• 동의생리병리학회지
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• 제26권3호
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• pp.381-385
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• 2012

We investigated the eradication rate and the adverse effects of combined treatment with western and oriental medication on Helicobacter pylori infected patients. We studied the eradication rate and the adverse effects of 1-week-triple therapy and 2-week-oriental medication(Banhasasimtang or Hyangsapeungeuysan) on Helicobacter pylori infected patients confirmed by urea breath test. Comparing 5 patients who took combined treatment with western and oriental medication, the results of this study showed that 4 patients got eradication effect of Helicobacter pylori with no influence on liver and kidney function. A patient had diarrhea and another patient had satiety after meals because of an adverse effect. Despite some possitive effect, the treatment did not make the Quality of Life improved. The findings of this study supports the adverse effects of combined treatment with western and oriental medication for the treatment of Helicobacter pylori infection.

• Tuberculosis and Respiratory Diseases
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• 제78권3호
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• pp.161-167
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• 2015

Tuberculosis (TB) remains a major global health problem, and the incidence of TB cases has not significantly decreased over the past decade in Korea. The standard short course regimen is highly effective against TB, but requires multiple TB-specific drugs and a long treatment duration. Recent studies using late-generation fluoroquinolones and/or high-dose rifapentine-containing regimens to shorten the duration of TB treatment showed negative results. Extending the treatment duration may be considered in patients with cavitation on the initial chest radiograph and positivity in sputum culture at 2 months of treatment for preventing TB relapse. Current evidence does not support the use of fixed-dose combinations compared to separate drugs for the purpose of improving treatment outcomes. All patients receiving TB treatment should be monitored regularly for response to therapy, facilitation of treatment completion, and management of adverse drug reactions. Mild adverse effects can be managed with symptomatic therapy and changing the timing of the drug administration, but severe adverse effects require a discontinuation of the offending drugs.

• 한방비만학회지
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• 제6권2호
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• pp.17-27
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• 2006

Objectives : Ma-huang (Ephedra sinica) is frequently prescribed for obesity management in oriental medicine. The main component is ephedrine alkaloids which can have serious adverse side effects such as heart attack, stroke, sudden death. There are no scientific guidelines for Ma-huang usage in the safe treatment of obesity in oriental medicine. We reviewed published studies on its safety to make evidence based guidelines. Methods : We searched electronic databases up to May 2006. We limited evidence to controlled trials for efficacy or safety, case reports for safety, and studies for Ma-huang contents analysis. Results and Conclusions : In clinical trials for weight loss, Ma-huang and ephedrine promote modest short-term weight loss but have no serious adverse effects, have only a few adverse effects associated with increased risk of psychiatric, autonomic, gastrointestinal symptoms and heart palpitations. In case reports, there have been serious adverse effects including stroke, heart attack, and death using typical doses of ephedrine or no associated illness. There are factors related to serious adverse effects, such as overuse, lack of standardization, individual sensitivity, and interactions with other drugs. Studies relating to these factors should be analyzed for safe use of Ma-huang and ephedrine. After analyzing related studies, we suggest guidelines for Ma-huang usage. We propose that the dosage should be within 4.5-7.5g per day for up to 6 months for generally healthy individual. It's use is contraindicated in individuals with heart disease, thyroid disease, diabetes mellitus, hypertension, psychiatric disorders, glaucoma, urination disorders, enlarged prostate, persons using MAOIs, methyldopa and sympathomimetic agents.

• 융합정보논문지
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• 제9권6호
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• pp.35-43
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• 2019

본 연구는 고등학생의 고카페인 에너지음료 섭취 실태와 부작용 경험을 파악하기 위한 실시된 조사연구이다. 수집된 245명의 자료를 SPSS 18로 기술통계와 ${\chi}^2-test$를 실시하였다. 본 연구대상자의 79.5%가 고카페인 에너지음료를 마신 경험이 있었다. 고카페인 에너지음료 섭취 후 50.6%가 부작용을 경험했으며, 부작용 중 가슴 두근거림이 가장 많았다. 일반적인 특성 중 한 달 용돈(p=.019)과 음주 여부(p=.033)에 따라 고카페인 에너지음료 섭취 경험과 유의한 차이가 있었고, 성별(p=.001)과 건강상태(p=.006)에 따라 부작용 경험과 유의한 차이가 있었다. 또한 고카페인 에너지음료 섭취 실태에 따른 부작용 경험과의 차이는 고카페인 에너지음료의 섭취 이유(p=.040)와 섭취 시기(p=.005)에 따라 유의한 차이가 있었다. 고등학생들의 고카페인 에너지음료의 소비를 줄이기 위해서는 고카페인 음료의 판매를 제한할 수 있는 정책적인 방안이 마련되어야 할 것이며, 학생 스스로가 조절할 수 있는 역량 함양을 위해 지속적인 건강교육이 필요할 것이다.

• 대한한의학회지
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• 제24권3호
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• pp.45-50
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• 2003

Background and Purpose : Chunghyul-dan has been widely used in the Department of Cardiovascular ＆ Neurologic Diseases, Kyung Hee Oriental Medical Center to prevent stroke by lowering serum cholesterol level. Previous experimental and clinical studies revealed that Chunghyul-dan had therapeutic effects on hyperlipidemia by inhibiting HMG-CoA reductase and pancreatic lipase. It was also reported that Chunghyul-dan showed an anti-oxidation effect by scavenging free radicals and inhibiting nitric oxide synthesis. Therefore, we examined the safety of Chunghyul-dan on all subjects who had been treated with it. Methods : We performed a retrospective study by reviewing the medical records of those who had been administrated Chunghyul-dan at Kyung Hee Oriental Medical Center from February 8,2001 to December 31,2002. The subjects' general characteristics (gender, age, medical history, and present illness), recorded adverse effects, and the results of laboratory findings were obtained and analyzed to assess the clinical safety of Chunghyul-dan. Results : Six hundred fifty six subjects were treated with Chunghyul-dan. Clinical adverse effects appeared in 13 subjects, the major symptom being indigestion (8 subjects). The apparent frequency of adverse effects was much lower than that in previous reports on the safety of certain medications. On investigation of laboratory findings, we could not find any hepatic or renal toxicity. Conclusion : We suggest that our results contribute towards confirming the safety of Chunghyul-dan by offering clinical evidence.

• 대한불안의학회지
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• 제18권2호
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• pp.65-71
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• 2022

Objective : This study was to examine the impact of adverse childhood experiences on social anxiety symptoms in young adults and verify the mediating effects of positive resources. Methods : Data from 1,317 young adults aged to 18 to 29 years who took part in the university-based cross-sectional survey were analyzed. All participants completed Adverse Childhood Experience (ACE) scale, Social Avoidance and Distress Scale (SAD), and Positive Resources Test (POREST). Results : In young adults, 9.3% had severe social anxiety symptoms. Based on 10 ACE categories, 32.7% of participants reported one or more adverse childhood experience, and 4.5% reported four or more different forms of adverse childhood experiences. Young adults with higher social anxiety symptoms were likely to report more adverse childhood experiences, and less positive resources. Multivariate regression analysis indicated that positive resources moderated the association between adverse childhood experiences and social anxiety symptoms. Conclusion : Based on the results, professionals need to consider early detection of adverse childhood experiences and comorbid social anxiety symptoms. In addition, various positive psychological interventions for individuals with adverse childhood experiences are needed.

• The Korean Journal of Pain
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• 제27권1호
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• pp.54-62
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• 2014

Background: The recently known analgesic action mechanisms of nefopam (NFP) are similar to those of anticonvulsants and antidepressants in neuropathic pain treatment. It is difficult to prescribe high doses of oral neuropathic drugs without titration due to adverse effects. Unfortunately, there are few available intravenous analgesics for the immediate management of acute flare-ups of the chronic neuropathic pain. The aim of this study was to determine the additional analgesic effects for neuropathic pain of NFP and its adverse effects during the titration of oral medications for neuropathic pain among inpatients with postherpetic neuralgia (PHN). Methods: Eighty inpatients with PHN were randomly divided into either the NFP or normal saline (NS) groups. Each patient received a 3-day intravenous continuous infusion of either NFP with a consecutive dose reduction of 60, 40, and 20 mg/d, or NS simultaneously while dose titrations of oral medications for neuropathic pain gradually increased every 3 days. The efficacy of additional NFP was evaluated by using the neuropathic pain symptom inventory (NPSI) score for 12 days. Adverse effects were also recorded. Results: The median NPSI score was significantly lower in the NFP group from days 1 to 6 of hospitalization. The representative alleviating symptoms of pain after using NFP were both spontaneous and evoked neuropathic pain. Reported common adverse effects were nausea, dizziness, and somnolence, in order of frequency. Conclusions: An intravenous continuous infusion of NFP reduces spontaneous and evoked neuropathic pain with tolerable adverse effects during the titration of oral medications in inpatients with PHN.

• 컴퓨터교육학회논문지
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• 제14권6호
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• pp.1-10
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• 2011

급속한 정보사회의 발달에 따른 사용자 윤리의식의 문제점을 논하는 기존의 많은 정책과 연구보고서에서는 그에 따른 해결책을 논의하고 있지만 이는 사후방법론의 한계를 벗어나지 못하고 있는 실정이다. 이에 본 논문에서는 역기능의 문제점을 사후 해결책이 아닌 예방차원에서의 해결책을 모색하고자 역기능분류의 표준안 모델을 제시하고자 한다. 본 연구자가 제시하는 역기능 분류의 표준 모델은 사회적 현상이라는 관점에서 현재까지 역기능의 피해사례를 조사 및 분석하여 1 2차 전문가 설문을 통해 미디어 중독, 유해콘텐츠, 사이버폭력, 권리침해, 사이버테러, 판단장해 등의 6영역으로 분류하였다. 제시된 표준안 모델은 현재의 정보화 사회에 발생할 수 있는 역기능뿐만 아니라 미래 사회에 발생할 수 있는 역기능의 문제점까지 포괄적으로 수용할 수 있도록 영역을 확장하였으며 이를 통해 역기능의 피해를 미연에 방지 혹은 예방할 수 있는 사회적 또는 교육적 방안을 제시할 수 있으리라 기대한다.

• 한국관개배수논문집
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• 제3권2호
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• pp.57-67
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• 1996

The purpose of this environmental study is to predict the environmental consequences of human development activity and to plan appropriate measures to eliminate or reduce adverse effects and to augment positive effects. The need to avoid adverse impacts a

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.149.1-149.1
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• 2003

Active ingredients, therapeutic and adverse effects of Aloe vera were comprehensively investigated. Aloe vera contains active components. including sugars, proteins, lipids, vitamins, minerals, phenolic compounds and other several compounds like phthalate esters, gibberellin, lectin-like substances, lignin, saponins, salicylic acid and uric acid. (omitted)