• 혜화의학회지
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• 제9권2호
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• pp.159-171
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• 2001

In the result of investigating the drugs for replenishing Qi in many herbal books, we could get consistent relation in their immunopharmacologic effects as follows: 1. The effects of drugs for replenishing Qi was shown in the Shen Nong's Herbal, but its classification was natural such as trees and plants, insects and beasts, fruits, vegetables, and we think that trial about classification of drugs for replenishing Qi was accomplished in the ben-cao-jiu-zhen(本草求眞). 2. Main drugs for replenishing Qi was Gingseng Radix, Codonopsis pilosulae Radix, Astragali Radix, Atractylodis macrocephalae Rhizoma, Dioscoreae Rhizoma, Glycyrrhizae Radix. 3. Drugs for replenishing Qi commonly contain polysaccharides as much, and it was thought that they have also immunopharmacolologic effects by means of activating T and B cells, secreting cytokines, making lymphocytes, activating NK cells, increasing abilities of voracity and generating antibodies. 4. Drugs for replenishing Qi mainly replenish lung-Qi and Wei-Qi so that they have also effects of activating T and B cells, secreting cytokines, making lymphocytes, activating NK cells, increasing abilities of voracity and generating antibodies. 5. Drugs for replenishing Qi modulate content of cAMP and inhibit Na(+)-K(+) ATPase, so that they have effects of treating indistinctive pulse from Qi deficiency by means of inhibition delivery of chemical substances, activating lymphocytes. promoting contraction of myocardium.

• 한국약용작물학회지
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• 제13권4호
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• pp.178-181
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• 2005

15종의 항어혈성 중국 약용식물의 추출물에 대하여 PAF 수용체 결합 억제활성을 검색한 결과 4종의 약용식물, Campsis grandiflora, Dalbergia odorifera, Zanthoxylum nitidum, Vaccaria segetalis에서 50% 이상의 강한 PAF 결합 저해 활성이 나타났다.

• International Journal of Naval Architecture and Ocean Engineering
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• 제11권1호
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• pp.244-255
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• 2019

Interest in renewable energy has been increasing in recent years for many reasons, and there have been many studies on new types of wave energy converters and mechanisms for them. However, in this paper, motion characteristics of a wave energy converter with a wave activating body type is studied with an experiment. In order to conduct the experiment, a simple wave activating body type's wave energy converter is proposed. Experimental variations consist of connection type and location. The connection type controls the rotation motions of structures, and the connection location controls the distance between structures. The movement of floating structures, such as rotation, velocity, and acceleration, is measured with a potentiometer and a motion capture camera. Using the recorded data, the motion characteristics derived from the experimental variations are investigated.

• 대한한방부인과학회지
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• 제19권4호
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• pp.17-32
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• 2006

Purpose : The aim of this study is to investigate the antibiotic effects of 14 herbs among blood-activating stasis-dispelling medicinals on vaginal microorganisms. Methods : Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, Candida albicans, and Gardnerella vaginalis were used for vaginal pathogenic microorganisms. Lactobacillus gasseri, Streptococcus spp. and Escherichia coli HB101 were used for vaginal normal flora. The blood-activating stasis-dispelling medicinals, Mucunae Caulis, Salviae Radix, Persicae Semen, Myrrha, Zedoariae Rhizoma, Achuranthis Radix, Leonuri Herba, Melandrii Herba, Gleditsiae Spina, Lycopi Herba, Scirpi Rhizoma, Caesalpiniae Lignum, Corydlais Tuber and Polygoni Cuspidati Radix were used in this study. In vitro antibiotic activities were observed by optical density and colony test. Results : The optical density and colony test showed that Gleditsiae Spina, Scirpi Rhizoma, Corydlais Tuber, Polygoni Cuspidati Radix and Melandrii Herba of herbs among blood-activating stasis-dispelling medicinals had antimicrobial effect. Gleditsiae Spina had antimicrobial susceptibility and selective toxicity in Gardnerella vaginalis and MRSA. Scirpi Rhizoma had antimicrobial susceptibility and selective toxicity in Staphylococcus aureus and MRSA. Corydlais Tuber had antimicrobial susceptibility and selective toxicity in MRSA. Polygoni Cuspidati Radix had antimicrobial susceptibility and selective toxicity in Gardnerella vaginalis, Staphylococcus aureus and MRSA. Melandrii Herba had antimicrobial susceptibility and selective toxicity in Gardnerella vaginalis. Conclusion : According to the above results, we could suggest that Gleditsiae Spina, Scirpi Rhizoma, Corydlais Tuber, Polygoni Cuspidati Radix and Melandrii Herba of herbs among blood-activating stasis-dispelling medicinals be available to antimicrobial agent of vaginal pathogenic microbial species in vitro.

• 대한한의학원전학회지
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• 제29권2호
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• pp.203-212
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• 2016

Objectives : In order to infer the effect of blood-activating and stasis-dispelling herbs by the analysis of effect terms which have extracted and refined, based on five tastes. Methods : I extracted the effect terms and five tastes of blood-activating and stasis-dispelling herbs written in Herbology. Extracted effect terms was divided into single meaning term and was refined as typical term. After that, I sorted herbs according to the five tastes and find the most highly mentioned effect terms. And I infered each herb's effects based on the relationship between five tastes and most highly mentioned terms. Results & Conclusions : I extracted 5 tastes and 53 effect terms and refined it as 43 effect terms. As the result of analyzing the effect term based the tastes, blood-activating and stasis-dispelling herbs are usually have blood-activating and pain-relieving. The herbs that have the hot taste, have the effect of moving-qi, stasis-breaking and aggregation-dispersing. And I supposed new effects of 5 kinds of herbs among them. The herbs that have the sweet tastes, have the effect of stasis-dispelling. And I supposed new effects of 2 kinds of herbs among them by analyzing the relationship between the tastes and effect terms.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2014년도 추계학술대회
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• pp.17-18
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• 2014

파력발전기의 유형은 진동수주형, 월파형, 가동물체형으로 나누어진다. 그 중 가동물체형은 파도에너지를 기계적 운동에너지로 전환하여 발전하기 때문에 가동물체의 운동량이 증가해야 발전량이 증가 할 수 있다. 본 논문에서는 가동물체형 파력발전기를 발전시스템이 있는 구조물 본체와 가동부유체로 구성하고 바 형태의 다리로 연결하였다. 다양한 정면파 조건에서 가동부유체와 구조물 본체 간 연결 방식 변화에 따른 운동 특성을 연구하고, 발전축의 모멘트와 각속도를 계산하였다. 이 연구는 가동물체형 파력발전기의 설계시 기초 자료로 사용 될 수 있다.

• Journal of Interdisciplinary Genomics
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• 제3권1호
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• pp.21-24
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• 2021

Purpose: Activating mutations of the calcium-sensing receptor (CASR) are a rare genetic disorder, and result in autosomal dominant hypocalcemia with hypercalciuria (ADHH). ADHH exhibited varying degrees of hypocalcemia. In this study, we report the clinical and molecular characteristics of activating variants in CASR patients diagnosed in Korea. Methods: This study included three patients with activating variants of CASR confirmed by biochemical and molecular analysis of CASR. Clinical and biochemical findings were reviewed chart retrospectively. Mutation analysis of CASR was performed by Sanger sequencing. Results: Subject 1 showed severe symptoms from the neonatal period and had difficulty in controlling the medications that were administered. Subject 2 was identified as having a novel variant of CASR with hypocalcemia and a low parathyroid hormone that were found in the neonatal period. During a course without medication, hypocalcemia occurred suddenly around 2 years of age. Subject 3 was diagnosed with hypoparathyroidism with hypocalcemic seizures starting from the neonatal period. About 4 years without taking medication with any symptom. However, at 10 years old revisited by repetitive hypocalcemic seizure events. Subject 1 and 3, were heterozygous for c.2474A>T (p.Y825F), c.2395G>A (p.E799K) located in the transmembrane domain (TMD) of CASR. Subject 2 was heterozygous for c.403A>C (S430L) located in the extracellular domain (ECD) of CASR. Conclusion: We reported 3 patients who have activating CASR variant with different onset and severity of symptoms. In the future, further study is needed to determine how the protein level according to the location of the mutation of CASR affects the degree of symptoms.

• 한국발생생물학회지:발생과생식
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• 제25권3호
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• pp.133-143
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• 2021

In contrast to the human lutropin receptor (hLHR) and rat LHR (rLHR), very few naturally occurring mutants in other mammalian species have been identified. The present study aimed to delineate the mechanism of signal transduction by three constitutively activating mutants (designated M410T, L469R, and D590Y) and two inactivating mutants (D383N and Y546F) of the eel LHR, known to be naturally occurring in human LHR transmembrane domains. The mutants were constructed and measured cyclic adenosine monophosphate (cAMP) accumulation via homogeneous time-resolved fluorescence assays in Chinese hamster ovary (CHO)-K1 cells. The activating mutant cells expressing eel LHR-M410T, L469R, and D590Y exhibited a 4.0-, 19.1-, and 7.8-fold increase in basal cAMP response without agonist treatment, respectively. However, inactivating mutant cells expressing D417N and Y558F did not completely impaired signal transduction. Specifically, signal transduction in the cells expressing activating mutant L469R was not occurred with a further ligand stimulation, showing that the maximal response exhibited approximately 53% of those of wild type receptor. Our results suggested that the constitutively activating mutants of the eel LHR consistently occurred without agonist treatment. These results provide important information of LHR function in fish and regulation with regard to mutations of highly conserved amino acids in glycoprotein hormone receptors.

• 유통과학연구
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• 제14권5호
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• pp.71-80
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• 2016

Purpose - In case of automobile parts, there has been a lot of progress in the study on supplier development plans and SCM in industrial progress study as well as on the relationship between ERP and SCM. But supplier development program providers have researched on SCM performance in accordance with the interests of the supplier development program most, thus, buyers were knowledgeable about the earlier program performance. Therefore, the purpose of this study is to prove correlation factor, supplier factor, purchaser factor affecting SCM performance and ERP activating diffusion through the process of supplier development. Supplier development maturity formation model is considered important variables as mediators related to the procedure. Finally, the performance formation model of the supplier development maturity through supplier development factor would be presented as the outcome of this study. Research design, data, and methodology - Data gathering was as follows: questionnaires were delivered to 87 companies that have business connection with H Company. The empirical research to test our hypothesis was grounded on statistical analysis (adapting SPSS 19.0 & AMOS 19.0). The hypothesis is that the supplier development factor variables consist of correlation factor, supplier factor, purchaser factor, and have non-negative effects on the next variables: mediators such as supplier development maturity; and the supplier development maturity variables have a positive effect on the next variables: ERP activating diffusion, ERP activating diffusion has a non-negative effect on supply chain performance. We experimented the hypothesized model using path analysis with latent variables. Results - First, it was known that cooperation

, reliability

, comprehension on the purpose of SDP

, adaptation of change

, knowledge transfer program

, have significant positive effects on supplier development maturity. Second, supplier development maturity has positive effects significantly on ERP activating diffusion

. Finally, the causal relationships from ERP activating diffusion to SCM performance were significantly accepted. Its significance, as through the hypotheses, presented a structural model for the elaboration, suppliers develop maturity, and ultimately SCM performance that affect ERP leveraging spread beyond the concept of maturity of information system. Therefore, it was a mainstay of research on the existing ERP has they believed. Conclusion - First, with the fast changes in business circumstances, company should get the right information to implement SCM appropriately. For successful SCM, firms should understand the supplier development maturity formation and ERP activating diffusion. Second, supplier development factor has significant effects on supplier development maturity. Third, mediator such as supplier development maturity significantly affects ERP activating diffusion. Finally, ERP activating diffusion has significant impacts on SCM performance. This study makes a meaningful contribution to further appreciation on how supplier development maturity formation affects SCM performance. This study shows implications. First, there would not have been dealt with introducing the concept of supplier development maturity. Second, through empirical analysis and provider factors, the providers will develop the maturity that affect interactive factors between purchaser and supplier.

• 한국어병학회지
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• 제26권3호
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• pp.275-282
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• 2013

활성처리제는 40~200배의 희석액에 최단시간 1분, 최장시간 3분 침지 후의 방사무늬김과 파래의 사세포율은 방사무늬김은 유엽 및 성엽 모두 100~150배 희석율이 사세포율이 낮게 나타났으며, 파래는 희석배율과 침지시간에 관계없이 90%이상 파래가 사멸하였다. 현장시험에서 방사무늬김 세포의 사세포율은 처리시기에 따라 차이가 나지만 처리 전은 2.1~17.6%였으며, 처리 후에는 2.1~15.0%로 처리 전후의 사세포율에는 차이가 없었다. 파래의 사세포율은 처리전에는 0~4.6%였지만, 처리 후에는 99.0~100%로 활성처리제의 처리는 파래 제거에 매우 효과적이었다. 또한 활성처리제 처리는 엽체의 부착 규조류는 33.3-97.2%, 부착 생균수는 1/10~1/100,000로 감소시킨 반면 엽체의 색택에는 영향을 미치지 않았다. 그러므로 방사무늬김 엽체의 상태와 수온 등을 고려하여 본 활성처리제를 100~150배의 희석농도에 1~3분간 처리함으로써 파래의 제거, 부착 규조류의 탈락, 엽체 부착 생균수의 감소 효과가 있으며, 방사무늬김의 색택에는 별다른 영향을 미치지 않아 방사무늬김 활성처리제로서 유효한 것으로 나타났다.