• Journal of the Korean Society for Nondestructive Testing
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• v.24 no.2
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• pp.164-170
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• 2004

Liquid Injection Nozzle(LIN) tube and Calandria tube(CT) in pressurized Heavy Water Reactor (PHWR) are .ross-aligned horizontally. These neighboring tubes can contact each other due to the sag of the calandria tube resulting from the irradiation creep and thermal creep, and fuel load, etc. In order to judge the contact which might be the safety concern, the remote field eddy current (RFEC) technology is applied for the gap measurement in this paper. LIN can be detected by inserting the RFEC probe into pressure tube (PT) at the crossing point directly. To obtain the optimal conditions of the RFEC inspection, the sensitivity, penetration and noise signals are considered simultaneously. The optimal frequency and coil spacing are 1kHz and 200mm respectively. Possible noises during LIN signal acquisition are caused by lift-off, PT thickness variation, and gap variation between PT and CT. The simulated noise signals were investigated by the Volume Integral Method(VIM). Signal analysis on the voltage plane describes the amplitude and shape of LIN and possible defects at several frequencies. All the RFEC measurements in the laboratory were done in variance with the CT/LIN gap and showed the relationship between the LIN gap and the signal parameters by analyzing the voltage plane signals.

• Journal of Pharmaceutical Investigation
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• v.41 no.4
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• pp.255-262
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• 2011

Method using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was developed and validated for the determination of pregabalin in plasma samples. Acquisition was performed by monitoring the transitions: m/z 160.1${\rightarrow}$142.2 for pregabalin and m/z 423.2${\rightarrow}$207.1 for losartan (as an internal standard). After cold acetonitrileinduced protein precipitation of the plasma samples, separation was performed with C18 column by isocratic mobile phase consisted of 10 mM ammonium acetate and acetonitrile (15:85, v/v). Results were linear over the concentration ranged from 0.1 to $10{\mu}g$/mL and the correlation coefficients (r) were $\geq0.99$. Intra- and inter-day precisions were $\leq6.02$ and $\leq11.04%$, respectively, and intra- and inter-day accuracies were 96.60-101.09 and 98.10-102.60%, respectively. This validated method was successfully applied to a bioequivalence study of two formulations of pregabalin, Daewoong pregabalin capsule (Daewoong Pharm. Co., Ltd.) and Lyrica$^{(R)}$ capsule (Pfizer Korea Ltd.) in twenty eight healthy Korean volunteers. The subjects received a single oral dose of each formulation (150 mg as pregabalin) in a randomized $2{\times}2$ crossover study and plasma samples were obtained from each subject at predetermined time intervals. Then, the pharmacokinetic parameters ($AUC_{0-t}$, $C_{max}$ and $T_{max}$) were calculated and statistically analyzed to assess the differences between two formulations. The 90% confidence intervals for the log-transformed data were acceptable range of log 0.8-log 1.25 (e.g., log 1.0048-log 1.0692 for AUC0-t, log 0.9142-log 1.0421 for $C_{max}$). Thus, $AUC_{0-t}$ and $C_{max}$ met the criteria of the Korea Food and Drug Administration (KFDA) for bioequivalence test indicating that Daewoong pregabalin capsule was bioequivalent to Lyrica$^{(R)}$ capsule.

• Economic and Environmental Geology
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• v.39 no.6 s.181
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• pp.711-717
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• 2006

In order to study gas hydrate, potential future energy resources, Korea Institute of Geoscience and Mineral Resources has conducted seismic reflection survey in the East Sea since 1997. one of evidence for presence of gas hydrate in seismic reflection data is a bottom simulating reflector (BSR). The BSR occurs at the interface between overlaying higher velocity, hydrate-bearing sediment and underlying lower velocity, free gas-bearing sediment. That is often characterized by large reflection coefficient and reflection polarity reverse to that of seafloor reflection. In order to apply depth migration to seismic reflection data. we need high performance computers and a parallelizing technique because of huge data volume and computation. Phase shift plus interpolation (PSPI) is a useful method for migration due to less computing time and computational efficiency. PSPI is intrinsically parallelizing characteristic in the frequency domain. We conducted conventional data processing for the gas hydrate data of the Ease Sea and then applied prestack depth migration using message-passing-interface PSPI (MPI_PSPI) that was parallelized by MPI local-area-multi-computer (MPI_LAM). Velocity model was made using the stack velocities after we had picked horizons on the stack image with in-house processing tool, Geobit. We could find the BSRs on the migrated stack section were about at SP 3555-4162 and two way travel time around 2,950 ms in time domain. In depth domain such BSRs appear at 6-17 km distance and 2.1 km depth from the seafloor. Since energy concentrated subsurface was well imaged we have to choose acquisition parameters suited for transmitting seismic energy to target area.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.14 no.3
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• pp.68-76
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• 2000

The stabilization control of Inverted Pendulum(IP) system is difficult because of its nonlinearity and structural unstability. Futhermore, a series of conventional techniques such as the pole placement and the optimal control based on the local linearizations have narrow stabilizable regions. At the same time, the fine tunings of their gain parameters are also troublesome. Thus, in this paper, an Evolving Neural Network Controller(ENNC) which its structure and its connection weights are optimized simultaneously by Real Variable Elitist Genetic Algorithm(RVEGA) was presented for stabilization of an IP system with nonlinearity. This proposed ENNC was described by a simple genetic chromosome. And the deletion of neuron, the according to the various flag types. Therefore, the connection weights, its structure and the neuron types in the given ENNC can be optimized by the proposed evolution strategy. And the proposed ENNC was implemented successfully on the ADA-2310 data acquisition board and the 80586 microprocessor in order to stabilize the IP system. Through the simulation and experimental results, we showed that the finally acquired optimal ENNC was very useful in the stabilization control of IP system.

• Journal of the Korean Magnetic Resonance Society
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• v.9 no.1
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• pp.48-60
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• 2005

Purpose: The purpose of this study was to design and build an optimized birdcage resonator configuration with a low pass filter, which would facilitate the acquisition of high-resolution 3D-image of small animals at 3T MRI system. Methods and Materials: The birdcage resonator with 12-element structures was built, in order to ensure B1 homogeneity over the image volume and maximum filling factor, and hence to maximize the signal to noise ratio (SNR) and resolution of the 3-dimensional images. The diameter and length of each element of a birdcage resonator were as follows: (1) diameter 13 cm, length 22 cm, (2) diameter 15 cm, length 22 cm, (3) diameter 17 cm, length 25 cm. Spin echo pulse sequence and fast spin echo pulse sequence were employed in obtaining MR images. The quality of the manufactured birdcage resonators wes evaluated on the basis of the return loss following matching and tuning process. Results: The experimental MR image of phantoms by the various manufactured birdcage resonators were obtained to compare the SNR in accordance with the size of objects. The size of an object to that of coil was identified by parameters that were estimated from the image of a phantom. First, the diameter of the birdcage resonator was 15cm, and the ratio of the tangerine to the birdcage resonator accounted for approximately 27%. The Q factor was 53.2 and the SNR was 150.7. Second, at the same birdcage resonator, the ratio of the orange was approximately 53%. The SNR and the Q parameter was 212.8 and 91.2, respectively. Conclusion: The present study demonstrated that if birdcage resonators have the same forms, SNR could be different depending on the size of an object, especially when the size of an object to that of coil is approximately 40~80%, the former is bigger than the latter. Therefore, when the size of an object to be observed is smaller than that of coil, the coil should be manufactured in accordance with the size of an object in order to obtain much more excellent images.

• Journal of Cadastre & Land InformatiX
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• v.48 no.1
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• pp.111-121
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• 2018

RIn this research, digital elevation models, true-ortho image and 3-dimensional digital complied data was generated and evaluated using unmanned aircraft vehicle stereoscopic images by applying photogrammetric principles. In order to implement stereoscopic vision, digital Photogrammetric Workstation should be used necessarily. For conducting this, in this study GEOMAPPER 1.0 is used. That was developed by the Ministry of Trade, Industry and Energy. To realize stereoscopic vision using two overlapping images of the unmanned aerial vehicle, the interior and exterior orientation parameters should be calculated. Especially lens distortion of non-metric camera must be accurately compensated for stereoscope. In this work. photogrammetric orientation process was conducted using commercial Software, PhotoScan 1.4. Fixed wing KRobotics KD-2 was used for the acquisition of UAV images. True-ortho photo was generated and digital topographic map was partially produced. Finally, we presented error analysis on the generated digital complied map. As the results, it is confirmed that the production of digital terrain map with a scale 1:2,500~1:3,000 is available using stereoscope method.

• Geophysics and Geophysical Exploration
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• v.14 no.4
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• pp.289-297
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• 2011

Chirp sub-bottom profilers (SBP) data are comparatively higher-resolution data than other seismic data and it's raw signal can be used as a final section after conducting basic filtering. However, Chirp SBP signal has possibility to include various noise in high-frequency band and to provide the distorted image for the complex geological structure in time domain. This study aims at the goal to establish the workflow of Chirp SBP data processing for enhanced image and to analyze the proper parameters for the domestic continental shelf. After pre-processing, we include the dynamic S/N filtering to eliminate the high-frequency component noise, the dip scan stack to enhance the continuity of reflection events and finally the post-stack depth migration to correct the distorted structure on the time domain sections. We demonstrated our workflow on the data acquired by domestically widely used equipments and then we could obtain the improved seismic sections of depth domain. This workflow seems to provide the proper seismic section to interpretation when applied to data processing of Chirp SBP that are largely used for domestic acquisition.

• Geophysics and Geophysical Exploration
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• v.8 no.2
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• pp.156-162
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• 2005

Particularly in research related to seawater intrusion the change of fluid electrical conductivity is one of major concerns, and effective monitoring can help to optimize a water pumping performance in coastal areas. Special considerations should be given to the mounting of sensors at proper depth during the monitoring design since the vertical distribution of fluid electrical conductivity is sensitive to the characteristics of seawater intrusion zone. This tells us the multi-channel electrical conductivity monitoring is of paramount consequence. It, however, is a rare event when this approach becomes routinely available in that commonly used commercial stand-alone type sensors are very expensive and inadequate for a long term monitoring of electrical conductivity or water level due to their restricted storage and difficulty of real-time control. For this reason, we have developed a real-time monitoring system that could meet these requirements. This system is user friendly, cost-effective, and easy to control measurement parameters - sampling interval, acquisition range, and others. And this devised system has been utilized for the electrical conductivity monitoring in boreholes, Yeonggwang-gun, Korea. Monitoring has been consecutively executed for 24 hours, and the responses of electrical conductivity at some channels have been regularly increased or decreased while pumping up water. It, with well logging data implemented before/after pumping water, verifies that electrical conductivity changes in the specified depths originate from fluid movements through sand layer or permeable fractured rock. Eventually, the multi-channel electrical conductivity monitoring system makes an effective key to secure groundwater resources in coastal areas.

• Journal of the Korean Society of Radiology
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• v.9 no.7
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• pp.425-431
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• 2015

Measurement accuracy was evaluated for the respiratory air flow transducer developed for applications under emergent situations. Pressure-Flow calibration equation was obtained by acquisition of air flow signals from the transducer in response to 6 flow waveforms, similar to those of artificial ventilation, generated by the standard flow generator system. Tidal volume and maximal flow rate were calculated on the flow signal then compared with the error-free data obtained by the linear displacement transducer of the flow generator system. Mean relative error of the tidal volume was within 3% and that of the maximal flow rate, approximately 5%, demonstrating accurate enough measurements. Therefore, the transducer could be applied to emergent situations to monitor the respiratory air flow signal as well as diagnostic parameters in real time.

• Journal of the Korean Magnetic Resonance Society
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• v.5 no.2
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• pp.99-109
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• 2001

Authors investigated neuronal changes of local cellular metabolism in the cerebral lesions of Parkinsonian symptomatic side between before and after stereotactic neurosurgery by follow-up 1H magnetic resonance spectroscopy (MRS). Patients with Parkinson's disease (PD) (n = 15) and age-matched normal controls (n = 15) underwen MRS examinations using a stimulated echo acquisition mode (STEAM) pulse sequence that provided 2${\times}$2${\times}$2 ㎤ (8ml) volume of interest in the regions of substantia nigra, thalamus, and lentiform nucleus. Spectral parameters were 20 ms TE, 2000 ms TR, 128 averages,2500 Hz spectral width, and 2048 data points. Raw data were processed by the SAGE data analysis package (GE Medical Systems). Peak areas of N-acetylaspartate (NAA), creatine (Cr), choline-containing compounds (Cho), inositols (Ins), and the sum (Glx) of glutamate and GABA were calculated by means of fitting the spectrum to a summation of Lorentzian curves using Marquardt algorithm. After blindly processed, we evaluated neuronal alterations of observable metabolite ratios between before and after stereotactic neurosurgery using Pearson product-moment analysis (SPSS, Ver. 6.0). A significant reduction of NAA/Cho ratio was observed in the cerebral lesion in substantia nigra of PD patient related to the symptomatic side after neurosurgery (P : 0.03). In thalamus, NAA/Cho ratio was also significantly decreased in the cerebral lesion including the electrode-surgical region (P : 0.03). A significant reduction of NAA/Cho ratio in lentiform nucleus was not oberved, but tended toward significant reduction after neurosurgery (P = 0.08). In particular, remarkable lactate signal was noted from the surgical thalamic lesions of 6 among 8 patients and internal segments of globus pallidus of 6 among 7 patients, respectively. Significant metabolic alterations of NAA/Cho ratio might reflect functional changes of neuropathological processes in the lesion of substantia nigra, thalamus, and lentiform nucleus, and could be a valuable finding fur evaluation of Parkinson's disease after neurosurgery. Increase of lactate signals, being remarkable in surgical lesions, could be consistent with a common consequence of neurosurgical necrosis. Thus, IH MRS could be a useful modality to evaluate the diagnostic and prognostic implications fur Parkinsons disease after functional neurosurgery.