• YAKHAK HOEJI
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• v.43 no.6
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• pp.756-761
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• 1999

Lipid peroxidation mediated by hydroxyl radicals which are generated during myocardial ischermia has suggested as a possible mechanism of ischemic myocardial damage. Recently, it has been reported that anti-arrhythmic action of lidocaine, a local anesthetic, is attributed to its "membrane-stabilizing" properties through scavenging free radicals, thus, inhibiting lipid peroxidation. Aldehyde oxidase and xanthine oxidase which catalyze the oxidation of many purine, pyrimidine and pteridine derivatives are known as free radical generating systems. In this experiment, we studied the effect of lidocaine and procainamide on the hepatic aldehyde and xanthine oxidase activity and antioxidative activities. It was found that lidocaine and procainamide inhibited both NADPH-dependent and independent lipid peroxidation. Both of tested compounds were found to be ineffective in inhibiting xanthine oxidase. Lidocaine and procainamide, however, inhibited aldehyde oxidase activity in vitro as well as in vivo. Based on the above results, lidocaine and procainamide could be employed as a therapeutic agent for aldehyde oxidaserelated disease.d disease.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.11a
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• pp.421-424
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• 2006

This study, in order for perceiving the mechanical attribute followed by the explosive spalling of high strength concrete material under high temperature and evaluating capacity of endurance of material, targets understanding capacity of endurance of material such as explosive spalling in high temperature, temperature by thickness of clothing, transformation extent, transformation speed and displacement, stocking the maximum load based on the Allowable Stress Design Method. As a result of experimenting the explosive spalling attribute of high strength concrete material, the one possibly causing serious damage is the 50 MPa concrete. In all aspects of 60 MPa concrete, explosive spalling happens. Especially, it is hazardous enough to reveal all the iron bar. All explosive spalling is intensively concentrated on the surface of concrete for the first $5{\sim}25$ minutes, which urges for the explosive spalling protection action. As a result of evaluating the structural safety by the transformation of high strength concrete, while beam assures the fire safety meeting regulation, 60 MPa shows the dramatic increase of transformation, which only counts 84% of safety. In a column, both the concrete exclusion and excessive explosive spalling are concentrated upper part of column, which brings about the dramatic transformation, so it only meets the 50% of safety regulation. Likewise, in 80, 100 MPa concrete which was never experimented considering the condition of domestic structural endurance stocking devices, the faster collapse is expected.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2003.05a
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• pp.128-134
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• 2003

Numerical study on interactions of waves and currents has considerable practical interests in coastal and ocean engineering. And wave-current interactions strongly influence wave characteristics, current profiles, and forces on offshore structures. Presence of currents affects wave properties such as wave height and wave profiles. Furthermore, in case of the irregular waves, it is more complicated problem. The propose of present study, using the one-dimensional wave-current numerical model is based on the extended Boussinesq equation(Madsen, 1991) and an alternative form of wave-current dispersion relation(Mohiuddin, 1999, 2000) including wave action concept, is to simulate wave propagation in a current field including the irregular waves and discuss applicability of the model in a wave-current field.

• Computers and Concrete
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• v.13 no.2
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• pp.255-270
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• 2014

Impact performance of high-performance concrete (HPC) and SFRC at 28-day and 56-day under the action of repeated dynamic loading was studied. Silica fume replacement at 10% and 15% by mass and crimped steel fiber ($V_f$ = 0.5%- 1.5%) with aspect ratios of 80 and 53 were used in the concrete mixes. Results indicated that addition of fibers in HPC can effectively restrain the initiation and propagation of cracks under stress, and enhance the impact strengths and toughness of HPC. Variation of fiber aspect ratio has minor effect on improvement in impact strength. Based on the experimental data, failure resistance prediction models were developed with correlation coefficient (R) = 0.96 and the estimated absolute variation is 1.82% and on validation, the integral absolute error (IAE) determined is 10.49%. On analyzing the data collected, linear relationship for the prediction of failure resistance with R= 0.99 was obtained. IAE value of 10.26% for the model indicates better the reliability of model. Multiple linear regression model was developed to predict the ultimate failure resistance with multiple R= 0.96 and absolute variation obtained is 4.9%.

• Proceedings of the KIEE Conference
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• 2006.07c
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• pp.1733-1734
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• 2006

In recent, it became necessary to develop the technology about electrodeless fluorescent lamp according to demand of the electrodeless fluorescent lamp system that used higher efficiency and advantage of long lifetime. Inductively coupled plasma is commonly used for electrodeless lamp due to its ease of plasma generation. An electric power efficiency of electrodeless fluorescent lamp has big relative property of gas in lamp, gas pressure, lamp formation, ingredients of magnetic substance and shape and action frequency etc. We used magnetic substance that open self-examination material of electrodeless fluorescent lamp antenna. Ferrite that is used in this experiment was Mn-Zn type. We have examined temperature and flux characteristic by frequency. Considering using frequency 2.65[MHz], Frequency was changed from 2.05[MHz] to 3.05[MHz] to recognize flux and temperature change of lamp. I used LMS(Lighting Measurement System) to measure flux and IR Camera to measure temperature of lamp.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1997.11a
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• pp.167-172
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• 1997

The electron swarm parameters and Energy distribution function have been calculated for electrons motion through CH$_4$ pure gas under the action of uniform electric field for 0.1$\leq$E/N(Td)$\leq$300, at the 300( $^{\circ}$K), using MCS method and Boltzmann transport equation. And then the resulting values of electron drift velocity were compared to experimental data and adjustment made in assumed cross sections until good agreement was obtained. The electron drift velocity is very useful in the fields of study relating to the conductive and dielectric phenomena of gas medium. The electron energy distribution in gas discharge are generally nonmaxwellian , and must be calculated by a numerical solution of the Boltzmann equation which takes in the elastic and inelastic collisions. To analyze the physical phenomena and properties (or electron swarm motion in a gas under the influence of an electric field, the energy distribution function of electrons and the theoretical deriveration of the electron drift velocity are calculated by the Backward Prolongation with respect to the Boltzmann transport equation as a parameter of E/N(Td).

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.2
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• pp.123-129
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• 2009

Aprotinin is used clinically in cardiopulmonary bypass surgery to reduce transfusion requirements and the inflammatory response. The mechanism of action for the anti-inflammatory effects of aprotinin is still unclear. We examined our hypothesis whether inhibitory effects of aprotinin on cytokine-induced inducible nitric oxide synthase (iNOS) expression (IL-$l\beta$ plus TNF-$\alpha$), reactive oxygen species (ROS) generation, and vascular smooth muscle cell (VSMC) proliferation were due to HO-l induction in rat VSMCs. Aprotinin induced HO-l protein expression in a dose-dependent manner, which was potentiated during inflammatory condition. Aprotinin reduced cytokine mixture (CM)-induced iNOS expression in a dose dependent manner. Furthermore, aprotinin reduced CM-induced ROS generation, cell proliferation, and phosphorylation of JNK but not of P38 and ERK1/2 kinases. Aprotinin effects were reversed by pre-treatment with the HO-l inhibitor, tin protoporphyrin IX (SnPPIX). HO-l is therefore closely involved in inflammatory-stimulated VSMC proliferation through the regulation of ROS generation and JNK phosphorylation. Our results suggest a new molecular basis for aprotinin anti-inflammatory properties.

• Korea Information Processing Society Review
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• v.11 no.6
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• pp.56-75
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• 2004

In this article we address some system characteristics and challenging issues in developing Context-aware Middleware for Ubiquitous Computing. The functionalities of a Context-aware Middleware includes gathering context data from hardware/software sensors, reasoning and inferring high-level context data, and disseminating/delivering appropriate context data to interested applications/services. The Middleware should facilitate the query, aggregation, and discovery for the contexts, as well as facilities to specify their privacy policy. Following a formal context model using ontology would enable syntactic and semantic interoperability, and knowledge sharing between different domains. Moddleware should also provide different kinds of context classification mechanical as pluggable modules, including rules written in different types of logic (first order logic, description logic, temporal/spatial logic, fuzzy logic, etc.) as well as machine-learning mechanical (supervised and unsupervised classifiers). Different mechanisms have different power, expressiveness and decidability properties, and system developers can choose the appropriate mechanism that best meets the reasoning requirements of each context. And finally, to promote the context-trigger actions in application level, it is important to provide a uniform and platform-independent interface for applications to express their need for different context data without knowing how that data is acquired. The action could involve adapting to the new environment, notifying the user, communicating with another device to exchange information, or performing any other task.

• Biomolecules & Therapeutics
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• v.4 no.2
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• pp.154-161
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• 1996

General pharmacological properties of LB-00014, an erythropoietin which was produced by recombinant DNA technique in Biotech Research Institute, LG Chemical Ltd. were examined. The administration of LB-00014 (60, 600, 6000 IU/kg, iv) in mice had no effect in general behavior and central nervous system, and no influences on normal body temperature, writhing syndromes induced by 0.7% acetic acid solution and chemoshock produced by strychnine and pentetrazole solution. LB-00014 (60, 600, 6000 IU/kg, iv) given to anesthetized rabbits showed no effect on blood pressure of carotid artery and respiration rates, and it did not influence the responses produced by injection of acetylcholine or epinephme. The administration of LB-00014 (601, 600, 6000 IU/kg, iv) in rats had no effect on the plasma prothrombin time, activated partial thromboplastin time and hemolytic action. The platelet aggregation induced by collagen in human plasma was not influenced by LB-00014 (10, 100, 1000 lU/kg, iv). It showed no direct effect at 100 and 1000IU/m1 in isolated stomach fundus and uterus of rats and ileum of guinea-pig, and it also had no inhibition of contraction produced by acetylcholine, oxytocin, serotonin and histamine in the above-mentioned preparations. It did not influence gastric secretion, pH and acid output at 6000 IU/kg, iv in rats, but showed a significant increase in intestinal propulsion of mice at 6000 IU/kg, iv. Its administration (60, 600, 6000 lU/kg, iv) caused no effect on urine and electrolyte excretion in rats. These results indicate that LB-00014 does not exsert any of serious pharmacological effects.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 1997.11a
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• pp.104-111
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• 1997

Cluster systems are microcrystals of vanadiumoxided compounds such as Barium, Calcium or Sodium Metavanadates or Sodium Vanadium Bronze which are distributed into dimethyl- or diethylphosphites or microcrystals of vanadium oxides, for instance, vanadium oxide (+3), distributed into the methylphosphonic acid melted. During the interaction of vanadium compounds with the correspondent phosphororganic substances biue viscous liquids are formed. These liquids have paramagnetic properties. According to the UV and IR spectroscopic investigations as well as the results of EPR spectra the substances obtained consist of the nucleus containing 6 to 12 of vanadium atoms and the shell including ligands which are molecules of phosphites or methylphosphonic acid. Here every atom of vanadium interacts with four of phosphorus containing molecules. Sizes of the particles in these systems donot exceed 200 nm. Introduction of cluster systems (0,1 -0,3 % vanadium) into epoxy compositions before the introduction of curing agent - polyethylenepolyamine 6 -8 % leads to the acceleration of composition crosslinking and to the combustion decreasing: 1) Oxygen Index grows to 35: 2)mass losses during combustion decrease to 1-2%, 3) combustion time does not exceed 1 s; 4) the intumescence of material sample is being observed during the burner action as well as the foam coke formation.