• KSBB Journal
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• 제25권4호
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• pp.387-394
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• 2010

본 연구에서는 갯장어 및 버섯 혼합추출물을 이용하여 아토피 피부염 및 여드름의 개선효과를 확인하기 위하여 항산화 테스트와 아토피 피부염 임상시험자 15명에게 4주동안 혼합추출물을 복용과 함께 환부에 도포하도록 하였다. DPPH 소거능은 혼합추출물 농도증가와 함께 증가하였다. 특히 혼합추출물농도가 1.0 mg/L에서 50 mg/L로 증가 할 경우 DPPH 소거능은 10.1에서 81.4%로 증가 하였다. 환원력도 추출물농도가 증가 함에 따라 증가 하였다. 특히 추출물 25 mg/L에서 75 mg/L로 증가 할 경우 0.05 OD (700 nm)에서 0.27 (700 nm)로 급격히 증가 하였고 추출물 농도가 100 mg/L일 경우는 0.31 (700 nm)였다. SOD활성은 추출물 농도가 100 mg/L일 경우는 45.7%였다. 아토피성 피부염의 가려움과 붉은 반점에 대하여 임상시험 결과 임상시험자 모두 완치에 가깝도록 개선되는 효과를 나타내었다. 여드름 피부의 임상시험자 5명 모두 임상시험 후 염증 면포가 완화되어 여드름의 등급이 낮아지는 결과를 나타내었다. 여드름 피부의 임상시험자 모두 얼굴피부의 유수분 및 거칠기 상태가 정상피부의 수준에 이르도록 긍정적인 변화를 나타내었다. 혼합추출물을 피부에 직접 적용하여 임상시험한 결과, 아토피 피부염 및 여드름 피부의 임상시험자 모두 어떠한 부작용도 나타내지 않았다. 이상의 결과는 갯장어 및 버섯 혼합추출물이 아토피 피부염 및 여드름 피부관리를 위한 의약품 및 화장품의 원료로 개발될 충분한 가치가 있는 것으로 사료된다.

• 셀메드
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• 제6권1호
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• pp.6.1-6.6
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• 2016

Polycystic Ovarian Syndrome (PCOS) has now become more common in occurrence in women of reproductive age, particularly in urban and semi-urban population in India. So there is a need to investigate this phenomenon taking into consideration various aspects including possible treatment method to ameliorate/eradicate this syndrome, which has far reaching socio-economic impact and consequences, in view of infertility and irregular menstrual cycles frequently associated with this syndrome. Homeopathy is a branch of traditional alternative medicine which is gaining popularity in India and some other developing countries, as also in some of the developed countries in Europe. With this background scenario, we have made an attempt to treat cases of confirmed PCOS and tried to compare the relative efficacy of two potentized homeopathic drugs, namely, Lycopodium clavatum (Lyco) and Calcarea carbonica (Calc), most frequently used by homeopathic practitioners, selecting different potencies of the drugs, depending on condition/guiding symptom(s) of the patients. While the main focus was pointed on total/partial removal of cysts, data pertaining to different PCOS associated symptoms were also compared for the sake of learning if the two drugs had differential effects on these symptoms also. The study parameters in this investigation included: regularity/irregularity of menstrual cycle, presence/absence of acne, hirsutism, male type alopecia, acanthosis nigricans, body/mass index (BMI) and waist-hip ratio. Overall results provided clear evidences that both these homeopathic drugs had great ameliorating effects on PCOS, although each drug had a little different effect in respect of the individual parameters of this study.

• 대한화장품학회지
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• 제34권1호
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• pp.67-73
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• 2008

웰빙 시대로 지칭되는 오늘날의 사회 특성으로부터 천연물에 대한 관심은 점점 증대되고 있다. 본 연구에서는 한국을 대표하는 생약재이자 향료식물인 인삼에 포함된 향료를 유기용매로 추출하여 앱솔루트 정유를 제조하고 그 성분을 분석하였다. 헥산과 에탄올 등 유기용제를 이용하여 제조된 인삼 앱솔루트 정유의 수율은 0.146%였으며, 주요성분은 neoclovene, panasinsene 및 calarene 등, sesquiterpene류가 주를 이루었다. 그 외에 110여 종의 인삼 향기 물질을 GC-MS 분석으로 확인하였다. 또한 일반세균 3종(대장균, 화농균, 녹농균), 효모균, 여드름균 및 비듬균에 대한 인삼정유 성분의 항균력을 측정한 결과 여드름균에 대한 강한 항균작용을 확인할 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제30권9호
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• pp.1379-1386
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• 2020

Acne is a chronic skin disease that typically occurs in the teens and twenties, and its symptoms vary according to age, sex, diet, and lifestyle. The condition is characterized by hyperproliferation of keratinocytes in the epidermis, sebum overproduction, excessive growth of Propionibacterium acnes, and P. acnes-induced skin inflammation. Interleukin (IL)-1α and IL-6 are predominant in the inflammatory lesions of acne vulgaris. These cytokines induce an inflammatory reaction in the skin in the presence of pathogens or stresses. Moreover, IL-1α accelerates the production of keratin 16, which is typically expressed in wounded or aberrant skin, leading to abnormalities in architecture and hyperkeratinization. Orobol (3',4',5,7-tetrahydroxyisoflavone) is a metabolite of genistein that inhibited the P. acnes-induced increases in IL-6 and IL-1α levels in human keratinocytes (HaCaTs) more effectively compared with salicylic acid. In addition, orobol decreased the IL-1α and IL-6 mRNA levels and inhibited the phosphorylation of inhibitor of kappa-B kinase, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, and mitogen-activated protein kinase induced by P. acnes. Finally, the expression of Ki67 was decreased by orobol. Thus, orobol ameliorated the inflammation and hyperkeratinization induced by heat-killed P. acnes and thus has potential for use in functional foods and cosmetics.

• Journal of Yeungnam Medical Science
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• 제30권1호
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• pp.55-57
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• 2013

Synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome is a rare disease that involves the skin, bones and joints. It is thought to be caused by infection with low-toxicity bacteria and to be the result of reactive infectious osteitis. However, this hypothesis has not yet been clearly established. New SAPHO syndrome treatment methods are needed because the disease does not respond to treatment in many cases. In this paper, a case is reported of SAPHO syndrome with pain in the acromioclavicular joint and with squamous and pustular macules on the palms and soles. First, the patient was treated with aceclofenac, prednisolon and sulfasalazine for two weeks. However, the symptoms were not relieved, so methotrexate and pamidronate were added to the treatment. Since no improvement was seen after four weeks of treatment, adalimumab was prescribed. The skin lesions were relieved two weeks later, and the bone pain and arthralgia, four weeks later. No recurrence or adverse effects were observed at the 22-week follow-up.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권4호
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• pp.347-350
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• 2018

Drug-induced autoimmune hepatitis (DIAIH) is an increasingly recognized form of drug-induced liver injury that leads to a condition similar to idiopathic autoimmune hepatitis. A number of drugs have been associated with DIAIH, minocycline is one of the most well characterized. Minocycline is a semisynthetic tetracycline antibiotic used in the treatment of acne vulgaris. Minocycline-induced autoimmune hepatitis presents with serologic and histologic features similar to idiopathic autoimmune hepatitis. However, the natural history and outcomes of these two conditions differ significantly. The majority of patients with minocycline-induced autoimmune hepatitis experience complete resolution of symptoms after withdrawal of the medication. Some patients may require a short course of steroids and rarely use of an immunomodulator to achieve resolution of disease. Recurrence of symptoms is rare and typically only occurs with reintroduction of minocycline. It is important for primary care providers to consider minocycline-induced autoimmune hepatitis when liver injury develops during minocycline therapy.

• 한방안이비인후피부과학회지
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• 제17권2호
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• pp.106-111
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• 2004

Vertigo is a symptom, not a disease. The tenn vertigo refers to the sensation of spinning or whirling that occurs as a result of a disturbance in balance. It's sometimes referred to as a hallucination of motion. The cause of vertigo is very various and generally divided into peripheral and central. A patient presented with severe vertigo, nystagmus and heteophoria. She has taken the BanHaBaekChulChunMa-tang and treated by acupuncture. After 2 days, her symptoms become disappeared and about 1 week, all symptoms except heterophoria were disapperaed. And after 2 weeks, heterophoria was disappeared. In conclusion, we diagnosed her case as vestbular neuronitis by her clinical course, but we also considered her illness as vertebrobasilar insufficiency, TIA etc.

• 대한한의학방제학회지
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• 제30권4호
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• pp.351-361
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• 2022

Objectives : The purpose of this study is to report the clinical effect of herbal medicine decoction on COVID-19 symptoms remaining after administering Western medicine and worsening eczema during the COVID-19 prevalence period in patients with chronic eczema. Methods : The two chronic eczema patients suffering from COVID-19 symptoms and worsening eczema received a series of herbal medicine decoction for treatment. The effectiveness of treatment was evaluated by VAS, NRS, EASI, PASI, DLQI, photography and subjective evaluation of the patient's improvement of symptoms. Results : After treatment, all symptoms of COVID-19 disappered and aggravated eczema lesions were remarkably improved in both cases. Compared to its peak, the first case shows that PASI improved by 88% and DLQI by 44%. According to photo and symptom changes, the size of the affected area of facial acne and lip eczema was decreased. The second case shows that EASI improved by 43% and DLQI by 65%. According to photo and symptom changes, redness, rash were stopped and pruritus was decreased. Conclusion : This study suggests that herbal medicine could induce effectiveness on both COVID-19 symptoms as well as chronic eczema.

• 한국임상약학회지
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• 제29권3호
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• pp.209-214
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• 2019

Doxycycline is frequently prescribed to treat urogenital infections or acne vulgaris. A 39-year-old man was prescribed doxycycline as a treatment for his skin infection. He took each tablet on an empty stomach in the morning, and just before going to bed with insufficient water. After taking the prescribed medication for approximately 3 weeks, he was diagnosed with esophageal ulcer. He had not experienced these symptoms before, and the drug label says that doxycycline rarely causes esophageal ulcer. After discontinuing the medication, the symptoms disappeared. Using the World Health Organization-Uppsala Monitoring Center criteria, the causality for doxycycline-induced esophageal ulcer was evaluated as "possible." Additionally, using the Naranjo scale and Korean causality assessment algorithm (Ver. 2), the causality was evaluated as "probable." Previous reports have stated that most patients who took doxycycline with insufficient water just before going to bed or in the supine position developed esophageal ulcer. Therefore, all patients taking doxycycline must be provided with detailed instructions about the appropriate administration methods.

• 대한한의학회지
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• 제25권1호
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• pp.161-171
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• 2004

Objectives: Sasang Constitutional Medicine is popularly appliedto treatment in Korea. Constitution is a holistic concept contained internal and external characteristics, and physical traits including ordinary symptoms. Skin is one of constitutional property elements. So we researched a correlation female facial skin and sasang constitution. This is a basic study to find constitution can be a major factor to care and manage skin. Methods: We examined sasang constitution and facial skin condition of 100 healthy women who aged from 30 to 59. Hydration and sebum of facial skin was measured by skin diagnostic instrument and skin type was calculated from the data. Keratin, pore size, acne, and brightness of face was measured by skin magnifying lens and subjective skin troubles in ordinary times was also investigated. Constitution diagnosis and Skin diagnosis was investigated separately as a blind test andthe data was statistically analyzed with chi-square test, Correlation analysis, One-way analysis of variance. Results: 1. In sasang constitution, Taeeumingroup bad significant tendencies of larger hydration and sebum amount, combination degree of forehead and cheek was also higher than other constitutions(p<0.05). 2. Facial skin type was significantly different according to Sasang Constitution, Soeumin and Soyangin had a tendency of dry skin comparatively, but Taeeumin had mainly a tendency of combination skin and secondly dry skin(p<0.05). On the other hand, there was no correlation between age and skin type. 3. In subjective skin trouble, Soeumin group had less acne trouble than Soyangin and Taeeumin group(p<0.1). Pore size trouble was more frequent in Soyangin group than Soeumin group(p<0.05). Keratin trouble was more frequent in Soeumin group than Soyangin and Taeumin group(p<0.1). Conclusions: Korean healthy women's skin condition was different according to sasang constitution.