• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5557-5563
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• 2015

Background: Cholelithiasis is associated in 54%-98% of patients with carcinoma of the gallbladder, and a high incidence among females suggests a role of female hormones in the etiology of the disease. Cytochrome $P450C17{\alpha}$ (CYP-17) is a key enzyme involved in estrogen metabolism and polymorphisms in CYP-17 are associated with altered serum levels of estrogens. Thus, we investigated whether the CYP-17 MspA1 gene polymorphism might impact on risk of gall bladder cancers or gallstones, as well as to determine if this gene polymorphism might be linked with estrogen serum levels and lipid profile among the North Indian gall bladder cancer or gallstone patients. Materials and Methods: CYP-17 gene polymorphisms (MspA1) were genotyped with PCR-RFLP in cancer patients (n=96), stone patients (n=102), cancer + stone patients (n=52) and age/sex matched control subjects (n= 256). Lipid profile was estimated using a commercial kit and serum estrogen was measured using ELISA. Results: The majority of the patients in all groups were females. The lipid profile and estrogen level were significantly higher among the study as compared to control groups. The frequency of mutant allele A2 of CYP17 MspA1 gene polymorphism was higher among cancer (OR=5.13, 95% CI+3.10-8.51, p=0.0001), stone (OR=5.69, 95%CI=3.46-9.37, p=0.0001) and cancer + stone (OR=3.54, 95%CI=1.90-6.60, p=0.0001) when compared with the control group. However there was no significant association between genotypes of CYP17 MspA1 gene polymorphism and circulating serum level of estrogen and lipid profile. Conclusions: A higher frequency of mutant genotype A1A2 as well as mutant allele A2 of CYP-17 gene polymorphism is significantly associated with risk of gallbladder cancer and stones. Elevated levels of estrogen and an altered lipid profile can be used as predictors ofgall bladder stones and cancer in post menopausal females in India.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.27 no.4
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• pp.306-312
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• 2016

Objectives: We aimed to compare the smoking behaviors in adolescents from monocultural and multicultural families and to evaluate the associations between their smoking behavior and number of suicide attempts. Methods: The data used in this study was collected from The Tenth Korea Youth Risk Behavior Web-based Survey. The differences in the sociodemographic characteristics between the adolescents in the multicultural and monocultural families were analyzed through the ${\chi}^2$-test, and a logistic regression was conducted to evaluate the relationships between the smoking behavior and number of suicide attempts of the adolescents in multicultural families. The process involved an analysis using a complex sample design. Results: There was significant difference in the weighted rates of the current smoking behavior (13.3% vs. 8.4%, p<0.001), experience of violence (6.8% vs. 2.3%, p<0.001), and number of suicide attempts (5.4% vs. 2.7%, p<0.001) between the adolescents from the multicultural and monocultural families. In both groups, the current smoking behavior was associated with the number of suicide attempts (multicultural families OR=6.5, p=0.005; monocultural families OR=1.5, p<0.001). Conclusion: Our results showed that the percentage of current smokers in the adolescents from multicultural families was higher than that in the monocultural families and that current smoking behavior is related to the number of suicide attempts in both groups, after adjustment for age, sex, socioeconomic status, academic achievement, current smoking behavior, depressive mood and experience of violence.

• Annals of Pediatric Endocrinology and Metabolism
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• v.23 no.4
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• pp.196-203
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• 2018

Purpose: The hemoglobin glycation index (HGI) represents the degree of nonenzymatic glycation and has been positively associated with cardiometabolic risk factors (CMRFs) and cardiovascular disease in adults. This study aimed to investigate the association between HGI, components of metabolic syndrome (MS), and alanine aminotransferase (ALT) in a pediatric nondiabetic population. Methods: Data from 3,885 subjects aged 10-18 years from the Korea National Health and Nutrition Examination Survey (2011-2016) were included. HGI was defined as subtraction of predicted glycated hemoglobin ($HbA1_c$) from measured $HbA1_c$. Participants were divided into 3 groups according to HGI tertile. Components of MS (abdominal obesity, fasting glucose, triglycerides, high-density lipoprotein cholesterol, and blood pressure), and proportion of MS, CMRF clustering (${\geq}2$ of MS components), and elevated ALT were compared among the groups. Results: Body mass index (BMI) z-score, obesity, total cholesterol, ALT, abdominal obesity, elevated triglycerides, and CMRF clustering showed increasing HGI trends from lower-to-higher tertiles. Multiple logistic regression analysis showed the upper HGI tertile was associated with elevated triglycerides (odds ratio, 1.65; 95% confidence interval, 1.18-2.30). Multiple linear regression analysis showed HGI level was significantly associated with BMI z-score, $HbA1_c$, triglycerides, and ALT. When stratified by sex, age group, and BMI category, overweight/obese subjects showed linear HGI trends for presence of CMRF clustering and ALT elevation. Conclusion: HGI was associated with CMRFs in a Korean pediatric population. High HGI might be an independent risk factor for CMRF clustering and ALT elevation in overweight/obese youth. Further studies are required to establish the clinical relevance of HGI for cardiometabolic health in youth.

• Journal of dental hygiene science
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• v.14 no.2
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• pp.107-113
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• 2014

This study was conducted to evaluate the association between periodontal disease and diabetes mellitus. The final analysis population of this study was composed of 4,830 adults with diabetes mellitus or periodontal disease and aged 19 years or older, based on the third-edition data of the 4th Korea National Health and Nutrition Examination Survey (KNHANES) (in 2009). Diabetic status and potential confounders were used in questionnaire materials and physical examination materials, and the presence of periodontal disease was used in the materials for oral health examination by a dentist. For diabetic status, fasting plasma glucose (FPG) levels <100 mg/dl were subcategorized into normal group and FPG levels ${\geq}100mg/dl$ into impaired fasting glucose group; glycosylated hemoglobin (HbA1c) levels <7% into normal group and HbA1c ${\geq}7%$ into diabetes group, on the basis of the American Diabetes Association. According to the 2009 Korea Health Statistics, the case where the pocket depth is 3 mm or more was defined as periodontal disease. The association between the two diseases was evaluated through $x^2$-test and logistic regression analysis using R-commander 2.14. In impaired fasting glucose group, community periodontal index (CPI) groups 3 to 4 had higher risks for periodontal disease 1.23 times (95% confidence interval, 1.07~1.42) than those of CPI groups CPI 0~2, even after adjustment for several confounders. In addition, periodontal disease and diabetes mellitus showed statistically significant differences depending on age, sex, income level, educational background, smoking status, alcohol consumption, and snack intake. The analyses of the third-edition data of the 4th KNHANES showed that there was a statistically significant association between periodontal disease and diabetes mellitus as examined by means of CPI in this study.

• Journal of Chest Surgery
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• v.31 no.2
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• pp.142-148
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• 1998

Video-assisted thoracic surgery(VATS) is emerging as a viable alternative to thoracotomy when surgical treatment of spontaneous pneumothorax is required. 20 patients with spontaneous pneumothorax underwent bullectomy between July 1995 and May 1996. The patients were divided into two groups : Control group ; the patients who received with mid-axillary approach(n=10), Experimental group ; the patients who received with VATS (n=10). The results were as follows ; 1. The total sex distribution was male predominance (male:female=17:3). Mean age of control group was 29.6$\pm$9.8 years and experimental group was 27.2$\pm$11.9 years. 2. The mean period of postoperative chest tube indwelling duration and hospital stay were 3.3$\pm$0.8 days and 7.9$\pm$1.2 days in control group and 2.1$\pm$0.9 days and 5.2$\pm$3.1 days in experimental group(p=0.005 and p=0.02). 3. The mean time of operation, vital signs and arterial blood gas analysis did not showed any statistical differences between the groups. 4. Percent recovery of tidal volume and forced vital capacity were significantly improved in experimental group comparing with control group (p<0.05). 5. The patients undergoing VATS experienced significantly less postoperative pain and limitation of motion. In conclusion, VATS is safe and offers the potential benefits of shorter postoperative hospital stays and less pain with cosmetic benefits.

• Journal of Haehwa Medicine
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• v.10 no.2
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• pp.155-165
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• 2002

From July 1th 2001 to October 31th 2001, the Clinical investigation studies were carried out 10 cases of patient with Bell' palsy using Trigger point treatment group, who had been treated in Han-seung Oriental Medical Clinic. The results were like below: 1. The distribution of sex : Male were 4cases. female were 6case and the female to male ratio was 1.5 : 1. 2. The distribution of contributing factor : Unknown reason was most predominant 4 cases, and then were revealed to labor too hard. mental stress(3 cases), trauma common cold(1 case) in turn. 3. The distribution of perid to fall ill : Under a week was the most number 6cases, and then were revealed a week under two weeks(3 cases), over two weeks(1 case) in turn. 4. About period of treatment : The Trigger Point treatment group is shorter than the Acupuncture treatment group. 5. The distribution of grade on admission in descending order : Gr I was the most number and then GrII, GrIII in turn. 6. The distribution of clinical symptoms on admission : Mastoid pain was the most number 9 cases and then lacrimal gland disorder 8 cases, dysgeusia 4cases, hyperacusis 2 cases, the others 2 cases in turn. 7. About effect of treatment : The Trigger point treatment group is more excellent than the Acupuncture treatment group. 8. The more patient age is young, the more effect of treatment was excellent, had nothing to do with both groups. 9. The more perid to fall ill is short, the more effect of treatment was excellent. had nothing to do with both groups. 10. About period of improved frontal belly : The Trigger point treatment group is more excellent than the Acupuncture treatment group.

• Journal of Korean Neurosurgical Society
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• v.65 no.6
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• pp.834-840
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• 2022

Objective : C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count are inflammatory markers used to evaluate postoperative infections. Although these markers are non-specific, understanding their normal kinetics after surgery may be helpful in the early detection of postoperative infections. To compliment the recent trend of reducing the duration of antibiotic use, this retrospective study investigated the inflammatory markers of patients who had received antibiotics within 24 hours after surgery according to the Health Insurance Review & Assessment Service guidelines and compared them with those of patients who had received antibiotics for 5 days, which was proven to be non-infectious. Methods : We enrolled 74 patients, divided into two groups. Patients underwent posterior lumbar interbody fusion (PLIF) at a single institution between 2019 and 2020. Group A included 37 patients who received antibiotics within 24 hours after the PLIF procedure, and group B comprised 37 patients who had used antibiotics for 5 days. A 1 : 1 nearest-neighbor propensity-matched analysis was used. The clinical variables included age, sex, medical history, body mass index, estimated blood loss, and operation time. Laboratory data included CRP, ESR, and WBC, which were measured preoperatively and on postoperative days (POD) 1, 3, 5, and 7. Results : CRP dynamics tended to decrease after peaking on POD 3, with a similar trend in both groups. The average CRP level in group B was slightly higher than that in group A; however, the difference was not statistically significant. Multiple linear regression analysis revealed operation time, number of fused levels, and estimated blood loss as significant predictors of a greater CRP peak value (r²=0.473, p<0.001) in patients. No trend (a tendency to decrease from the peak value) could be determined for ESR and WBC count on POD 7. Conclusion : Although slight differences were observed in numerical values and kinetics, sequential changes in inflammatory markers according to the duration of antibiotic administration showed similar patterns. Knowledge of CRP kinetics allows the assessment of the degree of difference between the clinical and expected values.

• Journal of the Korean Society of Radiology
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• v.11 no.4
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• pp.273-278
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• 2017

Among 45 patients of herniation of intervertebral disc with $L_4$ to $L_5$ herniation, who underwent infrared thermography, the number of female was larger than male and the age of 50s was highest. From the results measured from the distribution table, we have confirmed that there was no significant difference depending on sex and age (p> 0.05). The region of the highest ROI temperature for patients with $L_4-L_5$ intervertebral disc prolapse was the back of the posterior right tibia, and followed by the back of the left shin bone-below the front right knee-below the front left knee. There was a significant difference depending on the measured site. The average ROI temperature for patients was $30.30{\pm}0.50$ whereas that for normal persons was $31.20{\pm}0.58$, yielding the temperature difference of $0.66{\pm}0.59$ between the two groups. The ROI of patients was lower than $31.20{\pm}0.58$ (p <0.05) because the significance of the sample, which has been obtained from the results of a sample t-test, was less than 0.05 (p <0.05). From further researches, it may necessary to develope the methodology for correcting data regarding thermal environment and, in addition, to develope a new thermal index based on it. Therefore, we can confirm that pre-treatment for infrared thermography is very important in order to minimize the procedure for correcting data. It is required that radiologists who inspect disc herniations should carefully observe and consider the patients during their measurements.

• Journal of Korean Academy of Nursing
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• v.4 no.3
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• pp.1-12
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• 1974

It is the purpose of this study to determine an effective method of communication between teachers and students. This study was done by using the theory, methods and tools of transactional analysis as developed by Borne and Harris. In order to achieve this objective: First; The teacher and student communication process is to be used, noting the student's reaction when the teacher uses "Adult" and "Parent" stimulus. Second; The effectiveness of the reaction toward the "Adult" and "Parent" stimulus is to be determined with these objectives in mind. The problems of this research study are as follows; What influence on the response of the student is brought about by the method of communication used by the teacher? 1) When the teacher uses the "Parent" Stimulus method what response of the student is shown? 2) When the teacher uses the "Adult" Stimulus method what response of the student is shown? 3) What method of communication helps to promote the student′s growth? In order to determine the answers to these questions data was collected from 40 first year students at a school of nursing in Inchon. These students were divided into two groups and the unstandardized interview technique was used to interview each student for ten minutes. A tape recording was made of each interview and the nonverbal communication was recorded by process recording immediately following each interview. The recorded material obtained from the two groups was analysed and then the Borne and Harris transactional analysis method was used in analysing the writer of this thesis undertook. Hypothesis 1. When the teacher used the "Parent" stimulus the student′s response was more frequently "Child" than "Adult", the results showed a significant difference of P〈0.001. Hypothesis 2. When the teacher used the "Adult" Stimulus the student′s response was more frequently of "Adult" than "Child", the results showed a significant difference of P〈0.001, The following conclusions are drawn from this study: 1) There is an indication that the teachers use of "Parent" stimulus communication is not an effective method to increase the growth of the student. 3) Since the teachers use of "Adult" stimulus resulted in an increase in the "Adult" response of the student there is ah indication that use of an effective communication method can help the student to develop. The writer of this research paper suggests for further study the following; 1) A comparison of the differences in response to the giving of both "Adult" and "Parent" stimulus to the same Students. 2) A comparison of the differences in student response to the communication method according to the student′s grade, age, sex and level in school.

• Journal of Trauma and Injury
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• v.24 no.2
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• pp.89-94
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• 2011

Purpose: A few studies have assessed the factors affecting the prognoses for major trauma patients and those improving the circumstances when dealing with the trauma system. In that light, we analyzed factors, such as pre-hospital factors, the time to admission, the length of stay in the emergency department (ED) and emergency operation, influencing the outcomes for trauma patients. Methods: The patients who visited our emergency department from April 1, 2009, to February 29, 2011, due to major trauma were enrolled in the study. The inclusion criterion was a revised trauma score (RTS) < 7 or injury severity score (ISS) ${\geq}$ 16. We used reviews of medical records, to analyze each step of emergency medical care with respect to patients' sex, age, visit time and visit date. Continuous variables were described as a median with an interquartile range, and we compared the variables between the survival and the mortality groups by using the Mann-Whitney U test. Fisher's exact test was used for nominal variables. Using the variables that showed statistical significance in univariate comparisons, we performed a logistic regression analysis, and we tested the model's adequacy by the using the Hosmer-Lemeshow method. Results: A total of 261 patients with major trauma satisfied either the RTS score criterion or the ISS score criterion. Excluding 12 patients with missing data, 249 patients were included in this study. The overall mortality rate was 16.9%. Time to ED arrival, time to admission, time of ED stay, RTS, ISS, and visit date being a holiday showed statistically significant differences between the survival and the mortality groups in the univariate analysis. RTS, ISS, length of ED stay, and visit date being a holiday showed statistical significance in the multivariate analysis. Conclusion: The mortality rate did not show a significant relationship with the time to ED arrival, use of 119, on time to admission. Rather, it elicited a quite significant correlation with the trauma scoring system (RTS and ISS), the time of ED stay, and the visit date being a holiday.