• YAKHAK HOEJI
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• v.15 no.3_4
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• pp.83-86
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• 1971

Nine novel compounds, namely, 2-(p-aminobenzenesulfonamideo)-6-sulfamylbenzothiozle, 2-benzamido-6-sulfamylbenzothiazole, 2-(p-toluenesulfonamide)-6-sulfamylbenzothiazole, 2-(3,5-dinitrobenzamido)-6-sulfamylbenzothiazole, 2-benzamido-6-nitrobenzothiazole, 2-(p-toluene-sulfonamido)-6-nitrobenzothiazole, 2-(3,5-dinitrobenzamido)-6-nitrobenzothiazole, 2-(p-toluenesulfonamido)-6-chlorobenzothiazole, 2-(3,5-dinitrobenzamido)-6-chlorobenzothiazole were synthesized and evaluated for their in vitro antimicrobial activity against Staphylococcus aureus wood 46, $\betha$-Streptococcus S86, Escherichia coli and antitubercular activity against Mycobacterium tuberculosis H$_{37}$ /Rv. 2-(p-Toluenesulfonamido)-6-chlorobenzothiazole showed antimicrobial activity at 25 $\mu$g/ml against $\betha$-Streptococcus S/86, 2-(3,5-Dinitrobenzamido)-6-sulfamylbenzothiazole was active at 5 $\mu$g/ml and 2-(3,5-dinitrobenzamido)-6-nitrobenzothiazole was consderably active at 1$\mu$g/ml against Mycobacterium tuberculosis H$_{37}$Rv.

• Proceedings of the Korea Contents Association Conference
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• 2005.11a
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• pp.644-648
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• 2005

Agent-Oriented Software Engineering is the one of the most recent contributions to the field of Software Engineering. This method has many benefits compared in existing development approaches. In particular the ability to let agents represent high level abstraction of active entity in software system. This paper gives an overview of research for agent-oriented software and industrial applications.

• Journal of Pharmaceutical Investigation
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• v.4 no.1_2
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• pp.19-24
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• 1974

The comparative studies were made on the analgesic antipyretic effects of aminopyrine used individually and combined with parasympathetic agents (atropine sulfate). The analgesic antipyretic effects were eximined by Writhing's method to the experimental groups(mouse), and the following effects were found : 1) The active intensity of aminopyrine by it's oral administration combined with atropine sulfate is as follows. Amiinopyrine 80 mg/kg combided with Atropine sulfate 0.005 mg/kg=Aminopyrine 100 mg/kg 2) The most active range of intensity of Atropine sulfate(adjuvant) by it's oral administration is as follows. Atropine sulfate $0.004{\sim}0.005\;mg/kg$.

• Archives of Pharmacal Research
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• v.21 no.5
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• pp.527-530
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• 1998

The antibacterial activity of novel ${\beta}$-lactamase inhibitors, 6-exomethylene penamsulfones (CH1240, CH2140), has been compared in vivo with that of sulbactam and clavulanic acid against b-lactamase producing strains. In vivo microbiological assessment was used as experimental mouse infection model by gram negative strains. Against Pseudomonas aeruginosa F0013, cefoperazone/CH 1240 was slightly less active than sulbactam. ampicillin/CH 2140 was less effective than sulbactam against escheriachia coli 3457. Especially against Citrobacter diversus 2046E, amoxicillin/CH 2140 was the most potent and amoxicillin/CH 1240 was slightly more active than clavulanic acid. consequently the difference in efficacy between the drug combinations appers to be related to the degree of protection afforded the animals by the b-lactamasse inhibitors. CH1240 and CH2140 are promising new agents and should undergo further investigations.

• Natural Product Sciences
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• v.28 no.2
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• pp.89-92
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• 2022

In Asia, the roots of Paeonia lactiflora and Astragalus membranaceus have been used as therapeutic agents for thousands of years. Once the medicinal plants are harvested, they are dried and their ingredients are extracted by heat-mediated reflux extraction. However, the condensed structure of organic products (especially roots) limits the extraction of bioactive components. In this study, we assessed the effect of the puffing method (using high temperature and pressure) before the extraction process in relation to the profile and antioxidant capacity of active ingredients. We demonstrated that the additional puffing process before extraction methods improves the yield of polyphenol concentrations and antioxidant activities from the roots of P. lactiflora and A. membranaceus.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3808-3814
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• 2023

The thermal stability of nitric acid solutions after contact with non-irradiated and irradiated tributyl phosphate (TBP) and its solution in Isopar-M has been studied. It has been established that exothermic processes occur during heating due to the interaction of soluble radiolysis products and the decomposition of the extractant with nitric acid. Such processes can occur at temperatures below 100 ℃, but unlike a thermal explosion that occurs in seconds, they are longer in time and are accompanied by weak heat evolution. Their intensity depends on the composition of the extractant, the concentration of HNO₃, and the volume ratio of the organic and aqueous phases. The presence of extractant degradation products in raffinates does not pose a risk of a rapid evolution of gaseous products during evaporation, however, the presence of reducing agents can significantly increase the intensity of the exothermic decomposition of raffinates.

• Journal of KIISE:Computer Systems and Theory
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• v.26 no.7
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• pp.778-787
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• 1999

이제까지 대부분의 다중 에이전트 시스템에서는 에이전트 사회에 속한 모든 응용 에이전트를 작업 요청에 관계없이 처음부터 구동시킨다고 가정하였다. 이러한 에이전트 정적 구동 방법은 에이전트 관리를 단순하게 해주는 이점을 제공하지만 워크플로우 관리나 전자상거래와 같이 매우 많은 수의 에이전트로 구성되는 응용 분야에서는 시스템 과부하와 자원의 낭비 등 많은 문제점을 초래한다. 동적 에이전트 관리는 이에 대한 해결책으로 아주 많은 수의 에이전트를 포함하는 다중 에이전트 시스템에서 현재 수행중인 작업에 관련된 에이전트만을 선별하여 구동시키고, 작업이 끝난 에이전트는 종료시킴으로써 자원의 낭비를 막고 에이전트간의 상호작용 시에 요구되는 에이전트 통신의 복잡도 부담을 감소시키는 효과를 낸다. 본 논문에서는 자바로 에이전트 관리 시스템을 구현하고, 이 관리 시스템을 통해 각기 다른 언어로 개발된 응용 에이전트가 분산된 환경에서 상호 협력을 통해 작업을 수행할 수 있는 기법을 제안한다. 사용자나 다른 에이전트의 요청으로 에이전트를 동적으로 수행시키기 위해 다른 언어로의 확장을 가능하게 하는 Java Native Interface(JNI)를 사용한 기술 및 이러한 이질적인 에이전트간의 원활한 통신을 위해서 KQML 언어 인터페이스를 통한 통신 기능을 제안한다. 이질적 에이전트의 동적 관리를 가능하게 함으로써 다중 에이전트 시스템의 자원 이용 효율성과 확장성을 높이고 다양한 환경 변화에 대한 적응성과 개선된 협동능력을 제공한다.Abstract It has been assumed that all application agents in a multi-agent system are pre-invoked and remain active regardless of whether they are actually used. Although this kind of static agent invocation simplifies the management of agents, it causes several problems such as the system overload and a waste of resources, especially in the areas of the workflow management and the electronic commerce that consist of tens and even hundreds of application agents. A solution for these problems is the scheme of dynamic agent management that selectively invokes only agents that are actually requested and terminates them when they are no longer needed. This method prevents a waste of system resources and alleviates the complexity of agent communications.This paper proposes an agent management system implemented in Java that supports interactions between application agents that are developed using different languages. Dynamic agent invocation is accomplished by Java Native Interface(JNI) that links two heterogeneous methods, and by KQML language interface that facilitates the communications between heterogeneous agents. This scheme of dynamic agent management provides efficient resource usage, easy extensibility, dynamic adaptibility to changes in the environment, and improved cooperation.

• Natural Product Sciences
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• v.6 no.4
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• pp.183-188
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• 2000

In order to discover novel potent antitumor agents, methanolic extracts of approximately 180 herbal medicines were prepared and primarily evaluated for cytotoxic activity in cultured human lung (A549) and colon (Col 2) cancer cells. As a result, 17 natural product extracts were found to be active in the criteria of $IC_{50}$<$20\;{\mu}g/ml$. Especially, the extracts of Aristolochia debilis, Cynanchum ascyrifolium, Cynanchum paniculatum, Daphne genkwa, Euphorbia lathyris, Ipomoea hederacea, Magnolia officinalis, Melia azedarach var. japonica, Solanum nigrum, Thuja orientalis, and Trichosanthes kirilowii showed a strong cytotoxic potential. The flower extract of Daphne genkwa was more selective cytotoxic activity against lung cancer cells $(IC_{50};\;0.2\;{\mu}g/ml)$ compared to colon cancer cells $(IC_{50}>20\;{\mu}g/ml)$. In addition, based on the cytotoxic potential of the root extract of Cynanchum paniculatum, the further fractionation of methylene chloride partition with silica gel column chromatography was performed. Several subfractions were considered to be active, and thus indicating that further studies for the identification of active principles from these fractions might be warranted.

• Korean Journal of Pharmacognosy
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• v.42 no.4
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• pp.336-340
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• 2011

The aim of this study was to investigate the possible utilization of Zanthoxylum schinifolium as a source of antimicrobial agents. The antimicrobial effects of Zanthoxylum schinifolium extracts were investigated against Acinetobacter baumannii, which is a multi-drug resistant pathogen, and 5 other pathogenic microorganisms. The hexane extract of Zanthoxylum schinifolium was more effective than the ethyl acetate, n-butanol and methanol extracts which were active against Acinetobacter baumannii 25, with minimum inhibitory concentrations(MIC) ranging from 0.8 mg/ml to 1.6 mg/ml. Tetracycline had no effect on Acinetobacter baumanniii. The hexane extract was highly active against Candida albicans IFO 6258, with an MIC of 1.5 mg/ml. In contrast, the ethyl acetate, n-butanol and methanol extracts showed no activity against the 5 pathogenic microorganisms. Furthermore, a combination of hexane extract and ethyl acetate extract was significantly more active against the 5 Acinetobacter baumannii strains than n-butanol and methanol. These results suggest that Zanthoxylum schinifolium extracts have great potential as antimicrobial compounds against multi-drug resistant pathogens, and further studies are warranted.

• Journal of the Korea Society of Computer and Information
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• v.8 no.2
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• pp.129-134
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• 2003

This paper describes an application level composition mechanism called Generic Modeling Environment(GME) for web caching on an Application Level Active Network(ALAN). Web caching on an ALAN requires the application level composition mechanism and a service composition to support adaptability for self-organization. ALAN was developed to solve the problems of the network level Active Network(AN) ALAN has the features of both AN as well as mobile agents. The efficient composition mechanism for the existing AN Projects has been supported primarily for the network level AN. Conversely, ALAN lacks support for the application level AN The existing web caching technology is inter-connected in a manually configured hierarchical tree. Since a self-organization system is intended to be adaptive, web caching for self-organization does not involve a manual configuration or any low-level tuning of the individual nodes of the entire system but requires service composition to support adapting intelligence and fault-tolerance to enable self-organization.