• Title/Summary/Keyword: activator

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Effect of PPARα activator and exercise on angiogenesis of white adipose tissue in high fat diet fed mice (고지방 사료를 섭취한 쥐에서 백색지방조직의 혈관신생에 대한 PPARα activator와 운동의 영향 )

  • Sun-Hyo Jeong
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.5
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    • pp.925-935
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    • 2023
  • It was investigated whether PPARα activator more effectively inhibits angiogenesis of white adipose tissue in exercise mice that ate high fat diet compared to non-exercise mice that ate high fat diet. Male mice were randomly divided into a control group not treated with a PPARα activator fenofibrate and exercise (Con), a group treated with fenofibrate alone (FF), a group treated with exercise alone (Ex), and a group treated with a combination of fenofibrate and exercise (Ex+FF). (Ex+FF). All mice was fed high-fat diet for 8 weeks. The weight of white adipose tissue and the size of white adipocytes decreased in FF, Ex, and Ex+FF compared to Con, and decreased more in Ex+FF Ex+FF compared to FF. In white adipose tissue, the gene expression of MMPs and angiogenic factors decreased in FF, Ex, and Ex+FF compared to Con, and more decreased in Ex+FF compared to FF. On the other hand, gene expression of angiogenic inhibitors increased in FF, Ex and Ex+FF compared to Con, and increased more in Ex+FF compared to FF. Therefore, this study revealed that the combined treatment of fenofibrate and exercise effectively inhibits the angiogenesis of white adipose tissue, reducing the increase in white adipose tissue and suppressing abdominal obesity, rather than the single treatment of fenofibrate.

Wunder Activator를 이용한 기능형 전치부 반대교합 치료효과에 관한 임상적 고찰

  • Jeon, Yun-Sik
    • The Journal of the Korean dental association
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    • v.24 no.12 s.211
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    • pp.1049-1060
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    • 1986
  • The author evaluated the effect of wunderer activator for correction of functional enterior corss-bite. The Data were obtained from super-imposition of pre. and post -treatment lateral cephalo-grams. The results were as follows. 1. Correction of anterior crossbite and improvement of facial profile were occurred. 2. Axial inclination of maxillary and mandibular anterior teeth were improved. 3. Slightly down and backwakd rotation of mandible was occurred by the increment of Y-axis angle, anterior facial height and SN-MP angle.

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A CASE REPORT OF MANDIBULAR PROGNATHISM TREATED WITH ACTIVATIOR (Activator를 이용한 하악전돌 치험예)

  • Lim, Jin Hwan;Nahm, Dong Seok;Yang, Won Sik;Suh, Cheong Hoon
    • The korean journal of orthodontics
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    • v.6 no.1
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    • pp.65-69
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    • 1976
  • A patient (Hellman dental age IIIA) who had anterior cross bite due to functional factor was treated with activator. Following results were obtained: 1) Anterior cross bite was crorrected 3 months after the initial application of the appliance. 2) Comparing pretreatment records with posttreatment, the main effects were labioversion of upper incisors, increase of upper arch length and downward-backward rotation of the mandible. 3) There was no damage on teeth and periodontal tissues and the patient had normal occlusion 1 year after the treatment.

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The Effect on the Alkali-Activator Mixture Ratio of fly Ash Mortar (알칼리 활성화제 혼합비가 플라이애시 모르타르에 미치는 영향)

  • Kang, Hyun-Jin;Kang, Su-Tae;Ko, Kyung-Taek;Ryu, Gum-Sung;Park, Jung-Jun;Lee, Jang-Hwa
    • Proceedings of the Korea Concrete Institute Conference
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    • 2009.05a
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    • pp.395-396
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    • 2009
  • The purpose of this study is to observe the effect of mixture ratio of alkali-activator on workability and compressive strength of alkali-activated mortar that using 100% fly ash.

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Polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene in Kawasaki disease (가와사키병 환아에서 plasminogen activator inhibitor-1 유전자 다형성에 관한 연구)

  • Han, Mi Young
    • Clinical and Experimental Pediatrics
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    • v.50 no.6
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    • pp.570-575
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    • 2007
  • Purpose : To demonstrate genetic background of pathogenesis of Kawasaki disease (KD), I examined the genetic polymorphism of plasminogen activator inhibitor-1 (PAI-1) in KD patients. Methods : PCR-RFLP of PAI- 1 promotor gene was analyzed in 56 KD patients admitted to Kyunghee University Hospital, Gachon Medical School Gil Hospital, and Eulji Hospital from March to August 2000 and 206 normal control populations. Results : There were no differences in the genotype and allelic frequency of the PAI-1-675 (4G/5G) and PAI-1-844 (G/A) polymorphic site (which are located in the promoter region) between KD and control subjects. Also I could not detect any significant differences in specific genotypes between patients with the coronary artery lesion (CAL) and patients without CAL. Conclusion : No association was observed in -844 G/A and -675 4G/5G of PAI-1 gene polymorphism with KD.

Effects of Eu3+ and Tb3+ Activator Ions on the Properties of SrSnO3 Phosphors (Eu3+와 Tb3+ 활성제 이온이 SrSnO3 형광체의 특성에 미치는 영향)

  • Kim, Jung Dae;Cho, Shinho
    • Korean Journal of Materials Research
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    • v.24 no.9
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    • pp.469-473
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    • 2014
  • $SrSnO_3$ phosphor powders were synthesized with two different contents of activator ions $Eu^{3+}$ and $Tb^{3+}$ using the solid-state reaction method. The structural, morphological, and optical properties of the phosphors were investigated using X-ray diffractometry, field-emission scanning electron microscopy, and fluorescence spectrophotometry, respectively. All the phosphors showed a cubic structure, irrespective of the type and the content ratio of activator ions. For $Eu^{3+}$-doped $SrSnO_3$ phosphors, the intensity of the 620 nm red emission spectrum resulting from the $^5D_0{\rightarrow}^7F_2$ transition of $Eu^{3+}$ was stronger than that of the 595 nm orange emission signal due to the $^5D_0{\rightarrow}^7F_1$ transition in the range 0.01-0.05 mol of $Eu^{3+}$, but the ratio of the intensity was reversed in the range 0.10-0.20 mol of $Eu^{3+}$. The variation in the emission intensity indicates that the site symmetry of the $Eu^{3+}$ ions around the host crystal was changed from non-inversion symmetry to inversion. For the $Tb^{3+}$-doped $SrSnO_3$ phosphors under excitation at 281 nm, one strong green emission band at 550 nm and several weak bands were observed. These results suggest that the optimum red and green emission signals can be realized when the activator ion content for $Eu^{3+}$- or $Tb^{3+}$-doped $SrSnO_3$ phosphors is 0.20 mol and 0.15 mol, respectively.

FUNCTIONAL TREATMENT OF PEDIATRIC CONDYLAR FRACTURES : A CASE REPORT (Activator를 이용한 소아의 하악과두골절의 치험례)

  • Lee, Jung-Ha;Park, Heon-Dong;Lee, Sang-Ho;Lee, Nan-Young
    • Journal of the korean academy of Pediatric Dentistry
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    • v.30 no.3
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    • pp.477-482
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    • 2003
  • The pediatric condylar fracture occurs very frequently in the mandible, but this injury is occasionally ignored due to difficulty of diagnosis and no cooperation of patient. The adequate initial diagnosis and active treatment must be performed because delayed and improper treatment lead to possible severe complication such as TMJ ankylosis and reta rdation of mandibular development. Most pediatric condylar fracture is mainly performed by the conservative or functional treatment, but it may be required open reduction according to cases. In this study, activator is applied for functional treatment of pediatric condylar fracture and fair recovery of jaw function is acquired.

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Electrochemical Properties of the AB2-type Metal Hydride Electrode Prepared by Ball Milling (Ball milling한 AB2계 금속수소화물 전극의 전기화학적 특성)

  • Choi, Seung-Jun;Shim, Jong-Su;Oh, Se-Ung;Noh, Hak;Choi, Jeon;Seo, Chan-Yeol;Park, Choong-Nyeon
    • Transactions of the Korean hydrogen and new energy society
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    • v.8 no.4
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    • pp.181-185
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    • 1997
  • The electrochemical properties of the $AB_2$-type (Zr-Ti-V-Ni-Cr-Co-Mn) metal hydride electrodes prepared by ball milling with $AB_5-type\{(LM)Ni_{3.6}Al_{0.4}Co_{0.7}Mn_{0.3}\}$(LM : Lanthanum-rich mischmetal) alloy powder as a surface activator were investigated. By ball milling with $AB_5$ type alloy powder, the activation of $AB_2$ type metal hydride electrode was accelerated resulting in an increase of discharge capacity from 35% to 85% of the maximum capacity at the first cycle. As the amount of surface activator increased the activation rate increased, whereas the discharge capacity increased with 10wt% and decreased with 20wt% addition of the surface activator. When the amount of the surface activator was kept constant as 10wt%, the discharge capacity and the activation rate increased with ball milling time up to 20 hours. However beyond 20 hours of ball milling time, they decreased drastically due to the nano-crystallization or amorphorzation of the alloy powder.

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Plasminogen Activator Inhibitor-1 as a Radiation-Responsive Gene in Bone Marrow Stromal Cells (골수기질세포에서 방사선 반응 유전자로서의 Plasminogen Activator Inhibitor-1)

  • Song, Jee-Yeon;Kwon, Hyung-Joo;Park, Chan-Kyu;Jo, Deog-Yeon;Lee, Young-Hee
    • Development and Reproduction
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    • v.9 no.1
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    • pp.43-48
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    • 2005
  • Bone marrow stromal cells, a constituent of the niche for hematopoietic stem cells in bone marrow, provide various factors involved in the fate decision of the hematopoietic stem and progenitor cells. Radiation, a widely used anti-cancer therapy, provokes side effects including the damage of the blood cells. Therefore, it is necessary to recover the blood cells shortly after radiation via promoting the differentiation of hematopoietic cells. In this study, we screened genes modulated by radiation in human bone marrow stromal cells in order to understand the mechanism involved in hematopoiesis after radiation. We performed differential display method by using polymerase chain reaction(PCR) and agarose gel electrophoresis. We found plasminogen activator inhibitor-1(PAI-1) was consistently induced by radiation. The significance of the PAI-1 gene modulation is to be determined.

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