• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.8 no.2
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• pp.11-19
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• 2013

Many companies are developing a numerous number of new products and business models for their sustainable growth. First, their unique technological capability needs to be obtained to develop new products and services. However, as the applicable period of a technology into its industrialization becomes shorter and shorter, the necessity of technological convergence is increasing. Therefore, this study aims to look at the patent status in Korea for the last ten years to analyze in which direction technological convergence had advanced and further compare the patent status in Korea with that in U.S., Europe, and Japan. In addition, this study looks at the impact of converged patent technology on the sales in relevant industries. To this end, this study collected 5,000 patents applied from 2000 to 2009 for the last ten years in Korea, U.S., and Europe every year and conducted network analysis by using UCINET, social network analysis program. In this study, we drew our research findings as follows: First, we could find that technological convergence increased over time and what technology was in the center of fusion. Second, our correlation analysis found that as we had more technological convergence, it was more related to the sales in relevant industries.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.4
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• pp.875-886
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• 2015

By promoting the international transportation and the improvement of advanced exchange between South and North Korea, the Asian Highway plan was expected to make considerable economical effects in the North-East Asian region. This study focuses on a part of AH6 route (i.e., South Korea-North Korea-China-Far East Russia) and aims to analyze the behavioral change of international passenger transport around the Korean Peninsula by assuming the non-existent North Korea land transport network connectivity. The study was performed using two main methods. First, a stated preference survey was performed to derive the actual modal share of each travel mode. Second, a disaggregate analysis was performed to develop possible mode-choice models for international passenger travel and find out the suitable choice. Based on the results of the model estimation, it is found that over 90% of the international passenger transport would be converted to land transport (rail+highway). In addition, international railroad modal share rate would be increased from 62.8% to 66.1% and international bus would be decreased from 29.6% to 21.9% as the distance lengthened (903km~1,631km).

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.12
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• pp.1175-1183
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• 2013

Even if some CFD software developers and its users think that a state-of-the-art CFD software can be used to reasonably solve at least single-phase nuclear reactor safety problems, there remain limitations and uncertainties in the calculation result. From a regulatory perspective, the Korea Institute of Nuclear Safety (KINS) is presently conducting the performance assessment of commercial CFD software for nuclear reactor safety problems. In this study, to examine the prediction performance of commercial CFD software with the porous model in the analysis of the scale-down APR (Advanced Power Reactor Plus) internal flow, a simulation was conducted with the on-board numerical models in ANSYS CFX R.14 and FLUENT R.14. It was concluded that depending on the CFD software, the internal flow distribution of the scale-down APR was locally somewhat different. Although there was a limitation in estimating the prediction performance of the commercial CFD software owing to the limited amount of measured data, CFX R.14 showed more reasonable prediction results in comparison with FLUENT R.14. Meanwhile, owing to the difference in discretization methodology, FLUENT R.14 required more computational memory than CFX R.14 for the same grid system. Therefore, the CFD software suitable to the available computational resource should be selected for massively parallel computations.

• Journal of Korean Society of Environmental Engineers
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• v.30 no.5
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• pp.534-543
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• 2008

The experimental study with the prototype provides more acceptable data than the others. But there are so many limited conditions to perform the experimental study with the prototype. So the theoretical similitude with the scaled model and the numerical study with the CFD method have been chosen alternatively to analysis the fume movement. In this study, the ventilation was estimated from the results of the numerical study based on the experimental results as the boundary conditions. The grid A and B were same size and shape with the models which was used in the experimental study and consisted with 163,839, 122,965 cells respectively. The height of the fume layer was estimated form the mole fraction of fume components and the ventilation was determined by the velocity and temperature of the fume. The results of this study showed that the fume movements estimated from the numerical study are enough to apply to the prototype if there are proper heat loss correction factors. The numerical study is easier to change study conditions and faster to get results from the study than the experimental study. So if we find some proper heat loss correction factors, it's possible to execute the various and advanced study with the numerical study.

• Archives of design research
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• v.19 no.5 s.67
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• pp.55-64
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• 2006

As digital systems were introduced to automotive design in the mid 1980s, the design process has adopted many digital programs to save time compared to the conventional hand drafting. Digital technology was introduced not only to satisfy the reeds of the global environment, as the number of automobiles exported to many different parts of the world has increased, but also to save time and effort in developing several models of quality automobiles. Therefore, every automotive manufacturer in the world has expanded its virtual reality(VR) studio to establish visualization systems that visualize automobiles in the actual size and a co-operation system that enables simultaneous feedback from all of its design studios around the world. Unlike the existing design reviewing methos, the new improved feedback system is assessed as a reasonable method to evaluates and understand how the automobiles are actually manufactured in simulation. It is especially helpful when advanced products and concept cars require fast results. Other strengths of the new system include shorter development period, cost efficiency, no more manual labor, various designs within a short period of time, and realistic visualization of concepts. Large-scale products, including automobiles, need to be projected in the actual size and high clarity through the Power-wall System and are examined in a virtual space called a Cave. Therefore, it took much time to establish digital infrastructure. An infrastructure would constantly require system improvement and performance enhancement, but it is certain that now is the right time for the take-off to utilizing the strengths of digital design and improve the weaknesses. In this respect, this study provided an understanding of the importance of digital design based on digital reinforcements and examined an effective utilization of digital technology for an efficient development of automobiles in the future.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.517-524
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• 2020

In line with the recent wave of the 4th Industrial Revolution, the environment for defense R&D is transforming into a center of high-tech military technology. In particular, developed countries are strengthening control of technology exports and technology transfer to protect advanced defense science and technology. For this reason, the budget demand for securing the ability to develop independently high-tech weapons and core technologies suitable for the future battlefield environment is increasing, and increasing efficiency in R&D investment has been highlighted for efficient distribution of limited budgets. This study examined the efficiency of the defense basic R&D project using the non-parametric approach, DEA. The R&D budget, R&D researcher, and R&D period were selected as the input variables, and the number of papers and patents were used as output variables. The efficiency of basic R&D projects was analyzed through CCR, BCC models, and SE. Lastly, based on the efficiency measurements, the cause of the inefficiency of R&D projects was suggested, and ways to improve efficiency were suggested. This study is expected to be used as useful information that can be applied to project performance management through efficiency analysis of basic defense R&D projects and be reflected in the project planning stage through feedback.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.12 no.4
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• pp.315-334
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• 2014

Wolsong Low- and Intermediate-level radioactive waste (LILW) disposal center has two different types of disposal facilities and interacts with the neighboring Wolsong nuclear power plant. These situations impose a high level of complexity which requires in-depth understanding of phenomena in the safety assessment of the disposal facility. In this context, multidimensional radionuclide transport model and hydraulic performance assessment model should be developed to identify more realistic performance of the complex system and reduce unnecessary conservatism in the conventional performance assessment models developed for the $1^{st}$ stage underground disposal. In addition, the advanced performance assessment model is required to calculate many cases to treat uncertainties or study parameter importance. To fulfill the requirements, this study introduces the development of two-dimensional integrated near-field performance assessment model combining near-field hydraulic performance assessment model and radionuclide transport model for the $2^{nd}$ stage near-surface disposal. The hydraulic and radionuclide transport behaviors were evaluated by PORFLOW and GoldSim. GoldSim radionuclide transport model was verified through benchmark calculations with PORFLOW radionuclide transport model. GoldSim model was shown to be computationally efficient and provided the better understanding of the radionuclide transport behavior than conventional model.

• Journal of Animal Science and Technology
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• v.44 no.4
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• pp.427-442
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• 2002

Conjugated linoleic acid(CLA) is a collective term for a group of positional (c8, c10; c9, c11; c10, c12, and c11, c13) and geometric(cis,cis; cis,trans; trans,cis; and trans,trans) isomers of octadecadienoic acid (linoleic acid) with conjugated double bond system. CLA has been shown to have a variety of biological effects. Major effects of CLA on health, such as anti-cancer, anti-oxidation, anti-atherosclerosis and improving immuno-responses, might be derived or partially derived from the alternated lipid metabolism after CLA feeding. Most of studies on the effect of CLA on fat metabolism are concentrated on rats, mice, pigs and other mammals. The CLA inhibited carcinogen-induced neoplasia in several animal models and inhibited the proliferation of human malignant melanoma, colorectal and breast cancer cells and CLA reduced the atherosclerosis. Several studies have determined the antioxidant property of CLA; however, the property still remains controversial. Some of the studies have shown that CLA acted as an antioxidant, whereas some other studies have demonstrated that CLA might be a prooxidant. Several studies suggested that CLA could reduce fat accumulation in mammals. CLA was suggested to promote muscle growth and reduce fat deposition in mouse, and improve feed efficiency in rats. CLA has been shown to inhibit the activity of stearoyl-CoA reductase. CLA also reduced the content of arachidonic acid. Since arachidonic acid, and eicosapentaenoic acid (EPA) and docosahexenoic acid (DHA) are synthesized by different pathways, reducing the synthesis of arachidonic acid may not mean reducing that of EPA and DHA. Many sutdies have been shown biological effects of CLA. Therefore, further research is needed to answer the following questions: 1) how to synthesize the new CLA by new methods, 2) why CLA has shown biological effects, 3) how to increase CLA effects in animal products.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2431-2440
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• 2015

Background: Registry data from four major public hospitals indicate trends in clinical care and survival from colorectal cancer over three decades, from 1980 to 2010. Materials and Methods: Kaplan-Meier productlimit estimates and Cox proportional hazards models were used to investigate disease-specific survival and multiple logistic regression analyses to explore first-round treatment trends. Results: Five-year survivals increased from 48% for 1980-1986 to 63% for 2005-2010 diagnoses. Survival increases applied to each ACPS stage (Australian Clinico-Pathological Stage), and particularly stage C (an increase from 38% to 68%). Risk of death from colorectal cancer halved (hazards ratio: 0.50 (0.45, 0.56)) over the study period after adjusting for age, sex, stage, differentiation, primary sub-site, health administrative region, and measures of socioeconomic status and geographic remoteness. Decreases in stage were not observed. Survivals did not vary by sex or place of residence, suggesting reasonable equity in service access and outcomes. Of staged cases, 91% were treated surgically with lower surgical rates for older ages and more advanced stage. Proportions of surgical cases having adjuvant therapy during primary courses of treatment increased for all stages and were highest for stage C (an increase from 5% in 1980-1986 to 63% for 2005-2010). Radiotherapy was more common for rectal than colonic cases. Proportions of rectal cases receiving radiotherapy increased, particularly for stage C where the increase was from 8% in 1980-1986 to 60% in 2005-2010. The percentage of stage C colorectal cases less than 70 years of age having systemic therapy as part of their first treatment round increased from 3% in 1980-1986 to 81% by 1995-2010. Based on survey data on uptake of adjuvant therapy among those offered this care, it is likely that all these younger patients were offered systemic treatment. Conclusions: We conclude that pronounced increases in survivals from colorectal cancer have occurred at major public hospitals in South Australia due to increases in stage-specific survivals. Use of adjuvant therapies has increased and the patterns of change accord with clinical guideline recommendations. Reasons for sub-optimal use of radiotherapy for rectal cases warrant further investigation, including the potential for limited rural access to impede uptake of treatments at metropolitan-based radiotherapy centres.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.139-143
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• 2014

Although correlations between platelets and lung cancer has been recognized, effects on non-small cell lung cancer (NSCLC) metastasis remain to be determined in detail. In the present study, wound healing assays revealed a role of platelets in NSCLC cell migration. Thus the mean migration rate of lung adenocarcinoma A549 cells was significantly elevated after co-culture with platelets ($81.7{\pm}0.45%$ vs $41.0{\pm}3.50%$, P<0.01). Expression of GAPDH was examined by reverse transcription-polymerase chain reaction to study the effect of platelets on NSCLC cell proliferation. The result showed that the proliferation of A549 and SPC-A1 cells was not affected. Mouse models were established by transfusing A549 cells and SPC-A1 cells into mice lateral tail veins. We found tumor metastasis nodules in lungs to be increased significantly after co-transfusion with platelets (in A549, $4.33{\pm}0.33$ vs $0.33{\pm}0.33$, P=0.01; in SPC-A1, $2.67{\pm}0.33$ vs $0.00{\pm}0.00$, P=0.01). In addition, consecutive inoperable patients with newly diagnosed NSCLC (TNM stage III or IV) between January 2009 and December 2011 were retrospectively reviewed. Using the Kaplan-Meier method, NSCLC patients with a high platelet counts demonstrated a significantly shorter progression free survival compared with those with a low platelet count (> $200{\times}10^9/L$, 3 months versus ${\leq}200{\times}10^9/L$, 5 months, P=0.001). An elevated platelet count was also identified as an independent prognostic factor by Cox regression analysis for prgression free survival (adjusted hazard ratio: 1.69; 95% CI: 1.16, 2.46; P=0.006). This study suggested that platelets might contribute to the hematogenous metastatic process by promoting cancer cell migration, which eventually affects the prognosis of NSCLC.