• Archives of Pharmacal Research
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• 제19권5호
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• pp.374-380
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• 1996

Sprague-Dawley male rats (150 g) were chronically treated with 5 v/v % ethanol admixed with nutritionally complete liquid diet and fed ad libitum for 3 weeks. One half of each group was exposed to cold stress at 4 ^{\circ}C either for 24 h (for determination of mRNA by in situ hybridization) or for 48 h (for determination of enzyme activity). Chronic ethanol treatment (ethanol) did not affect tyrosine hydroxylase(TH) mRNA level in locus coeruleus(LC) of brain and adrenal medulla(AM) compared to controls. Cold stress showed strong increase of TH mRNA level in LC and AM compared to controls. Pretreated ethanol reduced the increased TH mRNA level by cold stress in LC and AM. Ethanol did not affect TH activity in LC and adenal glands(adrenals). Cold stress increased TH activity in LC but not in adrenals. Pretreated ethanol did not reduce the increased TH activity by cold stress in LC but this result was not shown in adrenals. Phenylethanolamine-N-methyltransferase(PNMT) activity in $C_{1}$$C_{2}$ and adrenals increased only in ethanol treated group. THese results suggest that ethanol does not affect TH mRNA level and activity in LC and adrenals, but increases PNMT activity in $C_{1}$$C_{2}$ and adrenals in normal rat. It is also suggested that pretreated ethanol reduces the magnitude of cold stress response, that is induction of TH mRNA in LC and AM, and does not reduce the protein activation of TH that is also cold stress response in LC.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2008년도 학술대회 1부
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• pp.522-527
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• 2008

사회적 감성 에이전트는 인간과 유사한 사회지능(Social Intelligence)을 가지고 있는 에이전트로서, 인간의 감정을 인지 및 학습하고 적응을 통하여 상대방의 감정과 상함에 따라 적절한 반응을 할 수 있는 능력을 가기고 있다. 이 에이전트는 인간이 에이전트를 더 살아 있는 것처럼(Believable) 느끼게 하여, 인간과 컴퓨터간의 상호작용을 도와줌으로써 인간에게 더욱더 개인화되고 적합한 서비스 창출하고 제공할 수 있는 에이전트 모델이다. 본 논문에서는 인간의 사고 과정과 동일한 3단계 사고 작용 모델(Three-Layered Affect Functioning Model)을 통해서, 에이전트가 사용자의 감정과 상황을 인식하여, 지능적 반응이나 행동을 가능하게 하는 프레임워크를 제안한다. 그리고 에이전트의 감정과 상황인식을 위해서는 심리학 모델인 OCC 모델과 결정트리 구성 알고리즘인 ID3를 활용하였다. 이를 통해서 교육, 예술, 연예, 디자인, 의료 등 다양한 분야에서 응용될 수 있는 사회적 감성지능형 에이전트를 개발할 수 있을 것으로 기대 된다.

• 산업경영시스템학회지
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• 제43권2호
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• pp.98-109
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• 2020

What is purchase motivation for luxury brands? and what kind of process through makes higher cult intention(i.e.,loyalty). How does consumption value affect loyalty? Theoretically, it was studied whether it could be explained. The luxury products and services were divided into categories and surveys were conducted at the national level. This research analyzed the influence of positive affect on cult intention by mediating luxury consumption value with S-O-R frame. The logic was developed with excitation transfer theory. Positive affect, compatibility mediating effect were investigated. Unlike the previous studies that have been recognized as important in terms of symbolic value in luxury brands, it was confirmed that experiential consumption value had the greatest impact. In addition, the influence of functional value and symbolic value had a significant effect. The effect of consumption value on cult intention was mediated by positive affect and compatibility. Therefore, emotional response can be seen as having an effect on cult intention through excitement transfer. These findings suggest that luxury brand marketers need to develop consumer values that can lead to arousal and positive emotional responses to suit consumer lifestyle. The research results are expected to contribute to the experience marketing and the hospitality service of luxury brands.

• 대한한방부인과학회지
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• 제19권4호
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• pp.1-16
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• 2006

Purpose : The purpose of this research was to investigate the effects of Kamibojoongikkitang (KBT) on the immune cells in C57BL/6 mice. Methods : KBT (500mg/kg) was administerd p.o. once a day for 7 days. Results : KBT decreased the cell viability of thymocytes in vivo and in vitro system and decreased the cell viability of splenocytes in vivo, but increased the viability of splenocytes in vitro system. In addition, KBT did not affect the population of helper T (Th) cells and cytotoxic T (Tc) cells in thymocytes and decreased the population of T- and B-lymphocytes and the population of Th and Tc cells in splenocytes. Furthermore, KBT did not affect the production of ${\gamma}%-interferon and interleukin-4 in splenocytes. KBT increased the production of nitric oxide in vivo but decreased the production of nitric oxide in vitro system. KBT enhanced the phagocytic activity of peritoneal macrophages in vivo, but decreased the phagocytic activity in vitro. Conclusion : KBT has an inhibitory action on the specific immune response via decrease of the cell viability of thymocytes and splenocytes and has a potent action on the non-specific immunity via increase of phagocytic activity of peritoneal macrophages.

• 한국환경성돌연변이발암원학회지
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• 제16권1호
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• pp.19-23
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• 1996

This study was performed by the sister chromatid exchanges (SCEs) and micronuclei (MN) assays to investigate the adaptive response to ultraviolet light (UV) or ethyl methanesulfonate (EMS) in Chinese hamster ovary (CHO) and Sarcoma 180 (S180) cells. The pretreatment with 1 J/m$^2$ UV or 2 mM EMS decreased the frequency of SCEs induced by the treatment with 5 J/m$^2$ UV or 8 mM EMS in CHO cells. The pretreatment with UV (1 or 2 J/m$^2$) or EMS (1, 2 or 3 mM) did not affect the SCEs induced by the treatment with 7 J/m$^2$ UV or 10 mM EMS in S180 cells. On the other hand, the pretreatment with 1 J/m$^2$ UV or 2 mM EMS decreased the frequency of MN induced by the treatment with 5 J/m$^2$ UV or 8 mM EMS in CHO cells. The pretreatment with UV (1 or 2 J/m$^2$) or EMS (1, 2 or 3 mM) did not affect the frequency of MN induced by the treatment with 7 J/m$^2$ UV or 10 mM EMS in S180 cells. It is suggested that there are adaptive responses at the level of chromosome and micronuclei to UV and EMS in CHO cells.

• The Korean Journal of Physiology and Pharmacology
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• 제14권5호
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• pp.291-297
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• 2010

The sleep homeostatic response significantly affects the state of anesthesia. In addition, sleep recovery may occur during anesthesia, either via a natural sleep-like process to occur or via a direct restorative effect. Little is known about the effects of isoflurane anesthesia on sleep homeostasis. We investigated whether 1) isoflurane anesthesia could provide a sleep-like process, and 2) the depth of anesthesia could differently affect the post-anesthesia sleep response. Nine rats were treated for 2 hours with $ad$ $libitum$ sleep (Control), sleep deprivation (SD), and isoflurane anesthesia with delta-wave- predominant state (ISO-1) or burst suppression pattern-predominant state (ISO-2) with at least a 1-week interval. Electroencephalogram and electromyogram were recorded and sleep-wake architecture was evaluated for 4 hours after each treatment. In the post-treatment period, the duration of transition to slow-wave-sleep decreased but slow wave sleep (SWS) increased in the SD group, but no sleep stages were significantly changed in ISO-1 and ISO-2 groups compared to Control. Different levels of anesthesia did not significantly affect the post-anesthesia sleep responses, but the deep level of anesthesia significantly delayed the latency to sleep compared to Control. The present results indicate that a natural sleep-like process likely occurs during isoflurane anesthesia and that the post-anesthesia sleep response occurs irrespective to the level of anesthesia.

• 대한한방부인과학회지
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• 제18권1호
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• pp.94-110
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• 2005

The purpose of this research was to investigate the effects of Kamikwibitang water extract (KKT) on immobilization stress in C57BL/6J mice. KKT decreased the serum level of histamine and corticosterone increased by immobilization stress. In addition, KKT decreased the cell viability of thymocytes and enhanced the cell viability of splenocytes decreased by immobilization stress. Also, KKT decreased the viability of thymocytes and splenocytes in vitro. KKT decreased DNA fragmentation of splenocytes increased by immobilization stress. KKT decreased the population of thymic $CD4^+CD8^-$ cells increased by immobilization stress, and did not affect the population of $B220^+$ cells and the population of $Thy1^+$ cells changed by immobilization stress and enhanced the population of splenic $CD4^-CD8^+$ cells increased by immobilization stress. KKT enhanced the production of ${\gamma}-interferon$ and did not affect the production of interleukin-2 and interleukin-4 decreased by immobilization stress. Also, KKT decreased the phagocytic activity and the level of nitric oxide decreased by immobilization stress. These results indicate that KKT may be useful for the prevention and treatment of stress via suppression of serum histamine and corticosterone level and enhancement of specific-immune response.

• The Plant Pathology Journal
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• 제37권6호
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• pp.566-579
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• 2021

Ralstonia syzygii subsp. indonesiensis (Rsi, former name: Ralstonia solanacearum phylotype IV) PW1001, a causal agent of potato wilt disease, induces hypersensitive response (HR) on its non-host eggplant (Solanum melongena cv. Senryo-nigou). The disaccharide trehalose is involved in abiotic and biotic stress tolerance in many organisms. We found that trehalose is required for eliciting HR on eggplant by plant pathogen Rsi PW1001. In R. solanacearum, it is known that the OtsA/OtsB pathway is the dominant trehalose synthesis pathway, and otsA and otsB encode trehalose-6-phosphate (T6P) synthase and T6P phosphatase, respectively. We generated otsA and otsB mutant strains and found that these mutant strains reduced the bacterial trehalose concentration and HR induction on eggplant leaves compared to wild-type. Trehalose functions intracellularly in Rsi PW1001 because addition of exogenous trehalose did not affect the HR level and ion leakage. Requirement of trehalose in HR induction is not common in R. solanacearum species complex because mutation of otsA in Ralstonia pseudosolanacearum (former name: Ralstonia solanacearum phylotype I) RS1002 did not affect HR on the leaves of its non-host tobacco and wild eggplant Solanum torvum. Further, we also found that each otsA and otsB mutant had reduced ability to grow in a medium containing NaCl and sucrose, indicating that trehalose also has an important role in osmotic stress tolerance.

• 한국지진공학회논문집
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• 제20권4호
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• pp.245-256
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• 2016

In the companion paper (I - Database and Site Response Analyses), site-specific response analyses were performed at more than 300 domestic sites. In this study, a new site classification system and design response spectra are proposed using results of the site-specific response analyses. Depth to bedrock (H) and average shear wave velocity of soil above the bedrock ($V_{S,Soil}$) were adopted as parameters to classify the sites into sub-categories because these two factors mostly affect site amplification, especially for shallow bedrock region. The 20 m of depth to bedrock was selected as the initial parameter for site classification based on the trend of site coefficients obtained from the site-specific response analyses. The sites having less than 20 m of depth to bedrock (H1 sites) are sub-divided into two site classes using 260 m/s of $V_{S,Soil}$ while the sites having greater than 20 m of depth to bedrock (H2 sites) are sub-divided into two site classes at $V_{S,Soil}$ equal to 180 m/s. The integration interval of 0.4 ~ 1.5 sec period range was adopted to calculate the long-period site coefficients ($F_v$) for reflecting the amplification characteristics of Korean geological condition. In addition, the frequency distribution of depth to bedrock reported for Korean sites was also considered in calculating the site coefficients for H2 sites to incorporate sites having greater than 30 m of depth to bedrock. The relationships between the site coefficients and rock shaking intensity were proposed and then subsequently compared with the site coefficients of similar site classes suggested in other codes.

• 한국지진공학회논문집
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• 제24권2호
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• pp.67-76
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• 2020

This study aims to optimize the cochlea-inspired artificial filter bank (CAFB) using El-Centro seismic waveforms and test its performance through a shaking table test on a two-span bridge model. In the process of optimizing the CAFB, El-Centro seismic waveforms were used for the purpose of evaluating how they would affect the optimizing process. Next, the optimized CAFB was embedded in the developed wireless-based intelligent data acquisition (IDAQ) system to enable response measurement in real-time. For its performance evaluation to obtain a seismic response in real-time using the optimized CAFB, a two-span bridge (model structures) was installed in a large shaking table, and a seismic response experiment was carried out on it with El-Centro seismic waveforms. The CAFB optimized in this experiment was able to obtain the seismic response in real-time by compressing it using the embedded wireless-based IDAQ system while the obtained compressed signals were compared with the original signal (un-compressed signal). The results of the experiment showed that the compressed signals were superior to the raw signal in response performance, as well as in data compression effect. They also proved that the CAFB was able to compress response signals effectively in real-time even under seismic conditions. Therefore, this paper established that the CAFB optimized by being embedded in the wireless-based IDAQ system was an economical and efficient data compression sensing technology for measuring and monitoring the seismic response in real-time from structures based on the wireless sensor networks (WSNs).