• 대한한의학회지
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• 제40권3호
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• pp.59-75
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• 2019

Objectives: The purpose of this study is to examine the current status of Korean medicine health technology assessment and explore realistic plans to activate it. Methods: We investigated all the applications for new health technology assessment related to Korean medicine from 2007 to 2016. The several expert meetings were held to draw out the barriers and improvement strategies of the new health technology assessment of Korean medicine field. Results: There were 31 cases in total except for duplications or reapplies falling into 3 main types. First, 19 of them were to try to enter a medical market and be covered by National Health Insurance. Eight cases were to apply western medicine technology as new health technology in Korean medicine area. The rest was 4 cases, which were totally not appropriate for the purpose of new health technology assessment system. According to the expert opinion, the obstacles of activation in new health technology assessment of Korean medicine were application of unstandardized technology, lack of understanding and experience, lack of clinical trial supporting system for Korean medicine, lack of committee members within the nHTA(new Health Technology Assessment) review board, ambiguous definition of medical practice and sharp conflict between western medicine and Korean medicine. Conclusions: Several suggestions were derived. First of all, to activate Korean medicine in the nHTA system, the existing system should be used sufficiently, and multifaceted efforts are needed to upgrade the system, if necessary. Also, self-help efforts, Korean medicine clinical trial supporting system and increasing R&D investment, establishing extra-committee for Korean medicine in nHTA could be needed. Finally, long-term strategy for improving collaboration between Korean medicine and western medicine should be considered.

• 분석과학
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• 제22권4호
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• pp.302-306
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• 2009

철강 중의 미량 붕소는 소재의 기계적, 물리적 특성에 중요한 영향을 준다. 즉발감마선 방사화 분석법에 의해 저합금강 시료 중의 미량 붕소를 측정하였다. 시료는 한국표준과학연구원에서 제조한 저합금강 표준물질KRISS 101-01-C21~C26을 이용하였으며, 측정방법의 유효성 확인을 위해 NIST SRM 362, 364, 1761, 1762를 정확도관리용 시료로 사용하였다. NIST SRM 362를 제외하고는 측정 농도가 인증값의 불확도 범위내에서 잘 일치하였다. 불확도는 ISO guideline에 따라 평가하였으며, 포함인자 2를 적용하여 확장불확도를 산출하였다. 붕소 농도 mg/kg수준에서 상대확장불확도는 3%에서 7% 사이였다. 그 결과를 용매추출-유도결합플라스마 방출분광분석결과와 비교하여 제시하였다.

• 수산해양교육연구
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• 제27권6호
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• pp.1602-1609
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• 2015

The purpose of this study is to design of prototype for developing webpage of fisheries and marine education especially in the field of Busan area. For this, we extract the guideline for development from literature review, need and task analysis, and advices of subject domain experts. Followings were the results of the research: (a) We make the prototype for main menu and screen based on institute, time, subject, and location. (b) We make the prototype for program approach guide, which is consisted of location based menu constructing prototype guide, activation prototype guide, and selection prototype guide. (c) We make the prototype for functional guide, which is consisted of information section, participation section and other sections.

• 농촌계획
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• 제22권3호
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• pp.11-19
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• 2016

The purpose of this study was to develop the strategy on activation of village by forest healing. Researcher conducted the questionnaire survey for forest healing village development to classify the mountain's characteristics by the three factors(linkage resource, program, facilities). In result, village characteristics were divided into two types: single element outstanding type(resource), complex element outstanding type(resource+program, resource+facilities). The development of forest healing village have to focused on the forest healing service recipient and mountain village characteristics. In conclusion, relationship between forest healing recipient and mountain characteristics was as follows: single type (resource) - public; complex type (resource+program) - chronic disease, social vulnerable people; complex type (resource+facilities) - severe disease. The detailed guideline for forest healing village needs to be established according to the mountain characteristics.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 춘계학술대회 논문집
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• pp.1954-1961
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• 2007

This project of total city plan is developed for the area of DONGDAEGU station in the field of new city-core which is adapted for a forefront city and rational restructuring of the city space and improving for balanced growth according to the first phase operation of Korean high speed line and its complete construction to BUSAN. Bring a new heart of this city of the area of DONGDAEGU station which is a gateway to DAEGU city so that the area contrives a new creation of the city space, balanced developing and activation of a region economy. Deliberate for plan of private capital for harmonious to develop a territory of station therefore it raises an emblem of DAEGU city and activates an economy of the city according to the new trend of the condition of transportation integrated administration of a large regionand new development of DONGDAEGU station.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.1254-1266
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• 2007

This project of total city plan is developed for the area of DONGDAEGU station in the field of new city-core which is adapted for a forefront city and rational restructuring of the city space and improving for balanced growth according to the first phase operation of Korean high speed line and its complete construction to BUSAN. Bring a new heart of this city of the area of DONGDAEGU station which is a gateway to DAEGU city so that the area contrives a new creation of the city space, balanced developing and activation of a region economy. Deliberate for plan of private capital for harmonious to develop a territory of station therefore it raises an emblem of DAEGU city and activates an economy of the city according to the new trend of the condition of transportation integrated administration of a large regionand new development of DONGDAEGU station.

• 한국분말재료학회지
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• 제6권1호
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• pp.81-87
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• 1999

Based on the pore filling theory, the microstructure evolution during liquid-phase sintering has been analyzed in terms of interrelationship between average grain size and relative density. For constant liquid volume fraction, the microsturucture trajectories reduced to a single curve in a grain size(x)-density(y) map, regardless of grain growth constant. The slope of curves in the map was inversely proportional to average pore size, while it increased fapidly with liquid volume fraction. Increase in pore volume fraction retarded the densification considerably, but showed marginal effect on the slope. The activation energy of densification was predicted to be the same as that of grain growth as long as the liquid volume fraction is constant for any temperature range studied. The present analyses on microstricture evolution may demonstrate the usefulness of pore filling theory and provide a guideline for process optimization of liquid-phase sintering.

• Biomolecules & Therapeutics
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• 제18권1호
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• pp.32-38
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• 2010

Activation of JNK has long been associated with the apoptotic response induced by various anti-cancer drugs including doxorubicin, vinblastine, and etoposide. In this study, we examined and compared patterns of apoptosis and JNK activation according to three different anti-cancer drugs (daunorubicin, vinblastine, and etoposide) and two different sources of HL60 cells (Jackson Laboratory and ATCC). HL60 cells from Jackson Laboratory (HL60/RPMI) were maintained in RPMI 1640 containing 5% fetal bovine serum and those from ATCC (HL60/IMDM) in IMDM containing 20% fetal bovine serum as to each manufacture's guideline. In general, HL60/RPMI cells were more sensitive to anti-cancer drugs compared to HL60/IMDM cells, demonstrated by the XTT and flow cytometric analyses. Apoptotic pathways after treatment with anti-cancer drugs seemed to be different between HL60/RPMI (daunorubicin and etoposide, caspase 3 dependent, but caspase 8 or 9 independent; vinblastine, caspase 3 independent) and HL60/IMDM (caspase 3 and caspase 9 dependent). The expression of apoptotic protein, BID, was consistent with caspase 3 activation. Immunoblotting of phospho-JNK and JNK kinase assay showed JNK activation by all three anti-cancer drugs in HL60/RPMI, while JNK activation was observed only in vinblastine-treated cells in HL60/IMDM. Our study results suggest that in vitro environmental conditions have a significant influence on JNK mediated apoptosis of HL60 cells by anti-cancer drugs and in vitro culture conditions are important factors in JNK or possibly other MAPK related studies.

• 대한예방한의학회지
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• 제4권1호
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• pp.1-16
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• 2000

From 1998, Oriental Medical Physicians(OMP) is distributed in Public Health Sector. but long term plan for Oriental Medicine in Public Health is not existed. So, this study is designed for the activation of OMP Subjects in this study were comprised 3 groups of oriental medicine related persons, the group of which are Students of 11 Oriental Medical Schools, Oriental Medical Physicians in Public Health Sector, Specialist Croup of Oriental medicine Policy(total 1,458 persons). Data were collected from July 1st to November 30, 1999. Direct interview with key persons, systematic interview by using of interview protocol, e-mail and facsimile have been conducted. The results of survey were coded by Excel 5.0, and analysed with SAS 6.12 statistical package. Inter-group difference determined by T-test, and descriptive statistics have been examined. Major findings can be epitomized as follows. 1) OMP disposition to multifarious organizations and institutes such as Public Health Centers, Public Health Sub-centers, Public Hospitals, Private Hospitals in Remote-Vulnerable Area, Community Social Welfare Centers, Institutes for Heath Policy Research, etc, will promise an effective use of Oriental Medical Physician. 2) Average number of patients treated by OMP was 22.8, average budget for oriental medical department, in which OMP were affiliated, was 39.6 million Won per year. Direct cost per every patient visit was 7,210.9 Won, which is considered expensive for public health service. Therefore, development and transformation for Oriental Medical Service in Public Health Sector is desirable in economic and political aspects. 3) It is recommended that ${\ulcorner}Advisory\;Committee{\lrcorner},{\ulcorner}Planning\;Commission\;for\; Public\;Health\;in\;Oriental\;Medicine{\lrcorner}$ should be established for the activation and for the support of Oriental Medical Physician in Public Health Sector, 4) Most effective programmes for oriental public health doctor are health service programmes for the elderly, Home health visit, chronic degenerative disease control services(p<0.001). 5) Standard guideline for facilities and equipments of Oriental Medicine Department in Public Health Center is needed for optimal supply of resources and activation of public health activity.

• Pediatric Infection and Vaccine
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• 제22권3호
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• pp.210-215
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• 2015

대식세포 활성 증후군(MAS, Macrophage activation syndrome)은 전신 홍반성 루푸스(SLE, systemic lupus erythematous) 환자에서 감염에 의해 나타날 수 있는 드문 합병증이다. MAS는 기저의 자가면역질환의 임상양상과 유사하게 나타나거나 혹은 감염성 합병증과 혼돈될 수 있어 감별에 주의 하여야 한다. 14세 여환이 2주간 지속되는 발열과 통증을 동반하는 얼굴의 피부 발진을 주소로 내원하였다. 피부 발진과 간비대, 범혈구 감소증, aspartate aminotransferase, lactate dehydrogenase, 혈청 ferritin이 상승하여, MAS를 의심하였다. 피부 병변과 항핵체 양성, C3와 C4의 감소, 간접 쿰스검사 양성으로 SLE를 진단하였다. 따라서 본 증례는 MAS가 HSV에 의하여 촉발된 것을, SLE의 첫 증상으로서 나타낸 증례로서, 촉발 요인 및 기저질환을 치료함으로써 중증의 합병증 없이 호전되었다.