• Mycobiology
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• 제42권1호
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• pp.52-58
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• 2014

A nucleoside diphosphate-linked moiety X (Nudix) hydrolase-like gene, YSA1, has been identified as one of the gromwell plant extract-responsive genes in Cryptococcus neoformans. Ysa1 is known to control intracellular concentrations of ADP-ribose or O-acetyl-ADP-ribose, and has diverse biological functions, including the response to oxidative stress in the ascomycete yeast, Saccharomyces cerevisiae. In this study, we characterized the role of YSA1 in the stress response and adaptation of the basidiomycete yeast, C. neoformans. We constructed three independent deletion mutants for YSA1, and analyzed their mutant phenotypes. We found that ysa1 mutants did not show increased sensitivity to reactive oxygen species-producing oxidative damage agents, such as hydrogen peroxide and menadione, but exhibited increased sensitivity to diamide, which is a thiol-specific oxidant. Ysa1 was dispensable for the response to most environmental stresses, such as genotoxic, osmotic, and endoplasmic reticulum stress. In conclusion, modulation of YSA1 may regulate the cellular response and adaptation of C. neoformans to certain oxidative stresses and contribute to the evolution of antifungal drug resistance.

• 한국치위생학회지
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• 제21권3호
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• pp.311-318
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• 2021

Objectives: The purpose of this study was to understand the level and patterns of college adjustment, major satisfaction, academic engagement, and attention deficit hyperactivity disorder (ADHD). This study examined the factors influencing adaptation to college life. Methods: This study was approved by the institutional review board of 00 university. We analyzed 166 survey data responses collected by distributing questionnaires from June 1 to July 2, 2020. Statistical product and service solutions version 23.0 was used for statistical analyses. The data were presented as frequencies and percentages or means and standard deviations, and pearson correlation analysis and multiple regression analysis were performed. Results: There was a significant difference in the average score of major satisfaction according to the type of college (university) and grades. For college adjustment, there was a significant difference in the average score according to major grades. Academic engagement showed a significant difference in the average score according to the college type and grade. Major satisfaction, college adjustment, and academic motivation showed significant positive correlations among the variables, whereas ADHD, major satisfaction, and college adjustment showed a significant negative correlation. Multiple regression analysis revealed that major satisfaction (p<0.001) and academic motivation (p<0.001) were factors affecting college adjustment (p<0.05). Conclusions: It is necessary to develop and apply specific and systematic adaptation programs to improve the understanding, control, and guidance methods for college students and to promote human relations, such as school life and social life.

• BMB Reports
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• 제47권1호
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• pp.15-20
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• 2014

Intracellular lipid-binding proteins (LBPs) impact fatty acid homeostasis in various ways, including fatty acid transport into mitochondria. However, the physiological consequences caused by mutations in genes encoding LBPs remain largely uncharacterized. Here, we explore the metabolic consequences of lbp-5 gene deficiency in terms of energy homeostasis in Caenorhabditis elegans. In addition to increased fat storage, which has previously been reported, deletion of lbp-5 attenuated mitochondrial membrane potential and increased reactive oxygen species levels. Biochemical measurement coupled to proteomic analysis of the lbp-5(tm1618) mutant revealed highly increased rates of glycolysis in this mutant. These differential expression profile data support a novel metabolic adaptation of C. elegans, in which glycolysis is activated to compensate for the energy shortage due to the insufficient mitochondrial ${\beta}$-oxidation of fatty acids in lbp-5 mutant worms. This report marks the first demonstration of a unique metabolic adaptation that is a consequence of LBP-5 deficiency in C. elegans.

• 공학교육연구
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• 제14권2호
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• pp.3-12
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• 2011

본 연구는 공학인증제도를 시행하고 있는 공과대학 편입생들의 대학생활적응과 대학생활 만족도를 살펴봄으로써 공과대학 편입생들의 대학생활에 관한 깊이 있는 이해와 편입생들의 공학인증 참여를 제고하고, 의미 있고 원만한 대학생활을 지원하기 위한 방안을 모색하는 데 그 목적을 두고 있다. 이러한 목적을 달성하기 위하여 K대학교와 D대학교의 공과대학에 편입학한 학생 193명을 대상으로 설문조사를 실시하였다. 연구결과 공과대학 편입생은 주로 일반편입학전형에 의해 편입하고 있었으며, 편입학 이후의 성적이 전적대학의 성적보다 낮 으나 편입학 이후의 학교생활에 대해서는 대체로 만족하고 있었으며, 공학인증의 참여는 저조한 것으로 나타났다. 따라서 공과대학 편입생들의 학교생활 적응과 공학인증참여를 제고하기 위한 노력이 필요하다고 판단된다. 또한 학교생활만족도에서 남학생이 여학생보다 교육성과측면에서의 만족도가 높았고, 전적대학에서 성적이 좋은 학생들이 편입학 이후의 학교생활에 더 잘 적응하고 있으며 그에 따라 만족도도 높은 것으로 나타났다. 따라서 편입 여학생들의 학교생활 적응을 위한 지원을 좀 더 적극적으로 할 필요가 있으며, 편입생들의 학교생활 만족도 제고를 위한 지원 노력이 필요하다고 판단된다.

• Child Health Nursing Research
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• 제27권3호
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• pp.201-210
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• 2021

Purpose: This study analyzed research trends related to childhood and adolescent cancer survivors (CACS) using word co-occurrence network analysis on studies registered in the Korean Citation Index (KCI). Methods: This word co-occurrence network analysis study explored major research trends by constructing a network based on relationships between keywords (semantic morphemes) in the abstracts of published articles. Research articles published in the KCI over the past 10 years were collected using the Biblio Data Collector tool included in the NetMiner Program (version 4), using "cancer survivors", "adolescent", and "child" as the main search terms. After pre-processing, analyses were conducted on centrality (degree and eigenvector), cohesion (community), and topic modeling. Results: For centrality, the top 10 keywords included "treatment", "factor", "intervention", "group", "radiotherapy", "health", "risk", "measurement", "outcome", and "quality of life". In terms of cohesion and topic analysis, three categories were identified as the major research trends: "treatment and complications", "adaptation and support needs", and "management and quality of life". Conclusion: The keywords from the three main categories reflected interdisciplinary identification. Many studies on adaptation and support needs were identified in our analysis of nursing literature. Further research on managing and evaluating the quality of life among CACS must also be conducted.

• 한국작물학회지
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• 제60권2호
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• pp.180-184
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• 2015

For waxy corn hybrid development, 23 waxy corn hybrids were planted and surveyed in both pericarp thickness and sugar content. Pericarp thickness showed average 50 to $49{\mu}m$ in field and greenhouse. Results like these advanced than previous other hybrids. Also, sugar content in developed waxy corn evaluated as 13.6 to 15.3 brix. Here, we concluded that edible quality of waxy corn depended on combing of two factors. Especially, CNU11H8 hybrid at field and CNU11H-38 at greenhouse were good in both factors. Accordingly, these hybrids will be planted in next time for productivity and area adaptation.

• 대한한의학회지
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• 제31권2호
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• pp.64-70
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• 2010

Objective: This study aimed to construct an overview of health-related quality of life (HRQOL) scales for application in studies of traditional Korean medicine (TKM). Methods: We analyzed all HRQOL scales from the PROQOLID web site (www.proqolid.org) regarding to classification, application purposes, and translation to Korean version. We also searched clinical studies focused on "Quality of Life" using TKM. Results: A total of 660 HRQOL instruments were analyzed; 99 were for general condition while 559 were disease-specific. Twenty clinical studies for TKM were conduced using HRQOL scales. Conclusion: The adaptation of the international HRQOL instrument is strongly recommended in TKM-associated clinical study, and development of a TKM-specific HRQOL scale is needed for globalization of TKM.

• 간호행정학회지
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• 제22권5호
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• pp.496-506
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• 2016

Purpose: This study was conducted to examine the adaptation experience of male nurses working in general wards. Methods: Experiential data was collected from 16 general ward nurses through in-depth interviews. Participants were selected from male nurses working in the general wards with over one year of clinical experience at a tertiary university hospital. The main question was "Can you describe your adaptation experience in the general ward as a nurse?" All interviews were recorded and transcribed, then analyzed using Colaizzi's method. Results: Four categories were derived from the analysis: 'difficulties from task adaptation by characteristics', 'limited nursing situation and circumstance as a male nurse', 'efforts to adapt at general nursing unit', and 'self-worth, and worry about something as a male nurse'. Conclusion: Male nurses had a difficulty adapting to work in wards due to lack of multi-tasking skills, as well as some social prejudice or negative views on male nurses. Establishing reasonable guidelines for male nurses in practice, promoting their responsibilities to patients, developing mentoring programs, and reassessing the policy of assigning male nurses to general wards are recommended to help in better adaptation.

• Child Health Nursing Research
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• 제23권2호
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• pp.238-248
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• 2017

Purpose: The main purpose of this study was to explore the adaptation experience of adolescent cancer survivors during and after cancer treatment, and their perceived social support networks. Methods: This study was a qualitative descriptive study using the in-depth interview. Eight adolescent cancer survivors who were diagnosed with cancer between 11 to 18 years old participated in the study. Results: The adaptation experiences of adolescent cancer survivors over time were identified within five categories for during their treatment such as "being catapulted from one's life," "standing at the center of discomfort," "falling behind the line," "accepting the change," "being developed", and another five categories for after the treatment including "being shackled," "encountering the forgotten reality," "overcoming and emerging from the reality," "growing into adulthood," "entering into a new orbit." Participants reported the various members of their social support network and their roles during and after the treatment as well. Conclusion: While adolescent cancer survivors adjusted to their changing situations after the cancer diagnosis, their internalized adaptation, as well as perceived social support from their diverse surrounding network, played significant roles. These findings will become a valuable asset for developing age-appropriate nursing interventions to promote psychosocial adjustment of adolescents with cancer.

• Journal of the Korean Data and Information Science Society
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• 제26권6호
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• pp.1439-1452
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• 2015

본 연구는 간호대학생의 대학생활적응에 영향을 미치는 변수를 확인하고 구체적인 경로와 그 영향력을 규명하여 간호대학생의 대학생활적응에 대한 모형을 개발하고자 시도되었다. 구조모형에 사용된 변수로는 모애착, 자아개념, 스트레스, 임상실습스트레스, 심리적 안녕감, 대처와 대학생활 적응이었다. 연구결과 수정모형의 적합도는 ${\chi}^2=231.1$ (p <.001), ${\chi}^2/df=2.36$로 적합한 것으로 나타났으며, GFI=.91, AGFI=.86, NFI=.91, PNFI=.73 RMSEA=.07, CFI=.95로 권장수준을 만족하였다. 변수들 중 애착, 자아개념, 스트레스, 대처방식과 심리적 안녕감은 직접으로 대학생활적응에 영향을 주었다. 자아개념은 대처방식과 심리적 안녕감을, 스트레스는 심리적 안녕감을 경유하여 대학생활적응에 영향을 주었다. 또한 이들 변수는 간호대학생의 대학생활적응을 71% 설명하는 것으로 확인되었다. 따라서 간호대학생의 대학생활적응을 증진시키기 위한 방안으로 스트레스감소와 함께, 심리적 안녕감과 대처능력을 증진시킬 수 있도록 자기관리능력 및 자아성장을 추구할 수 있는 학생관리 프로그램 개발 등을 모색하는 것이 중요할 것으로 사료된다.