• Proceedings of the Materials Research Society of Korea Conference
• /
• 2012.05a
• /
• pp.56.2-56.2
• /
• 2012

Clinically-favored materials for bone regeneration are mainly based on bioceramics due to their chemical similarity to the mineral phase of bone. A successful scaffold in bone regeneration should have a 3D interconnected pore structure with the proper biodegradability, biocompatibility, bioactivity, and mechanical property. The pore architecture and mechanical properties mainly dependent on the fabrication process. Bioceramics scaffolds are fabricated by polymer sponge method, freeze drying, and melt molding process in general. However, these typical processes have some shortcomings in both the structure and interconnectivity of pores and in controlling the mechanical stability. To overcome this limitation, the rapid prototyping (RP) technique have newly proposed. Researchers have suggested RP system in fabricating bioceramics scaffolds for bone tissue regeneration using selective laser sintering, powder printing with an organic binder to form green bodies prior to sintering. Meanwhile, sintering process in high temperature leads to bad cost performance, unexpected crystallization, unstable mechanical property, and low bio-functional performance. The development of RP process without high thermal treatment is especially important to enhance biofunctional performance of scaffold. The purpose of this study is development of new process to fabricate ceramic scaffold at room temperature. The structural properties of the scaffolds were analyzed by XRD, FE-SEM and TEM studies. The biological performance of the scaffolds was also evaluated by monitoring the cellular activity.

• Management & Information Systems Review
• /
• v.6
• /
• pp.267-290
• /
• 2001

Today's firms are experiencing severe competition and lots of change under uncertainty of the future. In order to survive in rapidly changing environment, companies have steadily adopted information technology(IT) environment. The advancement of information technology allows people to access information and knowledge resources without the limitation of time and location through internet. Many organizations have developed their own information systems not only for internal efficiency but also for effectiveness of external customer services. This study is intended to provide a theoretical framework of information and knowledge and their relationship, that the infusion of powerful information networks into business environments is beginning to have a profound a significant difference of the nature between information satisfaction and accounting information system(AIS) in the business activity. This paper is to maximize the efficiency of university libraries human resources management by determining the followings the relationship between the level of information technology implement and the job satisfaction of the librarian, the main factors that affect job satisfaction. Questionnaire was sent to 120 companies from 20 corporations chosen by random sampling and the methods of ANOVA, T-test, and correlation analysis were used. The results of the analysis are as follows; 1) There is a unsignificant difference in the level of information satisfaction by accounting information system and the motivation factor according to the level of implementation of IT. 2) There is a relatively high in a significant difference in information satisfaction by the level of net income. 3) There is high a significant difference is shown in the accounting years while implementing the IT and information satisfaction.

• Journal of Digital Convergence
• /
• v.18 no.9
• /
• pp.297-305
• /
• 2020

The purpose of this study was to identify the factors associated with subjective age among community-dwelling older adults in South Korea. Cross-sectional analyses were performed on 8,040 older adults aged 65 years and over from the 2017 National Survey of Older Koreans. We used univariable analysis and multivariable analysis by the logistic regression test. The significant factors associated with subjective age in older adults were gender, education level, living arrangements, limitation of instrumental activities of daily living, number of chronic diseases, perceived health status, depression, and current economic activity. Based on the results of this study, nursing intervention will be needed to lower subjective age. This study may contribute to the older adults to have a healthy and successful old age.

• Research in Community and Public Health Nursing
• /
• v.28 no.2
• /
• pp.118-128
• /
• 2017

Purpose: The purpose of this study is to measure health-related quality of life (HRQoL) and to investigate the affecting factors according to gender in older adults by using the 2012 Korea Health Panel data. Methods: The Korea Health Panel data 2012 were collected from February to August 2012 by Korea Institute for Health and Social Affairs and National Health Insurance Corporation and the number of respondents were 1,921. The data were analyzed by t-test, chi-square, Pearson correlation coefficient and multiple regression using SPSS/WIN program. Results: The limitation of activity was the most influential factor for health-related quality of life of both male and female. For male, the affecting factors on HRQoL were hearing problems and frustration. For female, the affecting factors on HRQoL were eating problems, depression and suicidal impulses. Drinking, moderate physical activities, vision problems and stress had a significant effect on HRQoL for both male and female. Conclusion: Health care providers should consider the differences between male and female when they design a program in order to improve HRQoL of older people.

• KIEAE Journal
• /
• v.10 no.1
• /
• pp.109-116
• /
• 2010

The city means not only a geographical area as a role of the spatial boundary, but also a socio-economic place to communicate with each area. It requires various functions to get the income and economic-activities. But city has a limitation of a available land to provide the required functions and a sufficient space to supply the urban activity. Therefore, the development trend of city has not been to spread to the horizontal area any more and considered the vertical area. In addition, various functions put into a massive building because many people want to solve the daily requirements without spending time and cost in outer area. In this paper, it aimed at classifying the mixed-use building into function, circulation, relation according to the public and private space and the building shape to provide the design information such as land area, functional complex, accessibility, etc.. The classification of the mixed-use buildings is divided into four areas. The data are collected with foreign countries in Japan, Europe and US. Results of the study are as follows; First, the commercial function is mainly centered with other functions. Second, after studied the development scale, accessibility, building form, the commercial and residential area overwhelmly share at the total area.

• Journal of Information Technology and Architecture
• /
• v.9 no.1
• /
• pp.1-10
• /
• 2012

To promote process effectiveness and efficiency, it is necessary that port logistics employ automated equipments for handling containers. There exists a system for automatically managing the container flow, called Control Module. However, it has limitation to assign the execution order to the machine and monitor the container flow in real time process. Business process management (BPM) provides a suitable and effective framework to address this problem including controlling and monitoring the flow of each container. Since the nature of container handling process is different with the common process in BPM that is conducted by human performer, it is necessary to adjust the BPM framework in the domain of port logistic management. This study presents a BPM framework corresponds with both human-based and machine-based activity to enhance the efficiency of port process flow including container flow. This framework is introduced as an integrated approach and mechanism of BPM application into the container handling system for the purpose of port logistics process automation.

• 사회경제평론
• /
• no.38
• /
• pp.129-161
• /
• 2012

This paper suggests that, in contrast to main argument of Efficient Market Hypothesis, hedge funds's financial speculation activity in the commodity markets are tending to generate a malfunction of making future price diverge from fundamental price. For this reason, we insist that stricter regulation on commodity derivative markets, including position limitation, is needed. Using some statistic analysis tools, we show that derivative transaction volume is getting so larger that financial speculation by hedge funds dominates price movement in commodity market and eventually slackens the speed of price's return to the fundamental price.

• Archives of Pharmacal Research
• /
• v.22 no.3
• /
• pp.279-287
• /
• 1999

Therapeutic use of anti-inflammatory steroids is limited due primarily to their systemic suppressive effects on pituitary function and the immune system.. To overcome the clinical limitation, a new approach toward the discovery of non-systemic anti-inflammatory steroids is based upon the antedrug concept introduced by this laboratory. The new concept describes locally active agents which are designed to undergo a predictable biotransformation to inactive metabolites upon entry into systemic circulation from the applied site. Thus, true antedrugs are devoid of systemic adverse effects. In a continuing effort, 16$\alpha$-carboxylate and isoxazoline derivatives of prednisolone have been synthesized and screened. In the croton oil-induced ear edema bioassay, the following relative potencies were obtained setting hydrocortisone=1.0; 3a, 1.5; 3b, 3.1; 4a, 4.0; 4b, 12.2; 5b, 8.2; 6b, 11.2; 7a, 1.9; 7b, 4.1; 8a, 3.3; 8b 6.8; 9a, 0.7; 9b 8.6; 10a 2.6; 10b, 7.4. Results of the five-day bioassay indicated that, in contrast to the parent compound, the novel steroidal antedrugs did not significantly alter body weight gain, thymus weights, adrenal weights or plasma corticosterone levels. Taken together, the antedrug concept appears to be a fundamentally sound strategy for the separation of local anti-inflammatory activity form systemic adverse effects.

• Journal of dental hygiene science
• /
• v.19 no.2
• /
• pp.86-95
• /
• 2019

The modern era of microbial genome analysis began in earnest in the 2000s with the generalization of metagenomics and gene sequencing techniques. Studying complex microbial community such as oral cavity and colon by a pure culture is considerably ineffective in terms of cost and time. Therefore, various techniques for genomic analysis have been developed to overcome the limitation of the culture method and to explore microbial communities existing in the natural environment at the gene level. Among these, DNA fingerprinting analysis and microarray chip have been used extensively; however, the most recent method of analysis is metagenomics. The study summarily examined the overview of metagenomics analysis techniques, as well as domestic and foreign studies on disease genomics and cluster analysis related to oral metagenome. The composition of oral bacteria also varies across different individuals, and it would become possible to analyze what change occurs in the human body depending on the activity of bacteria living in the oral cavity and what causality it has with diseases. Identification, isolation, metabolism, and presence of functional genes of microorganisms are being identified for correlation analysis based on oral microbial genome sequencing. For precise diagnosis and treatment of diseases based on microbiome, greater effort is needed for finding not only the causative microorganisms, but also indicators at gene level. Up to now, oral microbial studies have mostly involved metagenomics, but if metatranscriptomic, metaproteomic, and metabolomic approaches can be taken together for assessment of microbial genes and proteins that are expressed under specific conditions, then doing so can be more helpful for gaining comprehensive understanding.

• Current Applied Physics
• /
• v.18 no.12
• /
• pp.1507-1512
• /
• 2018

The development of an organic-based aqueous redox flow battery (RFB) using quinone as an electroactive material has attracted great attention recently. This is because this battery is inexpensive, produces high energy density, and is environment friendly in stationary electrical energy storage applications. Herein, we investigate the redox potentials and solubilities of indole-5,6-quinone and indole-4,7-quinone derivatives in terms of the substituent effects of functional groups using theoretical calculations. Our results indicate that full-site substituted derivatives of indolequinone are more useful as active materials compared to single-site substituted derivatives. In particular, our calculations reveal that the substitution of $-PO_3H_2$ and $-SO_3H$ functional groups with multiple polar bonds is very effective in increasing the activity of the aqueous RFB. As a strategy to overcome the limitation that the aqueous solubility is intrinsically low because they are organic molecules, we suggest the substitution of functional groups with multiple polar bonds to the backbones of active organic materials. Among 180 indolequinone derivatives, 17 candidates that meet the redox potential standards ($${\leq_-}0.2V$$ or $${\geq_-}0.9V$$) and eight candidates with solubility exceeding 2 mol/L are identified. Three indolequinone derivatives that satisfy both conditions are finally presented as promising electroactive candidates for an aqueous RFB.