• Molecular & Cellular Toxicology
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• v.5 no.3
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• pp.216-221
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• 2009

Bisphenol A (BPA) is commonly used in the production of pharmaceutical, industrial, and housing epoxy, as well as polycarbonate plastics. Owing to its extensive use, BPA can contaminate the environment either directly or through derivatives of these products. BPA has been classified as an endocrine disruptor chemicals (EDCs), and the primary toxicity of these EDCs in males involves the induction of reproductive system abnormality. First, in order to evaluate the direct effects on the Y chromosome associated with reproduction, we evaluated Y chromosome abnormalities using a Y chromosome microdeletion detection kit. However, we detected no Yq abnormality as the result of BPA exposure. Secondly, we performed high-density oligonucleotide array-based comparative genome hybridization (CGH) to assess genomic alteration as a component of our toxicity assessment. The results of our data analysis revealed some changes in copy number. Seven observed features were gains or losses in chromosomal DNA (P-value<1.0e-5, average log2 ratio>0.2). Interestingly, 21 probes of chr7:7312289-10272836 (qA1-qA2 in cytoband) were a commonly observed amplification (P-value 3.69e-10). Another region, chr14:4551029-10397399, was also commonly amplified (P-value 2.93e-12, average of log2 ratios in segment>0.3786). These regions include many genes associated with pheromone response, transcription, and signal transduction using ArrayToKegg software. These results help us to understand the molecular mechanisms underlying the reproductive effects induced by BPA.

• Journal of the Korea Society of Computer and Information
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• v.26 no.10
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• pp.139-145
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• 2021

In this paper, by using the cattle feed intake, rumination, and in heat monitoring technology, RFI (Residual Feed Intake) monitoring and wearable devices and PCs for predicting abnormalities in budding target web and smart A monitoring system using a phone application was designed and implemented. With the development of this system, the farmer is expected to increase economic efficiency. By analyzing the feed intake, it is possible to identify the difference between the recommended feed amount based on the cow's weight and the feed amount consumed by the cow, and it is expected that early detection of metabolic disorders (abnormality of metabolism) is possible. Farmers using the results of this thesis can distinguish the cows with the most efficient performance, and the 6-axis motion sensor signals input from the wearable device attached to the cow's skin (neck) and the microphone attached to the wearable device. It is possible to measure the cow's rumination and feed intake through the sound of the cow's throat. In the future, improvements will be made to measure additional vital signs such as heart rate and respiration.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1996.04a
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• pp.414-418
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• 1996

This paper aims at reviewing the possibility application over normal or abnormal, detection used by AE and the characteristics of grinding process. In this study, when diamond bur in dentistry with chosen grinding conditions were tuned at grinding. The variation of grinding resistance and AE signal is detected by the use of AE measuring system. The tests are carried out in accordance with diamond burs and workpiece: arcyl and cowteeth. According to the experiment results, the following can be expected; AE has the possibility to detect the state normality and abnormality. However, the grinding resistance measuring can find it difficult to detect it. It can be accurately excepted from AE occurrence pattern in contact start point of diamond but and cowteeth, grinding condition and derailment point. It is known that AErms is well compatible with grinding resistance.

• Sleep Medicine and Psychophysiology
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• v.2 no.1
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• pp.31-43
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• 1995

Recently, the methods that measure and analyze brain electrical activity quantitatively have been available with the rapid development of computer technology. The quantitative electroencephalography(QEEG) is a method of computer-assisted analyzing brain electrical activity. The QEEG allows for a more sensitive, precise and reproducible examination of EEG data than that can be accomplished by conventional EEG. It is possible to compare various EEG parameters each other by using QEEG. Neurometrics, a kind of the quantitative EEG. is to compare EEG characteristics of the patient with normative data to determine in what way the patient's EEG deviates from normality and to discriminate among psychiatric disorders. Nowadays, QEEG is far superior to conventional EEG in its detection of abnormality and in its usefulness in psychiatric differential diagnosis. The abnormal findings of QEEG in various psychiatric disorders are also discussed.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.579-582
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• 1997

The two dimnesional echocardiography is widely used to evaluate regional wall motion abnormaility, because of its abilities to depict left ventricluar wall motion. A new method, color kinesis is a technology or echocardiographic assessment of left ventricular wall motion. In this paper, we proposed a algorithm or color kinesis which is based on acoustic quantification and automatically detects endocardial motion during systole on a frame-by-frame basis. The echocardiograms were obtained in the short-axis views in normal subjects. Automated edge detection and endocardial contour tracing algorithm was applied to each frames, quantitative analysis based on segmentation was performed, and pre-defined color overlays superimposed on the gray scale images. Segmental analysis of color kinesis provided automated, quantitative diagnosis of regional wall motion abnormality.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.183-184
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• 1998

Respiration monitoring is important in many clinical situations due to its relationship to vitality. But present commercial monitoring systems are bulky and expensive, so they are inadequate to be used for long term recording or out-patients application. We have developed a low cost, low power, handhold respiration monitoring system based on airflow measurement. Respiration flow is indirectly detected using a thermister or a themocouple sensor. Real time recording of respiration rate, abnormality detection and apnea alarming are available.

• Progress in Superconductivity
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• v.8 no.1
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• pp.1-7
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• 2006

We have developed magnetocardiography(MCG) and impedance magnetocardiography(I-MCG) for detecting heart disease by using dc-SQUID technology. The MCG system, using low-Tc SQUID, is being applied commercially for diagnosing heart disease. Using the low-Tc MCG system, many clinical studies on detection of abnormality have been performed. Furthermore, we have developed a portable MCG system using high-Tc SQUID. For detecting changes in kinetic impedance in the heart, an I-MCG system has been demonstrated. The I-MCG system could detect the mechanical movement of the heart. In this report, we review current clinical applications of magnetocardiography and impedance magnetocardiography.

• Korean Journal of Head & Neck Oncology
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• v.34 no.1
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• pp.29-32
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• 2018

The parathyroid glands are usually located in the posterolateral area of the thyroid gland. Due to their embryologic origin, they are sometimes found in an ectopic position from the angle of the jaw to the mediastinum. However, their incidental detection in the hypopharyngeal wall is rare. Herein, we report a case of an ectopic parathyroid gland found in the hypopharyngeal wall of a 39-year old woman with no known endocrine abnormality.

• Journal of Genetic Medicine
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• v.14 no.1
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• pp.34-37
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• 2017

5p deletion syndrome, also known as Cri-du-Chat syndrome, is a chromosomal abnormality caused by a deletion in the short arm of chromosome 5. Clinical features of 5p deletion syndrome are difficult to identify prenatally by ultrasound examination, thus most cases of 5p deletion syndrome have been diagnosed postnatally. Here, we report eight cases of 5p deletion syndrome diagnosed prenatally, but were unable to find common prenatal ultrasound findings among these cases. However, we found that several cases of 5p deletion syndrome were confirmed prenatally when karyotyping was performed on the basis of abnormal findings in a prenatal ultrasound scan. Hence, it is necessary to carefully perform prenatal ultrasonography for detection of rarer chromosomal abnormalities as well as common aneuploidy.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.10
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• pp.5035-5048
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• 2016

Nano scale networks are futuristic networks deemed as enablers for the Internet of Nano Things, Body area nano networks, target tracking, anomaly/ abnormality detection at molecular level and neuronal therapy / drug delivery applications. Molecular communication is considered the most compatible communication technology for nano devices. However, connectivity in such networks is very low due to inter-symbol interference (ISI). Few research papers have addressed the issue of ISI mitigation in molecular communication. However, many of these methods are not adaptive to dynamic environmental conditions. This paper presents an enhancement over original Memory-1 ISI cancellation scheme using maximum likelihood estimation of a channel parameter (λ) to make it adaptable to variable channel conditions. Results of the Monte Carlo simulation show that, the connectivity (P_conn) improves by 28% for given simulation parameters and environmental conditions by using enhanced Memory-1 cancellation method. Moreover, this ISI mitigation method allows reduction in symbol time (Ts) up to 50 seconds i.e. an improvement of 75% is achieved.