• Korean Journal of Construction Engineering and Management
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• v.13 no.4
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• pp.25-32
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• 2012

The current VE activity is recognizing the VE object selection in job-plan simply as formal procedure. Therefore, many problems are happening in the process of selecting VE object during the preparatory stage. As a result of trying to analysis problems through literature review and expert interview, the problems were surveyed such as the lack of connectivity between preparatory stage and analytical stage, the temporal cost-based restrictions, and lack of recognition in VE team members in the existing method of selecting subjects centering on the high-cost field. Accordingly, this study suggested the improved method of selecting VE objects in order to solve this problem in the stage of selecting VE objects. An improvement method of selecting VE objects is what selects the secondary VE subjects by applying again Fish-Bone diagram and Worth technique based on the primary VE objects, which were selected by the conventional technique of selecting objects in the high-cost field. To verify effectiveness in the proposed improvement method, it tried to apply it to the actual case of the road construction VE project. As result of, the improvement method was analyzed to be considerably effective in comparison with the existing selection method of VE objects. Therefore, the Improvement method will contribute to increasing the VE performance.

• Journal of dental hygiene science
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• v.11 no.3
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• pp.189-197
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• 2011

Objectives : The systematic health education to form the basic healthy lifestyle should be realized from elementary school, so oral health education at elementary school can determine the whole lifetime oral health. The elementary school health teacher's recognition and behavior who in charge of health promotion of students is important. Therefore, the study was conducted to enhance oral health education. Methods : Total 114 people among of 131 from health teacher Gwangju elementary school. Survey system is configured by referring to PRECEDE model. Results : In behavioral diagnosis the proportion of oral Health Education is less than 10%(58.8%), mostly educated in activity time (86.0%), the health teachers educate when it is needed(53.5%). In predisposing diagnosis in the eight areas of health education, the oral health education is ranked as fourth, fifth. Even in the next year project, the oral health education ratio was 21.9 percent. In enabling diagnosing every year the Oral health education training experienced rate is 13.2%, satisfaction rate is 33.3%. In reinforcing diagnosing disability element in the regular education course are the lack of oral health-related information (46.7%), lack of materials needed for education (30.6%), lack of training opportunities (21.4%). Conclusion : In further research, oral health education textbooks, materials and methods should be developed. At the foundation of there developments, the elementary oral health education program should be more fully developed and conducted and also the evaluation of its effectiveness will need.

• IMMUNE NETWORK
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• v.2 no.3
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• pp.175-181
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• 2002

Background: S100A6 is a calcium-binding protein overexpressed in several tumor cell lines including melanoma with high metastatic activity and involved in various cellular processes such as cell division and differentiation. To detect S100A6 protein in patient' samples (ex, blood or tissue), it is essential to produce a monoclonal antibody specific to the protein. Methods: First, cDNA coding for ORF region of human S100A6 gene was amplified and cloned into the expression vector for GST fusion protein. We have produced recombinant S100A6 protein and subsequently, monoclonal antibodies to the protein. The specificity of anti-S100A6 monoclonal antibody was confirmed using recombinant S100A recombinant proteins of other S100A family (GST-S100A1, GST-S100A2 and GST-S100A4) and the cell lysates of several human cell lines. Also, to identify the specific recognition site of the monoclonal antibody, we have performed the immunoblot analysis with serially deleted S100A6 recombinant proteins. Results: GST-S100A6 recombinant protein was induced and purified. And then S100A6 protein excluding GST protein was obtained and monoclonal antibody to the protein was produced. Monoclonal antibody (K02C12-1; patent number, 330311) has no cross-reaction to several other S100 family proteins. It appears that anti-S100A6 monoclonal antibody reacts with the region containing the amino acid sequence from 46 to 61 of S100A6 protein. Conclusion: These data suggest that anti-S100A6 monoclonal antibody produced can be very useful in development of diagnostic system for S100A6 protein.

• Journal of Digital Convergence
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• v.11 no.5
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• pp.325-334
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• 2013

The study is to observe a degree of relation between quality of life and a degree of walking exercise for adult residents of cities of Korea. From data of the 4th round 3rd-year Korea National Health and Examination Survey, 7,851 in which 3,892 were male residents and 3,959 females, were selected as subjects, excluding 723 who didn't answer at least more than one question for 5th degree of EQ-5D and physical activities. As a result, quality of life showed statistically significant relation among gender, education level, spouses, average monthly income, stress, a number of chronic diseases, health recognition and whether walking exercise undertaken. Especially one who carried out walking exercise showed higher quality of life than one who did not. This showed more significant difference of quality of life between whether the exercise was undertaken and whether it is intensified or intermediate. Therefore, in accordance with results of this study, it is necessary to develop an effective exercise program that is designed to let residents to exercise in a regular basis and to guarantee a sustainable support from government.

• The Journal of Korean society of community based occupational therapy
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• v.9 no.3
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• pp.11-19
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• 2019

Objective : The purpose of this study was to investigate the awareness of job task importance and performance of occupational therapists in the community care system for the elderly. Methods : We conducted an online questionnaire survey of 152 occupational therapists nationwide from May 31, to June 24, 2019. General characteristics and institutional awareness, role and performance awareness were analyzed by descriptive statistics. One way ANOVA were conducted to compare the differences of working days, working places, and the field of work. Results : The recognition of the community care system for the elderly was low at 2.93 ± 1.0 but the importance of the community care system was 3.94 ± 0.7 and the importance of the occupational therapist in the system was 4.34 ± 0.7. Fall prevention (4.63 ± 0.7) was the most important in occupational therapist's jobs, and performance was high in instrumental activity daily living training (3.94 ± 0.8) and physical function training (3.94 ± 0.8). Conclusion : This study can be presented as basic data on job task importance and performance awareness of occupational therapists in the elderly community care system. In addition, it is expected to be used as basic data for establishing the role of occupational therapist in the elderly community care system.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.1
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• pp.11-18
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• 2020

The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid artery occlusion for 20 min, which was followed by reperfusion for 24 h by restoring the blood flow to the brain. The extent of cerebral injury was assessed after 24 h of global ischemia by measuring the locomotor activity (actophotometer test), motor coordination (inclined beam walking test), neurological severity score, learning and memory (object recognition test) and cerebral infarction (triphenyl tetrazolium chloride stain). Ischemia-reperfusion injury produced significant cerebral infarction, impaired the behavioral parameters and decreased the expression of connexin 43 and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in the brain. A single dose administration of imatinib (20 and 40 mg/kg) attenuated ischemia-reperfusion-induced behavioral deficits and the extent of cerebral infarction along with the restoration of connexin 43 and p-STAT3 levels. However, administration of AG490, a selective Janus-activated kinase 2 (JAK2)/STAT3 inhibitor, abolished the neuroprotective actions of imatinib and decreased the expression of connexin 43 and p-STAT3. It is concluded that imatinib has the potential of attenuating global ischemia-reperfusion-induced cerebral injury, which may be possibly attributed to activation of JAK2/STAT3 signaling pathway along with the increase in the expression of connexin 43.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.12
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• pp.8147-8156
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• 2015

This study analyzes the Pattern Language of Insadong-gil in street environmental design analysis for street vitalization. The urban public spaces, such as pedestrian streets, parks and plazas, have been increased with rapid urbanization and industrialization. But the fact is the satisfied spaces with the behavior patterns of users is little. This is because of the too much slanted thought toward formal supply and management of spaces without enough consideration for people and spatial quality of public spaces. The purpose of this study is to find out the factors to make the street more vital and diverse and to give the characteristic of region through the research on Insadong street with the pattern language of Christopher Alexander. So, throughout the value recognition of the changing urban street environment that has been changed by age selected spatial characteristic of public spaces. By selecting a suitable pattern language for each spatial characteristics provide the basis for street environmental design analysis. For this study, look at the relationship between pattern language focused on Insadong street, pattern language as the vitalization factor of street were analyzed 16 elements, including Pedestrian Street(100), Building Fronts(122), Activity Nodes(30) etc. This study focuses on street environmental design analysis of Insadong-gil through the Pattern Language, it propose the criteria and guidelines that will help enable street vitalization.

• Journal of The Korean Association For Science Education
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• v.34 no.5
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• pp.479-490
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• 2014

The purpose of this study is to develop an argument-based modeling strategy, utilizing writing and argumentation for communication in science education. We need to support students and teachers who have difficulty in modeling in science education, this strategy focuses on development of four kinds of factors as follows: First, awareness of problems, recognizing in association with problems by observing several problematic situations. Second is science concept structuralization suggesting enough science concepts by organization for scientific explanation. The third is claim-evidence appropriateness that suggests appropriate representation as evidence for assertions. Last, the use of various representations and multimodal representations that converts and integrates these representations in evidence suggestion. For the development of these four factors, this study organized three stages. 'Recognition process' for understanding of multimodal representations, and 'Interpretation process' for understanding of activity according to multimodal representations, 'Application process' for understanding of modeling through argumentation. This application process has been done with eight stages of 'Asking questions or problems - Planning experiment - Investigation through observation on experiment - Analyzing and interpreting data - Constructing pre-model - Presenting model - Expressing model using multimodal representations - Evaluating model - Revising model'. After this application process, students could have opportunity to form scientific knowledge by making their own model as scientific explanation system for the phenomenon of the natural world they observed during a series of courses of modeling.

• Journal of Life Science
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• v.26 no.3
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• pp.364-375
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• 2016

Post-translational modification is an efficient process to rapidly transduce external stimulus into cellular response. Ubiquitination is a typical post-translational modification which is a highly conserved process in eukaryotes. UPS (Ubiquitin/Proteasome System) mediated by the ubiquitination is to target diverse cellular proteins for degradation. Among E3 ubiquitin ligases that function as the key determinant for substrate recognition, CRL (cullin–RING E3 ubiquitin ligase) is the largest family and forms the complex composed of cullin, RBX1, adaptor and substrate receptor. Although CRL1, also known as SCF complex, has been widely researched for its biological role, the functional studies of CRL4 have been relatively elusive. In Arabidopsis, there are 119 substrate receptors named DCAF (DDB1 CUL4 Associated Factor) proteins for CRL4 and a fraction of DCAF proteins have been identified for their potential functions so far. In this paper, current understanding on structure and biological roles of plant CRL4 complexes in a diverse of cellular events is reviewed, especially focusing on CRL4 substrate receptors. Moreover, the regulatory mechanism of CRL4’s activity is also introduced. These studies will be helpful to further understand the signal transduction pathways in which such CRL4 complexes are involved and give a clue to establish the action network of entire CRL4 complexes in plants.

• Korean Security Journal
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• no.41
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• pp.327-356
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• 2014

The ultimate goal of the local government is the owner of the residents welfare of the community. Welfare of the residents will start from the protection of life and property of the inhabitants. Much of this protective activity is a function of the police. Therefore, to be a municipal & local police that is based on the autonomy of the local conceptual prerequisites for the welfare of the population. Municipal & local police activities are activities for the local community rooted in the community that the police and to rejoin the community, municipal & local police activities taking place in the center of the area to solve the problem, but to reduce the fear of crime and disorder, crime as an expression of the efforts of the local residence themselves to improve the overall quality of life of the community as a partner recognition local residents. Municipal & local police in this case be introduced across the board in the central and local governments is careful review of the various alternatives been prepared on analysis is crucial to reduce the trial and error by providing the best alternative. priority should be to figure out exactly what the reason to introduce a municipal police. in other words, the introduction of the municipal & local police in the central and local governments, state police and municipal & local police, the ruling party and the opposition, regional self-government initiative unseen conflict between organizations and local governments are not welcomed by local residence in local time truly 'safe' and will have to face that the 'improve quality of life'.