• 대한한의학회지
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• 제34권3호
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• pp.54-68
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• 2013

Objectives: This study aimed to evaluate the effects of microparticles of Socheongryong-tang (SCRT) on chronic obstructive pulmonary disease (COPD) in a mouse model. Methods: The inhalable microparticles containing SCRT were produced by spray-drying with leucine as an excipient, and evaluated with respect to the aerodynamic properties of the powder by Andersen cascade impactor (ACI). Its equivalence to SCRT extract was evaluated using lipopolysaccharide (LPS) and a cigarette-smoking (CS)-induced murine COPD model. Results: SCRT microparticles provided desirable aerodynamic properties (fine particle fraction of $49.6{\pm}5.5%$ and mass median aerodynamic diameter of $4.8{\pm}0.3{\mu}m$). SCRT microparticles did not show mortality or clinical signs over 14 days. Also there were no significant differences in body weight, organ weights or serum chemical parameters between SCRT microparticle-treated and non-treated groups. After 14 days the platelet count significantly increased compared with the non-treated group, but the values were within the normal range. Inhalation of SCRT microparticles decreased the rate of neutrophils in blood, granulocytes in peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage fluid (BALF) and level of TNF-${\alpha}$ and IL-6 in BALF on COPD mouse model induced by LPS plus CS. This effect was verified by histological findings including immunofluorescence staining of elastin, collagen, and caspase 3 protein in lung tissue. Conclusions: These data demonstrate that SCRT microparticles are equivalent to SCRT extract in pharmaceutical properties for COPD. This study suggests that SCRT microparticles would be a potential agent of inhalation therapy for the treatment of COPD.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2003년도 유체기계 연구개발 발표회 논문집
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• pp.482-486
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• 2003

A high-efficiency turbo steam compressor has been successfully developed for the MVR desalination system, first one in Korea. The state-of-the-art design methods using real gas properties were applied to get all the aerodynamic design results. Bull and pinion gear trains, tilting-pad bearings and investment cast impellers were developed also to be integrated into the integral gear-driven turbo steam compressor. System tests show highly efficient performance.

• Journal of Biosystems Engineering
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• 제15권1호
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• pp.1-13
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• 1990

Aerodynamic property is the most important factor in designing the pneumatic separator and handling equipment for grains and seeds. Particularly the correct information about the terminal velocities of the corresponding grains and seeds is indispensible. However, a few studies with relation to the terminal velocities of grains and seeds were conducted in this country, even though the terminal velocities of the domestic grains and seeds are required to design those equiments which can be used for the domestic grains and seeds having specific aerodynamic properties. In this study, the terminal velocities for four varieties of varley and six varieties of paddy were investigated by means of two different methods, the suspension method and the drop method in an upward current of air. For measuring the terminal velocities, the vertical wind tunnel which had been examined about the uniform air flow in the previous study was used. In addition, the effect of the size of grains and the moisture content of grain kernel on the terminal velocity was examined. The following conclusions were derived from the study : 1. The different terminal velocities of grains are resulted from the different measuring methods. The terminal velocity measured by the drop method is smaller than that by the suspension method. It is considered that the difference in the terminal velocities is caused by the difference in the projection area of grain which is faced to the air stream. 2. The terminal velocity of grain increases as the size and the moisture content of the kernel increase. 3. The linear regression equations for the terminal velocities of grains were derived in terms of the moisture content of grains by the variety of grains and the measuring method. Also, the linear regression equations for the terminal velocity, based on the weighted size of grains, were derived in terms of the moisture contents of granis.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(환경)
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• pp.585-595
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• 1994

The region of the respiratory tract where inhaled particles deposit can have important implications for the causation of local or systemic toxic effects. For most aerosols of occupational importance, respiratory tract deposition can be predicted from the aerodynamic diameter of the particles. With the advent of cascade impactors, particularly those of personal sampler size, the determination of the aerodynamic diameters of aerosols has become more common. Some limitations of cascade impactor use are well recognized (e.g., particle bounce and substrate overloading) and are generally correctable. However, two important limitations of the instruments may not be receiving adequate attention: relative humidity effects on potentially hygroscopic aerosols and the collection characteristics of fibrous aerosols as compared to their actual deposition site potential. The results of this study, when compared to results of previous controlled laboratory trials, suggest that, while potentially hygroscopic lead aerosols from lead acid battery plant operations do not appear to be affected by changes in plant environmental humidity levels, the potential - exists for significant size changes upon inhalation. Secondly, fibers were detected in aerodynamic size ranges that would be associated with deep lung deposition; however, upon microscopic examination, these same fibers would actually be predicted to deposit in the upper airways. This study suggests that the physicalchemical properties and morphological features of an aerosol should be carefully considered by industrial hygienists before cascade impactors are used in attempts to predict the effects of inhaled aerosols.

• 한국항공우주학회지
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• 제36권3호
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• pp.264-270
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• 2008

하이브리드 로켓 고체 연료의 연소율(Burning Rate)을 묘사하는 후퇴율은 연료 유속, 산화제 유속과 더불어 연료길이의 함수로 나타내어지나 일반적으로 가장 영향이 큰 산화제 유속만의 함수로 모델링된다. 그러나 이는 연료가 갖고 있는 고유의 열화학적 특성에 대한 영향이 내포되어 있지 않아 다양한 연료에 대한 공통된 관계를 나타내기 어렵다. 본 연구에서는 고체연료의 열화학적 특성과 연소에 따른 공기역학적 특성이 고려된 물질전달수(B Number)를 도입하여 다양한 연료에 공통으로 사용될 수 있는 연소율 관계식을 제시하고, 물질전달수 내의 공기역학적 특성의 영향을 분석하였다. 물질전달수와 산화제 유속의 함수로 표현된 연소율 식은 고정된 실험 지수항과 상수항으로 PMMA, PP 및 PE의 연소율을 모두 묘사할 수 있었고, 연소율 관계식에서 B Number에 내포된 공기역학적 효과는 미미하였다.

• 한국항공우주학회지
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• 제40권11호
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• pp.917-926
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• 2012

본 연구는 고효율 복합재 프로펠러를 개발하기 위하여, 항공기 프로펠러 효율 특성 해석을 수행하였다. 비선형 수치해석을 이용하여 프로펠러의 공력 특성을 분석하고, 풍동 실험결과와 비교 분석하였다. 유동해석코드는 비선형 유동방정식인 RANS(Reynolds Averaged Navier-Stocks)를 수치해석화한 코드를 사용하였다. 해석 결과, 수치해석을 통하여 얻어진 프로펠러의 추력 및 출력계수는 실험결과와 비교하여 다소 높게 분석되었으며, 추력과 출력의 비로부터 계산된 프로펠러 효율은 실험결과와 잘 부합하는 것으로 확인하였다.

• 항공우주기술
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• 제8권1호
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• pp.32-41
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• 2009

본 연구에서는 한국형기동헬기(KUH) 주로터 블레이드의 축소 설계를 수행하였다. 축소 모델은 공력하중, 익단 와류 및 소음원 측정 시험을 위해 설계되었다. 실제 로터와 동일한 공력 하중을 모사하기 위하여 마하스케일링 기법이 적용되었다. 마하스케일 모델은 블레이드의 익단 마하수가 동일하며, 정규화된 진동수 또한 동일하다. 즉, 마하스케일된 모델은 공력하중 및 구조동역학적 과점에서 상사된 모델이다. 공기역학적 축소과정은 외형 치수의 축소와 회전수의 증가를 통해 완료된다. 구조동역학적 측면에서는 블레이드 단면 설계를 통해 생성된 강성 및 관성 분포가 실제 로터의 회전고유진동수 분포를 나타내는지 확인하는 과정을 통해 완료된다. 본 연구에서는 국내에서 수급 가능한 복합재 프리프레그를 이용한 블레이드 단면 설계를 수행하고, 설계된 모델의 동역학적 특성을 고찰하였다.

• Advances in aircraft and spacecraft science
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• 제2권2호
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• pp.125-168
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• 2015

Dynamic aeroelastic behavior of structurally nonlinear Joined Wings is presented. Three configurations, two characterized by a different location of the joint and one presenting a direct connection between the two wings (SensorCraft-like layout) are investigated. The snap-divergence is studied from a dynamic perspective in order to assess the real response of the configuration. The investigations also focus on the flutter occurrence (critical state) and postcritical phenomena. Limit Cycle Oscillations (LCOs) are observed, possibly followed by a loss of periodicity of the solution as speed is further increased. In some cases, it is also possible to ascertain the presence of period doubling (flip-) bifurcations. Differences between flutter (Hopf's bifurcation) speed evaluated with linear and nonlinear analyses are discussed in depth in order to understand if a linear (and thus computationally less intense) representation provides an acceptable estimate of the instability properties. Both frequency- and time-domain approaches are compared. Moreover, aerodynamic solvers based on the potential flow are critically examined. In particular, it is assessed in what measure more sophisticated aerodynamic and interface models impact the aeroelastic predictions. When the use of the tools gives different results, a physical interpretation of the leading mechanism generating the mismatch is provided. In particular, for PrandtlPlane-like configurations the aeroelastic response is very sensitive to the wake's shape. As a consequence, it is suggested that a more sophisticate modeling of the wake positively impacts the reliability of aerodynamic and aeroelastic analysis. For SensorCraft-like configurations some LCOs are characterized by a non-synchronous motion of the inner and outer portion of the lower wing: the wing's tip exhibits a small oscillation during the descending or ascending phase, whereas the mid-span station describes a sinusoidal-like trajectory in the time-domain.

• 한국자동차공학회논문집
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• 제19권1호
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• pp.25-31
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• 2011

The purpose of the study is to enhance the vehicle handling stability of the PACE formula vehicle. Required data for the dynamic analysis of the vehicle are as follows: Mass, moment of inertia, and tire's dynamic properties. Mass and moment of inertia data were calculated using Siemens NX 5.0 which results were verified with VIMF measurements of GMDAT. Dynamic data for the tire were supplied by Kumho Tire. Aerodynamic forces play an important role in the formula vehicle which forces were calculated by using Fluent. Full vehicle dynamic analysis using Carsim software has been carried out to find out the improvement of the vehicle stability by changing the shapes of the rear wing.

• 한국항공우주학회지
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• 제41권7호
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• pp.509-515
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• 2013

본 연구에서 익형 형상 설계를 위해 전역적 다목적 최적화 기법인 적응영역 다목적 유전자 알고리즘 코드를 개발하였다. 저마하수에서 최대 양력과 순항조건에서 최대 양항비를 동시에 만족시키기 위해 목적함수로 양력계수와 양항비를 선정하였으며, 익형 형상 설계를 위해 PARSEC 기법을 이용하였다. 그 결과 참조 익형 대비 나은 공력 특성을 나타내는 2개의 익형이 선택되었으며 최대 양력과 양항비는 첫 번째 익형에 대해 약 4.89%, 5.38% 증가하였으며, 두 번째 익형에 대해 약 7.13%, 4.33% 증가하였다.