• 대한두경부종양학회지
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• 제36권2호
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• pp.21-25
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• 2020

Sebaceous carcinoma is a relatively rare and aggressive malignant tumor. Periocular area (especially eyelid) is the most common lesion to occur, and the most common extraocular lesion is the parotid gland. Because the lesion also mimic other benign inflammatory diseases, this leads to delayed diagnosis or misdiagnosis. Here, we report a 58-year-old male patient who presented with a non-tender painless left parotid mass after wide excision of sebaceous carcinoma in the left eyelid two years ago. When he was diagnosed with sebaceous carcinoma of left eyelid, there was a small left parotid tumor on the computed tomography. But no further examination and treatment were performed. Two years later, physical examination revealed growing parotid tumor and multiple neck nodes on the left side. After radical parotidectomy and neck dissection, histological examination showed a sebaceous carcinoma and neck node metastasis. Considering the aggressiveness of sebaceous carcinoma, further evaluation for parotid glands should be considered when sebaceous carcinoma of the eyelid was discovered. Postoperative chemoradiotherapy was performed for disease control. Follow up after two years, and computed tomography showed no sign of recurrence.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4577-4580
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• 2012

Diagnostic and therapeutic strategies of prostate cancer may largely influenced by patients' age at presentation. This study is aimed to evaluate the characteristics, diagnostic and treatment strategies in prostate cancer patients in our centres. A cross-sectional analytic study of prostate cancer data in two main referral cancer centres, Cipto Mangunkusumo General Hospital and Dharmais National Cancer Centre from 1995-2010, was therefore performed. Patients were divided into 2 sub-populations; below 60 years (younger patients) and 75 years old and above (older patients). PSA levels, diagnostic modalities, Gleason score and therapeutic options were analysed for both and compared using bivariate analysis. 152 patients were <60 years and 210 were ${\geq}75$ years. There was no statistical difference in mean PSA level (797.9ng/mL vs 345.3 ng/mL, respectively; p>0.05) and diagnosis was made by biopsy in majority of patients in both groups (68.2% and 71.6% in younger and older groups respectively). Most presented with an advanced disease stage (65.1% and 66.0%, respectively) and there was no statistically significant difference in mean Gleason scores f (8.1 vs 7.7; p>0.05). Primary androgen deprivation therapy (PADT) was the main treatment for overall patients (48.0% and 50.7%, respectively). Radiotherapy and radical prostatectomy are the main therapeutic modalities for younger patients with local and locally advanced disease (39.6% and 35.4% respectively), while the majority of older patients with the same disease stage were treated with radiotherapy and PADT (45.8% and 39.0% respectively). Differences observed in treatment modalities were statistically significant (p<0.0003). We conclude that there is no difference in disease clinical aggressiveness of the two groups but significant differences were observed in therapeutic strategies utilised with younger and older patients.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3625-3630
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• 2013

Reactive oxygen species (ROS) are known to promote mesothelial carcinogenesis that is closely associated with asbestos fibers and inflammation. Epithelial to mesenchymal cell transition (EMT) is an important process involved in the progression of tumors, providing cancer cells with aggressiveness. The present study was performed to determine if EMT is induced by $H_2O_2$ in human malignant mesothelioma (HMM) cells. Cultured HMM cells were treated with $H_2O_2$, followed by measuring expression levels of EMT-related genes and proteins. Immunohistochemically, TWIST1 expression was confined to sarcomatous cells in HMM tissues, but not in epithelioid cells. Treatment of HMM cells with $H_2O_2$ promoted EMT, as indicated by increased expression levels of vimentin, SLUG and TWIST1, and decreased E-cadherin expression. Expression of stemness genes such as OCT4, SOX2 and NANOG was also significantly increased by treatment of HMM cells with $H_2O_2$. Alteration of these genes was mediated via activation of hypoxia inducible factor 1 alpha (HIF-$1{\alpha}$) and transforming growth factor beta 1 (TGF-${\beta}1$). Considering that treatment with $H_2O_2$ results in excess ROS, the present study suggests that oxidative stress may play a critical role in HMM carcinogenesis by promoting EMT processes and enhancing the expression of stemness genes.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2559-2564
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• 2016

Purpose: To compare Ki-67 index and microvessel density MVD) in multiple myeloma and non-myeloma patients and their correlation with each other and other prognostic markers. Materials and Methods: Forty patients were enrolled in this study between 2011-2013, 30 with multiple myelomas and 10 with non-malignant disease as controls. Proliferative activity was analyzed by Ki-67 and microvessel density (MVC) was assessed by CD34 and compared between two groups. In myeloma patients, correlation between Ki-67, MVD and other prognostic factors was assessed by Pearson correlation coefficient. Results: According to Durie Salmon staging criteria, 13 patients were of stage 1, 5 of stage II and 12 of stage III. Ki-67 expression showed a positive correlation with MVD (r=0.729, p<0.001) and was significantly higher (p<0.0001) in myeloma patients (range 35-80%, mean 60.1 %) as compared to controls (range 8-25%, mean 18.1%). $MVD/mm^2$ was also significantly (p<0.0001) higher in myeloma patients (range $62-237/mm^2$, mean $178.0/mm^2$) than controls (range $5.2-50/mm^2$, mean $18.3/mm^2$). Ki-67 and MVD, both increased progressively with increasing stage of myeloma. Ki-67 showed significant positive correlation with blood urea and lactate dehydrogenase and a significant negative correlation with serum albumin. MVD showed a significant positive correlation with blood urea, lactate dehydrogenase, serum creatinine, ${\beta}2$ microglobulin and skeletal lesions. Conclusions: Ki-67 and MVD are indicators of aggressiveness and poor prognosis having significant correlation with each other and other prognostic markers of multiple myeloma. Routine assessment of these markers may help to identify high risk patients, who may benefit from with more aggressive therapy.

• 환경위생공학
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• 제18권4호
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• pp.52-63
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• 2003

This paper investigated Taxi drivers physical subjective symptoms and what factors were interviewed caused the symptoms. The 600 owning taxi-drivers in Seoul during four months from August 1st, 2003 to November 30th, 2003. 1. The average age of the owning taxi-drivers was generally quite high 54 years old. It was very high index compared with the Todai Health Index(THI) and Cornell Medical Index(CMI) of health check tables. 2. According to the age in THI health check table, the complains of mental subjective symptom by reason of age was high among 31 to 40 years old. People who belonged that age group showed high fabrication(L), digestion(C) and aggressiveness(F). The results showed the complains of mental subjective symptom. All items except tiredness(I), melancholia(N), and hypersensitivity(P) were commonly reported by people in their sixties. On the other hand, melancholia(N) and hypersensitivity(P), people in their forties were investigated highly. Statistically, the items of heartㆍblood stream(C) and digestion(D) systems were similar between the two ages, but anger(Q) was different. (p<0.05) 3. From the complains of mental and physical subjective symptoms about work satisfaction on the THI health check table, all items except eyeㆍskin trouble(B) showed strong dissatisfaction. From the complains of mental and physical subjective symptoms about work satisfaction on the CMI health check table, the items of respiratory system(B), digestion(D), nervous system(G), miscellaneous(K), inadequancy(M), and anger(Q) showed similar results. Otherwise, heartㆍblood stream(C) showed statistically different. 4. From the complains of mental and physical subjective symptoms on salary satisfaction in the THI health check table, in the case of people receiving around 1 million won, the complains of physical symptoms showed high among all items except for the respiratory(A) and digestion(C) systems. The eyeㆍskin trouble(B) item showed statistical similarity. The complains of mental and physical subjective symptoms according to a salary degree on the CMI health check table was completely different from the above results. In people received around 1~1.5million won, all items except anxiety(O) showed high. The hypersensitivity(P) item showed statistically different.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권6호
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• pp.497-501
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• 2010

Primary nasal type natural killer (NK)/T cell (NKTC) lymphoma, a specific form of malignant lymphoma, has a higher geographic incidence in Oriental, Mexican, and South American populations than the Western population. In Koreans, it comprises 9-12% of all cases of non-Hodgkin's lymphoma. This type of lymphoma has also been named as angiocentic lymphoma and lethal midline granuloma because the most common site is the upper airway area and its clinical aggressiveness presents with a necrotic and destructive pattern. NKTC lymphoma can also be detected in different organs (testis, spleen, parotid gland, skin, gastroinstinal tract, central nervous system, lungs, bone marrow, etc.) other than the upper airway including the oral cavity. The lymphoma detected in the oral cavity shows various destructive and inflammatory changes, similar to the signs of inflammation and infection from periodontitis and pulpal disease, making a diagnosis difficult with just the clinical signs. For early detection, clinical, radiological, and pathological examinations are required. This report describes the clinical, radiological and histological characteristics with a case report for the early detection of NKTC lymphoma in the oral cavity.

• Tribology and Lubricants
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• 제13권1호
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• pp.34-41
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• 1997

Frictional behavior of three automotive friction materials (brake pads) containing different amounts of antimony trisulfide ($Sb_2S_3$) and zirconium silicate ($ZRSiO_4$) were investigated using a front brake system. The friction materials were tested on a brake dynamometer (dyno) with gray cast iron rotors. The dynamometer(dyno) test simulated the dragging of a ehicle maintaining 70 km/h and vehicle stops from 100 km/h using 20 different combinations of initial brake temperature (IBT) and input pressure (IP). The results showed a strong influence of the relative amount of $Sb_2S_3$ and $ZrSiO_4$ in friction materials on friction characteristics. Friction stability was improved with the higher concentration of $Sb_2S_3$ in the friction material. Torque variation during drag cycle was increased with an increase of the $ZrSiO_4$ concentration in the friction material. Average friction coefficient and the wear rate of the friction material increased by using more aggressive friction materials containing more $ZrSiO_4$ and less $Sb_2S_3$. Generation of the disk thickness variation (DTV) increased when friction materials with higher concentration of $ZrSiO_4$ were used Careful examination of DTV change showed that aggressiveness of the friction material played an important role in determining torque variation.

• 한국정보통신학회논문지
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• 제9권1호
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• pp.45-57
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• 2005

본 논문에서는 종단간 네트워크 시스템에서 전송 율 기반하의 혼잡 제어를 제안하여 양방향 TCP 연결의 성능을 개선한다. TCP의 패킷과 승인들은 종단 시스템의 공통 버퍼를 공유하기 때문에 소스노드에 패킷과 승인이 집단적으로 도착되는 승인 압축 결과를 초래함으로서 불공성과 처리 율이 감소한다. 양방향 트래픽에 의한 처리율 감소는 매우 중요하다. TCP 비율제어를 이용한 백그라운드 트래픽이 2.5Mbps에서 5.0Mbps로 대역폭이 높아짐으로서 중간 노드의 혼잡이 어느 정도 해소되어 2.5Mbps에서 나타낸 것보다 왕복 지연 시간에 대한 처리 율이 적어짐으로서 연결의 효율성이 증가한다. 또한 백그라운드 트래픽을 7.5Mbps로 설정한 지터 처리 율에 대한 시뮬레이션 결과는 혼잡을 제어함으로서 2.5Mbps나 5.0Mbps에 발생한 지터 처리 율보다 개선됨으로서 제안된 비율 제어 방식의 연결 효율성의 성능 개선이 이루어짐을 알 수 있다.

• 한국전자통신학회논문지
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• 제1권2호
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• pp.102-109
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• 2006

본 논문에서는 전송 율 기반 흐름과 혼잡 제어를 이용한 종단 간 네트워크 시스템을 통한 양방향 TCP 연결의 성능을 개선한다. TCP 패킷과 승인에 의해 버퍼를 공유하는 것은 ACK 압축이라는 결과를 초래하며, ACK 프레임 압축은 소스가 집단적으로 도착할 때 승인하며 불공정성과 처리 율 감소를 초래한다. 양방향 트래픽 때문에 발생한 처리 율 감소는 중요하다. 적절한 윈도의 크기를 가진 대칭적인 연결인 경우에서 연결의 효율은 2.0Mbps, 5.0Mbps, 7.5Mbps 세 가지 레벨의 백그라운드 트래픽에 대해서 약 20%정도의 성능이 개선된다. 반면에 지터의 처리율은 소스 노드와 목적 노드 사이에 왕복 지연 시간이 적기 때문에 약 50%정도 감소되는 것을 알 수 있다. 또한 처리 율 곡선이 2.5Mbps, 5Mbps, 7,5Mbps 백그라운드 트래픽에 대한 TCP 혼잡 회피를 위해 제안된 전송 율 기반 알고리즘에 의해 개선되어짐을 알 수 있다.

• 한국전자통신학회논문지
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• 제2권1호
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• pp.10-18
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• 2007

본 논문에서는 MTS(Multiple Time Scale) 트래픽 제어 프레임워크를 TCP(Transfer Control Protocol) 기반의 신뢰할 수 있는 전송 및 윈도우 기반 혼잡제어로 확대 적용한다. 이 작업은 TCP의 대역폭 소비 반응의 적극성을 LTS 네트워크 상태의 함수 형태, 즉 RTT(Round-Trip Delay Time)가 결정한 피드백 루프의 한계를 넘어서는 정보의 형태를 조정하는 LTS(Large Time Scale) 모듈과 TCP를 연계시키는 방법으로 수행된다. 혼잡 제어 성능 평가 방식은 자기 유사성 네트워크 트래픽의 물리적 모델링으로부터 얻은 시뮬레이션 기반 하에서 결과를 나타낸다. 자기 유사 버스트 환경 하에서 RTT가 450ms일 때 소스 트래픽이 초과되지 않는 경우에 TCP-SSC(Selective Slope Control)의 성능 이득은 각각 ${\alpha}$가 1.05일 45%정도 높아지는 반면에 ${\alpha}$가 1.95일 때는 20%정도의 성능 이득을 얻을 수 있다. 그러므로 비율 기반 피드백 혼잡 제어에 TCP-MTS를 적용함으로서 TCP-SCC 처리 이득의 성능이 약 2배정도의 개선이 이루어짐을 시뮬레이션 결과로부터 알 수 있다.