Structural reliability assessment using an enhanced adaptive Kriging method
-
- Structural Engineering and Mechanics
- /
- 제66권6호
- /
- pp.677-691
- /
- 2018
Reliability assessment of complex structures using simulation methods is time-consuming. Thus, surrogate models are usually employed to reduce computational cost. AK-MCS is a surrogate-based Active learning method combining Kriging and Monte-Carlo Simulation for structural reliability analysis. This paper proposes three modifications of the AK-MCS method to reduce the number of calls to the performance function. The first modification is related to the definition of an initial Design of Experiments (DoE). In the original AK-MCS method, an initial DoE is created by a random selection of samples among the Monte Carlo population. Therefore, samples in the failure region have fewer chances to be selected, because a small number of samples are usually located in the failure region compared to the safe region. The proposed method in this paper is based on a uniform selection of samples in the predefined domain, so more samples may be selected from the failure region. Another important parameter in the AK-MCS method is the size of the initial DoE. The algorithm may not predict the exact limit state surface with an insufficient number of initial samples. Thus, the second modification of the AK-MCS method is proposed to overcome this problem. The third modification is relevant to the type of regression trend in the AK-MCS method. The original AK-MCS method uses an ordinary Kriging model, so the regression part of Kriging model is an unknown constant value. In this paper, the effect of regression trend in the AK-MCS method is investigated for a benchmark problem, and it is shown that the appropriate choice of regression type could reduce the number of calls to the performance function. A stepwise approach is also presented to select a suitable trend of the Kriging model. The numerical results show the effectiveness of the proposed modifications.
비정렬 격자계에서 continuous adjoint 방정식을 사용하여 제자리 비행을 하는 헬리콥터 로터 블레이드에 대한 공력 형상 최적설계 기법을 개발하였다. 효율적인 민감도 계산을 위해 회전좌표계에서 continuous adjoint 민감도 해석 기법을 유도하였다. 설계과정의 반복적인 수치계산의 효율을 높이기 위해서 영역 분할 기법에 기반을 둔 병렬처리 기법을 도입하였다. 끝단 와류의 정확한 포착을 위해서 끝단와류를 따른 격자적응을 수행하였다. 이러한 방법은 Caradonna와 Tung의 실험형상 및 UH60 헬리콥터 로터 블레이드의 공력 최적설계에 적용되었으며, 본 연구에서 사용된 최적설계 기법을 이용하면 일정한 추력을 유지하면서 요구동력을 현저하게 줄일 수 있음을 보였다.
의료정보는 환자의 프라이버시 침해 뿐 아니라 환자의 생명에도 직결되기 때문에, 견고하고 유연한 보안모델에 대한 지속적인 연구가 필요하다. 특히, u-헬스케어 환경은 사용자 상황변화가 다양하기 때문에, 보다 더 유연하고 세밀한 접근 권한제어가 필요하다. 본 논문은 u-헬스케어 영역에서 상황타입(Context Type)과 상황제한(Context Constraint)을 정의하고, 의료정보의 비밀등급, 사용자의 권한등급, 사용자의 역할, 사용자 상황에 따른 권한 변경 등을 정의하였다. 또한, 사용자 역할을 기반하여 상황정보 변화에 적용할 수 있는 상황기반 접근제어 모델을 설계하였다. 상황기반 접근제어 모델은 K2BASE를 이용하여 자원과 권한의 관계성과 접근 포인트로 부터 도달 가능한 모든 자원에 대한 권한을 분석하였다. 상황기반 접근제어 모델은 u-헬스케어 영역에서 상황을 기반으로 권한변경과 역할을 유연하게 변경할 수 있고, 권한이 부여된 자원에 의미적으로 연결된 자원을 획득할 수 있어, 상황변화가 다양한 u-헬스케어 영역에서 유연하고 적응적인 접근제어 모델로서 적용 가능할 것이다.
In recent years the interest in online monitoring of lightweight structures with ultrasonic guided waves is steadily growing. Especially the aircraft industry is a driving force in the development of structural health monitoring (SHM) systems. In order to optimally design SHM systems powerful and efficient numerical simulation tools to predict the behaviour of ultrasonic elastic waves in thin-walled structures are required. It has been shown that in real industrial applications, such as airplane wings or fuselages, conventional linear and quadratic pure displacement finite elements commonly used to model ultrasonic elastic waves quickly reach their limits. The required mesh density, to obtain good quality solutions, results in enormous computational costs when solving the wave propagation problem in the time domain. To resolve this problem different possibilities are available. Analytical methods and higher order finite element method approaches (HO-FEM), like p-FEM, spectral elements, spectral analysis and isogeometric analysis, are among them. Although analytical approaches offer fast and accurate results, they are limited to rather simple geometries. On the other hand, the application of higher order finite element schemes is a computationally demanding task. The drawbacks of both methods can be circumvented if regions of complex geometry are modelled using a HO-FEM approach while the response of the remaining structure is computed utilizing an analytical approach. The objective of the paper is to present an efficient method to couple different HO-FEM schemes with an analytical description of an undisturbed region. Using this hybrid formulation the numerical effort can be drastically reduced. The functionality of the proposed scheme is demonstrated by studying the propagation of ultrasonic guided waves in plates, excited by a piezoelectric patch actuator. The actuator is modelled utilizing higher order coupled field finite elements, whereas the homogenous, isotropic plate is described analytically. The results of this "semi-analytical" approach highlight the opportunities to reduce the numerical effort if closed-form solutions are partially available.
The structural analysis module is an essential part of any integrated structural system. Diverse integrated systems today require, from the analysis module, efficient real-time responses to real-time input such as earthquake signals, extreme weather-related forces, and man-made accidents. An integrated system may also be for the entire life span of a civil structure conceived during the initial conception, developed throughout various design stages, effectively used in construction, and utilized during usage and maintenance. All these integrated systems' essential part is the structural analysis module, which must be automated and computationally efficient so that responses may be almost immediate. The finite element method is often used for structural analysis, and for automation, many effective finite element meshes must be automatically generated for a given analysis. A computationally efficient finite element mesh generation scheme based on the r-h method of mesh refinement using strain deviations from the values at the Gauss points as error estimates from the previous mesh is described. Shape factors are used to sort out overly distorted elements. A standard cantilever beam analyzed by four-node plane stress elements is used as an example to show the effectiveness of the automated algorithm for a time-domain dynamic analysis. Although recent developments in computer hardware and software have made many new applications in integrated structural systems possible, structural analysis still needs to be executed efficiently in real-time. The algorithm applies to diverse integrated systems, including nonlinear analyses and general dynamic problems in earthquake engineering.
Introduction: TLR-5, a member of the toll-like receptor (TLR) family, is a element of the type I transmembrane receptors, which are characterized by an intracellular signaling domain homolog to the interleukin-1 receptor. These receptors recognize microbial components, particularly bacterial flagellin. All-trans retinoic acid (atRA, tretinoin), a natural metabolite of vitamin A, acts as a growth and differentiation factor in many tissues, and is also needed for immune functions. In this study, THP-1 human macrophage-monocytes were used to examine the mechanisms by which atRA regulated the expression of TLR-5. Because the molecular mechanism underlying this regulation at the transcriptional level is also unclear, this study examined which putative transcription factors are responsible for TLR-5 expression by atRA in immune cells. Materials and Methods: This study examined whether atRA induces the expression of TLR-5 in THP-1 cells using reverse transcription-polymerase chain reaction (RT-PCR), and which transcription factors are involved in regulating the TLR-5 promoter in RAW264.7 cells using a reporter assay system. Western blot analysis was used to determine which signal pathway is involved in the expression of TLR-5 in atRA-treated THP-1 cells. Results: atRA at a concentration of 10 nM greatly induced the expression of TLR-5 in THP-1 cells. Human TLR-5 promoter contains three Sp-1/GC binding sites around -50 bp and two NF-kB binding sites at -380 bp and -160 bp from the transcriptional start site of the TLR-5 gene. Sp-1/GC is primarily responsible for the constitutive TLR-5 expression, and may also contribute to NF-kB at -160 bp to induce TLR-5 after atRA stimulation in THP-1 cells. The role of NF-kB in TLR-5 expression was further confirmed by inhibitor pyrrolidine dithiocarbamate (PDTC) experiments, which greatly reduced the TLR-5 transcription by 70-80%. Conclusion: atRA induces the expression of the human TLR-5 gene and NF-kB is a critical transcription factor for the atRA-induced expression of TLR-5. Accordingly, it is conceivable that retinoids are required for adequate innate and adaptive immune responses to agents of infectious diseases. atRA and various synthetic retinoids have been used therapeutically in human diseases, such as leukemia and other cancers due to the antiproliferative and apoptosis inducing effects of retinoids. Therefore, understanding the molecular regulatory mechanism of TLR-5 may assist in the design of alternative strategies for the treatment of infectious diseases, leukemia and cancers.
The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70
The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70