• Journal of Families and Better Life
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• v.25 no.2 s.86
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• pp.137-153
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• 2007

The purpose of this study was to explore the similarities and differences of elements of successful aging in Western and Korean society using a background of time and dominant values of each society. Content analysis of concepts and components of 'successful aging' was performed based on 12 Korean articles and 23 Western articles. The major findings were: (1) The studies of successful aging accomplished since 2001 and the studies that explore the elements of successful aging perceived by the elderly mentioned diverse elements as essential to successful aging. (2) There were both common and distinct components of successful aging in Western and Korean society. Some of the essential components for successful aging were commonly accepted, but others were varied and unique, reflecting the period of experience and cultural values. These results could be used to better understand unique successful aging of the Korean elderly, as well as to establish a basis of intervention that meets the specific demands of this population.

• Nutrition Research and Practice
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• v.14 no.3
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• pp.188-202
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• 2020

BACKGROUND/OBJECTIVES: Brain aging is a major risk factor for severe neurodegenerative diseases. Conversely, L-histidine and L-carnosine are known to exhibit neuroprotective effects. The aim of this study was to examine the potential for L-histidine, L-carnosine, and their combination to mediate anti-brain aging effects in neuronal cells subjected to D-galactose-induced aging. MATERIALS/METHODS: The neuroprotective potential of L-histidine, L-carnosine, and their combination was examined in a retinoic acid-induced neuronal differentiated SH-SY5Y cell line exposed to D-galactose (200 mM) for 48 h. Neuronal cell proliferation, differentiation, and expression of anti-oxidant enzymes and apoptosis markers were subsequently evaluated. RESULTS: Treatment with L-histidine (1 mM), L-carnosine (10 mM), or both for 48 h efficiently improved the proliferation, neurogenesis, and senescence of D-galactose-treated SH-SY5Y cells. In addition, protein expression levels of both neuronal markers (β tubulin-III and neurofilament heavy protein) and anti-oxidant enzymes, glutathione peroxidase-1 and superoxide dismutase-1 were up-regulated. Conversely, protein expression levels of amyloid β (1-42) and cleaved caspase-3 were down-regulated. Levels of mRNA for the pro-inflammatory cytokines, interleukin (IL)-8, IL-1β, and tumor necrosis factor-α were also down-regulated. CONCLUSIONS: To the best of our knowledge, we provide the first evidence that L-histidine, L-carnosine, and their combination mediate anti-aging effects in a neuronal cell line subjected to D-galactose-induced aging. These results suggest the potential benefits of L-histidine and L-carnosine as anti-brain aging agents and they support further research of these amino acid molecules.

• Nutrition Research and Practice
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• v.14 no.5
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• pp.438-452
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• 2020

BACKGROUND/OBJECTIVES: Brain senescence causes cognitive impairment and neurodegeneration. It has also been demonstrated that curcumin (Cur) and hesperetin (Hes), both antioxidant polyphenolic compounds, mediate anti-aging and neuroprotective effects. Therefore, the objective of this study was to investigate whether Cur, Hes, and/or their combination exert anti-aging effects in D-galactose (Dg)-induced aged neuronal cells and rats. MATERIALS/METHODS: SH-SY5Y cells differentiated in response to retinoic acid were treated with Cur (1 μM), Hes (1 μM), or a combination of both, followed by 300 mM Dg. Neuronal loss was subsequently evaluated by measuring average neurite length and analyzing expression of β-tubulin III, phosphorylated extracellular signal-regulated kinases, and neurofilament heavy polypeptide. Cellular senescence and related proteins, p16 and p21, were also investigated, including their regulation of antioxidant enzymes. In vivo, brain aging was induced by injecting 250 mg/kg body weight (b.w.) Dg. The effects of supplementing this model with 50 mg/kg b.w. Cur, 50 mg/kg b.w. Hes, or a combination of both for 3 months were subsequently evaluated. Brain aging was examined with a step-through passive avoidance test and apoptosis markers were analyzed in brain cortex tissues. RESULTS: Cur, Hes, and their combination improved neuron length and cellular senescence by decreasing the number of β-gal stained cells, down-regulated expression of p16 and p21, and up-regulated expression of antioxidant enzymes, including superoxide dismutase 1, glutathione peroxidase 1, and catalase. Administration of Cur, Hes, or their combination also tended to ameliorate cognitive impairment and suppress apoptosis in the cerebral cortex by down-regulating Bax and poly (ADP-ribose) polymerase expression and increasing Bcl-2 expression. CONCLUSIONS: Cur and Hes appear to attenuate Dg-induced brain aging via regulation of antioxidant enzymes and apoptosis. These results suggest that Cur and Hes may mediate neuroprotective effects in the aging process, and further study of these antioxidant polyphenolic compounds is warranted.

• Journal of Korea Water Resources Association
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• v.53 no.spc1
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• pp.773-784
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• 2020

In this study, legislative and policy issues related to advancing the maintenance system of water resource facilities were presented by investigating and analyzing the degree of aging and management status of water resource facilities. Data from the comprehensive Facility Management System (FMS) operated by the Korea Infrastructure Safety Corporation were collected and used to analyze the aging of water resource facilities. Using safety grade data categorized by facility, type, local area, and grade, the ratio of dangerous facilities and the aging rate were calculated to analyze the status of water resource facilities and guidelines and manuals related to water resource facilities were investigated. Through this, four required actions to address legislative and policy issues were presented: 1) Readjusting the scope of water resource facilities and supplementing guidelines and manuals, 2) Establishing a maintenance system considering changes in disaster conditions, 3) Improving the FMS and activating standard linkage services, and 4) Establishing a facility asset management system.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.9 no.1
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• pp.20-24
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• 2013

Reactor Vessel Internals(RVIs), which are installed within the reactor pressure vessel and support the fuel assembly, take responsibility for safety of reactor core. In operating Nuclear Power Plants(NPPs), the RVIs have been exposed to severe conditions such as neutron irradiation, high temperature, high pressure, and high velocity of coolant flow and have degraded by materials aging with long-term operation. Therefore, the effective aging management plan and the appropriate regulatory requirements are necessary to maintain the integrity of RVIs. The purpose of this paper is to provide a review guide for Periodic Safety Review(PSR) of RVIs in presurized water reactor. The review guide is developed based on the revised review guides and reports established from IAEA and USNRC, and the analysis results of design characteristics, aging mechanisms, and operating experiences of RVIs in domestic and international NPPs. Consequently, the developed review guide for PSR of RVIs is expected to contribute an overall strategy and standard for the PSR of RVIs.

• Journal of Families and Better Life
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• v.23 no.2 s.74
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• pp.1-10
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• 2005

This study was conducted to examine how Korean elderly perceive elements of successful aging, and to explore the meanings of a successful life in the contexts of the life experiences of the Korean elderly. From life-contextual perspectives, this study explored differences in perception on successful aging by gender and by class (economic status). Forty elderly persons aged 65 and over participated in this study. The data on the perceptions of successful aging in their own life contexts were collected through in-depth interviews. The major result of this study indicates that there are differences in the key theme of successful aging by class (economic status), because cultural and economic contexts influenced the elderly persons' perception of successful aging. This study will help researchers, educators, and practitioners to understand successful aging experience as well as establish the concept of successful aging among Koreans.

• Journal of Korean Public Health Nursing
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• v.29 no.3
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• pp.426-440
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• 2015

Purpose: This qualitative study aimed to understand older adults' perspectives on successful aging and develop a model of a successful aging process, within the Korean socio-cultural context. Methods: This study used a Grounded Theory approach. Through theoretical sampling, 14 participants were selected from older adults at a public health center and a volunteer institution in Gyeonggi Province, South Korea. Results: The basic social process identified was "expanding the aging self", which was preceded by three phases, namely, adjusting to the changes, developing the valuable self, and embracing the environment. Participants used 2-3 strategies for successful aging in each phase. For adjusting to the changes, participants used strategies such as "adopting a positive attitude", "accepting the changes", and "being at the center of life". To develop the valuable self, "re-identifying capacities", "having something to do", and "advancing to a healthy lifestyle" were used. Participants embraced their environments with "sharing with others" and "embracing younger generations". The causal condition for expanding the aging self was the changes in participants' physical, mental, or psychosocial situations. Conclusion: These findings suggest a theoretical foundation for the development of potential nursing interventions to promote self-care management and the interpersonal relationship for successful aging among Korean elderly individuals.

• Journal of Families and Better Life
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• v.21 no.2
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• pp.145-154
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• 2003

As the life-expectancy is ever-increasing, and the proportion of the elderly population is growing steadily in every society of the world, it is ever more important to establish what factors allow certain elderly people to age successfully and remain relatively independent while others grow old less successfully and require extensive intervention. However, there is no consensus yet as to what successful aging means. Researchers have defined successful aging in a variety of ways. This study attempted to define the concept of successful aging and to clarify some dimensions of it through literature review. Previous approaches of studying successful aging and related themes were examined. Early perspectives including activity, disengagement, and continuity theories, Selective Optimization with Compensation (SOC) model by Baltes and Baltes, three different conceptions of successful aging, that is, psychological well-being, physical health, and wisdom, and MacArthur research on successful aging have been reviewed for this study. The definition derived from the review is: Keeping up continuous developmental processes to achieve wisdom or ego-integrity, without suffering any major disabilities in either physical or mental functioning, while maintaining psychological well-being and employing SOC strategies, and participating in positive relationships with significant others. The dimensions of successful aging are 1) personal resources, including physical health, cognitive competences, self esteem, and social support 2) adaptation process of SOC, and 3) psychological aspects, including psychological well-being and wisdom.

• Journal of Families and Better Life
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• v.23 no.3 s.75
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• pp.1-16
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• 2005

This study explored the elements, types, and determining factors of successful aging for the Korean elderly. In order to examine the expectations of the Korean elderly, a sample of 377 elderly aged 65 and over living in Seoul and Kyunggi areas was selected and interviewed. The elements of successful aging that the Korean elderly pointed out in the interviews were: 'peaceful and comfortable life', 'self-maintenance,' 'secure social support,' and 'ostentation.' The expected elements of successful aging were further classified into three types of successful aging: 'idealized expectation.' 'self-centered expectation,' 'balanced self-other expectation.' The elderly groups sorted by the types exhibited significant differences in terms of demographic characteristics, self-evaluated economic status, and self-evaluated health status. The variables that affected the expectations were age, level of education, marital status, gender, and self-evaluated health condition. However, further analysis revealed that the factors that affected the expectation for successful aging were different for male and female elderly. The results suggest that the successful aging of Korean elderly should be understood in the context of Korean society and culture. The results could be used to better understand varied and unique life of Korean elderly, as well as in establishing a basis of intervention that meets the specific demands of the Korean elderly.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.518-520
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• 2019

As life expectancy has increased, health status becomes an important factor on life. The Fourth Industrial Revolution has led to the development of a variety of healthcare devices and applications that make it easier and more convenient to manage health. In particular, the area of individual genetic analysis with Single Nucleotide Polymorphism (SNP) has expanded, and genetic information is used to treat and prevent diseases according to individual differences. This study analyzes the genetic information of individuals, that is, SNP variant, and identifies specific chronic disease risk groups such as obesity, diabetes and hypertension. After then we will propose a customized nutrition information service. In addition the service of regional exercise management will be provided, to encourage exercise based on walking courses and sports center information in residential areas. Based on the GPS, it will design the service of exercise management that can encourage exercise by providing walking course and sports center information in the residential area.