• Natural Product Sciences
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• v.9 no.4
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• pp.260-263
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• 2003

Ethanol extract of the root of Clitoria ternatea Linn (CTEE) was evaluated for different neuropharmacological actions, such as general behaviour, exploratory behaviour, muscle relaxant activity and phenobarbitone induced sleeping time, in rats and mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and Y- maze test, reduction in the muscle relaxant by rotarod, $30^{\circ}C$ inclined screen and traction tests. In addition CTEE significantly potentiated the phenobarbitone-induced sleeping time. Preliminary tests indicate that the ethanol extract of Clitoria ternatea Linn. At the doses of 100 and 150 mg/kg showed significant neuropharmacological activity.

• Microbiology and Biotechnology Letters
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• v.22 no.6
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• pp.700-706
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• 1994

Lactic acid bacteria in Kimchi fermentation were tested for inhibitory activity against Gram positive bacteria and Gram negative bacteria. The Lactobacillus brevis (KCCM 35464) was found to produce a antimicrobial substance. It showed relatively wide range of inhibition spectrum against gram positive and gram negative bacteria and maintained the inhibitory activity between pH 4.0 and pH 9.0. The antimicrobial substance was obtained in the stationary growth phase and was purified by gel chromatography. The inhibitory effect of the antimicrobial substance on sensitive bacterial strains was determined by filter paper test. The activity of antimicrobial substa- nce was stable at 75$\circ$C. On the basis of its electrophoretic pattern is SDS-PAGE, antimicrobial substance appeared as a single band of 59 KDalton.

• Development and Reproduction
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• v.19 no.2
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• pp.61-67
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• 2015

The immediate early gene c-fos has long been known as a molecular marker of neural activity. The neuron's activity is transformed into intracellular calcium influx through NMDA receptors and L-type voltage sensitive calcium channels. For the transcription of c-fos, neural activity should be strong enough to activate mitogen-activated protein kinase (MAPK) signaling pathway which shows low calcium sensitivity. Upon translation, the auto-inhibition by Fos protein regulates basal Fos expression. The pattern of external stimuli and the valence of the stimulus to the animal change Fos signal, thus the signal reflects learning and memory aspects. Understanding the features of multiple components regulating Fos signaling is necessary for the optimal generation and interpretation of Fos signal.

• Korean Journal of Microbiology
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• v.26 no.1
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• pp.44-51
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• 1988

The intracellular free radicals produced at different stages of cell cycle of Saccharomyces cerevisiae ATCC 24858 were investigated by means of electron spin resonance(ESR) spectroscopy. The synchronized cells by repeated starvation and refeeding revealed different ESR spectral pattern compared to that of asynchronized cells. Each spectrum centered at g=2.005, which indicates free radicals. The relative spin concentration was maximat at the end of DNA increase. The variation of the relative spin concentration at each distinct stage of the cell cycle was evaluated in relation to ascorbate concentration, L-galactonolactone oxidase activity, and ascorbate oxidase activity. The highest activities of L-galactonolactone oxidase and ascorbate oxidase were detected just before and at the maximum of relative spin concentration, respectively. And ascorbate concentration fluctuated through each stage of cell cycle with the changes of relative spin concentration, L-galactonolactone oxidase activity, and ascorbate oxidase activity. Thus it is suggested that intracellular free radicals should be related to cell cycle, interacted with ascorbate, and may play an important role in the cell cycle of Saccharomyces cerevisiae.

• International Journal of Computer Science & Network Security
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• v.21 no.4
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• pp.131-139
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• 2021

In current time, anomaly detection is the primary concern of the administrative authorities. Suspicious activity identification is shifting from a human operator to a machine-assisted monitoring in order to assist the human operator and react to an unexpected incident quickly. These automatic surveillance systems face many challenges due to the intrinsic complex characteristics of video sequences and foreground human motion patterns. In this paper, we propose a novel approach to detect anomalous human activity using a hybrid approach of statistical model and Genetic Programming. The feature-set of local motion patterns is generated by a statistical model from the video data in an unsupervised way. This features set is inserted to an enhanced Genetic Programming based classifier to classify normal and abnormal patterns. The experiments are performed using publicly available benchmark datasets under different real-life scenarios. Results show that the proposed methodology is capable to detect and locate the anomalous activity in the real time. The accuracy of the proposed scheme exceeds those of the existing state of the art in term of anomalous activity detection.

• Journal of Applied Tourism Food and Beverage Management and Research
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• v.12 no.1
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• pp.79-110
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• 2001

Tourist Destination is based on tourism attractions. Components of Tourism attraction are included tourism resources, entertainment facilities, transportation, accommodation, infrastructure, assistance facilities & service, hospitality, information facilities & service, and retailing & service. Tourism resources of them is the key to determine destination development pattern, because tourism attraction that attract tourists is based on tourism resources. Therefore, there are need to study what is tourism attraction of destination at the view of tourists and what is destination development pattern based on it to develop tourism attraction that is able appeal tourists. The purpose of this study is to examine what effect of tourism attraction affects destination development pattern. This study defined Haeundae, Kwanganri, Songjung, Taejongdae in Pusan, Korea as research areas. Research data were collected from 300 respondents by a simple random sampling method. A final 284 usable questionaries were used for empirical analysis after data purification process. Reliability and validity of the scale on the tourism attraction, destination image, and facility needs have been evaluated using Cronbach $\alpha$, item-total correlations. This study analyzed the factors of the tourism attraction and destination images. The result obtained that tourism attraction is divided relaxation attraction, local activity attraction, culture . nature attraction and touring circuit attraction, and destination image is divided culture . urban attractiveness, touring attractiveness, local . stay attractiveness, convenience of travel and relativeness for destination investigated. ANOVA and regression (stepwise) were used to test hypotheses. Based on the results of hypotheses testing, major findings of the empirical research are as follow : 1. The tourism attraction and destination image are significantly different, but facility needs are not significantly by destinations (e. g. Haeundae, Kwanganri, Songjung, Taejongdae) . 2. Destination development pattern is a(fact by the tourism attraction in partial. In case of Haeundea, relaxation attraction take effect partially spa, history and marine/spa tourism. 3. The destination development pattern is influenced by the destination image in partial. In case of Kwanganri, the natural . activity attractiveness and urban tourism images have been found as influential factors that affect marine tourism. 4. The destination images are influenced the physical attributes in literature review, but the destination image are taken effect partially the tourism attraction in this study. 5. Destination development pattern are influenced by the tourism attraction and the destination image partially. This research has provided a variety of practical suggestions. Especially, it was suggested that the destination have appeal to tourists by strengthening attraction and improving weakness. Also, we need to specialize destination in same destination development pattern.

• BMB Reports
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• v.33 no.2
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• pp.103-111
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• 2000

Phosphorylation of the eukaryotic elongation factor 2 (eEF-2) blocks the elongation step of translation and stops overall protein synthesis. Although the overall rate of protein synthesis in mitosis reduces to 20% of that in S phase, it is unclear how the protein translation procedure is regulated during the cell cycle, especially in the stage of peptide elongation. To delineate the regulation of the elongation step through eEF-2 function, the changes in phosphorylation of eEF-2, and in activity of corresponding $Ca^{2+}$/calmodulin (CaM)-dependent protein kinase III (CaMK-III) during the cell cycle of NIH 3T3 cells, were determined. The in vivo level of phosphorylated eEF-2 showed an 80% and 40% increase in the cells arrested at G1 and M, respectively. The activity of CaMK-III also changed in a similar pattern, more than a 2-fold increase when arrested at G1 and M. The activity change of the kinase during one turn of the cell cycle also demonstrated the activation at G1 and M phases. The activity change of cAMP-dependent protein kinase (PKA) was reciprocal to that of CaMK-III. These results indicated: (1) the activity of CaMK-III was cell cycle-dependent and (2) the level of eEF-2 phosphorylation followed the kinase activity change. Therefore, the elongation step of protein synthesis might be cell cycle dependently regulated.

• The Journal of Korean Academy of Prosthodontics
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• v.28 no.2
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• pp.175-182
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• 1990

This study was performed to investigate the influence of occlusal change on the masticatory muscle activity. 8 students without any symptom of T.M.J. dysfunction, any history of prosthodontic or orthodontic treatment on dental college of WonKwang Univ. were participated in this study. The activity of masseter and anterior temporal muscles were measured by bioelectric processor(EM2, Myotronics, Inc., U.S.A.) during voluntary maximal clenching on natural teeth, by splint with bilateral posterior surface contact, by splint with unilateral posterior surface contact, and by splint without unilateral posterior teeth contact. The obtained results were as follows ; 1. The loss of posterior contact on noe side resulted in change of the activity of anterior temporal and masseter muscle during clenching on ipsilateral side, but there was no change of muscle activity on contralateral side. 2. The activity of anterior temporal and masseter muscle during clenching were not affected by the pattern of occlusal contact. 3. There were no difference between the activity of anterior temporal and masseter miuscle during clenching by natural teeth and by occlusal splint.

• Advances in Traditional Medicine
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• v.6 no.3
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• pp.221-231
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• 2006

The aim of the present study is to investigate central nervous system (CNS) activity of the methanol extracts of leaves of Caesalpinia bonducella (MECB) and stem bark of Bauhinia racemosa (MEBR) (Caesalpinaceae) in Swiss albino mice and Wistar albino rats. General behavior, exploratory behavior, muscle relaxant activity and phenobarbitone sodium-induced sleeping time were studied. The results revealed that the methanol extracts of leaves of Caesalpinia bonducella at 100 - 200 mg/kg and stem bark of Bauhinia racemosa 100 - 200 mg/kg caused a significant reduction in the spontaneous activity (general behavioral profile), remarkable decrease in exploratory behavioral pattern (Y-maze and head dip test), a reduction in muscle relaxant activity (rotarod and traction tests), and also significantly potentiated phenobarbitone sodium-induced sleeping time. The results suggest that MECB and MEBR exhibit CNS depressant activity in tested animal models.

• The Korean Journal of Ecology
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• v.14 no.1
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• pp.101-111
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• 1991

Amoeba sp. was cultured under the light and the dark conditions, and the activity of phosphatases was investigated. There was a linear correlation between the early reaction time and the activity of phosphatases when phosphatases were incubated at 30℃. Then the activity of acid phosphatase was about 2 times higher than that of alkaline phosphatase. The activity of phosphatase was optimal at pH 5.0 in acidic part and at pH 8.0 in alkaline part, respectively. The optimal temperature of phosphatases was near the 40℃. The isozyme patterns of cytoplasmic acid phosphatase were compared with those of membraneous one. Both the isozyme patterns were shown to bo polymorphic on the polyacyamide gel, but different band patterns were observed in the isozymes of the cytoplasmic and the membraneous acid phosphatases. The number of Amoeba sp. under the light stimulus for 48 hours decreased negative exponentially from the illumination. The activity of acid and alkaline phosphatases under the illumination of light incresed 1.7 and 1.5 times higher, respectively, than the activity of those under the dark condition. This result apperars to be related to the mechanism of the autophosphorylation.