• Korean Journal of Acupuncture
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• 제25권3호
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• pp.43-51
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• 2008

배경 : 최근까지 이루어진 천식의 침치료 무작위 대조군 연구들에 의한 결과는 뚜렷한 효과를 보여주지 못하고 있다. 이러한 요인의 하나로 적절한 피험자 수를 정하기 위한 예비 임상시험의 부재가 거론되고 있다. 따라서 천식에 대한 침치료의 본 임상시험에 앞서 이의 실행 가능성 및 규모를 예측하는 예비임상시험이 필요한 상황이다. 목적 : 예비임상시험을 통해 서양의학적 치료를 받고 있는 천식환자들에 대한 침치료의 부가적 효과를 검증하기 위한 본 임상시험의 실현 가능성을 예측하기 위함. 방법 : 본 시험은 무작위 단일 맹검 대조군 평행 설계 예비 임상시험이다. 1차 평가변수는 최대 호기량 검사기로 집에서 아침, 저녁으로 매일 측정한 수치로 구해진 최대 호기 유속 일중 변동률의 1주간 평균치 변화이며 2차 평가변수는 의료기관에서 시행하는 폐기능 검사, 기준시점 호흡곤란 지수, 호흡곤란 변화에 대한 지수, 천식환자들의 삶의 질 평가를 위한 설문 등이다. 피험자 수는 총 45명으로 선정 및 제외기준을 통해서 참여하게 되며 1주간의 최대 호기 유속 기저치 평가 기간을 거친 후 진짜침 처치 군, 가짜침 처치 군, 대기군 세 군에 각각 무작위로 15명씩 할당된다. 모든 피험자에게 기존의 천식관련 약물의 사용을 허용하며, 진짜침 처치군 및 가짜침 처치군은 주 3회 4주간 해당 처치를 받고 2주 후에 각 평가 항목에 대하여 추적, 관찰하게 된다. 대기군은 기존의 천식관리를 유지하면서 2주마다 방문하여 총 6주간 평가를 받고 진짜침 처치를 4주간 받게 된다. 고찰 : 본 연구는 국내에서 최초로 이루어지는 천식에 대한 침 무작위 대조군 예비 임상시험으로 향후 적절한 피험자 수와 실행가능성을 예측할 수 있으리라 기대된다.

• Korean Journal of Acupuncture
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• 제30권3호
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• pp.193-200
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• 2013

Objectives : This study is to examine the effects of moxibustion at Junggeuk(CV3), Singwol(CV8) on women's urinary incontinence and quality of life. The study is a research based on the non-equivalent control group pretest-posttest design. Methods : The subjects of the study were 45 women who were using either of 2 health clinics located in Ulsan. They were sampled in accordance with predetermined standards and then divided into the experimental and control groups, respectively consisting of 22 and 23 members. In treating those women through moxibustion, this researcher applied 2 sheets of 'shingigu' to each of the women on 40 min, per time basis. This experiment was conducted 6 times in total for 2 weeks on every two day basis. Data from all of the measurements were statistically processed and analyzed using SPSS/WIN 12.0. Demographic characteristics of the subjects were examined and indicated in frequency and percentage. The homogeneity test of the two groups was conducted using $x^2$-test, Fisher's exact test, t-test and Mann-Whitney U Test. Hypotheses set for the study were verified through t-test and Mann-Whitney U Test. Results : The experimental group who take moxibustion will be lower in the severeness of urinary incontinence than the control group who do not was supported(p<0.001). 2. The experimental group who take moxibustion will be higher in score for life quality than the control group who do not was supported(U=42.00, p<0.001). Conclusions : These findings suggest that moxibustion can be an effective intervention for women having urinary incontinence because it treats the symptom with no adverse effect and it is non-invasive and easily applicable.

• Korean Journal of Acupuncture
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• 제30권3호
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• pp.161-170
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• 2013

목적 : 침치료는 침자극을 가한 뒤, 발침한 뒤에 효과를 나타낸다. 그러므로 침연구에 있어서 침자극을 가하고 발침한 뒤에 나타나는 침의 반응을 관찰하여야 할 필요가 있다. 이에 본 연구에서는 안정성 네트워크를 이용하여 침자극 후의 반응을 관찰하여 발침 후에 뇌에 미치는 침의 반응을 관찰하였다. 방법 : 침자극에 의하여 나타나는 안정성 네트워크의 변화를 관찰하기 위하여 기능성 자기공명 영상장치를 사용하여 12명의 건강인을 대상으로 우측 양릉천 혈자리에 자침한 후, 침자극 전후의 뇌를 촬영하였다. 그리고 regional homogeneity(ReHo)와 amplitude of low frequency fluctuation(ALFF)를 이용하여 데이터를 분석하였다. 결과 : ReHo와 ALFF에서 공통적으로 안정성 네트워크가 증가된 영역은 좌우측 중전두이랑, 좌측 내측전두이랑, 좌측 상전두이랑, 그리고 우측 뒤쪽 띠이랑의 뇌부위였다. 특히 ReHo분석 결과 섬엽, 앞쪽 띠이랑과 선조체에서 안정성 네트워크가 증가된 것이 관찰되었는데, 이들 영역은 침의 진통작용과 관련된 영역들이다. 하지만 ALFF 분석결과에서는 이들 영역들이 나타나지 않았다. 결론 : ReHo와 ALFF 모두에서 침자극에 의한 안정성 네트워크의 변화를 관찰할 수 있었다. 또한 ReHo분석을 통하여 침자극에 의한 진통관련 영역들의 반응을 관찰할 수 있었다.

• Korean Journal of Acupuncture
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• 제18권1호
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• pp.11-20
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• 2001

댑싸리하고초 약침액을 이용하여 phase II detoxification 효소인 quinone reductase (QR 및 GST) 유도, GSH 생성량, phase I 효소 cytochrome P4501A1 활성억제, 발암물질 B[a]P-DNA adduct 형성의 저해효과 등을 측정하였다. QR 생성 유도를 Hepa1c1c7로 실험한 결과, 댑싸리하고초 약침액및 열수추출액 모두에서 유도 되었으며, 농도가 높아질수록 유도율이 더 높게 나타났으며, GSH와 GST의 유도율도 약침액에서 나타났다. 댑싸리하고초 약침액 $5{\times}$에서 45.2%의 cytochrome P4501A1 효소활성 저해효과를 측정할 수 있었다. 또한 B[a]P-DNA binding 저해효과를 실험한 결과, 약침액 $3{\times}$ 농도에서 45.0%의 저해효과가 있었다. 이상의 결과에 의하면 댑싸리하고초 약침액은 암억제 물질로서의 기능을 충분히 발휘할 것으로 사료된다.

• Korean Journal of Acupuncture
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• 제18권1호
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• pp.65-80
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• 2001

Effects of $LR_3$(太衝), $GB_{39}$(懸鍾) and $SP_4$(公孫) acupuncture on lipid composition were investigated in rat fed high fat diet. The results obtained from this study are as follows : 1. In the all treatment groups, the body weight values after feeding the basal diet for 4 weeks were significantly decreased compared to the initial body weight. However the decrement of body weight showed a high in acupuncture groups compared to those of control group. In the acupuncture groups, the decrement of body weight showed a high in the $LR_3$ acupuncture groups. 2. The contents of plasma ${\beta}$-lipoprotein and free fatty acids showed a tendency to decrease in the acupuncture groups compared to those of control group and the values of $LR_3$ acupuncture groups showed a low in the acupuncture groups. 3. The contents of plasma triglyceride showed a low values in the complex treatment group of $LR_3,\;GB_{39}$ and $SP_4$. However among the other treatment groups, this values showed no significantly different. The contents of liver triglyceride showed a tendency to decrease in all acupuncture groups except to the complex treatment group of $GB_{39}$ and $SP_4$ acupuncture and in the acupuncture groups, $LR_3$ acupuncture groups were lower than $GB_{39}$ and $SP_4$ acupuncture groups. 4. The contents of plasma glucose showed a tendency to decrease by the acupuncture treatment and $LR_3$ acupuncture groups showed a lower values than other acupuncture groups. 5. In the values of plasma glutamic oxaloacetate transferase activity, $LR_3$ acupuncture group and the complex treatment group of $LR_3,\;GB_{39}$ and $SP_4$ acupuncture were a lower values than other treatment groups and among the other treatment groups showed no significantly different. The values of plasma glutamic pyruvate transferase activity showed no significantly different among all the treatment groups. 6. Contents of plasma and liver total cholesterol showed a tendency to decrease in $LR_3$ acupuncture groups. However those of the other groups showed no significantly different. 7. In the contents of plasma LDL-cholesterol, $LR_3$ acupuncture groups were a lower values than other groups, however among the other groups showed no significantly different. The contents of plasma HDL-cholesterol showed a tendency to increase in the acupuncture groups, however these values showed no significantly different.

• Korean Journal of Acupuncture
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• 제18권1호
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• pp.105-116
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• 2001

We examined and referred to some literatures on the meaning, Dai meridian and Meridian points of joining with circulation of Dai meridian through literatures of every generation. And then we came to get a few conclusions as follows. 1. Dai meridian starts below the hypochondriac region. Running obliquely downward, it runs transversely around the waist like a belt. Its function is to bind up all the meridians to circulate in a proper way. 2. The coalescent points of dai meridian are $D\grave{a}im\grave{a}i$(帶脈), $W\check{u}sh\bar{u}$(五樞) and $W\acute{e}id\grave{a}o$(維道). 3. Location of $D\grave{a}im\grave{a}i$(帶脈) is on the lateral side of the abdomen, 1.8 cun below $Zh\bar{a}ngm\grave{e}n$(章門), at the crossing point of vertical line through the free end of the 11th rib and a horizontal line through the umbilicus. Location of $W\check{u}sh\bar{u}$(五樞) is on the lateral side of the abdomen, anterior to the anterosuperior iliac spine, 3 cun below the level of the umbilicus. Location of $W\acute{e}id\grave{a}o$(維道) is on the lateral side of the abdomen, anterior and inferior to the anterosuperior iliac spine, 0.5 cun anterior and inferior to $W\check{u}sh\bar{u}$(五樞). 4. Indication of $D\grave{a}im\grave{a}i$(帶脈) is irregular menstruation, leukorrhea with reddish discharge, hernia, pain in the lumbar and hypochondriac region. Indication of $W\check{u}sh\bar{u}$(五樞) is prolapse of the uterus, leukorrhea with reddish discharge, irregular menstruation, hernia, pain in the lower abdomen, constipation and lumbosacral pain. Indication of $W\acute{e}id\grave{a}o$(維道) is edema, pain in the side of the lower abdomen, prolapse of the uterus, hernia and morbid leukorrhea. 5. The Dai meridian binds all meridians, produces pregnancy, grasps lumbar and abdomen region and controls leukorrhea. 6. Diseases of the Dai meridian manifested as distention and fullness in the lumbar region and abdomen, leukorrhea with reddish discharge, pain the navel, lumbar and spinal regions, flaccidity and hypoactivity of the lower limbs, etc.

• Korean Journal of Acupuncture
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• 제18권1호
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• pp.157-164
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• 2001

Radix Asteris has been used in Korea for many centuries as a treatment for respiratory disease. The effect of Radix Asteris on tracheal smooth muscle is not known. The purpose of the present study is to determine the effect of Radix Asteris on histamine induced tracheal smooth muscle contraction in rats and guinea pigs. Guinea pig(500g, male) and Sprague Dawley rats (250g, male) were killed by $CO_2$ exposure and a segment (8-10mm) of the thoracic trachea from each rat and guinea pig was cut into equal segments and mounted 'in pairs' in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine (His) which evoked 50% of maximal response ($ED_{50}$) was obtained from cumulative dose response curves for histamine $(10^{-7}{\sim}10^{-4}M)$. Contractions evoked by His ($ED_{50}$) were inhibited significantly by Radix Asteris. In guinea pig tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was 120.5% (p<0.01) after $100{\mu}l/ml$ Radix Asteris. In rat tracheal smooth muscle, the mean percent inhibition of histamine induced contraction was 135.4% (p<0.01) after $100{\mu}l/ml$ Radix Asteris. Propranolol $(10^{-7}M)$ slightly but significantly attenuated the inhibitory effects of Radix Asteris. Following treatment with propranolol, the mean percent inhibition caused by $100{\mu}l/ml$ Radix Asteris fell to 44.6% in guinea pig induced by histamine contraction and by $100{\mu}l/ml$ Radix Asteris fell to 18.7% (p<0.05) in rat induced by histamine contraction. Indomethacin and methylene blue$(10^{-7}M)$ did not significantly alter the inhibitory effect of Radix Asteris. These results indicate that Radix Asteris can relax histamine induced contraction of guinea pig and rat tracheal smooth muscle, and that this inhibition involves sympathetic effects.

• Korean Journal of Acupuncture
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• 제18권1호
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• pp.165-170
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• 2001

전북 진안지역에서 재배된 백하수오 2년생 생근을 공시재료로 이용하여 백하수오의 적정 기계박피 조건을 구명하고자 박피날은 돌기형 고무, 플라스틱 패드, 마름모형 철제날과 솔브러시를 공시하고 연마재로서 인조석, 모래, 잔자갈을 이용하여 박피시험을 수행한 결과를 요약하면 다음과 같다. 1. 손박피의 경우 철제칼을 이용하여 1kg을 박피하는 시간이 36분으로 가장 적게 걸렸고 기계박피는 통일 무게 처리에 2분이 소요되는 것으로 나타났으며 명도의 경우 손박피가 기계박피에 비해 다소 높게 나타나는 경향이었다. 2. 백하수오 기계박피시 박피날과 연마재 처리조건에서 수율은 마름모형 철제날에 모래을 처리한 조합에서 89.9%로 가장 낮게 나타났으며 박피율은 마름모형 철제날에 잔자갈을 처리 한 조합에서 71.3%로 가장 높게 나타났다. 3. 백하수오의 박피후 품질결정에 중요한 요소중의 하나인 명도의 경우 마름모형 철제날에 잔자갈을 연마재로 사용한 조합에서 61.90.으로 가장 높게 나타났다. 4. 백하수오 기계박피시 적정 회전속도를 구명하기 위한 조건에서는 박피 회전속도가 빨라 칠수록 수율은 낮은 경향을 나타냈으며 박피율의 경우 회전속도 30r.p.m.에서 66.8%로 가장 높게 나타났으며 명도 또한 57.16으로 나타나 백하수오 기계박피시 적정 회전속도는 30r.p.m.으로 처 리 하는 것이 타당하다고 분석 되었다.

• Korean Journal of Acupuncture
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• 제23권2호
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• pp.69-78
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• 2006

Objectives: TuRo, defined as a dance therapy applying the meridian Qi system into the dancing movements, may have effects on ameliorating the psychological symptoms that often appear in adolescent students in a stressful situation. The Objective of the present study was to examine whether TuRo training relieves the psychological symptoms in adolescent female students. Methods: Symptom Check List-90-Revision (SCL-90-R), a 5 point Likert scale, consisted of 90 items that represent psychological symptoms, were used to measure the psychological health status in healthy adolescent female. Twenty two adolescent female students were trained TuRo dancing for two months while 29 in control group were trained mimicked movements without the concept of Qi for the same period. Changes in Somatization, Obsessive-Compulsive behaviors, Interpersonal Sensitivity, Depression, Anxiety, Hostility, Phobic Anxiety, Parinoid Ideation and Psychotic symptoms by the two months of training were compared between TuRo and control groups using SCL-9Q-R. Results: Among the nine-categorized psychological symptoms, the somatization and hostility were significantly reduced in TuRo group (p

• Korean Journal of Acupuncture
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• 제22권2호
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• pp.107-125
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• 2005

Objectives : The aim of this study was to investigate the asthma-suppressive and immuno-regulatory effect of NR-HA(Notopterygii Rhizoma Herbal-acupuncture) at Pyesu(BL13) on OVA(ovalbumin)-induced asthma in mice. Methods : C57BL/6 mice out of all the experimental sloops, except the Normal group and the NR-HA group, were sensitized and challenged with OVA. The mice in the NR-HA group and the OVA-NR-HA group were treated with NR-HA(1%) at Pyesu(BL13). The mice in the OVA-Saline group were injected with saline at Pyesu(BL13). The mice in the OVA-Needle-prick group were treated with a single prick with an injection needle at Pyesu(BL13). NR-HA, saline injection and needle prick were administered for 8 weeks, three times a week Results : in vitro 1. The populations of granulocytes, $CD3e^-/CCR3^+$cells, $CD69^+/CD3e^+$ cells, $CD4^+\;cells\;and\;CD23^+/B220^+$ cells in the OVA-induced asthmatic mouse lungs decreased significantly by NR-HAS(Notopterygii Rhizoma Herbal-acupuncture solution). 2. The lung weight and total cells in lung of the OVA-NR-HA group decreased significantly compared with those of the OVA-Control group. 3. Total leukocytes and eosinophils in BALF of the OVA-NR-HA group decreas ed significantly compared with those of the OVA-Control group. 4. The collagen accumulation in the lung sections of the OVA-NR-HA group decreased significantly compared with that of the OVA-control group. 5. The concentrations of IL-4, IL-5, IL-13, IgE in BALF and serum of the OVA-NR-HA group decreased significantly compared with those of the OVA- Control group. 6. The numbers of $Gr-1^+/CD11b^+,\;CCR3^+,\;CD3e^+, \;CD19^+,\;CD3e^+/CD69^+$ cells in the OVA-NR-HA group decreased significantly compared with those of the OVA-Control group. 7. The mRNA expressions of $TNF-{\alpha}$, IL-5, IL-4 and IL-13 in lung of the OVA-NR-HA group decreased significantly compared with those of the OVA- Control group. 8. The NR-HA group did not show my considerable difference from the Normal group. The OVA-saline group and the OVA-Needle prick group showed suppressive effects on OVA-induced asthma however they were not statistically significant. Conclusion : These results suggest that NR-HA at Pyesu(BL13) is considered to be effective in treating asthma and to be put to practical use in the future asthma clinic.