• The Korean Journal of Physiology and Pharmacology
• /
• 제10권5호
• /
• pp.255-261
• /
• 2006

Melittin-induced nociceptive responses are mediated by selective activation of capsaicin-sensitive primary afferent fibers and are modulated by excitatory amino acid receptor, cyclooxygenase, protein kinase C and serotonin receptor. The present study was undertaken to investigate the peripheral and spinal actions of voltage-gated calcium channel antagonists on melittin-induced nociceptive responses. Changes in mechanical threshold and number of flinchings were measured after intraplantar (i.pl.) injection of melittin $(30\;{\mu}g/paw)$ into mid-plantar area of hindpaw. L-type calcium channel antagonists, verapamil [intrathecal (i.t.), 6 or $12\;{\mu}g$; i.pl.,100 & $200\;{\mu}g$; i.p., 10 or 30 mg], N-type calcium channel blocker, ${\omega}-conotoxin$ GVIA (i.t., 0.1 or $0.5\;{\mu}g$; i.pl., $5\;{\mu}g$) and P-type calcium channel antagonist, ${\omega}-agatoxin$ IVA (i.t., $0.5\;{\mu}g$; i.pl., $5\;{\mu}g$) were administered 20 min before or 60 min after i.pl. injection of melittin. Intraplantar pre-treatment and i.t. pre- or post-treatment of verapamil and ${\omega}-conotoxin$ GVIA dose-dependently attenuated the reduction of mechanical threshold, and melittin-induced flinchings were inhibited by i.pl. or i.t. pre-treatment of both antagonists. P-type calcium channel blocker, ${\omega}-agatoxin$ IVA, had significant inhibitory action on flinching behaviors, but had a limited effect on melittin-induced decrease in mechanical threshold. These experimental findings suggest that verapamil and ${\omega}-conotoxin$ GVIA can inhibit the development and maintenance of melittin-induced nociceptive responses.

• 생약학회지
• /
• 제30권2호
• /
• pp.137-144
• /
• 1999

Torilin was isolated from haxane fraction of Torilis Fructus extract. Torilin produced inhibition of the acetic acid-induced and phenylquinone-induced writhing syndrome at the oral doses of 30 and 90 mg/kg in mice. It also increased the pain threshold at the oral doses of 30, 90 and 270 mg/kg in the tail pressure method and the Randall-Selitto method. However, it did not show a hypothermic action at the oral doses of 30 and 90 mg/kg in mice. The compound exhibited strong anticarrageenan activity at the oral doses of 90 and 270 mg/kg in rats, and had inhibitory effect on the vascular permeability at the oral doses of 30 and 90 mg/kg in mice. It also showed potent inhibition of leucocyte emigration in CMC-pouch at the doses of 3 and 9 mg/rat, sc. The acute toxicity of torilin was very weak: the $LD_{50}$ values were more than 5000 mg/kg, po and 2000 mg/kg, ip in mice. From the above mentioned results, it was suggested that torilin had potent analgesic and anti-inflammatory activities.

• Geomechanics and Engineering
• /
• 제13권6호
• /
• pp.977-995
• /
• 2017

It is well accepted that rock failure mechanism influence the cutting efficiency and determination of optimum cutting parameters. In this paper, an attempt was made to research the factors that affect the failure mechanism based on discrete element method (DEM). The influences of cutting depth, hydrostatic pressure, cutting velocity, back rake angle and joint set on failure mechanism in rock-cutting are researched by PFC2D. The results show that: the ductile failure occurs at shallow cutting depths, the brittle failure occurs as the depth of cut increases beyond a threshold value. The mean cutting forces have a linear related to the cutting depth if the cutting action is dominated by the ductile mode, however, the mean cutting forces are deviate from the linear relationship while the cutting action is dominated by the brittle mode. The failure mechanism changes from brittle mode with larger chips under atmospheric conditions, to ductile mode with crushed chips under hydrostatic conditions. As the cutting velocity increases, a grow number of micro-cracks are initiated around the cutter and the volume of the chipped fragmentation is decreasing correspondingly. The crack initiates and propagates parallel to the free surface with a smaller rake angle, but with the rake angle increases, the direction of crack initiation and propagation is changed to towards the intact rock. The existence of joint set have significant influence on crack initiation and propagation, it makes the crack prone to propagate along the joint.

• 한국항행학회논문지
• /
• 제14권3호
• /
• pp.439-445
• /
• 2010

인체의 신호정보전달은 각 세포 단위에서 발생되는 활동전위에 의하여 이루어지고 있다. 이러한 활동전위는 세포막을 통한 이온들의 움직임에 의해서 발생, 전달되고 있으며, 궁극적으로는 전기적인 신호의 개념으로 설명될 수 있다. 즉, 생체에서 발생되는 각종 감각을 비롯한 정보의 전달이 전기적인 현상으로 이루어진다는 것이 그간의 수많은 연구를 통하여 밝혀지고 있다. 그런데 그동안에는 이러한 신경전달관계가 정성적으로 기술되고 분석되었다. 따라서 본 논문에서는 이러한 관계를 정량적으로 분석하기 위해서 알고리즘을 세우고 이미 제시된 데이터를 이용하여 이를 구현하고자 하였다. 단, 이미 언급한 것처럼 본 논문에서는 외부 자극이 신경계가 발화를 필요로 하는 임계치 이상이 아니라 그 이하인 경우를 분석하였다. 이는 전기회로의 과도현상과 매우 유사하며, 이와의 유사성에 근거하여 분석하였다. 본 논문에서 제시하여 연구 및 분석한 결과를 나타내어 앞으로의 연구 주제의 기초가 되도록 하였다.

• JSTS:Journal of Semiconductor Technology and Science
• /
• 제17권2호
• /
• pp.210-215
• /
• 2017

We have developed the neuromorphic system that can work with the four-terminal Si-based synaptic devices and verified the operation of the system using simulation tool and printed-circuit-board (PCB). The symmetrical current mirrors connected to the n-channel and p-channel synaptic devices constitute the synaptic integration part to express the excitation and the inhibition mechanism of neurons, respectively. The number and the weight of the synaptic devices affect the amount of the current reproduced from the current mirror. The double-stage inverters controlling delay time and the NMOS with large threshold voltage ($V_T$) constitute the action-potential generation part. The generated action-potential is transmitted to next neuron and simultaneously returned to the back gate of the synaptic device for changing its weight based on spike-timing-dependent-plasticity (STDP).

• 셀메드
• /
• 제4권1호
• /
• pp.3.1-3.8
• /
• 2014

Spa represents a treatment widely used in many rheumatic diseases (RD). The mechanisms by which immersion in mineral or thermal water ameliorates RD are not fully understood. The net benefit is probably the result of a combination of factors, among which the mechanical, thermal and chemical effects are most prominent. Buoyancy, immersion, resistance and temperature play important roles. According to the gate theory, pain relief may be due to the pressure and temperature of the water on skin; heat may reduce muscle spasm and increase the pain threshold. Mud-bath therapy increases plasma ${\beta}$-endorphin levels and secretion of corticotrophin, cortisol, growth hormone and prolactin. It has recently been demonstrated that thermal mud-bath therapy induces a reduction in circulating levels of prostaglandin E2, leukotriene B4, interleukin-$1{\beta}$ and tumour necrosis factor-${\alpha}$, important mediators of inflammation and pain. Furthermore, balneotherapy has been found to cause an increase in insulin-like growth factor-1, which stimulates cartilage metabolism, and transforming growth factor-${\beta}$. Beneficial anti-inflammatory and anti-degenerative effects of mineral water were confirmed in chondrocytes cultures, too. Various studies in vitro and in humans have highlighted the positive action of mud-packs and thermal baths, especially sulphurous ones, on the oxidant/antioxidant system. Overall, thermal stress has an immunosuppressive effect. Many other non-specific factors may also contribute to the beneficial effects observed after spa therapy in some RD, including effects on cardiovascular risk factors (e.g. adipokines) and changes in the environment, pleasant surroundings and the absence of work duties.

• 대한의용생체공학회:의공학회지
• /
• 제38권3호
• /
• pp.123-128
• /
• 2017

Background and aims: The KCNQ1 S140G mutation involved in $I_{ks}$ channel is a typical gene mutation affecting atrial fibrillation. However, despite the possibility that the S140G gene mutation may affect not only atrial but also ventricular action potential shape and ventricular responses, there is a lack of research on the relationship between this mutation and ventricular fibrillation. Therefore, in this study, we analyzed the correlation and the influence of the KCNQ1 S140G mutant gene on ventricular fibrillation through computer simulation studies. Method: This study simulated a 3-dimensional ventricular model of the wild type(WT) and the S140G mutant conditions. It was performed by dividing into normal sinus rhythm simulation and reentrant wave propagation simulation. For the sinus rhythm, a ventricular model with Purkinje fiber was used. For the reentrant propagation simulation, a ventricular model was used to confirm the occurrence of spiral wave using S1-S2 protocol. Results: The result showed that 41% shortening of action potential duration(APD) was observed due to augmented $I_{ks}$ current in S140G mutation group. The shortened APD contributed to reduce wavelength 39% in sinus rhythm simulation. The shortened wavelength in cardiac tissue allowed re-entrant circuits to form and increased the probability of sustaining ventricular fibrillation, while ventricular electrical propagation with normal wavelength(20.8 cm in wild type) are unlikely to initiate re-entry. Conclusion: In conclusion, KCNQ1 S140G mutation can reduce the threshold of the re-entrant wave substrate in ventricular cells, increasing the spatial vulnerability of tissue and the sensitivity of the fibrillation. That is, S140G mutation can induce ventricular fibrillation easily. It means that S140G mutant can increase the risk of arrhythmias such as cardiac arrest due to heart failure.

• Journal of Ginseng Research
• /
• 제21권2호
• /
• pp.109-114
• /
• 1997

The effect of total saponin fraction of Ginseng injected intrathecally (i.1.) or in- tracerebroventricularly (i.c.v.) on the antinociception induced by D-$Pen^{2,5}$- enkephalin (DPDPE) ad ministered i.c.v. was studied in ICR mice in the present study. The antinociception was assessed by the tail-flick test. Total saponin fraction at doses 0.1 to 1.0 $\mu\textrm{g}$, which administered i.t. Alone did not affect the latencies of tail-flick threshold, attenuated dose-dependently the inhibition of the tail-flick response induced by i.c.v. administered DPDPE (10 $\mu\textrm{g}$). However, total saponin fraction at doses 1 to 20 $\mu\textrm{g}$, which administered i.c.v. Alone did not affect the latencies of the tail-flick response, did not affect i.c.v. administered DPDPE (10 $\mu\textrm{g}$)-induced antinociception. The duration of antagonistic action of total saponin fraction against DPDPE-induced antlnociception was lasted at least for 6 hrs. Various doses of ginsenosides Rd, but not $\Rb_2$, Rc, Rg1, and $\Rb_1$ and Re, injected i.t. Dose-dependently attenuated antinociception induced by DPDPE administered i.c.v. Our results indicate that total saponin fraction injected spinally appears to have antagonistic action against the antinociception induced by supraspinally applied DPDPE. Ginsenoside Rd appears to be responsible for blocking j.c.v. administered DPDPE-induced antinociception. On the other hand, total ginseng fraction, at supraspinal sites, may not have an antagonistic action against the antinociception induced by DPDPE.

• Journal of applied mathematics & informatics
• /
• 제29권5_6호
• /
• pp.1097-1115
• /
• 2011

We consider the global stability of a general tuberculosis model with two differential infectivity, n classes of latent individuals and mass action incidence. This system exhibits the traditional threshold behavior. There is always a globally asymptotically stable equilibrium state. Depending on the value of the basic reproduction ratio $\mathcal{R}_0$, this state can be either endemic ($\mathcal{R}_0$ > 1), or infection-free ($\mathcal{R}_0{\leq}1$). The global stability of this model is derived through the use of Lyapunov stability theory and LaSalle's invariant set theorem. Both the analytical results and numerical simulations suggest that patients should be strongly encouraged to complete their treatment and sputum examination.

• 품질경영학회지
• /
• 제22권1호
• /
• pp.214-218
• /
• 1994

An inventory supplies stock continuously at a constant rate. A deliveryman arrives according to a Poisson process. If the level of the inventory, when he arrives, exceeds a threshold, no action is taken, otherwise a delivery is made by a random amount. Costs are assigned to each visit of the deliveryman, to each delivery, to the inventory being empty and to the stock being kept. It is shown that there exists a unique arrival rate of the deliveryman which minimizes the average cost per unit time over an infinite horizon.