• Journal of Ginseng Research
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• v.38 no.3
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• pp.161-166
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• 2014

Ginseng is widely used for its promising healing and restorative properties as well as for its possible tonic effect in traditional medicine. Nowadays, many studies focus on purified individual ginsenoside, an important constituent in ginseng, and study its specific mechanism of action instead of whole-plant extracts on cardiovascular diseases (CVDs). Of the various ginsenosides, purified ginsenosides such as Rb1, Rg1, Rg3, Rh1, Re, and Rd are the most frequently studied. Although there are many reports on the molecular mechanisms and medical applications of ginsenosides in the treatment of CVDs, many concerns exist in their application. This review discusses current works on the countless pharmacological functions and the potential benefits of ginseng in the area of CVDs. Results: Both in vitro and in vivo results indicate that ginseng has potentially positive effects on heart disease through its various properties including antioxidation, reduced platelet adhesion, vasomotor regulation, improving lipid profiles, and influencing various ion channels. To date, approximately 40 ginsenosides have been identified, and each has a different mechanism of action owing to the differences in chemical structure. This review aims to present comprehensive information on the traditional uses, phytochemistry, and pharmacology of ginseng, especially in the control of hypertension and cardiovascular function. In addition, the review also provides an insight into the opportunities for future research and development on the biological activities of ginseng.

• Journal of Power System Engineering
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• v.18 no.6
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• pp.58-63
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• 2014

This paper deals with the effects of counterpart materials on the wear behavior of thermally sprayed STS316 coatings. STS316 powders were flame-sprayed onto a carbon steel substrate. Dry sliding wear tests were performed using the applied loads of 15 N. AISI52100, $Al_2O_3$, $ZrO_2$ and $Si_3N_4$ balls were used as counterpart materials. Wear behavior of STS316 coatings against different counterpart materials were studied using a scanning electron microscope(SEM) and energy dispersive X-ray spectroscopy (EDS). The results show that the wear behavior of thermally sprayed STS316 coatings strongly depends on the type of counterpart material. Dominant wear mechanism was similar for all studied materials as failure of adhesion film except for Si3N4 used as counterpart material. In the case of Si3N4 used as counterpart material, dominant wear mechanism was abrasion.

• Korean Journal of Metals and Materials
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• v.48 no.11
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• pp.1003-1008
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• 2010

In this study, the effect of the reinforcement on the wear behaviour and mechanical properties of hypereutectic Al-Si alloys was investigated. The Gas atomized hypereutectic Al-20Si alloy powders were mixed with 1, 3, and 5 wt.% AlN and TiC ceramic particles and consolidated by hotpress. The Al-20Si powder has both finely dispersed primary Si phases and eutectic structures. The Al-20Si-AlN, TiC composites showed that the reinforcements were distributed along the boundary of the Al-20Si alloy. The UTS increased with increasing the AlN, TiC contents. At a lower load, with an increasing weight fraction of reinforcements, the wear rate decreased in both composites and the wear mechanism was adhesive wear. At a higher load, the shape of the debris changes the mechanism of the AlN composites to abrasive-adhesion wear and this resulted in an increase of the wear rate.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.28 no.2
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• pp.111-117
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• 2006

An area of current research is investigating the app1ication of human mesenchymal stem cells or hMSCs as a cell-based regenerative therapy. In order to achieve effective bone regeneration, appropriate matrices functioning as cell-carriers must be identified and optimized in terms of function, efficacy and biocompatibility. Two methods of approaching optimization of matrices are to facilitate adhesion of the donor hMSCs and furthermore to facilitate recruitment of host progenitor cells to osteoblastic differentiation. Pleiotrophin is an extracellular matrix protein that was first identified in developing rat brains and believed to be associated with developing neuronal pathways. A recent publication by Imai and colleagues demonstrated that transgenic mice with upregulated pleiotrophin expression developed a greater volume of cortical as well as cancellous bone. The proposed mechanism of action of pleiotrophin is demonstrated here. Through either environmental stresses and/or intracellular regulation, there is an increase in pleiotrophin production. The pleiotrophin is released extracellularly into areas requiring bone deposition. A receptor-mediated process recruits host osteoprogenitor cells into these areas. Therefore, the aim of our study was to investigate the osteoconductive properties of pleiotrophin. We wanted to determine if pleiotrophin coating facilitates cellular adhesion and furthermore if this has any effect on hMSCs derived bone formation in an animal model. The results showed a dose dependent response of cellular adhesion in fibronectin samples, and cellular adhesion was facilitated with increasing pleiotrophin concentrations. Histologic findings taken after 5 weeks implantation in SCID mouse showed no presence of bone formation with only a dense fibrous connective tissue. Possible explanations for the results of the osteogenesis assay include inappropriate cell loading.

• Tuberculosis and Respiratory Diseases
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• v.58 no.3
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• pp.276-284
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• 2005

Backgraound : There have been many reports on the pathogenesis of sepsis-induced acute respiratory distress syndrome(ARDS) but, the precise mechanism has not been elucidated. This study examined the protective effect of an inhibition of platelet activating factor(PAF) remodeling and the adhesion molecule on the oxidative stress of the lungs in rats with an endotoxin induced acute lung injury(ALI). Methods : ALI was induced in Sprague-Dawley rats by instilling an E-coli endotoxin into the trachea. Ketotifen and fucoidan were used respectively to inhibit PAF remodeling and adhesion molecule. The lung leak index, lung myeloperoxidase(MPO) activity, bronchoalveolar lavage(BAL) fluid neutrophil count and lyso PAF acetyltransferase activity(AT), were measured and an ultrastructural study and cytochemical electron microscopy were performed. Results : The lung leak index, lung MPO activity, BAL fluid neutrophil count and lyso PAF AT activity was higher in the endotoxin-treated rats. In addition, severe destruction of the pulmonary architecture and increased hydrogen peroxide production were identified. These changes were reversed by ketotifen. However, fucoidan did not appear to have any protective effects. Conclusion : The inhibition of PAF remodeling appeared to be effective in decreasing the endotoxin-induced ALI. In addition, this effect might be derived from the inhibition of neutrophilic oxidative stress. However, the inhibition of the adhesion molecules by fucoidan appeared to be ineffective in decreasing the endotoxin-induced ALI.

• KSBB Journal
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• v.24 no.6
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• pp.541-548
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• 2009

For investigation of anti-angiogenesis mechanism of Anthrisci radix, Psoraleae semen, Siegesbeckiae herba and Corni fructus, anti-cell adhesion experiment was performed. The adhesion of U937 cells to IL-$1\beta$-stimulated HUVECs was completely suppressed by 276% at 0.2 mg/L of Anthrisci radix, 220% at 5 mg/L of Psoraleae semen, 158% at 10 mg/L of Siegesbeckiae herba and 132% at 20 mg/L of Corni fructus, respectively. And the adhesion of PMA-chemical stimulated U937 cells to HUVECs, it was inhibited 139% at 0.2 mg/L of Anthrisci radix, 442% at 5 mg/L of Psoraleae semen, 720% at 10 mg/L of Siegesbeckiae herba and 664% at 20 mg/L of Corni fructus. Also, the adhesion of chemical stimulated U937 cells to IL-$1\beta$/chemical stimullated HUVECs, it was inhibited by 286% at 0.2 mg/L of Anthrisci radix, 146% at 5 mg/L of Psoraleae semen, 436% at 10 mg/L of Siegesbeckiae herba and 297% at 20 mg/L of Corni fructus, respectively. It would be a useful substance for anti-cell adhesion based on anti-angiogenesis for anti-obesity and anti-cancer.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 1995.06b
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• pp.7-13
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• 1995

현재 교통인구 비중에 큰 비중을 차지하고 있는 철도 차량은 기술의 발전으로 인한 고속화에 성공하여 300km/h대의 속도를 달성하기에 이르렀다. 열차가 고속화됨으로 인하여 열차 주행시 운동에너지가 더욱 커졌고 이를 소산하기 위한 제동 역시 더욱 중요하게 되었다. 열차의 제동시 중요한 점은 wheel의 skidding을 방지함으로 wheel의 편마멸을 줄이는 것이며 이를 위해선 제동장치의 설계시 wheel과 rail간의 점착현상의 이해가 필수적이다. 제동력이 점착력보다 클 경우는 skidding이 발생하며 제동력이 점착력보다 작은 경우는 충분한 제덩을 하지 못한다는 것을 의미한다. 그러므로 열차의 제동장치를 설계함에 있어서 점착계수는 필수적인 요소가 되었으며 미국, 일본, 독일 등의 선진 각국에서는 점착계수를 측정하여 그 특성을 파악하려는 실험이 실험실 및 실차 차원에서 많이 행하여졌다. 각각 다른 접척조건, 속도 등에 따른 실험이 진행되어 왔으나 각 연구의 결과는 조금씩 다른 결향을 나타내었고, 점착현상에 관한 물리적인 설명은 못하고 있는 실정이다. 본 연구에서는 wheel과 rail의 접촉인 경우에 있어 점착현상의 변화를 속도, 하중, 접촉조건에 따른다고 보고 점착현상의 특성을 각각 sliding, pure rolling실험을 통해 파악하고 기타 참고문헌에서 발표된 점착계수와 비교하여 물리적으로 이해하고자 하였다.

• Proceedings of the Korea Concrete Institute Conference
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• 2002.10a
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• pp.593-598
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• 2002

Routinely, strength method for the determination of the nominal moment of reinforced concrete beam is assumed to also be suitable for strengthening beams with carbon fiber sheets since typically strengthening beams compromise 98% by volume of reinforced concrete. Flexural capacity of strengthening beam is absolutely dependent upon the type of reinforcement materials, amount of reinforcement, anchoring system, adhesion capacity between reinforcement material and concrete. Therefore, it might be incorrect to use strength method for analysis and design of strengthening beam without considering the differences in the load-deflection curves, mechanism of failure, state of stress distribution, failure strain of the reinforcement. An flexural analysis based on force equilibrium and strain comparability has been developed for strengthening beam. Systematic experimental investigations are compared with analytical results. Then, the adaptation of strength method for strengthening beam have also been discussed.

• The Journal of Korean Physical Therapy
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• v.14 no.1
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• pp.219-226
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• 2002

Vascular endothelial growth factors(VEGFs) constitute a group of structurally and functionally related growth factor that modulate many important physiological functions of endothelial cells, especially angiogenesis. This paper explain substance, which participate in signaling transduction of VEGF, including Bcl-2, caspase, focal adhesion kinase(FAK), integrin ${\alpha}v{\beta}3$, MAP kinase, nitric oxide(NO)and prostacyclin(PGI2). Physical therapy enhance angiogenesis for repairment of injury which as wound healing, muscle contusion, cerebrovascular disease, rheumatoid arthritis. Therefore this review assist understanding for mechanism of physical therapy as therapeutic angiogenesis.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2000.05a
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• pp.146-152
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• 2000

As an improvement in the standard of living and economic growth the demand for air conditioning equipment is increasing rapidly. Nowadays air conditioning equipments are being used for industry large building house and car. Thess equipments was concentrated on improving heat efficiency of economic aspects while they design heat exchanger for cooling and heating,. These air conditioning equipments using heat exchanger cause a discomfort to user due to generating mist at the beginning of operating. Therefore the user demand air of high class and quality. In this experimental study to acquire elementary data for development of heat exchanger which be able to supply air of high quality that is to say possess a restraint effect of mist generation. We estimate an effect on cooling plate kind supply air velocity supply air temperature cooled plate temperature and supply air relative humidity which have an influence on outlet air condition of heat exchanger.