• Archives of Pharmacal Research
• /
• v.29 no.5
• /
• pp.348-353
• /
• 2006

In this study, a 40% ethanol extract of Chinese yam flour (Dioscoreae rhizoma), containing $177{\pm}58{\mu}g/mL$ of dioscin, was tested in order to evaluate its pharmacological effects on the gastrointestinal tracts of Sprague-Dawley rats. Via the ingestion of the Chinese yam extract, the secretion of gastric acid was suppressed in the rats, and gastrointestinal motility increased by as much as 10%. The fecal quantity of rats fed on the Chinese yam extract also increased, by more than 40% as compared with that of the controls. The Chinese yam extract was found not to affect the growth of normal intestinal bacteria. However, a great deal of lactose-fermenting bacteria was observed in the fecal samples of rats fed for 6 weeks on 2% Chinese yam extract. This finding would appear to suggest that Chinese yam extract not only induces an improvement in digestive capability, but also affects the conversion of some intestinal flora to helpful bacteria. Our serochemical analyses indicated that serum glucose, neutral lipid, and total cholesterol levels were reduced to some degree by long-term feeding on Chinese yam extract. This finding bolsters the notion that Chinese yam extract may prove helpful as a digestion-aiding agent for patients suffering from hyperglycemia or hyperlipidemia.

• The Journal of Information Systems
• /
• v.19 no.2
• /
• pp.37-71
• /
• 2010

This article identifies factors affecting successful ERP systems by focusing on the stages after stabilizing ERP systems and overcoming temporary performance dip by introduction of ERP systems, and suggests change management tactics to control those identified factors. We can not expect that every users are familiar with the usage of an ERP system even after they are informed about the expected advantage of the newly implemented ERP system and trained intensively for changed business process and system usage while implementing a new ERP system. Moreover, even after more than six months usage of the system, the users may still have some trouble due to the reason why they have insufficient information about the expected advantage of the system (recognition gap) and insufficient knowledge about the changed usage of the system (knowledge gap). Hence, this article diagnoses by conducting a case study that those recognition and knowledge gap would have a severe bad influence upon the users' trust and satisfaction on ERP systems. This article suggests an appropriate change management tactics to overcome those recognition and knowledge gap by considering the relationship with the efforts for change management before, during, and after the introduction of ERP systems and performing an in-depth analysis on the users' dissatisfaction and request for update during the stages after the stabilization of the ERP systems. This article also shows a corroborative evidence that these efforts of change management consequently contributes to the solution of users' distrust and dissatisfaction. In sum, this article identifies the factors influencing badly on the magnitude and seriousness of knowledge and recognition gap, and suggests a conceptual research model which says that the satisfaction of ERP users could be uplifted by the solution of their knowledge and recognition gap if we keep making efforts on appropriate change management considering those identified factors during the stages after the stabilization of an ERP system.

• Journal of Acupuncture Research
• /
• v.22 no.2
• /
• pp.171-180
• /
• 2005

Background & Objective : Angiogenesis consists of the proliferation, migration, and differentiation of endothelial cells, and angiogenic factors and matrix protein interactions modulate this process. The aim of this study was to determine whether Puerariae radix could induce angiogenic activity in human umbilical vein endothelial cells (HUVECs). Methods: The angiogenic activity of Puerariae radix were evaluated by using BrdU assay, chemotactic migration assay, tube formation assay, measurement of bFGF in HUVECs, and Matrigel plug assay in mice. Results : Puerariae radix significantly increased HUVECs proliferation in a dose-dependent manner. In addition, Puerariae radix increased migration and tube-like formation in HUVECs. Interestingly,the expression of basic fibroblast growth factor (bFGF), an angiogenesis-stimulating growth factor, was dose-dependently increased by Puerariae radix. The angiogenic activity of Puerariae radix was confirmed using an in vivo Matrigel angiogenesis model, showing promotion of blood vessel formation. Conclusion : Puerariae radix significantly induces angiogenesis in vitro and in vivo. These results suggest that Puerariae radix is a potent angiogenic agent, and a promising drug, for the induction of neovascularization.

• Journal of Korean Academy of Nursing
• /
• v.8 no.1
• /
• pp.43-84
• /
• 1978

미국에 이민 온 한 한국가정을(정씨 가족) 대상으로 세 번의 면담 (interview) 및 art session을 통해서 이 핵가족 및 확대가족을 다음과 같은 방법으로 분석하여 가족의 유형(family Pattern)과 관계된 이론적 모델(Theocratical model)을 理이해하고 변화되고 있는 Health Program에 있어 간호원이 "변화인자(change agent)"로써의 역활을 재발견하고자한다. 이러한 방법은 가족 및 간호과학에 새로운 접근법이며 간호의 영역이 얼마만큼 확대될 수 있는가를 나타내고 있다. (1) Toman의 Family Cnstellation 이론과 일치되는 점 및 일치되지 않는 점 (2) 한국인 핵가족에서 관찰된 비언어적 의사소통(non-verbal communication)및 이것과 Scheflen의 이론과의 관계 (3) family Theory Bowen의 "differentiation of self"와 "family projection Process"이론에 의한 분석 (4) 핵가족에서 관찰된 상호작용 유형(interactional pattern)을 분석 (5) Art Session을 통해서 관찰된 사항 및 Critique 결과적으로 이 핵가족은 사회적 가치관이 변화된데서 오는 갈등에 직면하고 있다. 우리 나라의 확대가족에서 강조된 경치관은 가족을 하나의 전체로써 보는 "우리 (we-ness)"였는데 이것은 일상사용하고 있는 언어에도 영향을 미치고 있는 것을 볼 수 있어 즉, "내 동생 (my sister)"이라고 하는 대신 "우리 동생 (our sister)"이라고 하는데 여기에서 언어가 뜻하는 의미와는 거리가 먼 것을 알 수 있다. 정씨 부부는 미국적 정치관을 인식해서 그들의 상호작용 유형을 긍정적이고 개방적인 토의방법으로(positive open-discuses) 접근해야 한다. 이 핵가족의 부부는 둘 다 유교사상이 강조된 가정에서 자라나, 이 부부가 결혼한지 오 년이나 되었으나 언어적 의사소통이 (verbal communication)굉장히 제한된 것을 쓸 수 있다. 인간의 경험들은 인간이 접하고 있는 사회와의 상호작용에 의해서 결정된다. 사회가 배화함에 따라서 가족도 변화할 것이다. "변화는 언제나 사회에서 부터 가족으로 온다. 이 변화는 절대 작은 단위에서 큰 단위로 오는 것이 아니다.…그러나 가족구조는(family structure) 환경이 변화함에 따라서 적응해야 한다."라고 Minuchin이 지적한 것 같이 정씨 부부가 직면하고 있는 여러 가지 갈등은 이 핵가족이 그들의 가치관 및 상호 작용유형을 변형(repattering) 시키므로써, 복잡하고 다양한 미국사회에서 성장할 수 있는 좋은 기회를 만들어 주고 있다. 세 번의 면담시간은 각 30분이었으나 Volume 생략한 것을 부기하여 둔다.

• Journal of Digital Convergence
• /
• v.11 no.1
• /
• pp.423-430
• /
• 2013

The development of information technology introduced digital contents and Social Network Services(SNS), and allowed the virtual transaction and communication between users called "the experience knowledge" advanced from "the objective knowledge." This paper will analyze interactive storytelling system creating different types of stories on narrative genre about family history, personal history and so on. Through analysis on narrative interviews, direct observations, documentations and visual records, contents about CEO story, corporate story, family story and especially family history will be categorized into sampleDB and informationDB. Accumulated contents will allow the user to increase the value and usage of the contents through interactive storytelling system by restructuring the contents on family history. This research has developed writing tool data model using different digital contents such as texts, images and pictures to encourage open communications between first generations and third generations in Korea. Furthermore, researched about connected system on interactive storytelling creation device using various genre of family story that has been data based.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.16 no.6
• /
• pp.244-257
• /
• 2017

Traffic congestion occurs from drivers' human factors such as driver reaction time, reckless lane change, and inexperienced driving. When Automated Vehicles are introduced, human factors are excluded, resulting in increased average vehicle speed, stabilizing traffic flow, and increasing road capacity. This study analyzed traffic flow changes through traffic volume-speed-density plots, and increased road capacity due to Automated Vehicles. As a result of the analysis, when rate of automated vehicles gests higher, the traffic flow became stable. Additionally, it was analyzed that when all vehicles were automated, the road capacity increased by about 120 %. It is expected that there will be a positive expectation in terms of traffic congestion and traffic demand management due to the introduction of Automated Vehicles.

• Journal of Ginseng Research
• /
• v.35 no.2
• /
• pp.138-148
• /
• 2011

Exponential rise in the use of mobile communication devices has generated health concerns due to radiofrequency (RF) exposure due to its close proximity to the head. Calcium binding proteins like calretinin regulate the levels of calcium ($Ca^{2+}$) which plays an important role in biological systems. Ginseng is known for maintaining equilibrium in the human body and may play a beneficial radioprotectant role against electromagnetic field (EMF) exposure. In the present study, we evaluated the radioprotective effects of red ginseng (RG) extract in a mouse model. Calretinin (CR) expression was measured using a free-floating immunohistochemical method in the hippocampus of mice after 835 MHz EMF exposure for 5 h/d for 5 d at specific absorption rate=1.6 W/kg for the different experimental groups. The control animals were treated with NaCl while the experimental animals received 10 mg/kg ginseng, or 30 mg/kg; EMF exposed mice were also treated with NaCl, 10 mg/kg ginseng (E10), or 30 mg/kg (E30). Decreases in CR immunoreactivity (IR) along with loss of CA1 and CA3 interneurons and infragranular cells were observed in the ENaCl group while such losses were not observed in the E10 and E30 groups. CR IR significantly increased in the RG-treated group compared to control and EMF-exposed groups treated with NaCl. The study demonstrates that RG extract can serve as a radioprotective agent that maintains $Ca^{2+}$ homeostasis and prevents neuronal loss in the brain hippocampal region caused by RF exposure.

• YAKHAK HOEJI
• /
• v.49 no.2
• /
• pp.140-146
• /
• 2005

Candida albicans, a polymorphic fungus, causes systemic and local infections. Recent reports show that the fungus is a main etiological agent for the arthritis. For trea tment, antifungal drugs and/or rheumatoid drugs are used, but resistance and side effects limit application of the drugs. In search of new sources for treatment of the fungal arthritis, we choose Egb 761 (extract of Ginkgo leaves 761), one of the most popular over-the-counter herbal medicines. The Egb 761 contains two major ingredients such as terpene and flavonoid. In the present study, we examined if the terpene portion of Egb 761 had anti-inflammatory activity against C.albicans-caused arthritis. The terpene was extracted with combination of methanol and water from the Egb 761, followed by gel-permeation chromatography. Presence of terpene was determined by the Salkowski colorimetric method and HPLC analysis. For an animal model of inflammation induction, mice were given an emulsion form of C.albicans cell wall mixed with Complete Freund's Adjuvant (CFA) by footpad-injection. Results showed that intraperitoneal administration of the water-soluble portion that contained terpene and flavonoid reduced the inflammation. Whereas the terpene had anti-inflammatory activity, flavonoid portion had no such activity, For determination of possible mechanism of the activity, the terpene seemed to be suppression of nitric oxide (NO) production from LPS-treated macrophages. Taken together the Ginkgo terpene may have anti-inflammatory effect against C.albicans-caused arthritis, possibly by blocking NO production.

• Journal of Life Science
• /
• v.21 no.12
• /
• pp.1721-1725
• /
• 2011

Mast cells are major effector cells associated with allergic responses. They are activated through the release of histamine, arachidonic acid, and proinflammatory cytokines. We investigated the effect of nodakenin, derived from the roots of Angelica gigas Nakai, on mast cell degranulation and on an allergic response in an animal model. We also investigated the effect of nodakenin on expression of multiple cytokines. Nodakenin suppressed the release of ${\beta}$-hexosaminidase, a marker of degranulation, as well as the expression of interleukin IL-4 and TNF-${\alpha}$ mRNA. Nodakenin inhibited the passive cutaneous anaphylaxis (PCA) reaction in ICR mice in a dose-dependent manner. These results suggest that nodakenin can inhibit mast cell degranulation through the inhibition of IL-4 and TNF-${\alpha}$ mRNA expression, and that nodakenin may potentially serve as an anti-allergic agent.

• Molecules and Cells
• /
• v.38 no.10
• /
• pp.851-858
• /
• 2015

Disturbed blood flow with low-oscillatory shear stress (OSS) is a predominant atherogenic factor leading to dysfunctional endothelial cells (ECs). Recently, it was found that disturbed flow can directly induce endoplasmic reticulum (ER) stress in ECs, thereby playing a critical role in the development and progression of atherosclerosis. Ursodeoxycholic acid (UDCA), a naturally occurring bile acid, has long been used to treat chronic cholestatic liver disease and is known to alleviate endoplasmic reticulum (ER) stress at the cellular level. However, its role in atherosclerosis remains unexplored. In this study, we demonstrated the anti-atherogenic activity of UDCA via inhibition of disturbed flow-induced ER stress in atherosclerosis. UDCA effectively reduced ER stress, resulting in a reduction in expression of X-box binding protein-1 (XBP-1) and CEBP-homologous protein (CHOP) in ECs. UDCA also inhibits the disturbed flow-induced inflammatory responses such as increases in adhesion molecules, monocyte adhesion to ECs, and apoptosis of ECs. In a mouse model of disturbed flow-induced atherosclerosis, UDCA inhibits atheromatous plaque formation through the alleviation of ER stress and a decrease in adhesion molecules. Taken together, our results revealed that UDCA exerts anti-atherogenic activity in disturbed flow-induced atherosclerosis by inhibiting ER stress and the inflammatory response. This study suggests that UDCA may be a therapeutic agent for prevention or treatment of atherosclerosis.