• Journal of Pharmacopuncture
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• v.23 no.4
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• pp.262-272
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• 2020

Objectives: Whiplash injury is one of the major diseases in recent times because of increasing traffic accidents. This review aims to analyze the overall trend of studies on pharmacopuncture for whiplash injury after traffic accidents. Methods: We searched through 4 Korean electronic databases from 2001 up to October 2020 for relevant clinical studies for whiplash injury after traffic accidents, regardless of the patients' age, gender, or race. We included studies that had an intervention group receiving pharmacopuncture therapy with or without other additional treatments, and also included studies that had a control group receiving sham treatment or active treatment such as physical therapy and herbal medication. For the clinical outcomes, we did not place any restrictions on evaluation scales if they are objective metrics. Results: We included 6 randomized controlled trials (RCTs) and 10 non-randomized controlled trials (nRCTs). 10 nRCTs were divided into 4 categories that were case-control studies, case series, case report, and retrospective observational study. In RCTs, Hwangryun-haedoktang (黃蓮解毒湯) pharmacopuncture was the most frequently used. In nRCTs, Jungsong-ouhyul (中性瘀血) pharmacopuncture, and bee venom pharmacopuncture were the most frequently used. As target points of Hwangryun-haedoktang pharmacopuncture, Ashi-points, Jianjing (GB21), and Fengchi (GB20) were the most frequently used. As target points of Jungsong-ouhyul pharmacopuncture, Ashi-points were the most frequently used. And as target points of Bee venom pharmacopuncture, Fengchi (GB20) was the most frequently used. Conclusion: Hwangryun-haedoktang pharmacopuncture, bee venom pharmacopuncture, and Jungsong-ouhyul pharmacopuncture were mainly used for whiplash injury, and their usual target points were Jianjing (GB21), Fengchi (GB20), and Ashi-points. However, a high level of evidence should be conducted through studies with systematic methodology in the future.

• Journal of Communications and Networks
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• v.7 no.3
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• pp.337-352
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• 2005

In this paper, a fuzzy logic implementation of the random early detection (RED) mechanism [1] is presented. The main objective of the proposed fuzzy controller is to reduce the loss probability of the RED mechanism without any change in channel utilization. Based on previous studies, it is clear that the performance of RED algorithm is extremely related to the traffic load as well as to its parameters setting. Using fuzzy logic capabilities, we try to dynamically tune the loss probability of the RED gateway. To achieve this goal, a two-input-single-output fuzzy controller is used. To achieve a low packet loss probability, the proposed fuzzy controller is responsible to control the $max_{p}$ parameter of the RED gateway. The inputs of the proposed fuzzy controller are 1) the difference between average queue size and a target point, and 2) the difference between the estimated value of incoming data rate and the target link capacity. To evaluate the performance of the proposed fuzzy mechanism, several trials with file transfer protocol (FTP) and burst traffic were performed. In this study, the ns-2 simulator [2] has been used to generate the experimental data. All simulation results indicate that the proposed fuzzy mechanism out performs remarkably both the traditional RED and Adaptive RED (ARED) mechanisms [3]-[5].

• Journal of Korean Academy of Fundamentals of Nursing
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• v.24 no.3
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• pp.167-180
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• 2017

Purpose: The aim of this study was to synthesize the best available evidence for active warming interventions during cesarean section. Methods: A database search was done for randomized controlled trials utilizing active warming interventions. Maternal temperature, shivering and neonatal temperature were evaluated as outcome variables. Data were analyzed using Cochrane Review Manager software Version 5.3. Results: Thirteen studies including 1306 patients were reviewed. The degree of lowering of maternal temperature decreased in the warmed fluids (MD 0.51; p=.004) and warming mattress interventions (MD 0.22; p<.001) compared with control groups. Incidence of shivering was also lower in the active warming group (OR 0.55; p=.003). There was no statistically significant difference in maternal temperature with a forced air warming intervention (MD 0.64; p=.15) or in neonatal temperature (MD 0.12; p=.26). Conclusion: Findings show that with warmed fluids and warming mattresses applied during cesarean sections maternal temperature decline was reduced and also the incidence of shivering declined, but no significant effect was observed for forced air warming interventions. These findings provide a basis for developing a warming guideline for women having a cesarean section and will help to improve the quality of care for cesarean section patients.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.11 no.1
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• pp.29-36
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• 2005

The purpose of this study was to evaluate change of path length center of body on sacroiliac joint mobilization. The subjects were consisted of sixty healthy adult two decade(28 females. 32 males; mean aged 22.2) from 20 to 29. All subjects randomly assigned to the control group, sacroiliac joint mobilization group. sacroiliac joint mobilization group received sacroiliac joint mobilization for 2-3 minutes per day and three times a week during 3 weeks period. The study carried out to determine the change of path length center of body on sacroiliiac joint mobilization from July 1, 2004 through september 30, 2004. Active balancer(SAKAI EAB-100) was used to measure equilibrium ability. All measurements of each subjects were measured at pre-experiment and post-experiment. The results of this study were summarized as follows: 1. The WPL of control group, sacroiliac joint mobilization group was no significantly differences at pre-experiment but significantly reduced post-experiment(p<.05). The results of analyzed effects of WPL was significantly reduced between experiment type of control group, sacroiliac joint mobilization group according to pre-experiment and post-experiment(p<.05). 2. The UPL of control group, sacroiliac joint mobilization group was no significantly differences at pre-experiment but significantly reduced post-experiment(p<.05). The results of analyzed effects of UPL was significantly reduced between experiment type of control group, sacroiliac joint mobilization group according to pre-experiment and post-experiment(p<.05). Conclusionally these data suggest that a 3-week S-I joint mobilization improved equilibrium. Additional randomized controlled trials to more fully investigate treatment effects and factors that may mediate these effects are needed.

• The Journal of Korean Physical Therapy
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• v.17 no.3
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• pp.285-295
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• 2005

The purpose of this study was to evaluate effects of sacroiliac joint mobilization and lumbopelvic stabilizing exercises on the equilibrium ability. The subjects were consisted of ninety healthy adult two decade(43 females. 47 males; mean aged 22.1) from 20 to 29. All subjects randomly assigned to the control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group. Lumbopelvic stabilizing exercises group received lumbopelvic stabilizing exercises for 30 minutes, sacroiliac joint mobilization group received sacroiliac joint mobilization for 2-3 minutes per day and three times a week during 3 weeks period. Active balancer(SAKAI EAB-100) was used to measure equilibrium ability. All measurements of each subjects were measured at pre-experiment, after 10 days, and post-experiment. The results of this study were summarized as follows: 1. The WPL of control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group was no significantly differences at pre-experiment(p>.05), but significantly reduced after 10 days and post-experiment(p<.05). The results of analyzed effects of WPL was significantly reduced between experiment type of control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group according to pre-experiment, after 10 days, and post-experiment(p<.05). 2. The RA of control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group was no significantly differences at pre-experiment(p>.05), but significantly reduced after 10 days, and post-experiment(p<.05). The results of analyzed effects of RA was significantly reduced between experiment type of control group, sacroiliac joint mobilization group, lumbopelvic stabilizing exercises group according to pre-experiment, after 10 days, and post-experiment(p<.05). Conclusionally these data suggest that a 3-week SI joint mobilization and lumbopelvic stabilizing exercises improved equilibrium. Additional randomized controlled trials to more fully investigate treatment effects and factors that may mediate these effects are needed.

• YAKHAK HOEJI
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• v.50 no.2
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• pp.118-123
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• 2006

The aim of this study was to investigate the effect of fluvastatin on the pharmacokinetics of diltiazem and its active metabolite, desacetyldiltiazem, in rats. Pharmacokinetic parameters of diltiazem and desacetyldiltiazem were deter-mined after an oral administration of diltiazem (15 mg/kg) to rats pretreated with fluvastatin (0.5 and 1.5 mg/kg). Compared with the control (given diltiazem alone), the pretreatment of fluvastatin significantly (p<0.05) increased the area under the plasma concentration (AUC), peak plasma concentration $(C_{max})\;and\;K_a$ of diltiazem. Relative bioavailability $(RB\%)$ of diltiazem increased from 1.36- to 1.55-fold. However there were no significant changes in $t_{max},\;K_{el}\;and\;t_{1/2}$ of diltiazem. The pretreatment of fluvastatin also altered the pharmacokintic parameters of desacetyldiltiazem. The pretreatment of fluvastatin (1.5 mg/kg) significantly (p<0.05) increased the AUC of desacetyldiltiazem, whereas the metabolite parent ratio (MR) of desacetyldiatlazem was decreased significantly (p<0.05), suggesting that fluvastatin might inhibit the metabolism of diltiazem. The pretreatment of fluvastatin enhanced the bioavailability of diltiazem in a dose dependent manner at doses ranging from 0.5 to 1.5 mg/kg. further studies for the drug Interaction will be needed in the clinical trials when dilitazem is administrated concomitantly with fluvastatin in humans.

• The Korean Journal of Applied Statistics
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• v.21 no.6
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• pp.947-957
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• 2008

Two-arm non-inferiority trials is often applied to parametric procedure suggested by Hauschke et al. (1999). Since this design does not allow a direct comparison of a new treatment group with placebo group, parametric procedure in a three-arm non-inferiority trial with a placebo group was suggested by Pigeot et al. (2003). But, procedures in these designs are necessary for distribution assumptions. Therefore we propose, in this paper, non parametric procedures employing Wilcoxon rank sum test in a two-arm design and linear contrast test suggested by Scheirer et al. (1976) in a three-arm design. The proposed nonparametric procedures and parametric procedures are compared by Monte Carlo simulation study.

• Journal of the Korean Applied Science and Technology
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• v.36 no.1
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• pp.113-124
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• 2019

The purpose of the study was to investigate the effects of sea cucumber extract on skin as a natural cosmetics functional material. Subjective evaluation of cosmetics before and after were conducted with questionnaires regarding moisture content, sebum content, melanin index, and erythema index. Experiments were conducted on improvement efficacy using skin clinical trials and questionnaires to evaluate changes in perception of skin condition and efficiency of products. With the aim of minimizing skin irritation, the efficiency of the solvent used for extraction was an important factor, and the sea cucumber extract was harvested with efficient extraction conditions at a ratio of 1:10 of 50% ethanol. The study aimed to identify the suitability of sea cucumber extract as a functional cosmetics material to improve the moisturizing ability of skin and its effect on the skin by adding marine natural animal sea cucumber extract. Clinical studies on cosmetics skin containing sea cucumber extract, excellent skin improvement effect from all items of clinical experiment in experimental and control groups. Sea cucumber extract was proved to be a stable, non-adverse physiologically active substance against abnormal symptoms or side effects of skin reactions and skin problems. In addition, the study found excellent results that can lead to its use as a cosmetics material. This is expected to contribute to the development of various cosmetics industries.

• Physical Therapy Korea
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• v.20 no.3
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• pp.81-88
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• 2013

Active straight-leg raise (ASLR) is a physical evaluation procedure to test lumbar spine stability. Several previous studies have reported various methods to control the activation of abdominal muscles during ASLR. We investigated the effects of three different hip positions in frontal plane on abdominal muscles to increase or decrease the difficulty level of lumbar spine stability exercise during ASLR in pain free subjects. Eleven young and healthy subjects voluntarily participated in this study (6 men, 5 women; mean age=$24.0{\pm}1.2$ years, height=$160.0{\pm}7.3cm$, weight=$55.0{\pm}10.6kg$, body mass index=$21.5{\pm}2.3kg/m^2$). The subjects had three trials on each ASLR with hip $10^{\circ}$ adduction, neutral hip, and hip $30^{\circ}$ abduction. Separate repeated-measures analysis of variance (ANOVA) and the post hoc Bonferroni tests (with ${\alpha}$=.05/3=.017) were performed for each muscle among the three different hip positions in frontal plane (ASLR with hip $10^{\circ}$ adduction, neutral hip, and hip $30^{\circ}$ abduction). The ipsilateral external oblique (EO), contralateral EO, ipsilateral internal oblique/transverse abdominis (IO/TrA), and contralateral IO/TrA were significantly greater in ASLR with hip $30^{\circ}$ abduction compared with ASLR with hip $10^{\circ}$ adduction. Also, the ipsilateral EO, contralateral EO, and ipsilateral IO/TrA were significantly greater in ASLR with hip $30^{\circ}$ abduction compared with ASLR with neutral hip. These results suggest that ASLR with hip $30^{\circ}$ abduction and neutral would be useful method to strengthen the EO and IO/TrA. And, ASLR with hip $10^{\circ}$ adduction would be effective in early stages of lumbar stabilization program due to low activation of EO and IO/TrA during maintaining of ASLR position with low load.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.213-221
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• 2020

Salvianolic acid B (SAB) is an active phytocomponent of a popular Chinese herb called Radix Salvia militiorrhiza with numerous biological properties. The anti-psoriasis activity of SAB was examined by evaluating various psoriasis inflammatory and keratin markers against imiquimod (IMQ)-induced psoriasis on BALB/c mice. Totally 50 healthy BALB/c mice were evenly divided into 5 groups including control, drug control (SAB; 40 mg/kg), IMQ-induced psoriasis (5%), IMQ exposure and treated with SAB (40 mg/kg), or standard methotrexate (MTX; 1 mg/kg). Mice supplemented with either SAB or MTX significantly lowered the values of psoriasis area severity index (PASI), erythema, scaling, skin thickness, inflammatory markers (interleukin [IL]-22/23/17A/1β/6) and lipid peroxidation product (malondialdehyde). Also, IMQ exposed BALB/c mice treated with SAB or MTX display lesser histopathological changes with enhanced antioxidant activities (catalase, superoxide dismutase). Moreover, the protein expression of keratin markers (K16 and K17) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling proteins (pAkt/Akt and pPI3K/PI3K) were significantly downregulated after administration with SAB and MTX as compared with IMQ induced mice. Taking together, SAB and MTX significantly ameliorate psoriatic changes by inhibiting psoriatic inflammatory and keratin markers through abolishing PI3K/Akt signaling pathway. However, further studies (clinical trials) are needed to confirm the anti-psoriatic property of SAB before recommending to psoriasis patients.