• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4577-4580
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• 2012

Diagnostic and therapeutic strategies of prostate cancer may largely influenced by patients' age at presentation. This study is aimed to evaluate the characteristics, diagnostic and treatment strategies in prostate cancer patients in our centres. A cross-sectional analytic study of prostate cancer data in two main referral cancer centres, Cipto Mangunkusumo General Hospital and Dharmais National Cancer Centre from 1995-2010, was therefore performed. Patients were divided into 2 sub-populations; below 60 years (younger patients) and 75 years old and above (older patients). PSA levels, diagnostic modalities, Gleason score and therapeutic options were analysed for both and compared using bivariate analysis. 152 patients were <60 years and 210 were ${\geq}75$ years. There was no statistical difference in mean PSA level (797.9ng/mL vs 345.3 ng/mL, respectively; p>0.05) and diagnosis was made by biopsy in majority of patients in both groups (68.2% and 71.6% in younger and older groups respectively). Most presented with an advanced disease stage (65.1% and 66.0%, respectively) and there was no statistically significant difference in mean Gleason scores f (8.1 vs 7.7; p>0.05). Primary androgen deprivation therapy (PADT) was the main treatment for overall patients (48.0% and 50.7%, respectively). Radiotherapy and radical prostatectomy are the main therapeutic modalities for younger patients with local and locally advanced disease (39.6% and 35.4% respectively), while the majority of older patients with the same disease stage were treated with radiotherapy and PADT (45.8% and 39.0% respectively). Differences observed in treatment modalities were statistically significant (p<0.0003). We conclude that there is no difference in disease clinical aggressiveness of the two groups but significant differences were observed in therapeutic strategies utilised with younger and older patients.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3625-3630
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• 2013

Reactive oxygen species (ROS) are known to promote mesothelial carcinogenesis that is closely associated with asbestos fibers and inflammation. Epithelial to mesenchymal cell transition (EMT) is an important process involved in the progression of tumors, providing cancer cells with aggressiveness. The present study was performed to determine if EMT is induced by $H_2O_2$ in human malignant mesothelioma (HMM) cells. Cultured HMM cells were treated with $H_2O_2$, followed by measuring expression levels of EMT-related genes and proteins. Immunohistochemically, TWIST1 expression was confined to sarcomatous cells in HMM tissues, but not in epithelioid cells. Treatment of HMM cells with $H_2O_2$ promoted EMT, as indicated by increased expression levels of vimentin, SLUG and TWIST1, and decreased E-cadherin expression. Expression of stemness genes such as OCT4, SOX2 and NANOG was also significantly increased by treatment of HMM cells with $H_2O_2$. Alteration of these genes was mediated via activation of hypoxia inducible factor 1 alpha (HIF-$1{\alpha}$) and transforming growth factor beta 1 (TGF-${\beta}1$). Considering that treatment with $H_2O_2$ results in excess ROS, the present study suggests that oxidative stress may play a critical role in HMM carcinogenesis by promoting EMT processes and enhancing the expression of stemness genes.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2559-2564
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• 2016

Purpose: To compare Ki-67 index and microvessel density MVD) in multiple myeloma and non-myeloma patients and their correlation with each other and other prognostic markers. Materials and Methods: Forty patients were enrolled in this study between 2011-2013, 30 with multiple myelomas and 10 with non-malignant disease as controls. Proliferative activity was analyzed by Ki-67 and microvessel density (MVC) was assessed by CD34 and compared between two groups. In myeloma patients, correlation between Ki-67, MVD and other prognostic factors was assessed by Pearson correlation coefficient. Results: According to Durie Salmon staging criteria, 13 patients were of stage 1, 5 of stage II and 12 of stage III. Ki-67 expression showed a positive correlation with MVD (r=0.729, p<0.001) and was significantly higher (p<0.0001) in myeloma patients (range 35-80%, mean 60.1 %) as compared to controls (range 8-25%, mean 18.1%). $MVD/mm^2$ was also significantly (p<0.0001) higher in myeloma patients (range $62-237/mm^2$, mean $178.0/mm^2$) than controls (range $5.2-50/mm^2$, mean $18.3/mm^2$). Ki-67 and MVD, both increased progressively with increasing stage of myeloma. Ki-67 showed significant positive correlation with blood urea and lactate dehydrogenase and a significant negative correlation with serum albumin. MVD showed a significant positive correlation with blood urea, lactate dehydrogenase, serum creatinine, ${\beta}2$ microglobulin and skeletal lesions. Conclusions: Ki-67 and MVD are indicators of aggressiveness and poor prognosis having significant correlation with each other and other prognostic markers of multiple myeloma. Routine assessment of these markers may help to identify high risk patients, who may benefit from with more aggressive therapy.

• Journal of environmental and Sanitary engineering
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• v.18 no.4
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• pp.52-63
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• 2003

This paper investigated Taxi drivers physical subjective symptoms and what factors were interviewed caused the symptoms. The 600 owning taxi-drivers in Seoul during four months from August 1st, 2003 to November 30th, 2003. 1. The average age of the owning taxi-drivers was generally quite high 54 years old. It was very high index compared with the Todai Health Index(THI) and Cornell Medical Index(CMI) of health check tables. 2. According to the age in THI health check table, the complains of mental subjective symptom by reason of age was high among 31 to 40 years old. People who belonged that age group showed high fabrication(L), digestion(C) and aggressiveness(F). The results showed the complains of mental subjective symptom. All items except tiredness(I), melancholia(N), and hypersensitivity(P) were commonly reported by people in their sixties. On the other hand, melancholia(N) and hypersensitivity(P), people in their forties were investigated highly. Statistically, the items of heartㆍblood stream(C) and digestion(D) systems were similar between the two ages, but anger(Q) was different. (p<0.05) 3. From the complains of mental and physical subjective symptoms about work satisfaction on the THI health check table, all items except eyeㆍskin trouble(B) showed strong dissatisfaction. From the complains of mental and physical subjective symptoms about work satisfaction on the CMI health check table, the items of respiratory system(B), digestion(D), nervous system(G), miscellaneous(K), inadequancy(M), and anger(Q) showed similar results. Otherwise, heartㆍblood stream(C) showed statistically different. 4. From the complains of mental and physical subjective symptoms on salary satisfaction in the THI health check table, in the case of people receiving around 1 million won, the complains of physical symptoms showed high among all items except for the respiratory(A) and digestion(C) systems. The eyeㆍskin trouble(B) item showed statistical similarity. The complains of mental and physical subjective symptoms according to a salary degree on the CMI health check table was completely different from the above results. In people received around 1~1.5million won, all items except anxiety(O) showed high. The hypersensitivity(P) item showed statistically different.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.36 no.6
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• pp.497-501
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• 2010

Primary nasal type natural killer (NK)/T cell (NKTC) lymphoma, a specific form of malignant lymphoma, has a higher geographic incidence in Oriental, Mexican, and South American populations than the Western population. In Koreans, it comprises 9-12% of all cases of non-Hodgkin's lymphoma. This type of lymphoma has also been named as angiocentic lymphoma and lethal midline granuloma because the most common site is the upper airway area and its clinical aggressiveness presents with a necrotic and destructive pattern. NKTC lymphoma can also be detected in different organs (testis, spleen, parotid gland, skin, gastroinstinal tract, central nervous system, lungs, bone marrow, etc.) other than the upper airway including the oral cavity. The lymphoma detected in the oral cavity shows various destructive and inflammatory changes, similar to the signs of inflammation and infection from periodontitis and pulpal disease, making a diagnosis difficult with just the clinical signs. For early detection, clinical, radiological, and pathological examinations are required. This report describes the clinical, radiological and histological characteristics with a case report for the early detection of NKTC lymphoma in the oral cavity.

• Tribology and Lubricants
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• v.13 no.1
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• pp.34-41
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• 1997

Frictional behavior of three automotive friction materials (brake pads) containing different amounts of antimony trisulfide ($Sb_2S_3$) and zirconium silicate ($ZRSiO_4$) were investigated using a front brake system. The friction materials were tested on a brake dynamometer (dyno) with gray cast iron rotors. The dynamometer(dyno) test simulated the dragging of a ehicle maintaining 70 km/h and vehicle stops from 100 km/h using 20 different combinations of initial brake temperature (IBT) and input pressure (IP). The results showed a strong influence of the relative amount of $Sb_2S_3$ and $ZrSiO_4$ in friction materials on friction characteristics. Friction stability was improved with the higher concentration of $Sb_2S_3$ in the friction material. Torque variation during drag cycle was increased with an increase of the $ZrSiO_4$ concentration in the friction material. Average friction coefficient and the wear rate of the friction material increased by using more aggressive friction materials containing more $ZrSiO_4$ and less $Sb_2S_3$. Generation of the disk thickness variation (DTV) increased when friction materials with higher concentration of $ZrSiO_4$ were used Careful examination of DTV change showed that aggressiveness of the friction material played an important role in determining torque variation.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.1
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• pp.45-57
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• 2005

In this paper, we extend the performance of bidirectional TCP connection over end-to-end network that uses transfer rate-based flow and congestion control. The sharing of a common buffer by TCP packets and acknowledgement has been known to result in an effect called ack compression, where acks of a connection arrive at the source bunched together, resulting in unfairness and degraded throughput. The degradation in throughput due to bidirectional traffic can be significant. Even in the simple case of symmetrical connections with adequate window size, the connection efficiency is improved about 20% for three levels of background traffic 2.5Mbps, 5.0Mbps and 7.5Mbps. Otherwise, the throughput of jitter is reduced about 50% because round trip delay time is smaller between source node and destination node. Also, we show that throughput curve is improved with connection rate algorithm which is proposed for TCP congetion avoidance as a function of aggressiveness threshold for three levels of background traffic 2.5Mbps, 5Mbps and 7.5Mbps. By analyzing the periodic bursty behavior of the source IP queue, we derive estimated for the maximum queue size and arrive at a simple predictor for the degraded throughput, applicable for relatively general situations.

• The Journal of the Korea institute of electronic communication sciences
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• v.1 no.2
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• pp.102-109
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• 2006

In this paper, we improve the performance of bidirectional TCP connection over end-to-end network that uses transfer rate-based flow and congestion control. The sharing of a common buffer by TCP packets and acknowledgement has been known to result in an effect called ack compression, where acks of a connection arrive at the source bunched together, resulting in unfairness and degraded throughput. The degradation in throughput due to bidirectional traffic can be significant. For example, even in the simple case of symmetrical connections with adequate window size, the connection efficiency is improved about 20% for three levels of background traffic 2.5Mbps, 5.0Mbps and 7.5Mbps. Otherwise, the throughput of jitter is reduced about 50% because round trip delay time is smaller between source node and destination node. Also, we show that throughput curve is improved with connection rate algorithm which is proposed for TCP congestion avoidance as a function of aggressiveness threshold for three levels of background traffic 2.5Mbps, 5Mbps and 7.5Mbps.

• The Journal of the Korea institute of electronic communication sciences
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• v.2 no.1
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• pp.10-18
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• 2007

In this paper, we extend the multiple time scale control framework to window-based congestion control, in particular, TCP. This is performed by interfacing TCP with a large time scale control module which adjusts the aggressiveness of bandwidth consumption behavior exhibited by TCP as a function of "large time scale" network state. i.e., conformation that exceeds the horizon of the feedback loop as determined by RTT. Performance evaluation of multiple time scale TCP is facilitated by a simulation bench-mark environment which is based on physical modeling of self-similar traffic. If source traffic is not extended exceeding, when RTT is 450ms, in self similar burst environment, performance gain of TCP-SSC is up to 45% for ${\alpha}$=1.05. However, its is acquired only 20% performance gain for ${\alpha}$=1.95 relatively. Therefore we showed that by TCP-MTS at large time scale into a rate-based feedback congestion control, we are able to improve two times performance significantly.

• Journal of Internet of Things and Convergence
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• v.3 no.2
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• pp.33-39
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• 2017

The purpose of this study is to analyze the characteristics of talents required in electronic companies in the 4th industrial revolution. we conducted a network analysis on the key talent of the companies presented in over 100 job announcements to companies in the electronics industry. The results of the study are as follows. First, electronic companies showed the most favored creative talents, preferring collaborative talent and challenging talent. Second, looking at the core definitions of talent, change, response, problem solving, performance creation, communication, challenge, professionalism, enthusiasm, development, aggressiveness and spontaneity were used. In other words, key keywords emerging from the 4^th industrial revolution were being used continuously. Third, in the Centrality analysis, talented people who emphasize humanity also appeared. Based on the study, it suggested that manpower training of the 4^th Industrial Revolution.