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Studies on Neuropharmacological Effects of Clitoria ternatea Linn. Root Extract in Rats and Mice  

Boominathan, R. (Division of Pharmacognosy and Phytochemistry Department of Pharmaceutical Technology Jadavpur University)
Devi, B.Parimaladevi (Division of Pharmacognosy and Phytochemistry Department of Pharmaceutical Technology Jadavpur University)
Mandal, Subhash.C (Regional Institute of Pharmaceutical Science and Technology Agartala)
Publication Information
Natural Product Sciences / v.9, no.4, 2003 , pp. 260-263 More about this Journal
Abstract
Ethanol extract of the root of Clitoria ternatea Linn (CTEE) was evaluated for different neuropharmacological actions, such as general behaviour, exploratory behaviour, muscle relaxant activity and phenobarbitone induced sleeping time, in rats and mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and Y- maze test, reduction in the muscle relaxant by rotarod, $30^{\circ}C$ inclined screen and traction tests. In addition CTEE significantly potentiated the phenobarbitone-induced sleeping time. Preliminary tests indicate that the ethanol extract of Clitoria ternatea Linn. At the doses of 100 and 150 mg/kg showed significant neuropharmacological activity.
Keywords
Clitoria ternatea; Roots; ethanol extract; neuropharmacological activity;
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1 Dixit, V. K, Varma, K. C., Effects of essential oil of leaves of Blumea lacera DC on central nervous system. Indian Journal of Pharmacology 18, 7-11 (1976)
2 Doff, M., Stienberg, H., Tomkiewiez, M., Joyee, D., Porosolt, R. D., Summerfield, A. Persistence of dose related behaviour in mice. Nature 231, 121-123 1971   DOI   ScienceOn
3 Kulkarni, S. K, Hand Book of experimental Pharmacology, 3rd edition. 122-123 (1999).
4 Parimaladevi, B., Boominarhan,R, Mandal, S. C, Anti-inflammatory, analgesic and antipyretic properties of Clitoria ternatea root. Fitoterpia, 74, 345-349 (2003)   DOI   ScienceOn
5 Subhash, C. Mandal., Dhara, A. K, Maity, B. C; Studies on neuropharmacological activity of Andrographis paniculata Extract. Phy. Res 15, 253-256 (2001)   DOI   ScienceOn
6 Woodson, R. F, Statistical Methods for the analysis of Biomedicinal Data Wiley Series in Probability and Mathematical Statistics) Wiley, New York. 3 15-316 (1987)
7 Dandiya, P. C, Collumbine, H. Studies on Acorus calamus (III): some pharmacological actions of the volatile oil. J. Pharmacology and Experi. Ther. 125, 353-359 (1959)
8 Chatterjee, .and Pakrashi, S. C; The Treatise on Indian Medicinal Plants.Vol. 1, C.S.I.R., New Delhi, 155 (1991)
9 Asolkar, L. V, Kakkar, K. K., and Chakre, O. J., Second supplement in Glossary of Indian Medicinal Plants with active priniciples vol. I New Delhi, 215 (1992)
10 Nadkami, K. M., and Nadkami, A. K, Indian Materia Medica. Popular Prakasan, Bombay. 1, 351 (1992)
11 Kirtikar, K R, and Basu, B. D., Indian Medicinal Plants, vol 2, 183-185 (1935)
12 Ghosh, M. N., Fundamental ExperimentalPharmacology, 2nd Edition, 153 (1984)
13 Ruston, R, Steinberg, H., Tinson, C. Modification of the effects of an amphetamine-barbiturate mixture by the past experience of rats. Nature 192, 533-535 (1961)   DOI   PUBMED   ScienceOn
14 Rai, K. S, Murthy, K. D., Karanth, K. S., Rao, M. S., Clitoria ternatea L. root extract treatment during growth spurt period enhances learning and memory in rats. Indian J. Physi. Pharmacol., 45(3), 305-13 (2001)
15 Anonymous, The Wealth of India, Council of Scientific and Industrial Research, New Delhi, Vol. 1, 231 (1966)
16 Courvoisier, S., Pharmacodynamic properties of chlorpromazine. J. of Clini. Experi. Neuropath. 17, 25-37 (1956)
17 Rudzik, A. D., Hester, J. B., Tang, A. H., Staw, R. N., and Friis, W.: The Benzodiazepines. Raven press, New York. 285-297 (1973)
18 Stahl, E., Thin Layer Chromatography, Springer-Ver-lag, New York (1969)