• Korean Journal of Psychosomatic Medicine
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• v.9 no.2
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• pp.194-202
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• 2001

Objectives : Many studies have shown an association between serum lipid concentrations and psychologic characteristics. However, conflicting results have also been reported. This study was designed to find the relationship between serum lipid levels(cholesterol and triglycerides) and psychologic characteristics(impulsiveness, aggressiveness, depressiveness) in adolescents. Methods : Serum cholesterol concentration, serum triglycerides concentration, complete blood count, electrolytes, liver function test, and blood sugar level were measured by overnight fasting blood sampling and urinalysis was also conducted in 407 high school students. Impulsiveness level was measured by Barratt Impulsiveness Scale(BIS). Aggressiveness level was measured by Buss-Durkee Hostility Inventory(BDHI). Depressiveness level was measured by Beck Depression Inventory(BDI). Serum cholesterol was measured by standard enzymatic assay and serum triglycerides was measured by Boehringer Mannheim method. Results : 1) Low cholesterol group(<15 percentile) were found to have significantly higher BIS score than high cholesterol group(>85 percentile) in female. Female low cholesterol group were also found to have significantly higher motor impulsivity score, a subscale of BIS, than high cholesterol group. 2) High triglycerides group(>85 percentile) were found to have significantly higher BDI score than low triglycerides group(<15 percentile) in male and female separately. Especially, male high triglycerides group were also found to have significantly higher BIS and motor impulsivity score than low triglycerides group. Conclusion : These results support the previous hypothesis that serum lipid levels(cholesterol and triglycerides) affect human psychologic characteristics.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.9 no.1
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• pp.3-12
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• 1998

The present study compared the self report and parental report on the behavior problems of adolescents as a way to explore similarities and differences in the ways that adolescents and their parents conceptualize behavior problems of adolescents. Specifically, K-CBCL and YSR data from 3271 adolescents between the ages of 12 and 17 were subjected to factor analyses. Five factors；Depression/Anxiety/Withdrawal, Aggressiveness, Somatic Symptom, Disruptiveness, Attention Getting were obtained from the YSR data with the first factor, Depression/Anxiety/Withdrawal explaining 14.23% of the total variance. K-CBCL data yielded somewhat different factor structure with Aggression/Delinquency as the first factor explaining 14.08% of the total variance, followed by Somatic Symptoms, Social Withdrawal, Disruptiveness, and Depression/Anxiety. Total K-CBCL and YSR score showed a moderate correlation(r=.51), and correlation between pairs of comparable K-CBCL and YSR factor scores were also moderate. Regression analyses of the variables contributing to the total problem score of the K-CBCL and YSR suggested that social competence and academic achievement are two important sources of influence on the evaluation of behavior problems both in self-report and parental report. However, externalizing problems such as aggressiveness/delinquency appeared to be more salient for parents, while adolescents themselves appeared to be more concerned with internalizing problems such as depression/anxiety. Implications of these subtle differences for assessment of adolescent behavior problems were discussed.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2935-2940
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• 2016

Breast cancer is the most frequent type of cancer diagnosed among women worldwide and also in Thailand. Estrogen and estrogen receptors exert important roles in its genesis and progression. Several cytokines have been reported to be involved in the microenvironment that promotes distant metastasis via modulation of immune and inflammatory responses to tumor cells. Estrogen receptor genetic polymorphisms and several cytokines have been reported to be associated with breast cancer susceptibility and aggressiveness. To investigate roles of genetic polymorphisms in estrogen receptor alpha (ESR1) and interleukin 6 (IL6), breast cancer patients and control subjects were recruited from the Division of Head, Neck and Breast Surgery (Siriraj Hospital, Bangkok, Thailand). Polymorphisms in ESR1 (rs3798577) and IL6 (rs1800795 and rs1800797) were evaluated by real-time PCR in 391 breast cancer patients and 79 healthy controls. Associations between genetic polymorphisms and clinicopathological data were determined. There was no association between genetic polymorphisms and breast cancer susceptibility. However the ESR1 rs3798577 CT genotype was associated with presence of lymphovascular invasion (OR=2.07, 95%CI 1.20-3.56, p=0.009) when compared to the TT genotype. IL6 rs1800795 CC genotype was associated with presence of extranodal extension (OR= 2.30, 95%CI 1.23-4.31, p=0.009) when compared to the GG genotype. Survival analysis showed that IL6 rs1800797 AG or AA genotypes were associated with lower disease-free survival. These findings indicate that polymorphisms in ESR1 and IL6 contribute to aggressiveness of breast cancer and may be used to identify high risk patients.

• Journal of KIISE:Computer Systems and Theory
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• v.36 no.1
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• pp.26-32
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• 2009

The multi-level storage architecture has been widely adopted in servers and data centers. However, while prefetching has been shown as a crucial technique to exploit sequentiality in accesses common for such systems and hide the increasing relative cost of disk I/O, existing multi-level storage studies have focused mostly on cache replacement strategies. In this paper, we show that prefetching algorithms designed for single-level systems may have their limitations magnified when applied to multi-level systems. Overly conservative prefetching will not be able to effectively use the lower-level cache space, while overly aggressive prefetching will be compounded across levels and generate large amounts of wasted prefetch. We design and implement a hierarchy-aware lower-level prefetching strategy called PMS(Prefetching strategy for Multi-level Storage system) that applicable to any upper level prefetching algorithms. PMS does not require any application hints, a priori knowledge from the application or modification to the va interface. Instead, it monitors the upper-level access patterns as well as the lower-level cache status, and dynamically adjusts the aggressiveness of the lower-level prefetching activities. We evaluated the PMS through extensive simulation studies using a verified multi-level storage simulator, an accurate disk simulator, and access traces with different access patterns. Our results indicate that PMS dynamically controls aggressiveness of lower-level prefetching in reaction to multiple system and workload parameters, improving the overall system performance in all 32 test cases. Working with four well-known existing prefetching algorithms adopted in real systems, PMS obtains an improvement of up to 35% for the average request response time, with an average improvement of 16.56% over all cases.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2000.06a
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• pp.180-186
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• 2000

Friction materials with four different sizes of zircon - l${\mu}{\textrm}{m}$, 6${\mu}{\textrm}{m}$, 75${\mu}{\textrm}{m}$, 140${\mu}{\textrm}{m}$- were investigated to evaluate the size effects of abrasive particles used in the automotive brake pads on brake performance. Although the brake pads with the largest size of zircon showed a good frictional stability and low wear, rotors were severely abraded due to the aggressiveness of coarse Bircon. As the siBe of zircon decreased. friction force and the amplitude of friction coefficient increased. Considering the above results, abrasive materials were thought to destroy transfer film and the extent of the destruction depends on the size of zircon. The small size zircon was not effective in developing a transfer layer on the rotor surface while minimizing the damage on the counter surface.

• The Korean Journal of Cytopathology
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• v.11 no.2
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• pp.75-81
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• 2000

Cathepsin D is a protease which is known to facilitate invasion and metastasis of breast carcinoma. Overexpression of cathepsin D is associated with poor clinical outcome and biologic aggressiveness of the breast cancer. We underwent immunocytochemical assay(ICA) for cathepsin D in fine needle aspiration cytology(FNAC) specimens from the breast carcinoma and benign breast diseases. In FNAC specimens cathepsin D was expressed in 21(42.9%) out of 49 cases of invasive ductal carcinoma, whereas negative result was observed in all 15 cases of benign breast diseases including 7 fibroadenomas, 6 fibrocystic diseases, and 2 benign ductal hyperplasias. Among the 11 FNAC specimens from ductal carcinoma in situ(DCIS), cathepsin D was expressed in 3 cases(27.3%). In FNAC specimens immunocytochemistry for cathepsin D showed positive result in 24 out of 60 carcinomas(sensitivity, 40%) and negative result in 15 out of all 15 benign breast diseases(specificity, 100%). No significant correlation was noted between cathepsin D expression in FNAC specimen and clinicohistological characteristics of the breast carcinoma, such as hormone receptors and cell differentiation. In conclusion, ICA of cathepsin D in FNAC specimens thought to be a good adjunct to differentiate malignancy from benign breast diseases.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2207-2212
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• 2013

Cancer prevention is rapidly emerging as a major strategy to reduce cancer mortality. In the field of breast cancer, significant strides have recently been made in the understanding of underlying preventive mechanisms. Currently, three major strategies have been linked to an increase in breast cancer risk: obesity, lack of physical exercise, and high levels of saturated dietary fat. As a result, prevention strategies for breast cancer are usually centered on these lifestyle factors. Unfortunately, there remains controversy regarding epidemiological studies that seek to determine the benefit of these lifestyle changes. We have identified crucial mechanisms that may help clarify these conflicting studies. For example, recent reports with olive oil have demonstrated that it may influence crucial transcription factors and reduce breast tumor aggressiveness by targeting HER2. Similarly, physical exercise reduces sex hormone levels, which may help protect against breast cancer. Obesity promotes tumor cell growth and cell survival through upregulation of leptin and insulin-like growth factors. This review seeks to discuss these underlying mechanisms, and more behind the three major prevention strategies, as a means of understanding how breast cancer can be prevented.

• Journal of the Korean Home Economics Association
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• v.37 no.10
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• pp.123-133
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• 1999

The purpose of the study was to develop the parenting style scale which is reflecting cultural background of Korean parent's parenting for their children. The instalment was designed based on the literature reviews and on the Baumrind's parenting style. A total of three hundred and sixty two mothers whose children from first and second grade in elementary school completed the Questionnaires. The questionnaires consisted with the items addressing different types of parenting style which include love and care, encouragement of independence, enjoyment in parenting, communication, control, control of aggressiveness, strategies of control , request of maturity. Factor of analysis was applied to examine validity of Korean parenting style scale. Based on the factor analysis, 33 items selected for final questionnaire and two factors discovered. The first factor which named 'warmth'included 20 items such as love and care toward their children, communication, enjoyment in parenting, encouragement toward independency. The second factor which named'control'included 13 items such as control of children's behavior and discipline of children. Warmth factor accounted for 46% of variance and control factor accounted for 18% of variance. Internal consistency was also checked. Although warmth and control factor represented a moderate internal consistency, control factor showed lower correlations then warmth factor. The reliability estimates (Cronbach alpha) were. 87 and 71 for warmth and control factor respectively. Korean parenting style scale can be used to address the appropriateness of Baumrind's theoretical assumptions in parenting style as well as to examine parenting style for Korean population. However, this instalment was developed with Korean mothers only. Further analysis need to be addressed with fathers.

• Journal of Families and Better Life
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• v.27 no.4
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• pp.161-175
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• 2009

This study examines how parenting behavior and abuse experience in childhood and temperaments affect problem behavior by sex as it relates to undergraduates. The subject of this research is 220 undergraduates (males, 94; females, 126) attending universities located in Gyeonggi-do. Data were collected through the use of questionnaires during class. According to the results, when parenting behavior experienced in childhood is negative, abuse experience is more frequent, the emotional characteristics of the subject's temperaments are negative, activity is higher, sociability is lower, and problem behaviors such as social withdrawal, hyperactivity, aggressiveness, and obsession are more prevalent. Moreover, for male students, the chief factors explaining their problem behavior are their father's lack of supervision, physical violence, their mother's excessive interference and irrational parenting behavior, and the temperaments of excessive worrying, high activity, and low sociability. In the cases of female students, the primary variables affecting their problem behavior are negative emotional temperaments, low sociability temperaments, their father's low affection, excessive interference, too rational explanation, and their mother's inconsistent parenting behavior.

• Research in Community and Public Health Nursing
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• v.10 no.1
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• pp.252-261
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• 1999

The purpose of this study was to investigate the daily stress and stress coping behavior of elementary school children. The subjects for this study were 372 children fourth, fifth and sixth graders from an elementary school in Pusan. We adopted Won - Joo Chung's research instrument (1997) for measuring stress and coping behavior in this study. Statistical techniques such as frequency, percentage, mean, standard deviation, order, and Pearson correlation were used to examine the research questions of this study. The results of this study were as follows: 1. The most common instance of stress to be experienced by all children was the stress from school life, followed by social pressures, individual pressures and family environment. 2. A positive revaluation was the most commonly used stress-coping behavior, followed by behavioral mood conversion, spiritual support, problem-facing behavior, an information search for problem-solving, physical separation for emotional relaxation, avoidance, emotional aggressiveness and emotional expression. 3. Stress-coping behavior had a positive and significant correlation with the stress score(r = .4391, p= .000). In conclusion, the stress from school life was the most common experienced by all children. While independent effort in problem-solving was unsufficient, stress coping behavior had positive results. Therefore, this study verified the necessity of minimizing the stress children experience from school life and of helping them attain desirable stress-coping behaviors.