• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.383-386
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• 2012

Background: Cancer survivors are at increased risk of second cancers. Lymphoproliferative disorders (LPD) are common neoplasms that are primary or subsequent cancers in cases of multiple primary cancer. We here analyzed metachronous or synchronous LPD in multiple primary cancers. Methods: Between 2001 and 2010, LPD were assessed retrospectively in 242 multiple primary cancers patients. Results: Forty nine (20.2%) patients with LPD were detected. Six patients had two LPD where one patient had three LPD. The median age of patients was 60.5 years (range: 28-81). LPD were diagnosed in 29 patients as primary cancer, in 23 patients as second cancer, and in three patients as third cancer in multiple primary cancers. Primary tumor median age was 56 (range: 20-79). Diffuse large B cell lymphoma (n=16), breast cancer (n=9), and lung cancer (n=6) were detected as subsequent cancers. Alklylating agents were used in 19 patients (43.2%) and 20 patients (45.5%) had received radiotherapy for primary cancer treatment. The median follow-up was 70 months (range: 7-284). Second malignancies were detected after a median of 51 months (range: 7-278), and third malignancies with a median of 18 months (range: 6-72). Conclusions: In this study, although breast and lung cancer were the most frequent detected solid cancers in LPD survivors, diffuse large B cell lymphoma was the most frequent detected LPD in multiple primary cancers.

• 복식문화연구
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• 제23권4호
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• pp.726-736
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• 2015

The apparel industry has recently been recognizing the important target market of middle-aged women. The aim of this study was to examine the anthropometric characteristics of US women of 46 to 65 years of age and identify distinctive body shape characteristics of US middle-aged women. A total of 1915 middle-aged women whose ages ranged from 46 to 65 were selected from the SizeUSA database. The age range was divided into two groups: 46-55 and 56-65. Twenty-four body measurements important for apparel development were chosen. Four factors-Girth Factor, Height Factor, Hip Drop Factor, and Bust Drop Factor-accounted for the US middle-aged women's body measurements. The body shapes were classified into four body shapes, which were Y-Shape in the overweight range, S-Shape in the overweight range, H-Shape in the overweight range, and the A-Shape in obese range. H-Shape, which was the least-defined waist in relation to the bust and hips with a short height, existed more in older middle-aged women than in younger middle-aged women. Y-Shape, S-Shape, and A-Shape existed more in the group of younger middle-aged women than in the group of older middle-aged women. In addition, compared with the younger middle-aged women, older middle-aged women had narrower shoulders, a larger waist, thinner legs, and a longer distance between side neck to bust point. The findings from the current study may be applied in the apparel industry for developing clothing sizing systems for US middle-aged women.

• 한국지형학회지
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• 제27권3호
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• pp.41-51
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• 2020

This study tried to reveal incision rate distribution of streams on the northern part of the Sobaek Mountain Range with OSL age dating and geomorphic analysis, and factors influencing on the distribution were also discussed. With results from the previous studies, a total of 10 sites from 7 streams in the study area showed the rates ranging from 0.220 m/ka to 0.297 m/ka. Namhan-gang and Geum-cheon indicated the highest and lowest rates, respectively. Both sides in the northern section in the study area showed similar rates, while the western side in the middle section and the eastern side in the southern section showed higher rates than the other sides. Higher rates were also found from the eastern and northern sides where the Range runs N-S and E-W directions, respectively. Certain relationships with altitude and distance from the divide can be recognized from the rates and may be attributed to active incision with altitude and location of the uplift axis near the present divide. The rates on granite and sedimentary rock were higher than those on metamorphic rock, indicating that bedrock type is one of the important factors influencing on stream incision. Tectonic movement seemed to play some roles in the rates, because areas with lineaments showed lower rates. This study suggests that incision rate distribution of streams on the northern part of the Sobaek Mountain Range reflects various local geomorphic and geologic conditions.

• 한국의류학회지
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• 제30권6호
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• pp.892-903
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• 2006

This study was to carry out interview and survey of currently marketed foundation garment, focusing on manufacturers, on the basis of data of Year 2004 SIZE KOREA in 2004, to re-establish suitable age range and standard size, to simplify size interval scale and size system and to revise the standard for consumers' easy understanding and availability; The findings of this study are as follows. 1. Considering the age, in which a bra is worn, has reduced socially, the applicable age range was expanded into $8{\sim}80$ years old, which was divided into for junior and for adult. 2. For bra size, the standard title changed into the foundation garments size standard, in which girdle and bodysuit were included. 3. Basic physical parts for establishing for bra size are underbust and bust. Interval scale of under bust and bust was 5cm and 2.5cm, respectively. And basic physical parts are waist and hip girth for girdle, and underbust, bust, and hip girth for bodysuit. 4. For bra size, underbust girth was applied together with bra-cup size without 'cm' unit. For bra-cup size, difference between underbust and bust was represented as English alphabet. In other words, AAA means that difference between under bust and bust is 5cm. AA, A, B, C and D means that the difference are 7.5cm, 10cm, 12.5cm, 15cm and 17.5cm. 5. For girdle size, waist girth was applied together with hip girth without 'cm' unit. And for bodysuit size, underbust girth was applied together with cup size like bra size, and English alphabet represented hip girth range.

• Journal of Oral Medicine and Pain
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• 제40권3호
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• pp.96-101
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• 2015

Purpose: Thermal sensory test as an essential part of quantitative sensory testing (QST) has been recognized as a useful tool in the evaluation of the trigeminal nerve function. Normative data in the orofacial region have been reported but the data on differences in the test site, sex and ethnicity are still insufficient. Thus, this study aimed to investigate the normal range of orofacial thermal QST data in the healthy Korean women, and assess sex difference of thermal perception in the orofacial regions. Methods: Thermal QST was conducted on 20 healthy women participants (mean age, 26.4 years; range, 21 to 34 years). The thermal thresholds (cold detection threshold, CDT; warm detection threshold, WDT; cold pain threshold, CPT; and heat pain threshold, HPT) were measured bilaterally at the 5 trigeminal sites (the forehead, cheek, mentum, lower lip and tongue tip). The normative thermal thresholds of women in the orofacial region were evaluated using one-way ANOVA and compared with the previously reported data from age- and site-matched 30 healthy men (mean age, 26.1 years; range, 23 to 32 years) using two-way ANOVA. One experienced operator performed the tests of both sexes and all tests were done in the same condition except the time variability. Results: Women showed significant site differences for the CDT (p<0.001), WDT (p<0.001), and HPT (p=0.047) in the orofacial region. The CDT (p<0.001) and the CPT (p=0.007) presented significant sex difference unlike the WDT and the HPT. Conclusions: The thermal sensory evaluation in the orofacial region should be considered in the context of site and sex and the normative data in this study could be useful for assessment of the sensory abnormalities in the clinical setting.

• 복식문화연구
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• 제8권4호
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• pp.549-561
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• 2000

The purpose of this study was to survey and analyze the age classification of women customers as a target market and sizes on a label that were actually produced by each brand in Korean national brands ; they were classified into size for bodice and bottom, and compared with the distribution of national data of women's body measurement. They were analyzed and classified by brand groups of 'miss', 'missy', 'Mrs.'and 'madam', The results were ; 1) It was found that recent products for ready-made for women's clothes tend to be designed with target to the measured ages classified by the range of five or ten years. The main practice was that for 'miss'brand group the age range was of five years, and for 'missy'brand group, ten years. And for 'Mrs'and 'madam'brand groups, it was of 15 or 20 years. So that, it is necessary to design their clothes based on their features of body considering the intervals of age. 2) 'Mrs'and 'madam'groups were most remarkable for their distribution into a vast range of sizes for three control dimensions and waist girth size when compared to 'miss'and 'missy'groups. The distribution of brand size had no relation with that of body measurement, and in particular, none was produced for short height size between 145 and 150 ㎝. For tall height size between 175 and 180 ㎝, many brand sizes were distributed while body measurement was few. It means that distribution of brand size was different from real distribution of body measurement was few. It means that distribution of brand size was different from real distribution of body measurement as a result that the larger the bust girth in such cases over 160 ㎝, the larger the size of hip girth. Even as for the height 155 and 160 ㎝ in which body measurement is concentrated, there were many problems because while sizes of 'large'bust girth and 'small'hip girth had a large distribution, their clothes were not produced.

• 대한한의학회지
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• 제26권1호
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• pp.85-92
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• 2005

Objective: A number of candidate genes have been in implicated in the pathogenesis of obesity in humans. Tumor necrosis factor-alpha $(TNF-{\alpha})$ is expressed primarily in adipocytes, and elevated levels of this cytokine have been linked to obesity and insulin resistance. Recently, the A allele of a polymorphism at position 308 in the promoter region of $TNF-{\alpha}$ (G-308A) has been shown to increase transcription of the gene in adipocytes. Therefore, we designed this study to test whether obese and non-obese subjects differ in $TNF-{\alpha}$ genotype distribution, and how the genotypes affect anthropometric parameters, including degrees of body mass index (BMI). Methods : The study included 153 obese but otherwise healthy women ($BMI{\geq}kg/m^2$, range 25-54.7, age range 15-40 years) and 82 non-obese healthy women ($BMI, age range 15-40 years). Total fat mass and percent body fat were determined by dual-energy X-ray absorptiometry. Genomic DNA was extracted and used for Ncol restriction fragment length polymorphism (RFLP) based genotyping of $TNF-{\alpha}$. Results: No differences were observed for allelic and genotype frequencies between the obese ($BMI{\geq}25$) and non-obese women. Also, no association of TNF-(l polymorphism was observed with body mass index (BMI) for genotype in obese women. In addition, age, pertent body fat, BMI, and cholesterol levels did not differ by $TNF-{\alpha}$ genotype. However, waist-to­hip ratio (WHR) was significantly lower in subjects with $TNF-{\alpha}$ GA or AA genotype (0.94 0.07 vs. 0.920.03, P<0.005). Conclusion: These results suggest that $TNF-{\alpha}$ promoter polymorphism at position-308 is not a significant factor for BMI, but affects the WHR in obese healthy women from Koreans.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.76-84
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• 2022

Purpose: Whole-exome sequencing (WES) has been a useful tool for novel gene discovery of various disease categories, further increasing the diagnostic yield. This study aimed to investigate the clinical utility of WES prospectively in undiagnosed genetic diseases. Materials and Methods: WES tests were performed on 110 patients (age range, 0-28 years) with suspected rare genetic diseases. WES tests were performed at a single reference laboratory and the variants reported were reviewed by clinical geneticists, pediatricians, neurologists, and laboratory physicians. Results: The patients' symptoms varied with abnormalities in the head or neck, including facial dysmorphism, being the most common, identified in 85.4% of patients, followed by abnormalities in the nervous system (83.6%). The average number of systems manifesting phenotypic abnormalities per patient was 3.9±1.7. The age at presentation was 2.1±2.7 years old (range, 0-15 years), and the age at WES testing was 6.7±5.3 years (range, 0-28 years). In total, WES test reported 100 pathogenic/likely pathogenic variants or variants of uncertain significance for 79 out of 110 probands (71.8%). Of the 79 patients with positive or inconclusive calls, 55 (50.0%) patients were determined to have good genotype-phenotype correlations after careful review. Further clinical reassessment and family member testing determined 45 (40.9%) patients to have been identified with a molecular diagnosis. Conclusion: This study showed a 40.9% diagnostic yield for WES test for a heterogeneous patient cohort with suspected rare genetic diseases. WES could be the feasible genetic test modality to overcome the diversity and complexity of rare disease diagnostics.

• Korean Circulation Journal
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• 제52권10호
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• pp.771-781
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• 2022

Background and Objectives: Although long QT syndrome (LQTS) is a potentially life-threatening inherited cardiac channelopathy, studies documenting the long-term clinical data of Korean patients with LQTS are scarce. Methods: This retrospective cohort study included 105 patients with LQTS (48 women; 45.7%) from a single tertiary center. The clinical outcomes were analyzed for the rate of freedom from breakthrough cardiac events (BCEs), additional treatment needed, and death. Results: LQTS was diagnosed at a median age of 11 (range, 0.003-80) years. Genetic testing was performed on 90 patients (yield, 71.1%). The proportions of genetically confirmed patients with LQTS types 1, 2, 3, and others were 34.4%, 12.2%, 12.2%, and 12.2%, respectively. In the symptomatic group (n=70), aborted cardiac arrest was observed in 30% of the patients. Treatments included medications in 60 patients (85.7%), implantable cardioverter-defibrillators in 27 (38.6%; median age, 17 years; range, 2-79 years), and left cardiac sympathetic denervation surgery in 7 (10%; median age, 13 years; range, 2-34). The 10-year BCE-free survival rate was 73.2%. By genotype, significant differences were observed in BCEs despite medication (p<0.001). The 10-year BCE-free survival rate was the highest in patients with LQTS type 1 (81.8%) and the lowest in those with multiple LQTS-associated mutations (LQTM). All patients with LQTS survived, except for one patient who had LQTM. Conclusions: Good long-term outcomes can be achieved by using recently developed genetically tailored management strategies for patients with LQTS.

• 복식문화연구
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• 제11권1호
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• pp.153-164
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• 2003

For this study, 148 female adults between the ages of 20 and 60 who satisfied the plus-size judgment criteria took part in this study. Criteria were Rohrer index is higher than 1.5, bust girth larger than 90cm, and RBW(relative body weight) index higher than 110. Using anthropometric measurement values, indirect measurement values, and index values, this study analyzed frequencies, Duncan multiple range, and ANOVA to obtain information on characteristics that determine a representative body shape, by age, 1'3r Plus-sized women. The results are as follows: Physical Characteristics of Pius-Sized Women by Their Age: Women in their 20s md 30s had broader shoulders with smaller waists, with large buttocks and thighs. Among women in their 50s and 60s, body fat level increased significantly in regions such as the chest and abdomen, which made their upper body heavier.