The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Clinical Assessment on the Safety of Chunghyul-dan (Qingwie-dan)

청혈단(淸血丹)의 임상적인 부작용에 대한 연구

  • 조기호 (경희대학교 한의과대학 2내과학교실) ;
  • 정우상 (경희대학교 한의과대학 2내과학교실) ;
  • 박성욱 (경희대학교 한의과대학 2내과학교실) ;
  • 문상관 (경희대학교 한의과대학 2내과학교실) ;
  • 김영석 (경희대학교 한의과대학 2내과학교실) ;
  • 배형섭 (경희대학교 한의과대학 2내과학교실)
  • Published : 2003.09.01
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Abstract

Background and Purpose : Chunghyul-dan has been widely used in the Department of Cardiovascular ＆ Neurologic Diseases, Kyung Hee Oriental Medical Center to prevent stroke by lowering serum cholesterol level. Previous experimental and clinical studies revealed that Chunghyul-dan had therapeutic effects on hyperlipidemia by inhibiting HMG-CoA reductase and pancreatic lipase. It was also reported that Chunghyul-dan showed an anti-oxidation effect by scavenging free radicals and inhibiting nitric oxide synthesis. Therefore, we examined the safety of Chunghyul-dan on all subjects who had been treated with it. Methods : We performed a retrospective study by reviewing the medical records of those who had been administrated Chunghyul-dan at Kyung Hee Oriental Medical Center from February 8,2001 to December 31,2002. The subjects' general characteristics (gender, age, medical history, and present illness), recorded adverse effects, and the results of laboratory findings were obtained and analyzed to assess the clinical safety of Chunghyul-dan. Results : Six hundred fifty six subjects were treated with Chunghyul-dan. Clinical adverse effects appeared in 13 subjects, the major symptom being indigestion (8 subjects). The apparent frequency of adverse effects was much lower than that in previous reports on the safety of certain medications. On investigation of laboratory findings, we could not find any hepatic or renal toxicity. Conclusion : We suggest that our results contribute towards confirming the safety of Chunghyul-dan by offering clinical evidence.

Keywords

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