• BMB Reports
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• v.52 no.1
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• pp.47-55
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• 2019

Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related pathologies in a mouse model, suggesting a direct link between SCs, longevity, and ARDs. Therefore, senotherapeutics, medicines targeting SCs, might be an emerging strategy for the extension of health span, and prevention or treatment of ARDs. Senotherapeutics are classified as senolytics which kills SCs selectively; senomorphics which modulate functions and morphology of SCs to those of young cells, or delays the progression of young cells to SCs in tissues; and immune-system mediators of the clearance of SCs. Some senolytics and senomorphics have been proven to markedly prevent or treat ARDs in animal models. This review will present the current status of the development of senotherapeutics, in relation to aging itself and ARDs. Finally, future directions and opportunities for senotherapeutics use will discussed. This knowledge will provide information that can be used to develop novel senotherapeutics for health span and ARDs.

• Korean Journal of Community Nutrition
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• v.26 no.5
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• pp.363-381
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• 2021

Objectives: This study examined the Korean elderly's dietary intake status, subjective health-related perception and chronic disease prevalence among age groups. Associations of dietary quality with subjective health-related perception and chronic diseases were also examined. Methods: Based on data from the 7th National Health and Nutrition Examination Survey, a total of 3,231 elderly were selected and categorized into 4 age groups of '65 ~ 69', '70 ~ 74', '75 ~ 79' and 'over 80'. Nutrient intakes, proportions of those with insufficient nutrient intakes, Korean Healthy Eating Index (KHEI), some subjective health-related perceptions and prevalence of major chronic diseases were compared according to the age groups. Differences in the subjective health-related perceptions and odds ratios of the chronic diseases according to the quartile levels of KHEI within the same age group were analyzed. Results: With the increase of age, several nutrient intakes (P < 0.001) and KHEI scores significantly decreased (P < 0.01). In women, activity restriction increased (P < 0.05), and EQ-5D score decreased with age (P < 0.001). Prevalence of hypertension (P < 0.0001), hypercholesterolemia (P < 0.05) and anemia (P < 0.01) significantly increased, while hypertriglyceridemia (P < 0.01) significantly decreased only in men. Obesity prevalence decreased, while underweight prevalence increased (P < 0.05). Subjective health status, EQ-5D score and PHQ-9 score significantly improved as KHEI score increased in certain age groups of women (P < 0.05). Odds ratio of hypercholesterolemia significantly increased with the increase of KHEI score in 65 ~ 69-year-old women. However, hypertension and anemia significantly decreased with the increase of KHEI score in 75 ~ 79-year-old women (P < 0.05). Conclusions: The study findings suggest that nutrition management and policy for the Korean elderly need to apply a segmented age standard that can better reflect their dynamic characteristics.

• Journal of Korean Biological Nursing Science
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• v.18 no.1
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• pp.60-67
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• 2016

Purpose: The purpose of this study was to investigate the disease-related knowledge, stress and quality of life for the patients with varicose veins. Methods: Data were collected via questionnaire from 138 patients with varicose veins in C University Hospital in Korea from November in Korea 2012 to August 2013. Results: Knowledge of the symptoms and diagnosis was the lowest. The scores from patients with disease-related knowledge tended to be low for both subjects over the age of 60 and subjects with low education (less than high school). The score for stress over complications was the highest. The level of stress is higher for women, subjects without spouses, subjects with higher severity of disease and patients who had been taking hormones in the past or are still taking hormones. The disease-related quality of life tended to be lower for women and subjects without spouses. 21% of the variance in quality of life was explained by the level of disease-related stress, disease severity and knowledge. Conclusion: Education and the management of nurses to improve disease-related knowledge for patients with varicose veins is highly recommended. Intervention, by reducing stress, is necessary to improve the quality of life for women, subjects without spouses, and subjects with higher severity of the disease.

• BMB Reports
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• v.56 no.9
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• pp.520-525
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• 2023

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline. Several recent studies demonstrated that impaired adult neurogenesis could contribute to AD-related cognitive impairment. Adult subventricular zone (SVZ) neurogenesis, which occurs in the lateral ventricles, plays a crucial role in structural plasticity and neural circuit maintenance. Alterations in adult SVZ neurogenesis are early events in AD, and impaired adult neurogenesis is influenced by the accumulation of intracellular Aβ. Although Aβ-overexpressing transgenic 5XFAD mice are an AD animal model well representative of Aβ-related pathologies in the brain, the characterization of altered adult SVZ neurogenesis following AD progression in 5XFAD mice has not been thoroughly examined. Therefore, we validated the characterization of adult SVZ neurogenesis changes with AD progression in 2-, 4-, 8-, and 11-monthold male 5XFAD mice. We first investigated the Aβ accumulation in the SVZ using the 4G8 antibody. We observed intracellular Aβ accumulation in the SVZ of 2-month-old 5XFAD mice. In addition, 5XFAD mice exhibited significantly increased Aβ deposition in the SVZ with age. Next, we performed a histological analysis to investigate changes in various phases of adult neurogenesis, such as quiescence, proliferation, and differentiation, in SVZ. Compared to age-matched wild-type (WT) mice, quiescent neural stem cells were reduced in 5XFAD mice from 2-11 months of age. Moreover, proliferative neural stem cells were decreased in 5XFAD mice from 2 to 8 months of age. Furthermore, differentiations of neuroblasts were diminished in 5XFAD mice from 2-11 months of age. Intriguingly, we found that adult SVZ neurogenesis was reduced with aging in healthy mice. Taken together, our results revealed that impairment of adult SVZ neurogenesis appears with aging or AD progression.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.17 no.2
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• pp.93-97
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• 2014

Purpose: Gastroesophageal reflux in infant is a physiological process. However, surgery is performed in high risk infants with severe gastroesophageal reflux disease (GERD) when medical management fails. This study focuses on efficacy and safety of Nissen fundoplication for GERD in infants under age 12 months. Methods: This study was a retrospective case analysis of 11 neonates and infants under 12 months of age who underwent Nissen fundoplication following a failure of medical treatment between June 2010 and June 2013 at Pusan National University Children's Hospital. The records were reviewed to determine the effect of fundoplication on symptoms and post-operative complications. Results: A total of 11 infants consist of four males and seven females. Mean birth weight was $2,305.5{\pm}558.6g$ (1,390-3,130 g). They had some underlying disease, which are not related with GERD such as congenital heart disease (54.5%), prematurity (45.5%), neurologic disease (18.2%), respiratory disease (18.2%), and other gastrointestinal disease. Mean body weight at surgery was $3,803.6{\pm}1,864.9g$ (1,938.7-5,668.5 g). Mean age at operation was $99.9{\pm}107.6days$ (17-276 days). Duration from operation to full enteral feeding was 10.9 days. Symptoms related GERD disappeared in all patients including one who got reoperation. One infant died of congenital heart disease unrelated to surgery. There were no complications related to fundoplication. Conclusion: Fundoplication is effective and safe treatment in the neonates and infants with severe GERD.

• Osteoporosis and Sarcopenia
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• v.3 no.3
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• pp.117-122
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• 2017

Sarcopenia is the degenerative loss of muscle mass and function with aging. Recently sarcopenia was recognized as a clinical disease by the International Classification of Disease, 10th revision, Clinical Modification. An imbalance between protein synthesis and degradation causes a gradual loss of muscle mass, resulting in a decline of muscle function as a progress of sarcopenia. Many mechanisms involved in the onset of sarcopenia include age-related factors as well as activity-, disease-, and nutrition-related factors. The stage of sarcopenia reflecting the severity of conditions assists clinical management of sarcopenia. It is important that systemic descriptions of the disease conditions include age, sex, and other environmental risk factors as well as levels of physical function. To develop a new therapeutic intervention needed is the detailed understanding of molecular and cellular mechanisms by which apoptosis, autophagy, atrophy, and hypertrophy occur in the muscle stem cells, myotubes, and/or neuromuscular junction. The new strategy to managing sarcopenia will be signal-modulating small molecules, natural compounds, repurposing of old drugs, and muscle-specific microRNAs.

• The Korean Journal of Health Service Management
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• v.14 no.1
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• pp.161-176
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• 2020

Objectives: The purpose of this study was to investigate the effects of health status and health behaviors on health-related quality of life in Korean adults. Methods: The study was based on the 2017 National Health and Nutrition Survey. Of the total 8,127 people, 5,780 (71.1%) participated: 2,553 (44.2%) were male and 3,227 (55.8%) were female. The variables for this study were demographic factors, disease count, subjective health status, health behaviors, and health-related quality of life (measured by the EQ-5D Index). Results: After analysis, the statistically significant factors associated with health-related quality of life were gender, age, income, education, daytime health status, number of comorbidities (6 or more) and stress. Conclusions: Seven demographic factors have been identified as having a significant impact on health-related quality of life, categorized by model, gender, age and income. Therefore, it is possible that quality of life can be improved through proactive management and by improving subjective health status and health behaviors while in considering of demographic and sociological factors by providing indicators as per gender and age.

• Korean Journal of Adult Nursing
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• v.24 no.4
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• pp.339-347
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• 2012

Purpose: The purpose of this study was to identify the influencing factors on health related quality of life in middle age. Methods: Data were as collected by self-reported questionnaires from 303 middle age adults. Data analysis was done using SPSS/WIN 17.0 program for descriptive statistics, Pearson correlation coefficients and stepwise multiple regression. Results: The average score of health related quality of life was $79.50{\pm}0.40$. Health related quality of life was statistically significant differences according to gender, education, economic status and disease. The health related quality of life was significantly correlated with fatigue, depression, stress, social support, somatic attribution, psychological attribution, normalizing attribution and type D personality. The major factors that affect health related quality of life in middle age were stress, fatigue, type D personality and normalizing attribution, which explained 51.3% of health related quality of life. Conclusion: The findings can provide the basis for the development of nursing interventions to improve health related quality of life. Furthermore, more studies are needed to explore variables that influence on the health related quality of life in middle age.

• Research in Community and Public Health Nursing
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• v.12 no.2
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• pp.513-531
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• 2001

Television news programs are becoming significant source of health information. This study aims at investigating the current state of health coverage of the prime time news program in Korea. Data were collected from KBS 9 0'clock news in the period of thirteen months. from December 1. 1998. to November 1. 1999. The data were analyzed using content analysis method. and the reliability degree was 99.7% according to the Holsti's inter-coder reliability test. The current research classified 489 health related news items into 49 sub-categories and five health categories through content analysis. Some of the basic results of this study are as follows. 1. The frequency according to health category, health maintenance promotion(57.3%) topped followed by disease prevention(23.2%), disease treatment(14.9%), life ethics(4.0%), and growth development(0.6%). 2. According to human developmental age. for the most part(80.1 %) is applicable to the entire range of human developmental age. 3. Health maintennance promotion category take top of health category by the rate of 57.3% and contain 20 sub-categories. 4. News items in the life ethics category, which had six sub-categories. occupied only four percent of the total health related news. News in the growth development category included two sub categories and occupied 0.6% of the total news items. 5. In disease prevention and disease treatment category, infectious disease(33.2%) showed the highest percentage according to the WHO's international disease classification system. Disease prevention occupied 23.2% and contained eleven sub-categories while disease treatment occupied 14.9% and included ten sub-categories. Television news coverage on health showed a wide variety of selection in terms that they are reporting various issues. This study, however, found that some news items were confusing and failing in presenting scientific evidences. It is suggested that the television coverage on health could be beneficial to most of viewers in receiving important health information and guidelines, only if they are utilizing their own sound discretion in consuming those news.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.15 no.4
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• pp.418-427
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• 2008

Purpose: This study was done to investigate the relationship of knowledge related to disease, awareness and practice of inhaler use in asthmatic patients. Method: The participants in this research were 124 patients with asthma who used inhalers, and were admitted to hospital or attended outpatient asthmatic clinics. Data were collected using a self-administered questionnaire which consisted of demographic characteristics, illness-related characteristics, and tools to measure knowledge of disease, awareness and practice related to inhaler use. Results: Knowledge related to disease was statistically significantly different for age (p<.001) and marital status (p=.017). The mean score for awareness of inhaler use was significantly higher than the mean score for practice in inhaler use (p<.001). There were significant correlations between awareness and practice of inhaler use (p<.001), knowledge related to disease and awareness of inhaler use (p<.001), and knowledge related to disease and practice of inhaler use (p<.001). Conclusion: Results indicate that due to the variation in degree of illness in patients with asthma, there is a need to develop appropriate education programs for people of different ages and also precise ${\alpha}$ II content for use of inhalers method of checking capacity washing and storing as well as directions about different kinds of the inhalers.