakanishi Y, Akitake R, Komekado H, Kawada K, Sakai Y, Mizoguchi E, Chiba T. Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer. Oncogene. 2012. 31: 3111-3123.   DOI   ScienceOn