• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.839-844
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• 2003

This paper presents a method to segment wafer ID marks on poor quality images under uncontrolled lighting conditions of the semiconductor process. The active multiple templates matching method is suggested to search ID areas on wafers and segment them into meaningful regions and it would have been impossible to recognize characters using general OCR algorithms. This active template model is designed by applying a snake model that is used for active contour tracking. Active multiple template model searches character areas and segments them into single characters optimally, tracking each character that can vary in a flexible manner according to string configurations. Applying active multiple templates, the optimization of the snake energy is done using Greedy algorithm, to maximize its efficiency by automatically controlling each template gap. These vary according to the configuration of character string. Experimental results using wafer images from real FA environment are presented.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.2486-2491
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• 2003

This paper presents a method to segment object ID marks on poor quality images under uncontrolled lighting conditions of FA inspection process. The method is based on multiple templates and normalized gray-level correlation (NGC) method. We propose a multiple template method, called as ATM (Active Template Model) which uses combinational relation of multiple templates from model templates to match and segment several characters of the inspection images. Conventional Snakes algorithm provides a good methodology to model the functional of ATM. To increase the computation speed to segment the ID mark regions, we introduce the Dynamic Programming based algorithm. Experimental results using images from real FA environment are presented.

• Proceedings of the KIEE Conference
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• 2003.07d
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• pp.2555-2557
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• 2003

본 논문에서는 열화된 이미지상에서의 자동 패턴 분할을 위해 농담 정규화 정합(NGC)법과 다중 템플레이트를 이용하여 검사 이미지내의 각 문자의 정합 계수치 합을 이용한 문자나 패턴을 자동으로 분할(segmentation)하는 알고리즘을 제안한다. 전통적인 NGC를 사용하는 검사 알고리즘은 기준 패턴의 기하학적인 level 값에 의해 계산되어 지기 때문에 검사 이미지의 획득이 불완전하다면 정합의 부독율(reject rate)은 높아진다. 제안한 알고리즘은 가시화가 좋지 않은 영상 회득 시 문자부와 배경부를 효과적으로 자동으로 분류하며 이미지 영역내의 정보와 정규화 된 상관관계를 이용하여 실제 영상에 적용시켜 제안된 알고리즘의 검증을 목표로 한다.

• Bulletin of the Korean Chemical Society
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• v.26 no.2
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• pp.285-291
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• 2005

The nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) is the viral RNA-dependent RNA polymerase (RdRp), which is the essential catalytic enzyme for the viral replication and is an appealing target for the development of new therapeutic agents against HCV infection. A small amount of serum from a single patient with hepatitis C was used to get the genome of a Korean HCV isolate. Sequence analysis of NS5B 1701 nucleotides showed the genotype of a Korean isolate to be subtype 1b. The soluble recombinant HCV NS5B polymerase lacking the C-terminal 24 amino acids was expressed and purified to homogeneity. With the highly purified NS5B protein, we established in vitro systems for RdRp activity to identify potential polymerase inhibitors. The rhodanine family compounds were found to be potent and specific inhibitors of NS5B from high throughput screening (HTS) assay utilizing the scintillation proximity assay (SPA) system. The binding mode of an inhibitor was analyzed by measuring various kinetic parameters. Lineweaver-Burk plots of the inhibitor suggested it binds not to the active site of NS5B polymerase, but to an allosteric site of the enzyme. The activity of NS5B in in vitro polymerase reactions with homopolymeric RNA requires interaction with multiple substrates that include a template/primer and ribonucleotide triphosphate. Steady-state kinetic parameter, such as Km, was determined for the ribonucleotide triphosphate. One of compounds found interacts directly with the viral polymerase and inhibits RNA synthesis in a manner noncompetitively with respect to UTP. Furthermore, we also investigated the ability of the compound to inhibit NS5B-directed viral RNA replication using the Huh7 cell-based HCV replicon system. The investigation is potentially very useful for the utility of such compounds as anti-hepatitic agents.