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http://dx.doi.org/10.5352/JLS.2011.21.12.1721

Anti-Allergic Effects of Nodakenin in IgE/Ag-Induced Type I Hypersensitivity  

Kim, Yong-Jae (Division of Biological Science and Technology, College of Science and Technology, Yonsei University)
Park, Sae-Jin (Division of Biological Science and Technology, College of Science and Technology, Yonsei University)
Kim, Tack-Joong (Division of Biological Science and Technology, College of Science and Technology, Yonsei University)
Publication Information
Journal of Life Science / v.21, no.12, 2011 , pp. 1721-1725 More about this Journal
Abstract
Mast cells are major effector cells associated with allergic responses. They are activated through the release of histamine, arachidonic acid, and proinflammatory cytokines. We investigated the effect of nodakenin, derived from the roots of Angelica gigas Nakai, on mast cell degranulation and on an allergic response in an animal model. We also investigated the effect of nodakenin on expression of multiple cytokines. Nodakenin suppressed the release of ${\beta}$-hexosaminidase, a marker of degranulation, as well as the expression of interleukin IL-4 and TNF-${\alpha}$ mRNA. Nodakenin inhibited the passive cutaneous anaphylaxis (PCA) reaction in ICR mice in a dose-dependent manner. These results suggest that nodakenin can inhibit mast cell degranulation through the inhibition of IL-4 and TNF-${\alpha}$ mRNA expression, and that nodakenin may potentially serve as an anti-allergic agent.
Keywords
Mast cells; allergic response; nodakenin; passive cutaneous anaphylaxis;
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