• 제목/요약/키워드: activity interpretation

검색결과 231건 처리시간 0.031초

Nitric Oxide Modulation of GABAergic Synaptic Transmission in Mechanically Isolated Rat Auditory Cortical Neurons

  • Lee, Jong-Ju
    • The Korean Journal of Physiology and Pharmacology
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    • 제13권6호
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    • pp.461-467
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    • 2009
  • The auditory cortex (A1) encodes the acquired significance of sound for the perception and interpretation of sound. Nitric oxide (NO) is a gas molecule with free radical properties that functions as a transmitter molecule and can alter neural activity without direct synaptic connections. We used whole-cell recordings under voltage clamp to investigate the effect of NO on spontaneous GABAergic synaptic transmission in mechanically isolated rat auditory cortical neurons preserving functional presynaptic nerve terminals. GABAergic spontaneous inhibitory postsynaptic currents (sIPSCs) in the A1 were completely blocked by bicuculline. The NO donor, S-nitroso-N-acetylpenicillamine (SNAP), reduced the GABAergic sIPSC frequency without affecting the mean current amplitude. The SNAP-induced inhibition of sIPSC frequency was mimicked by 8-bromoguanosine cyclic 3',5'-monophosphate, a membrane permeable cyclic-GMP analogue, and blocked by 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, a specific NO scavenger. Blockade of presynaptic $K^+$ channels by 4-aminopyridine, a $K^+$ channel blocker, increased the frequencies of GABAergic sIPSCs, but did not affect the inhibitory effects of SNAP. However, blocking of presynaptic $Ca^{2+}$ channels by $Cd^{2+}$, a general voltage-dependent $Ca^{2+}$ channel blocker, decreased the frequencies of GABAergic sIPSCs, and blocked SNAP-induced reduction of sIPSC frequency. These findings suggest that NO inhibits spontaneous GABA release by activation of cGMP-dependent signaling and inhibition of presynaptic $Ca^{2+}$ channels in the presynaptic nerve terminals of A1 neurons.

상류(上流) 전통주거(傳統住居) 해남(海南) 녹우당(綠雨堂)의 해석(解釋) -거주자(居住者) 생활(生活)과 농업경영(農業經營)으로- (Interpretation of the Nok-U-dang, Traditional Upper-Class Mansion in Haenam -with Dweller's Life and Agricultural Production-)

  • 이희봉;이향미
    • 건축역사연구
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    • 제11권1호
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    • pp.65-84
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    • 2002
  • This study has main purpose to understand and interpret the house Nok-U-dang, an upper class built in Chosun dynasty, not by outsider researcher's view but insider dweller's view. To interpret correctly, dweller's everyday life in the space and form is examined on a microscale beyond the physical space and form of the house, main object of architectural history To understand the present form exactly, the study restore traditional life in past era, 1940s. Main method of restoration is the ethnographic interview, based on cultural anthropology. Like any other upper-class house, the house has been influenced under ruling Confucian ideology in Chosun dynasty: separation of man's and woman's quarters and hierachical arrangement by generation, and worshipping ceremony for ancestor. However, it is by practical management for agricultural production that every court and building of the Noku-Dang can be explained correctly; preparing seed for sowing, tool storing, preparing and serving meal for laborers, making manure, harvesting, threshing grain, storing grain and so on. Precedent studies interpreted the house by the Confucian principle too much and made conclusion of dignity and austerity of ritual: woman's quarter, is closed and serene space. However this study shows that the space is semi-opened and composite space by agricultural works. And the Sarangchae, master's quarter, is located properly at visual center to control every agricultural activity.

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국제상사중재에서 UNIDROIT원칙의 적용사례 분석 (The Analyzing on Application Cases of UNIDROIT Principles In International Commercial Arbitration)

  • 홍성규
    • 한국중재학회지:중재연구
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    • 제21권1호
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    • pp.131-155
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    • 2011
  • PICC executes its role as a useful lex mercatoria in the continuously increasing international trade to be adopted as the standard criterion of prevention or dispute resolution. When considering the fact that GISG has not presented results beyond expectation in the past due to hard laws and legal deficiency, PICC, which possesses interpretation and supplementation function, is considered undoubtedly useful particularly in international commercial arbitration. As observed in the previously mentioned analysis on cases accumulated in UNILEX, PICC application and Arbitral tribunal in international contract between parties possess considerably large claim possibility and the number of actual application cases is continuously increasing. The fact that PICC has been composed as maximum common measures of continental and common law systems by traditional comparative legal scholars familiar with international trade can function as the fundamental principle in future global trade activity and can also act as the model law for uniting contract laws of nations. In this aspect, PICC can be evaluated to have considerably achieved enactment purpose of previous intention. However, additional topics that had not been accepted in the revised edition of PICC remain as assignments requiring solution, such as analysis and acceptance problem of comparative law, PR of PICC unfamiliar even to the relative parties of international trade and application in international contract, and absorption problem as model law in various domestic laws.

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Monitoring Mangrove Plantation along the Coastal Belts of Bangladesh (1989-2010)

  • Rahman, M. Mahmudur;Pramanik, Md. Abu Taleb
    • Journal of Forest and Environmental Science
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    • 제31권3호
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    • pp.225-234
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    • 2015
  • Mangroves are important coastal ecosystems and are located at the inter-tidal zones of tropical and sub-tropical belts. The global mangrove forests are declining dramatically because of the conversion of forests to shrimp farming, over-exploitation, pollution and freshwater diversion. The Bangladesh Forest Department initiated mangrove afforestation throughout the coastal belts of Bangladesh in 1966 to provide better protection for the coastal communities. Up to 1990, 120,000 ha of mangroves had been planted and it is one of the largest coastal afforestaton programs in the world. The objective of this study is to exploit the spatial extent of mangrove plantation and their dynamics of changes over the last two decades using multispectral Landsat imagery. The study area covers the coastal areas of Bangladesh that is extended over the eastern part of Sundarbans up to Teknaf, the southern tip of mainland Bangladesh. Mangrove plantations were interpreted visually on computer screen and interactive delineation of forest boundary was done. The mangrove plantation area has been estimated as 32,725, 47,636 and 43,166 ha for the year of 1989, 2000 and 2010, respectively. Mangrove deforestation by human activity has increased almost six times in the recent decade in comparison to the previous one. The mangrove forest loss due to coastal erosion has slightly declined in the 2000s. Mangroves have been lost primarily because of agricultural expansion. The result of this investigation will be helpful to understand the dynamics of mangrove plantation and the main drivers of changes in this coastal ecosystem.

웹 미디어 시스템을 위한 확률 분포 함수와 사용자 프로파일에 기반 한 동적 적응 모델 (Dynamic Adaptive Model based on Probabilistic Distribution Functions and User's Profile for Web Media Systems)

  • 백영태;이세훈
    • 컴퓨터교육학회논문지
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    • 제6권1호
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    • pp.29-39
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    • 2003
  • 이 논문에서는 웹 미디어(웹 기반의 하이퍼미디어) 시스템에서 이산 확률 분포 함수와 사용자 프로파일 기반의 동적 적응 모델을 제안하였다. 이 모델은 응용 영역을 동적 적응 객체의 가중치 방향성 그래프로 표현하며, 사용자 행위를 이산 확률 함수를 동적으로 구축하는 접근 방식을 이용하여 모델링한다. 제안한 확률적 해석은 웹 미디어 구조에서 사용자의 탐색 행위를 추적하여 사용자 행위에 대한 잠재적 속성을 나타내는데 사용될 수 있다. 이러한 접근 방식은 사용자에게 가장 알맞은 프로파일을 동적으로 할당할 수 있다.

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Daily Profiles of Blood Insulin, Insulin-Like Growth Factor-I, Thyroxine and Triiodothyronine in Ewes Under Three Levels of Feed Intake

  • Caldeira, R.M.;Vasques, M.I.;Vaz Portugal, A.
    • Asian-Australasian Journal of Animal Sciences
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    • 제13권8호
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    • pp.1121-1126
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    • 2000
  • Daily variation in the serum concentrations of insulin and insulin-like growth factor-I and in the plasma concentrations of thyroxine and triiodothyronine were evaluated in ewes fed 30%, 100% and 200% of theoretical maintenance energy requirements. The single daily meal has had significant effects (p<0.05) on almost all profiles. In general, serum or plasma hormone concentrations have increased after the meal, in particular at the two higher levels of energy intake. In the group submitted to the lowest level of energy intake, the consequences of the meal on circulating levels were almost imperceptible. The effects of feeding levels on serum or plasma concentrations have widely varied among hormones, not showing any objective pattern or relationship. Because these variations may affect the interpretation of these blood indicators, knowledge of daily profiles and of the effect of feed level must be considered. In order to maximize the diagnostic value of those indicators, the most suitable times for blood collection seem to be 16 h after the meal and (or) just before the meal. The collection 16 h after the meal apparently allows the characterization of a relatively steady metabolic state, intermediate between the close effects of food intake and the final phase of the intensification of body reserves mobilization. The collection just before the meal will give a good indication of the level of activity of those mobilization mechanisms.

Cloning and Expression of Pseudomonas cepacia catB Gene in Pseudomonas putida

  • Song, Seung-Yeon;Jung, Young-Hee;Lee, Myeong-Sok;Lee, Ki-Sung;Kim, Young-Soo;Kim, Chi-Kyung;Choi, Sang-Ho;Min, Kyung-Hee
    • Journal of Microbiology
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    • 제34권4호
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    • pp.334-340
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    • 1996
  • The enzyme, cis,cis-muconate lactonizing enzyme has been proposed to play a key role in the $\beta$-ketoadipate pathway of benzoate degradation. A 3.2-kb EcoRI fragment termed as pRSU2, isolated from a Pseudomonas cepacia genomic library was able to complement the catB defective mutant. Several relevant restriction enzyme sites were determined within the cloned fragment. In Pseudomonas putida SUC2 carrying pRSU2, the enzyme activity was relatively higher than those of the induced or partially induced state of wild type P. putida PRS2000. It was probably due to higher expression of P. cepacia catB in P. putida PRS2000. It was probably due to higher expression of P. cepacia catB in P. putida. One possible interpretation of these results is that the catB promoter in P. cepacia is recognized within P. putida, resulting in the almost same expression level.

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신경성 발성장애와 기능성 발성장애의 감별 진단 (Differential Diagnosis between Neurogenic and Functional Dysphonia)

  • 김소연;이상혁
    • 대한후두음성언어의학회지
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    • 제28권2호
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    • pp.71-78
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    • 2017
  • Voice disorder is classified into three categories, structural, neurogenic and functional dysphonia. Neurogenic dysphonia refers to a disruption in the nerves controlling the larynx. Common examples of this include complete or partial vocal cord paralysis, spasmodic dysphonia. Also it occurs as part of an underlying neurologic condition such as Parkinson's disease, myasthenia gravis, Lou Gehrig's disease or disorder of the central nervous system that causes involuntary movement of the vocal folds during voice production. Functional dysphonia is a voice disorder in the absence of structual or neurogenic laryngeal characteristics. A near consensus exist that Muscle tension dysphonia (MTD) is functional voice disorder wherein hyperfunctional laryngeal muscle activity whereas Spasmodic dysphonia (SD) is neurogenic, action-induced focal laryngeal dystonia including several subtype. Both Adductor type spasmodic dysphonia (AdSD) and MTD may be associated with excessive supraglottic contraction and compensation, resulting in a strained voice quality with spastic voice breaks. It makes these two disorders extremely difficult to differentiate based on clinical interpretation alone. Because treatment for AdSD and MTD are quite different, correct diagnosis is important. Clinician should be aware of the specific vocal characteristics of each disease to improve therapeutic outcome.

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대중가수 이미지의 청소년 수용에 관한 연구 -팬코스프레 집단을 중심으로- (A Study on the Acceptance of Pop Musician's Image among Korean Adolescent: - Focusing on Subculture, Fan Costume play -)

  • 한자영;유송옥
    • 한국의류학회지
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    • 제28권5호
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    • pp.570-581
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    • 2004
  • The purpose of this study is to analyze the acceptance and interpretation of pop musician's image in the Korean youth subculture, Fan Costume play(Fancos). Fancos subculture took the most active attitude to accepts of the pop musician's image and therefore was assumed to have various and differential acceptance aspects. The ethnographic method was used in order to approach more closely from their point of view. The cultural activity of Fancos subculture was imitation and reappearance of pop musician's appearance. Actually Fancos is a kind of fan-culture which idolized Korean pop music star. The acceptance of musician's appearance in Fancos is found out in two aspects. One is passive acceptance aspects that inforces conformity of star fashion and follows servilely ideal body image which promoted by cultural industry. The other is unique acceptance aspects that Fancos members interpret the musician's image in their own way. Those members experience pleasure through their own meaning. And homology of their appearance makes a distinction between of themselves from other youth and intensifies their group identity. As above analyzed, Fancos subculture has differential acceptance of pop music star's image comparing to other youth and even their stylistic appearance reflects not only their fandom but also their own meaning. Consequently, pop musician's image as a popular cultural text is accepted not equal to all populace but dissimilar along with contexts and trails of the acceptance group.

FAR-INFRARED [C II] EMISSION FROM THE CENTRAL REGIONS OF SPIRAL GALAXIES

  • MOCHIZUKI KENJI
    • 천문학회지
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    • 제37권4호
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    • pp.193-197
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    • 2004
  • Anomalies in the far-infrared [C II] 158 ${\mu}m$ line emission observed in the central one-kiloparsec regions of spiral galaxies are reviewed. Low far-infrared intensity ratios of the [C II] line to the continuum were observed in the center of the Milky Way, because the heating ratio of the gas to the dust is reduced by the soft interstellar radiation field due to late-type stars in the Galactic bulge. In contrast, such low line-to-continuum ratios were not obtained in the center of the nearby spiral M31, in spite of its bright bulge. A comparison with numerical simulations showed that a typical column density of the neutral interstellar medium between illuminating sources at $hv {\~} 1 eV $ is $N_H {\le}10^{21}\;cm^{-2}$ in the region; the medium is translucent for photons sufficiently energetic to heat the grains but not sufficiently energetic to heat the gas. This interpretation is consistent with the combination of the extremely high [C Il]/CO J = 1-0 line intensity ratios and the low recent star-forming activity in the region; the neutral interstellar medium is not sufficiently opaque to protect the species even against the moderately intense incident UV radiation. The above results were unexpected from classical views of the [C II] emission, which was generally considered to trace intense interstellar UV radiation enhanced by active star formation.