• Journal of Pharmaceutical Investigation
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• v.37 no.2
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• pp.73-78
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• 2007

The aim of this study was to investigate the absorption properties of ketoprofen. The in-situ perfusion model has advantages over in vitro models as it provides intact lymphatic and blood flow circulation. The absorption properties of six different concentrations of ketoprofen have been studied in single pass in-situ rat intestine model. $^{14}C-PEG$ 4000 was used as a permeability marker and the possibility of an energy dependent contribution to ketoprofen absorption was also Investigated using the metabolic inhibitor sodium azide. Three different concentrations of sodium azide were studied to examine its effect on absorption of ketoprofen from the rat intestine. The findings of this study suggest that mono-carboxylic type drugs like ketoprofen cause permeability changes in the intestine. This is shown by the increase in absorption of $^{14}C-PEG$ 4000 as the concentration of ketoprofen is increased. However, the trend for ketoprofen permeability is to decrease over the concentration ranges. It was observed that the Papp values for ketoprofen with sodium azide shows a trend towards reduction in the amount of ketoprofen absorbed from the rat intestine which was significantly different (p<0.05) from that of ketoprofen with sodium azide 3.0mM. This indicates that sodium azide has an affect on the absorption of ketoprofen. The pH of all the perfusion solutions was altered to ${\sim}pH\;6.7$ by the buffering capacity of the small intestine secretions. The results suggest that mechanisms other than passive diffusion may be involved in ketoprofen absorption. This would be consistent with the involvement of active transport or saturatable processes in the absorption of drugs containing monocarboxylic acid group, as has been previously suggested from in vitro data.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.3
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• pp.602-606
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• 2009

The absorption capacity and initial absorption rate in 5 %, 10%, 15 % and 20% $Na_{2}CO_{3}$ under the constant temperature at $40^{\circ}C$ and the initial absorption rate in mixture of different alkaline salts such as $KHCO_3$, $CaCO_3$ and $K_{2}CO_{3}$ were measured using batch type stirred cell contractor. 10% $Na_{2}CO_{3}$ showed the highest absorption capacity and $Na_{2}CO_{3}$ and $K_{2}CO_{3}$ showed the somewhat increased absorption capacity and initial absorption rate respectively. Further more, we have studied the effect of adding Pz and Pp to $Na_{2}CO_{3}$. The result showed that absorption rate of $CO_2$ was increased by adding these additives.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.21 no.4
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• pp.588-592
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• 2012

This study concentrates the effect of hybridisation on the collapse mode and energy absorption for composite cylinders. The static collapse behavior of laminated(Al/CFRP/GFRP) circular-cylindrical composite shell under quasi-static axial compressive load has been investigated experimentally. Eight different hybrids of laminated(Al/CFRP/GFRP) circular-cylindrical composite shell were fabricated by autoclave. Eight types of composites were tested, namely, Al/carbon fiber/epoxy, Al/glass fiber/epoxy, Al/carbon-carbon-glass/epoxy, Al/carbon-glass-carbon/epoxy, Al/carbon-glass-glass/epoxy, Al/glass-glass-carbon/epoxy, Al/glass-carbon-glass/epoxy and Al/glass-carbon-carbon/epoxy. Collpase modes were highly dominated by the effect of hybridisation. The results also showed that the hybrid member with material sequence of Al-glass-carbon-carbon/epoxy exhibited good energy absorption capability.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.11a
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• pp.536-538
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• 2011

In this study, the moisture absorption behaviors of the CNT reinforced unsaturated polyester composites were investigated along with exposure temperature and time. The tensile properties of the specimens were evaluated to identify the effect of absorbed moisture on the mechanical properties. The exposure temperatures of $25^{\circ}C$ and $75^{\circ}C$ were considered and the exposure time up to 600 hours was applied. According to the results, moisture absorption rate was increased as CNT content and exposure temperature were increased. The rate of decrease in tensile strength of the CNT reinforced unsaturated polyester composites was reduced due to the reinforcing effect of CNT compared to the unsaturated polyester resin.

• Journal of Biomedical Engineering Research
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• v.31 no.1
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• pp.33-39
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• 2010

During running, the human body experiences repeated impact force between the foot and the ground. The impact force is highly associated with injury of the lower extremity, comfort and running performance. Therefore, shoemakers have developed shoes with various midsole properties to prevent the injury of lower extremity, improve the comfort and enhance the running performance. The purpose of this study is to investigate influence of midsole hardness on shock absorption along the human body during running. Thirty two expert runners consented to participate in the study and ran at a constant speed with three different pairs of shoes with soft, medium and hard midsole respectively. Using accelerometers we measured the shock absorption from shoe heel to cervical vertebral column. In conclusion, at the shoe heel, shock was the greatest with the hard midsole. However because most shock was absorbed between shoe heel and the knee, notable influence of midsole was not detected upper knee. At shoe heel, regardless of midsole hardness, the shock of younger female was the greatest. The authors expect to apply this result for providing a guideline for utilizing proper midsole hardness for manufacturing age and gender-specific shoe.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.16 no.1
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• pp.26-33
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• 2004

In general, an absorption chiller or heat pump is operated under the constant cooling water flow rate condition even though the system works with a partial load. The objective of this paper is to study the effect of the cooling water flow rates and the temperature of cooling water on the system performance to find the energy saving methode for the partial load operation of the double effect $H_2O$/LiBr absorption chiller. It is found that the performance of the system is sensitive to the temperature of cooling water than the cooling water flow rate, so the decrease of the performance due to reducing the cooling water flow rate can be overcome with the reduction of the cooling water temperature by 1$^{\circ}C$. The flow rate of the cooling water flow rate ranges from 50％ to 100％ of the flow rate at normal conditions with a partial load. It is also found that the operation cost of the cooling water pump and the cooling tower can be reduced by 23％.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2001.11a
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• pp.92-97
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• 2001

This paper was studied on the effect of temperature on corrosion of absorption refrigeration systems using LiBr-$H_2O$ working fluids. In the fresh water and 62 %lithium bromide solution at $70^{\circ}C$, polarization test of SS 400, Cu(Cl220T-OL) and Ni-Al bronze was carried out. And Polarization behavior, polarization resistance characteristics, corrosion rate(mmpy) and corrosion sensitivity of materials forming absorption refrigeration systems was considered. The main results are as following: As the experimental temperature increase, the change of corrosion rate of Ni-Al bronze become duller than SS 400 and Cu in 62 % lithium bromide solution. Open circuit potential of SS 400 is less noble than that of Cu and Ni-Al bronze in fresh water, but that becomes noble than Cu and Ni-Al bronze in 62 % lithium bromide solution. The corrosion sensitivity of Ni-Al bronze was controlled than that of Cu and SS 400 in 62% LiBr solution.

• Advanced Composite Materials
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• v.17 no.4
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• pp.359-372
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• 2008

The moisture absorption behavior of carbon fiber-reinforced plastic (CFRP) and its effect on dimensional stability were examined. Moisture diffusivity in CFRP was determined by measuring a specimen's weight during the moisture absorption test. Three types of CFRP specimens were prepared: a unidirectionally reinforced laminate, a quasi-isotropic laminate and woven fabric. Each CFRP was processed into two geometries - a thin plate for determination of diffusivity and a rod with a square cross-section for the discussion of two-dimensional diffusion behavior. By solving Fick's law expanded to 3 dimensions, the diffusivities in the three orthogonal directions were obtained and analyzed in terms of the anisotropy of CFRP moisture diffusion. Coefficients of moisture expansion (CMEs) were also obtained from specimen deformation caused by moisture absorption. During moisture absorption, the specimen surfaces showed larger deformation near the edges due to the distribution of moisture contents. This deformation was reasonably predicted by the finite element analysis using experimentally determined diffusivities and CMEs. For unidirectional CFRP, the effect of the fiber alignment on CME was analyzed by micromechanical finite element analysis (FEA) and discussed.

• Advances in aircraft and spacecraft science
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• v.6 no.4
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• pp.315-331
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• 2019

The stiffness degradation of the cross-ply composite laminates containing a transverse cracking and delamination in $90^{\circ}$ layer is predicted by using a modified shear-lag model by introducing the stress perturbation function. The prediction shows better agreement with the experimental results published by Ogihara and Takeda 1995, especially for laminates with thicker $90^{\circ}$ plies in which extensive delamination occurs. A homogenised analytic model for average transient moisture uptake in composite laminates containing periodically distributed matrix cracks and delamination is presented. It is shown that the model well describes the moisture absorption in a cross-ply composite laminate containing periodically distributed transverse matrix cracks in the $90^{\circ}$ plies. The obtained results represent well the dependence of the stiffness degradation on the crack density, thickness ratio and moisture absorption. The present study has proved to be important to the understanding of the degradation of the material propertiesin the failure process when the laminates in which the delamination grows extensively.

• Journal of Nutrition and Health
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• v.23 no.7
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• pp.492-503
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• 1990

This study was performed to investigate nutritional effect of various dietary fibers on lead absorption, and protein and lipid metabolisms in growing rats. Sixty male rats of Sprague-Dawley strain weighing 140$\pm$1.1g were blocked into 10 groups according to body weight and fed 10 kinds of diet different with fiber sources [non-fiber, cellulose, pectin, guar gum or carboxymethylcellulose(CMC)] and lead levels (0 or 1%) for 4 weeks. Results were summerized as follows : 1) Food intake, weight gain, FER and PER were remarkably decreased in lead(Pb)-added groups. Weight gain, FER and PER in Pb-added pectin group were significantly lower than those in Pb-added non-fiber group. 2) Liver and kidney weights, femur weight and length, hematocrit and hemoglobin content were decreased in Pb-added groups. Especially femur and liver weights in pectin groups were the lowest among groups. 3) Total protein content in serum was significantly decreased in Pb-added groups but was not different with dietary fiber sources. Total lipid content in serum was not different with dietary Pb levels and fiber sources, but cholesterol content in serum of guar gum group was significantly decreased by Pb addition. 4) Nitrogen, lipid and cholesteol contents in liver were significantly decreased in Pb-added groups, and lipid content in liver of pectin and CMC groups was lower than other groups. 5) Daily urinary and fecal excretions of nitrogen, kipid and cholesterol were decreased in Pb-added groups, and fecal nitrogen was significantly increased in Pb-added groups, and fecal nitrogen of cellulose and guar gum groups was significantly higher than other groups. Fecal excretions of lipid and cholesterol were increased by dietary fibers, and especially fecal lipid was remarkably increased in pectin and guar hum group. 6) Pb contents in liver and femur were decreased by dietary fibers. Especially Pb contents in liver, kidney and femur were significantly decreased in guar gum group. 7) Daily urinary and fecal excretions of Pb were significantly increased in cellulose and guar gum groups, and fecla excretion of Pb in guar gum group was twice of non-fiber group. Pb absorption ratio was significantly decreased in guar gum group. In conclusion, dietary fibers have effect on protein and lipid metabolisms, and decreased intestinal absorption of Pb by increasing fecal excretion. But the degree of effect was different with dietary fiber sources.