• Biomolecules & Therapeutics
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• 제17권3호
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• pp.288-292
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• 2009

Interactions between tumor cells and the extracellular matrix (ECM) strongly influence tumor development, affecting cell survival, proliferation and migration. Fibronectin, a major component of ECM, has been shown to interact with integrins especially the ${\alpha}5{\beta}1$ integrin. Cell invasion and metastasis are often associated with matrix metalloproteinases (MMPs) which are capable of digesting the different components of the ECM and basement membrane. MMP-2 is produced as a latent pro-MMP-2 (72 kDa) to be activated, resulting the 62 kDa active MMP-2. In this study, we investigated the effect of fibronectin on activation of pro-MMP-2 and the cellular invasiveness in H-Ras-transformed MCF10A human breast epithelial cells. Here we show that fibronectin induces activation of pro-MMP-2 and up-regulation of MT1-MMP and TIMP-2 in H-Ras MCF10A cells. These results demonstrate that H-Ras MCF10A cells secrete high levels of active MMP-2 when cultured with fibronectin, suggesting a possible interaction between the ECM network and H-Ras MCF10A cells to generate active MMP-2 which is important for proteolysis and ECM remodeling. Invasive and migratory abilities of H-Ras MCF10A cells were enhanced by fibronectin. Fibronectin up-regulated the expression of ${\beta}1$ integrin which may play a role in cellular responses exerted by fibronectin. Since acquisition of pro-MMP-2 activation can be associated with increased malignant progression, this study provides a mechanism for the cell surface-matrix degrading effect of fibronectin which will be crucial to breast cell invasion and migration.

• Journal of Information Display
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• 제7권4호
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• pp.21-23
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• 2006

We developed a 4.5" 192${\times}$64 active matrix organic light-emitting diode display on a glass using organic thin-film transistor (OTFT) switching-arrays with two transistors and a capacitor in each sub-pixel. The OTFTs has bottom contact structure with a unique gate insulator and pentacene for the active layer. The width and length of the switching OTFT is 800${\mu}m$ and lO${\mu}m$ respectively and the driving OTFT has 1200${\mu}m$ channel width with the same channel length. On/off ratio, mobility, on-current of switching OTFT and on-current of driving OTFT were $10^6,0.3{\sim}0.5$ $cm^2$/V·sec, order of 10 ${\mu}A$ and over 100 ${\mu}A$, respectively. AMOLEDs composed of the OTFT switching arrays and OLEDs made using vacuum deposition method were fabricated and driven to make moving images, successfully.

• 한국음향학회지
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• 제38권3호
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• pp.290-301
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• 2019

본 논문에서 제안하는 알고리즘은 수중에서 협대역 지속파 능동 소나를 이용하여 표적 반향음을 탐지하는 문제를 다루고 있다. 능동 소나에서 표적 탐지를 위해 방사한 핑 신호는 주변의 많은 산란체에 의해 반사되는 신호를 만들어내며, 이를 잔향이라 한다. 본 논문에서 제안하는 알고리즘은 잔향 환경에서 낮은 도플러의 표적 반향음을 탐지하는 것을 목표로 한다. 제안하는 알고리즘은 빔공간 다채널 비음수 행렬 분해 기법을 기반으로 하여 방위, 주파수, 시간 기저를 추정하며, 특히 기저를 두 개의 기저집단 -잔향음 기저집단과 반향음 기저집단으로 나누어 독립적으로 추정한다. 제안하는 알고리즘의 성능을 평가하기 위하여 합성된 잔향 신호를 이용하여 시뮬레이션을 진행하였으며, 시뮬레이션 결과 제안하는 알고리즘이 기존의 알고리즘에 비해 향상된 성능을 보이는 것을 확인할 수 있었다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1995년도 추계학술대회 논문집
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• pp.513-517
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• 1995

In this paper, a relation of matrix Q in cost function to distances between the closed-loop and open-loop poles of a multi input controllable systems is studied. Futhmore, the state feedback gain with exact desired eigenvalues in the LQR is computed. The proposed scheme is applied to designing automotive active suspension control system for a half-car model and its performance is compared with the existing LQR control system design methodology.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2003년도 춘계학술발표대회 논문집
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• pp.5-9
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• 2003

Stress and deflection of Active Fiber Composite(AFC) embedded and/or attached composite structures are numerically investigated at the constituent level by the Direct Numerical Simulation(DNS). The DNS approach which models and simulates the fiber and matrix directly using 3D finite elements need to be solved by efficient way. To handle this large scale problem, parallel program for solving piezoelectric behavior was developed and run on the parallel computing environment. Also, the stress result from DNS approach is compared with that from uniform field model.

• Journal of Mechanical Science and Technology
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• 제20권5호
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• pp.643-651
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• 2006

The theory for a novel fault-tolerant 4-active-pole homopolar magnetic bearing is developed. If any one coil of the four coils in the bearing actuator fail, the remaining three coil currents change via an optimal distribution matrix such that the same opposing pole, C-core type, control fluxes as those of the un-failed bearing are produced. The hompolar magnetic bearing thus provides unaltered magnetic forces without any loss of the bearing load capacity even if any one coil suddenly fails. Numerical examples are provided to illustrate the novel fault-tolerant, 4-active pole homopolar magnetic bearings.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권5호
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• pp.365-374
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• 2011

Introduction: Research on dental bone graft material has been actively conducted. Recently, demineralized dentin matrix material has been developed and introduced. This study examined the effect of demineralized dentin matrix material on bone healing. Subjects and Methods: The patients who received no treatment after extraction were used as the control group and patients who underwent demineralized dentin matrix material application in the extraction socket after extraction were used as the experimental group. Panorama radiography was performed at the baseline and at 3.5 months after graft material placement and CT was taken at 3.5 months after graft material placement for a radiologic evaluation. Bony tissue specimens were collected from the alveolar crest in the middle of the extraction socket using a 2 mm trephine bur after 3.5 months for the histology and hostomorphometric study. Results: 1. On the panoramic view, a higher bone density was observed in the subject group. 2. On the panoramic view, the bone density increased significantly in the extraction socket, from the baseline to 3.5 months: a 7 and 10 gray-level scale was observed in the control and experimental group, respectively (P<0.05). 3. The CT view evaluation at 3.5 months revealed significantly higher bone density in the subject group than the control group (P<0.05). 4. The histological findings showed more active new bone and lamellar bone formation in the subject group. Dentin with osteoinduction ability and enamel with osteoconduction ability appeared. 5. On histomorphometric analysis, the subject group showed significantly more new bone, lamellar bone area and lower soft tissue area (P<0.05). The difference between the groups was significant (P<0.05). Conclusion: Bone healing was improved after the application of demineralized dentin matrix material and there was active new bone and lamellar bone formation.

• 대한암한의학회지
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• 제15권1호
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• pp.47-61
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• 2010

Objective : The aim of this present study is to evaluate the inhibitory effect of allergen removed Rhus verniciflua (ARV) on Matrix Metalloproteinase-9 (MMP-9), Matrix Metalloproteinase-2 (MMP-2) which is considered to have a clinically important role in tumor metastasis. Methods : The inhibitory effects of standardized extract of ARV on the MMP-2, MMP-9 were investigated by spectrofluorometer while the inhibitory effects on the active MMP-2, pro MMP-2, pro MMP-9 were investigated by zymography. Antimetastatic effect of standardized extract of ARV was investigated in vitro on human fibrosarcoma cell (HT1080)'s invasion through Matrigel. Results : The standardized extract of ARV showed inhibitory effects on the active MMP-2 (IC50, $1.01{\mu}g$/ml), active MMP-9 (IC50, $2.5{\mu}g$/ml) depending on concentrations which was determined by spectrofluorometer. The standardized extract of ARV showed inhibitory effects on the active MMP-2, pro MMP-2, pro MMP-9 depending on concentrations which was determined by zymography. However its inhibitory effect on pro MMP-9 was relatively weaker rather than active MMP-2, pro MMP-2. The standardized extract of ARV showed inhibitory effects in vitro on human fibrosarcoma cell (HT1080)'s invasion through Matrigel according to concentration. Conclusions : These results indicate that standardized extract of ARV has antimetastatic effect through inhibit again MMP-2, MMP-9. Also its inhibitory effect is more powerful on active MMP-2, pro MMP-2 than on active MMP-9, pro MMP-9. It is necessary to conduct further studies on other MMP families, TIMP, and each component of standardized extract of ARV.

• 제어로봇시스템학회논문지
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• 제5권3호
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• pp.314-323
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• 1999

This paper introduces a methodology of active calibration of a camera pose (orientation and position) using the images of cylindrical objects that are going to be manipulated. This active calibration method is different from the passive calibration where a specific pattern needs to be located at a certain position. In the active calibration, a camera attached on the robot captures images of objects that are going to be manipulated. That is, the prespecified position and orientation data of the cylindrical object are transformed into the camera pose through the two consecutive image frames. An ellipse can be extracted from each image frame, which is defined as a circular-feature matrix. Therefore, two circular-feature matrices and motion parameters between the two ellipses are enough for the active calibration process. This active calibration scheme is very effective for the precise control of a mobile/task robot that needs to be calibrated dynamically. To verify the effectiveness of active calibration, fundamental experiments are peformed.

• 대한전기학회논문지
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• 제33권10호
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• pp.410-422
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• 1984

This paper presents a new practical method for optimal active and reactive power control for the economic operation in electrical power system, and the programs are developed for digital computer solution. The major features and techniques of this paper are as follows: 1) The method is presented for finding the equivalent active power balance equation applying the sparse Jacobian matrix of power flow equation instead of using B constant as active power balance equation considering transmission loss, and thus for determining directly optimal active power allocation berween generator unitw satisfying the equality and inequality constraints. 2) The method is proposed for solving directly the optimum economim dispatch problem without using gradient method and penalty function for both active and reactive power control. As a result, the computing time are reduced and convergence characteristic is remarkably improved. 3) Unlike most of conventional methods which adopt the transmission loss as a objective function for reactive power control, the total fuel cost of themal power plant is adopted as objective function for both active and reactive power control. consequently, more reasonable and economic profit can be achieved.