• Journal of Animal Science and Technology
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• 제62권3호
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• pp.374-384
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• 2020

Two experiments were conducted to determine apparent metabolizable energy (AME), nitrogen-corrected AME (AMEn), and ileal digestible amino acid (AA) content of brown rice (BR) and to investigate the effect of dietary supplementation of BR on laying performance and egg quality of laying hens. In Exp. 1, 72 Hy-line Brown layers (49-week-old) were allocated to two treatments using a completely randomized block design, and each treatment included six cages per treatment and six hens per cage. A semi-purified diet was formulated to include BR as the sole source of AA and energy and an N-free diet was used to determine basal endogenous loss of AA. The hens were fed a commercial layer diet for adaptation to the experimental environment and diet for 7 days from d 0, and then fed experimental diets for 5 days from d 7. Excreta were collected from d 10 to 11 and ileal digesta were collected on d 12. On a dry matter (DM) basis, the AME and AMEn of BR was determined at 3,773 and 3,729 kcal/kg, respectively. The apparent ileal digestibility (AID) of BR ranged from 32.7% for Thr to 73.7% for Arg. The range of the standardized ileal digestibility (SID) value was between 79.4% for Met and 96.6% for Lys. In Exp. 2, 252 Hy-line Brown layers (44-week-old) were divided into four groups, comprising seven replicates of nine birds each and assigned to four experimental diets containing 0 (Control), 5%, 10%, or 15% BR for 5 weeks. The BR-containing diets were formulated to be equal in the content of AMEn and digestible AA to those of the diet without BR. No significant differences were observed in laying performances. Egg quality and blood profiles were not linearly or quadratically affected by dietary treatments. These results suggest that up to 15% BR can be included into layer feed without any adverse effects on laying performance and egg quality, if its energy and digestible AA values are well evaluated.

• Restorative Dentistry and Endodontics
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• 제23권2호
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• pp.656-669
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• 1998

Hydrogen peroxide at high concentration during walking bleaching may cause damage to the tooth structure and to the surrounding periodontal tissues and may develop external root resorption. Clinically, It is so important to find a method of prevention or minimization of these complications. The efficacy of various chamber-irrigating agents to eliminate residual hydrogen peroxide after walking bleaching was examined and compared with water rinse in this study. Extracted human 46 premolars without any cementoenamel junction defects were treated endodontically and based with IRM to 1 mm below CEJ and totally bleached 3 times for each tooth with 30% hydrogen peroxide and sodium perborate. Upon completion of the 3rd walking bleaching procedure, the cervical portion and pulp chamber of each group of teeth were irrigated with catalase, 70% ethylalcohol, acetone, and distilled water. And then, a radicular hydrogen peroxide penetration was measured with spectrophotometer immediately after each bleaching and following treatment with each chamber-irrigating agents, and the significance of their eliminating efficacy of residual hydrogen peroxide was analyzed by Kruskal-Wallis test. The results were obtained as follows. 1. Cervical root penetration of hydrogen peroxide was increased as the bleaching procedure was repeated(P<.01). 2. The most effective irrigant that removed residual hydrogen peroxide was the catalase, and the least effective one was water rinsing (P<.01).; there was no significant difference between the acetone and ethanol group. 3. The Irrigation with antioxidant enzyme or water-displacement solutions can eliminate residual oxygen radicals from the pulp chamber effectively after walking bleaching. So, these agents can reduce adverse effects such as cervical external resorption and periapical inflammation and prevent residual $O_2$ from impeding composite resin polymerization, thus increase the bonding strength of composite resin. This, in turn reduces microleakage and discoloration of the esthetic restoration, extending its service-life.

• Journal of Animal Science and Technology
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• 제51권4호
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• pp.307-314
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• 2009

육계사료 내 마늘분말의 첨가급여가 육계의 성장성적과 간 HMG-CoA reductase의 발현에 미치는 영향을 규명하기 위해 본 연구를 수행하였다. 1일령의 육계 Ross 수평아리에게 마늘분말을 0%(항생제 첨가 또는 항생제 무첨가), 1%, 3% 및 5%의 수준으로 첨가한 실험사료를 각각 6주간 급여하였다. 증체량은 항생제 무첨가 대조구에 비하여 마늘분말 3% 및 5%를 첨가한 처리구에서 유의하게 증가하였으며(P<0.05), 사료섭취량은 처리구간 차이가 없었다. 육계 사료 내 5%까지의 마늘분말의 첨가급여는 증체량과 사료섭취량에 부정적인 영향을 주지 않았다. 간, 비장, 맹장 및 가슴 근육에 대한 상대적 중량은 처리가 유의한 차이가 관찰되지 않았다. 근육 내 콜레스레롤 함량은 항생제 첨가 대조구에 비해 감소하였으나 통계적인 유의차는 나타나지 않았다. IB 항체 생성량은 항생제 무첨가 대조구에 비하여 유의적으로 증가하였다(P<0.05). 간의 HMGCoA reductase mRNA의 발현은 대조구에 비해 마늘분말을 첨가한 모든 처리구에서 저하된 것으로 관찰되었다. 본 연구에서 사료 내 마늘의 첨가급여는 육계의 성장촉진 효과를 나타내었으며, 콜레스테롤 대사에 영향을 미칠 수 있음이 시사되었다.

• 보건행정학회지
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• 제16권1호
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• pp.1-16
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• 2006

Recently, there has been prevailing of the combined utilization (CU) with herbs and prescribed drugs in medical therapies in the world. But the information about frequency, efficacy and safety of this CU has not well known in Korea, yet. This study aimed to identify the status of CU by Koreans, and to inquire which side effects of CU represent to those people. A self-completed questionnaire survey was performed through each health examination center in twenty general hospitals and one oriental hospital. Of the initial 2,100 health examinees, 1,851 were participated in this survey, resulting in a response rate of 88.1%. The proportion of CD was 26.3%. The most commonly mentioned reason of CD was 'to promote general health and well-being' (17l persons, 35.5%). The main route of taking CD was self-purchase at drugstore or at herbs market, followed by the prescription of (oriental)physicians. 33.0% (151 persons) of those who took the CD rated it as effective. 93 respondents (19.8%) were experienced several adverse effects including nausea, fatigue, and dizziness. The growing simultaneous use of herbal products and pharmaceutical drugs by Korean consumers may be continuously increased the risk of herb-drug interactions. The medical professionals should be provided with comprehensive and up-to-date information about potential benefits and risks of herbs and prescribed drugs. In the future studies it may be recommended to deal common cold, health promotion, indigestion, headache, and hypertension for the effect and safety of the CD by well-organized prospective study design.

• 한국축산식품학회지
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• 제28권5호
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• pp.521-528
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• 2008

본 연구는 누에분말 및 누에동충하초분말을 첨가하여 제조한 돈육 패티의 $5^{\circ}C$ 냉장저장 기간(0, 3, 6, 9일)동안의 품질변화를 평가하기 위해 실시하였다. 저장 6일차까지 처리구가 대조구보다 유의적으로 높은 pH값을 보였으며 육색의 경우 누에분말과 누에 동충하초 분말 첨가비율이 높을수록 L과 a값은 감소했으며 b값은 증가하였다(p<0.05). 누에분말과 누에 동충하초 분말 첨가가 보수력에는 크게 영향을 미치지 않는 것으로 나타났으며 T2 처리구에서 낮은 가열감량을 보여 0.4%의 누에분말이 가열감량을 억제하였다(p<0.05). 지방산패도는 누에분말과 누에동충하초분말 첨가구 및 혼합 첨가구에서 모두 대조구보다 낮은 수준을 보였다(p<0.05). 그러나 누에분말과 누에동충하초분말 처리간의 뚜렷한 차이는 보이지 않았다. 돈육 패티의 관능적 특성은 저장기간이 증가함에 따라 감소하였으나 풍미의 경우 저장초기에는 처리구의 기호도가 높았으나 저장기간이 증가하면서 차이는 보이지 않았다. 냄새도 대조구와 차이가 없었으며 종합적기호도에서도 저장초기에 대조구보다 높은 기호도를 보였으나 저장기간이 증가하면서 대조구에 비해 높거나 차이가 없었다. 누에분말과 누에동충하초분말 처리구간의 뚜렷한 기호도 차이는 보이지 않았다. 따라서 누에 및 누에동충하초분말은 돈육 패티의 pH값을 증가시키며 가열감량과 지방산패도를 억제시켰으며 보수력과 관능적 특성에도 부정적인 영향을 보이지 않아 추후 가공육제품의 첨가제로의 이용 가능성을 나타내었다.

• 한국건축시공학회지
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• 제20권4호
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• pp.331-338
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• 2020

본 연구는 CGS를 콘크리트용 혼합골재로서 활용성을 검토하기 위하여 양호한 입도분포의 부순잔골재(CSa) 및 미립자인 해사와 굵은 입자의 부순잔골재를 혼합한 혼합골재(MS)에 CGS의 치환율 변화에 따른 콘크리트의 기초적 특성 및 내구성을 분석하였다. 실험결과, 슬럼프 및 슬럼프 플로는 CSa 및 MS 모두 CGS 치환율이 증가할수록 증가하였으며, 공기량은 반대로 감소하였다. 압축강도는 CSa를 사용한 경우 CGS 치환율이 증가할수록 저하하였지만, MS를 사용한 경우는 CGS 50 %에서 최대치를 나타내었다. 콘크리트 내구성을 검토한 결과로, 건조수축 및 탄산화 깊이측정의 경우는 CGS 치환율에 따라 양호한 성능을 나타내었다. 하지만, 내동해성에서는 전반적으로 CGS 치환율이 증가할수록 감소하는 것으로 나타났다. 따라서, CGS를 치환 사용하는 혼합잔골재 콘크리트의 경우는 공기량 감소를 보완할 수 있도록 AE제 추가 투입 등의 대책을 수립한다면, 큰 문제 없을 것으로 판단된다.

• 약학회지
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• 제41권1호
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• pp.60-73
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• 1997

In order to design a 24 hr sustained release preparation of sulindac for oral administration, fast release pellet (FR), slow release pellet (SR) and two combined formulation (1 : 1 and 1 : 2) were prepared. The pharmacokinetic effect of such preparations has been evaluated using rabbits as a suitable in vivo model, and tested in man. Dose determination was carried out using curve fitting according to RSTPJP II program. In bioavailability test using rabbit, AUCs of sulindac in a few designed formulations were similar to each other. $C_{max}$- of RF and SR were 1.8 times and 1.2 times higher, respectively, compared to that of combined formulation (FR:SR=1:1). While plasma concentration of FR and SR decreased rapidly, that of combined formulation (FR:SR 1:1) lasted at the level close to $C_{max}$ for 24 hrs. Plasma concentration of sulfide form from the combined pellet(FR:SR=1:1) lasted for 24 hrs, and its AUC value was 1.4-fold, 2.7-fold. and 1.2-fold greater than FR pellet, SR pellet and combined pellet (FR:SR 1 : 2). Thus, the combined pellet of 1:1 ratio was found to be the most effective for oral sustained release formulation. Bioavailability test in human showed that AUC of sulfide from TSRP (1 : 1) was approximately 1.5 times greater than total AUC of Immbaron$^{\circledR}$ administered twice in a day. While $T_{max}$ of sulfide from lmmbaron$^{\circledR}$ was 4.33 +/- 1.37 hr (lst administration) and 3.33 ${pm}$ 0.82 hr (2nd administration), respectively, that of sulfide from TSRP increased to 7.17 ${pm}$ 2.86 hr. Plasma concentration of sulfide from TSRP was sustained at more, than 1.0 ${\mu}g{\cdot}$hr/ml until 24 hrs after one dose administration. In addition, TSRP may decrease local adverse reaction in the stomach, since plasma concentration of sulfide from the combined pellet was low within 2hrs in the stomach. In conclusion, it is suggested that TSRP formulation may be effective for oral 24 hr sustained release formulation of sulindac dosing 300 ~ 350mg once a day.

• 한국환경생태학회지
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• 제29권4호
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• pp.590-598
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• 2015

소나무재선충병에 대한 다양한 방제방법에도 고사목은 해마다 급격히 증가하고 있다. 그러나 현 방제방법 문제에 대한 연구는 매우 미흡한 실정이다. 재선충 확산 방지를 위해 가장 널리 쓰이는 방법은 병의 매개충인 솔수염하늘소 유충 폐사를 위한 감염목 훈증처리방법이다. 본 연구는 산림 내 소나무재선충 감염목 훈증처리지역에서 훼손 정도를 확인하고자 경상남도 밀양시 일대에 $100m^2$의 조사구 32개소를 설치하여 근원단면적과 수관단면적을 분석하였다. 훼손되지 않은 수목에서 도출한 근원단면적과 수관단면적의 회귀식(침엽수: $R^2=57.4$, 낙엽활엽수: $R^2=63.8$)을 바탕으로 훼손된 수목의 수관단면적을 유추하였다. 분석결과 수관단면적을 기준으로 재선충감염목은 18.7%이었으며 재선충과 무관하게 베어진 수목은 35.5%에 달했다. 소나무류의 경우 8.4%가 재선충과 관계없이 훼손되었으나 참나무류를 포함한 낙엽활엽수류는 훼손비율이 62%에 달했다. 소나무재선충 방재를 위한 훈증처리작업에 따른 아교목층 낙엽활엽수의 무분별한 제거는 산림의 온도저감, 습도조절 등 공익적 기능을 저하할 우려가 높았다.

• Restorative Dentistry and Endodontics
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• 제22권2호
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• pp.505-518
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• 1997

The objective of this investigation was to compare the effects of water storage on the aspect of hardness and diametral tensile strengths of four hybrid glass ionomer cements(two compomers and two resin-reinforced glass ionomers) with a resin composite material. One composite resin(Degufill Ultra), two compomers(Dyract, Compoglass Cavifil), and two resin-reinforced glass ionomers(Fuji Duet, Vitremer) were used in this study. Cylindrical specimens were prepared and stored at $36{\pm}1^{\circ}C$ in distilled water for 10 minutes after set, and then tested on an Instron testing machine(No.4467) at 1.0 mm/min displacement rate. Vicker's hardness and diametral tensile strengths as time elapsed were measured after aging in water for 10 minutes, 1 hour, 3 hours, 1 day, 3 days, 5 days and 7 days at $36{\pm}1^{\circ}C$. During the test of diametral tensile strength, stress-strain curves were obtained, from which the compressive modulus were calculated and compared. The structure of four set glass ionomer cement mass was observed on SEM(Hitachi, S-2300) after being etched with 9.6% hydrofluoric acid for 1 minute. The results were as follows; 1. The hardness of the experimental group(compomer and the resin reinforced glass ionomer cement) did not exceed the value of control group(Degufill Ultra). 2. Vicker's hardness of the Fuji Duet tended to increase succeedingly, Dyract was decreased after 3 hours in water, and Vitremer was the lowest. 3. The control group(Degufill Ultra) presented progressively on increased diametral tensile strength with time, Fuji Duet were decreased after 3 days, Compoglass Cavifil and Vitremer were decreased after 5 days in water storage. 4. Compressive modulus of the control group(Degufill Ultra) and Dyract were increased sharply timely, Fuji Duet and Vitremer were increased smoothly by lapse of time in water. Fuji Duet were stronger than Vitremer. On the other hand, Vitremer exhibited the lowest toughness. 5. The microstructure of compomer was similar with that of the composite resin(Degufill Ultra), and the fillers in resin-reinforced glass ionomer cements were noticed. It can be concluded that mechanical properties of hybrid glass ionomer cements is weaker than composite resin, and that the compomers or the resin-reinforced glass ionomers can not substitute the composite resins. A plenty of considerations should be done on the application of them to the area under the loading and high wear has a little adverse effect on the mechanical properties on the water storage for 7 days. The further research should be needed to confirm the advantage of the compomer.

• 한국식품저장유통학회지
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• 제19권2호
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• pp.315-321
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• 2012

본 연구는 김치에서 분리한 항진균 및 항세균 활성을 나타내는 $Lb.$ $plantarum$ AF1을 분리하여 이 균의 천연 식품보존제 및 사료보존제로서 사용 적합성 및 안전성을 평가하고자 단회 급성독성시험을 실시하였다. 급성독성시험을 위하여 경구 혹은 복강으로 1회 시험물질을 최고 용량(경구: 5,000 mg/kg, 복강: 2,500 mg/kg)으로 하여 ICR계통 암 수 마우스에게 용량별 각 군당 10마리씩 투여한 후 14일간의 일반증상, 사망률, 체중, 임상증상 및 육안적 소견을 관찰하였다. 단회 경구투여 혹은 복강주사한 후 모든 시험군에서 사망례가 관찰되지 않았으며, 시험동물은 시험 종료 시까지 계속 생존하여 평균치사량을 산출할 수 없었다. 복강 혹은 경구투여한 후 마우스의 체중변화에 있어서도 암 수 모두 대조군과 시료물질 투여군 사이에 유의성 있는 차이는 보이지 않았으며, 용량 의존적인 차이도 볼 수 없었다. 경구구투여 혹은 복강주사 단회 투여한 후 시험 종료한 다음 생존동물 모두를 부검하여 주요 장기의 육안적 소견을 관찰한 결과 대조군과 시료투여군 모두에서 외관상이나 내부장기에 어떠한 이상소견이나 병변이 관찰되지 않았다. 이상의 결과로부터 시험물질인 $Lb.$ $plantarum$ AF1는 경구투여 혹은 복강주사 시 ICR계통 암 수 마우스에서 독성학적인 변화가 관찰되지 않았으며, $LD_{50}$은 복강주사가 2,500 mg/kg, 경구투여가 5,000 mg/kg 이상인 저독성의 안전한 물질로 사료된다.