• Title/Summary/Keyword: accelerated experiment

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Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H+/K+-ATPase

  • Hwang, In Young;Jeong, Choon Sik
    • Biomolecules & Therapeutics
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    • v.23 no.5
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    • pp.458-464
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    • 2015
  • Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer. To elucidate their gastroprotective effects, the inhibitions of $HCl{\cdot}tOH$-induced gastritis and indomethacin-induced gastric ulcers were assessed in rats. It was observed that both sennoside A and sennoside B increased prostaglandin $E_2$ ($PGE_2$) levels and inhibited $H^+/K^+$-ATPase (proton pump). In a rat model, both compounds reduced gastric juice, total acidity and increased pH, indicating that proton pump inhibition reduces gastric acid secretion. Furthermore, sennoside A and B increased $PGE_2$ in a concentration-dependent manner. In a gastric emptying and intestinal transporting rate experiment, both sennoside A and sennoside B accelerated motility. Our results thus suggest that sennoside A and sennoside B possess significant gastroprotective activities and they might be useful for the treatment of gastric disease.

Characteristics of Morphological and Production from Different Origin of Foeniculum vulgare Mill.

  • Chung, Hae-Gon;Kim, Seong-Min;Nemeth, E.
    • Korean Journal of Medicinal Crop Science
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    • v.11 no.4
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    • pp.259-263
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    • 2003
  • This study was carried out to get basic information about the morphological and production characteristics of fennel populations different origin under different ecological conditions in Hungary. The Korean population can be registered as a medium high genotype and showed a more accelerated growth characters than Hungarian taxon and the two populations have a medium homogeneity $(CV\;=\;4{\sim}22%)$. In the second year plant height in Hungarian taxon was significantly higher than that of the Korean population. The shooting dynamic of individual plants might be heterogeneous in both taxa and the Korean population was not only shorter in the height but had also less shoots by 16% than the Hungarian one. The Hungarian taxon exceeded the umbel size and numbers to the Korean one (by 3.62 cm in the average) and the variability in the populations was high $(CV\;=\;29{\sim}49%)$. Seed size was proved to be also a discriminative feature between the examined taxa. With small deviations (CV < 2) the Hungarian population produced seeds longer by 38%. Homogeneity in the populations was dependent more on the vegetation years and on the characteristics measured but less on the origins, respectively.

The Phase Transition of TiO2 fine Powders by Heat Treatment (열처리에 의한 TiO2 미립자의 상전이)

  • Kim, S.J.;Chang, G.H.;Byuon, Y.S.;Jin, Y.C.;Jheong, G.R.
    • Journal of the Korean Society for Heat Treatment
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    • v.6 no.4
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    • pp.204-212
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    • 1993
  • The preparation of $TiO_2$ fine particles from $TiCl_4$ and oxygen by the vapor-phasereaction was investigated at $850^{\circ}C$ with an emphasis on the effect of its experimental conditions on the crystal type of the products. Anatase $TiO_2$ particles prepared by experiment were used to study anatase-rutile transition by calcination temperature, the additives and gas atmosphere. The results were as follows. The kinetics of anatase-rutile transition was well agreed with A vrami equation, and the activation energy of transition was 35kcal/mol. The addition of CuO in anatase $TiO_2$ particles accelerated the anatase-rutile transition, and its transition was retarded in vaccum.

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The Effect of Gonadotrophic Hormones on Compensatory Response in Unilateral Ovariectomized Mice (한쪽 난소를 제거한 흰 생쥐에 있어서 보상작용에 미치는 생식선자극홀몬의 영향)

  • 강영선;조완규;김성례;류경자
    • The Korean Journal of Zoology
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    • v.8 no.2
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    • pp.23-27
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    • 1965
  • The present study is an analysis of some alterations occurring in the population of folliclesin the ovary treated with the gonadotrophins in intact and unilaterally ovariectomized mice. the differences between the findings inthe intact and semispayed animals and those in gonadotrophintreated intact and semispayed animals were disucssed. 1) When mice were semispayed at the stage of diestrus, the remaining ovary showed an increase of secondary follicles in number, while a decrease of atretic folicles, compared with those in intact animals. 2) After injection of PMS and HCG following semispaying at the diestrus stage, the remaining ovary contained larger number of secondary follicles and corpora lutea than those in semispayed animals with no treatment , while showed smaller number of atretic follicles. 3) It is sure that follicular development is remarkably accelerated in the intact mice treated with PMS and HCG. 4) The effect of PMS and HCG on the follicular development was gradually decreased with time in the intact and semispayed animals afte rexogenous hormone therapy. 5) It is believed in the experiment that a decrease of follicular atresia in number and an increase of secondary follicles may be responsible for compensatory reaction after semispaying.

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Development and demonstration of an erosion-corrosion damage simulation apparatus (배관 침부식 손상 연속모사 장비 개발 및 실증)

  • Nam, Won Chang;Ryu, Kyung Ha;Kim, Jae Hyoung
    • Corrosion Science and Technology
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    • v.12 no.4
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    • pp.179-184
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    • 2013
  • Pipe wall thinning caused by erosion and corrosion can adversely affect the operation of aged nuclear power plants. Some injured workers owing to pipe rupture has been reported and power reduction caused by unexpected pipe damage has been occurred consistently. Therefore, it is important to develop erosion-corrosion damage prediction model and investigate its mechanisms. Especially, liquid droplet impingement erosion(LDIE) is regarded as the main issue of pipe wall thinning management. To investigate LDIE mechanism with corrosion environment, we developed erosion-corrosion damage simulation apparatus and its capability has been verified through the preliminary damage experiment of 6061-Al alloy. The apparatus design has been based on ASTM standard test method, G73-10, that use high-speed rotator and enable to simulate water hammering and droplet impingement. The preliminary test results showed mass loss of 3.2% in conditions of peripheral speed of 110m/s, droplet size of 1mm-diameter, and accumulated time of 3 hours. In this study, the apparatus design revealed feasibility of LDIE damage simulation and provided possibility of accelerated erosion-corrosion damage test by controlling water chemistry.

A Study on Micro-Hole Drilling by EDM (미세구멍의 방전가공에 관한 연구)

  • 윤재웅;양민양
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.14 no.5
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    • pp.1147-1154
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    • 1990
  • Micro-hole drilling by EDM and production of fine rods for the tool electrode or other purpose have become very important in industry. This paper suggests a new method for production of very fine rods by ultrasonic-assisted chemical machining and describes the machining characteristics of micro-hole drilling by EDM. For fine rods, copper wires of initial diameter of 250.mum are used and successfully machined into a diameter of less than 30.mum with good repeatability. The ultrasonic agitation not only accelerated the material removal rate uniformly, but also produced smooth surfaces of fine rods. To drill the micro-hole, kerosene and pure water is used as a dielectric. From the experiment, water is superior to kerosene with respect to surface roughness of inlet and outlet of hole and machined surface as well as electrode wear. However, due to the electrochemical reaction of water, small pits are remained on the workpiece surface.

A Study on the Displacement Characteristics of Cut-and Cover Tunnel Lining by Centrifuge Model Experiment (원심모형시험에 의한 복개터널 복공의 변위특성에 관한 연구)

  • Lee, Myung-Woog;Park, Byung-Soo;Lee, Jong-Ho;Yoo, Nam-Jae
    • Journal of Industrial Technology
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    • v.23 no.A
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    • pp.119-130
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    • 2003
  • This thesis is results of experimental works on the behavior of the cut-and-cover tunnel. Centrifuge model tests were performed to simulate the behavior of the cut-and-cover tunnels having cross sections of national road and subway tunnels. Model experiments were carried out with changing the cut slope and the slope of filling ground surface. Displacements of tunnel lining resulted from artificially accelerated gravitational force up to 40g of covered material used in model tests, were measured during centrifuge model tests. In model tests, Jumunjin Standard Sand with the relative density of 80 % and the zinc plates were used for the covered material and the flexible tunnel lining, respectively. Basic soil property tests were performed to obtain it's the property of Jumumjin Standard Sand Shear strength parameters of Jumunjin Standard Sand were obtained by performing the triaxial compression tests. Direct shear tests were also carried out to find the mechanical properties of the interface between the lining and the covered material. Compared results model tests estimation with respect to displacements of the lining.

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Hydrocarbon-Organic Composite Membranes for Improved Oxidative Stability for PEMFC Applications (연료전지용 탄화수소 전해질 막의 산화안정성 향상을 위한 유기물 복합막의 제조 및 특성 분석)

  • Park, Satbyul;Lee, Hyejin;Bae, Byungchan
    • Journal of the Korean Electrochemical Society
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    • v.19 no.2
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    • pp.45-49
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    • 2016
  • In order to mitigate oxidative degradation of polymer membrane during fuel cell operation, an organic radical quencher was introduced. Rutin was selected as a radical quencher and mixed with sulfonated poly(arylene ether sulfone) to prepare composite membrane. Physicochemical properties of the composite membranes such as water uptake and proton conductivity were characterized. Hydrogen peroxide exposure experiment, which can mimic accelerated oxidative stability test during fuel cell operation, was adopted to evaluate the oxidative stability of the membranes. The composite membranes containing Rutin showed similar proton conductivity and enhanced oxidative stability compared to pristine ones.

An experimental study on carbonation and compressive strength of cementitious materials containing CO2 reactive materials (CO2 반응물질을 혼입한 시멘트계 재료의 탄산화 진행 및 압축강도 발현에 관한 실험적 연구)

  • Seong, Myung-Jin;Kim, Yeung-Kwan;Lee, Han-Seung
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2015.05a
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    • pp.30-31
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    • 2015
  • Usually, carbonation of concrete causes pH reduction and corrosion of steel, it leads to decrease of durability. However, CaCO3, as results of reaction with hydrates products and CO2, can contribute to improvement of compressive strength. Based on this theory, using carbonation depth, the researches about CO2 absorption of plain concrete and concrete containing CO2 reactive materials has been performed. But, the researches has limitation about using one material, therefore, for this study, considering various CO2 reactive materials, experiment has been proceeded. With water to binder ratio 50%, after initial curing for 2days, accelerated carbonation was performed for 28days, and carbonation depth and compressive strength were measured. As results of carbonation depth, specimen containing desulfurized slag, zeolite showed the highest CO2 absorption, in case of compressive strength, specimens with MgO were indicated as highest compressive strength.

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Elasticity Modulus Change Research of Polymer Ultraviolet Dosage by using ESPI (ESPI를 이용한 자외선조사량에 따른 폴리머애자의 탄성계수 변화 연구)

  • Kim, Kyeong-Suk;Kim, Dong-Soo;Chang, Ho-Sub;Pack, Chan-Joo;Jang, Wan-Sik;Jung, Hyun-Chul
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.19 no.4
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    • pp.485-490
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    • 2010
  • Recently, environment problems have effects on the electronic equipments. Security problems are presented. For security reasons, it is necessary to study electronic equipments. In this paper, we handle the Elasticity modulus on the polymer insulator by UV irradiation. The types of material are used in this experiment, is the EPDM (Ethylene Propylene Diene Monomer). For increasing the reliability, real material specimens are used. For this study, we used ESPI (Electronic speckle pattern interferometry), UTM (Universal thesting machine) device, Accelerated weathering tester. Through this measurement, we evaluated how much UV irradiation has effect on polymer insulator and how long does it take to change the polymer insulator. Also this paper will give a help in electronic industry and the method of measuring the insulator elasticity modulus of polymer could be utilized in life estimation and replacement time of the products of electronic equipment that is used in real industrial fields.