Browse > Article

Anitimicrobial Effects of Zanthoxylum schinifolium Extracts against Multi-drug Resistant Acinetobacter baumannii  

Lee, Keyong-Ho (Kolon Life Science Inc.)
Rhee, Ki-Hyeong (College of Industrial Sciences, Kongju National University)
Publication Information
Korean Journal of Pharmacognosy / v.42, no.4, 2011 , pp. 336-340 More about this Journal
Abstract
The aim of this study was to investigate the possible utilization of Zanthoxylum schinifolium as a source of antimicrobial agents. The antimicrobial effects of Zanthoxylum schinifolium extracts were investigated against Acinetobacter baumannii, which is a multi-drug resistant pathogen, and 5 other pathogenic microorganisms. The hexane extract of Zanthoxylum schinifolium was more effective than the ethyl acetate, n-butanol and methanol extracts which were active against Acinetobacter baumannii 25, with minimum inhibitory concentrations(MIC) ranging from 0.8 mg/ml to 1.6 mg/ml. Tetracycline had no effect on Acinetobacter baumanniii. The hexane extract was highly active against Candida albicans IFO 6258, with an MIC of 1.5 mg/ml. In contrast, the ethyl acetate, n-butanol and methanol extracts showed no activity against the 5 pathogenic microorganisms. Furthermore, a combination of hexane extract and ethyl acetate extract was significantly more active against the 5 Acinetobacter baumannii strains than n-butanol and methanol. These results suggest that Zanthoxylum schinifolium extracts have great potential as antimicrobial compounds against multi-drug resistant pathogens, and further studies are warranted.
Keywords
Zanthoxylum schinifolium; Acinetobacter baumannii; mult-drug resistant;
Citations & Related Records
Times Cited By KSCI : 7  (Citation Analysis)
연도 인용수 순위
1 Kim, K. W., Baek, J. K., Jang, Y. W., Kum, E. J., Kwon, Y. S., Kim, H. J. and Shon, H. Y. (2005) Screening of antibacterial agent against Streptococcus mutans from natural and medicinal plants. J. Life Sci. 15: 715-725.   DOI
2 Kim, S. I. and Han, Y. S. (1997) Isolation and identification of antimicrobial compound from sancho(Zanthoxylum schinifolium). Korean J. Food Sci. Technol. 13: 56-63.
3 Lee, J. W. (1998) Volatile flavor components of korean sancho fruit and tree(Zanthoxylum schinifolium). J. Kor. Soc. Food Sci. Nutr. 11: 493-498.
4 Lee, M. S. and Chung, M. S. (2000) Analysis of volatile flovor components from Zanthoxylum schinifolium and sensory evaluation as natural spice. Kor. J. Food Cookery Sci. 16: 216-220.
5 Manikal, V. M., Landman, D., Saurina, G., Oydna, E., Lal, H. and Nale, J. (2000) Endemic carbapenem-resistant Acinetobacter species in Brooklyn, NewYork city, videprevalence, interinstitutional spread, and relation to antibioticus age. Clin. Infect. Dis. 31: 101-106.   DOI   ScienceOn
6 Min, K. H. (1998) Antifungal activity of the extracts of Zanthoxylum schinifolium Sieb. et Zucc. against dermatophytes. Mokche. Konhak. 26: 78-85.
7 National Committee for Clinical Laboratory Standards. (1997) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically approved standard M7-A3. NCCLS, Villanova, Pa.
8 Park, A. J. and Hong, H. R. (2003) Evaluation of methods for detection of antimicrobial resistance of Acinetobacter baumannii to imipenem. Korean J. Lab. Med. 23: 388-394.
9 Rhee, K. H. and Lee, K. H. (2011) Antimicrobial effects of Lonicera japonica against gram positive and gram negative anaerobic bacteria. Nat. Prod. Sci. 17: 23-25.
10 Ryu, K. H., Kwon, J. H., Lee, S. S., Ahn, Y. J. and Yoo, J. K. (1998) Fungicidal activity of oriental medicinal plant extracts against plant pathogenic fungi. Agri. Chem. Biotechnol. 41: 600-604.
11 Baraibar, J. H., Correa, D., Mariscal M., Gallego, J., Valles, J. and Rello, M. (1997) Risk factors for infection by Acinetobacter baumannii inintubated patients with nosocomial pneumonia. Chest. 112: 1050-1054.   DOI   ScienceOn
12 Bergogne-Berezin, E. and Towner, K. J. (1996) Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin. Microbiol. Rev. 9: 148-165.
13 Bello, H., Gonzalez, G., Dominguez, M., Zemelman, R.. Garcia, A. and Mella, S. (1997) Activity of selected beta-lactams, ciprofloxacin, and amikacin against different Acinetobacter baumannii biotypes from Chilean hospitals. Diagn. Microbio. Infect. Dis. 28: 183-186.   DOI
14 Cho, M. G. and Kim, H. (2003) Analysis of volatile compounds in leaves and fruits of Zanthoxylum schinifolium Siebold et Zucc.& Zanthoxylum piperiyum DC. by headspace SPME. Kor. J. Med. Crop. Sci. 11: 40-45.
15 Getchell-White, S. I., Donowitz, L. G. and Groschel, D. H. (1989) The inanimate environment of an intensive care unit as a potential source of nosocomial bacteria: evidence for long survival of Acinetobacter calcoaceticus. Infect. Control. Hosp. Epidemiol. 10: 402-407.   DOI   ScienceOn
16 Hanberger, H., Garcia-Rodriguez, J. A., Gobernado, M., Goossens, H., Nilsson, L. E. and Struelens, M. J. (1999) Antibiotic susceptibility among aerobic Gram-negative bacilli in intensive care units in 5 European countries. J. A. M. A. 281: 67-71.   DOI   ScienceOn
17 Kim, B. S., Jang, H. S., Choi, C. S., Kim, J. S., Kon, G. S., Kwun, I. S., Son, K. H. and Sohn, H. Y. (2008) Antifungal of Zanthoxylum schinifolium against Fusarium graminearum, barey powedery mildew fungus. J. Life. Sci. 18: 974-979.   DOI
18 Kim, J., Lee, Y. A., Kim, Y. S., Jung, H. J., Kwak, D. J., Jie, W. D. and Yoon, S. H. (2000) Antimicrobial activities of sancho( Zanthoxylum schinifolium S. et Z) on oral bacteria. J. Kor. Soc. Hygiene. Sci. 6: 41-46.
19 Kim, J. H. (2003) Variation on the leaf monotrpenes concentration of Zanthoxylum schinifolium at Mt. Muhak. J. Basic Sci. 18: 137-149.
20 Kim, J. S., Gu, G. M., Jeong, Y. H., Yang, J. G. and Lee, G. G. (2004) Antimicrobial activities of Zanthoxylum schinifolium extract against Vibrio parahaemolyticus. J. Kor. Soc. Food Sci. Nutr. 33: 500-504.   DOI
21 Jang, M. J., Woo, M. H., Kim, Y. H., Yoon, D. Y. and Cho, S. H. (2007) Anti-throbogenic and anti-inflammatory effects of solvent fractions from leaves of Zanthoxylum schinifolium (sancho namu) in rats fed high fat diet. Kor. J. Nutrition. 40: 606-615.
22 Aswapokee, N. S., Tiengrim, B., Charoensook, K. and Sangsiriwut, K. (1998) Antimicrobial resistant pattern of Acinetobacter sp. J. Infect. Dis. 15: 43-48.