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Comparison of Diagnostic Accuracy for Detecting Coronary Artery Disease of Dipyridamole $^{99m}Tc$-MIBI Myocardial SPECT and It's Defect Map between Men and Women (디피리다몰 부하 $^{99m}Tc$-MIBI 심근 SPECT 극성결손지도를 이용한 관동맥질환 진단의 남녀 비교)

  • Bae, Sang-Kyun;Lee, Dong-Soo;Oh, Byung-Hee;Chung, June-Key;Lee, Myoung-Mook;Park, Young-Bae;Lee, Myung-Chul;Seo, Jung-Don;Lee, Young-Woo;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.27 no.1
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    • pp.59-64
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    • 1993
  • To evaluate the usefulness and differences in diagnosing coronary artery disease (CAD) between men and women of intravenous dipyridamole $^{99m}Tc$-MIBI myocardial SPECT, we obtained $^{99m}Tc$-MIBI myocardial SPECT and compared with the findings of coronary angiographies. Ninety eight male and 37 female patients who underwent dipyridamole $^{99m}Tc$-MIBI myocardial imaging within one month of cardiac catheterization were studied. Scans were considered abnormal if perfusion defect was detected and the defect size was more than 12% for left anterior descending artery (LAD) and circumflex (LCX) and 8% for right coronary artery (RCA) territories. Lesions${\geqq}$50% luminal diameter narrowing were considered significant CAD. Overall sensitivity for detection of CAD was 94.3% in men and 96.4% in women; specificity was 70% in men and 52.6% in women (P=not significant, ns). Vessel-matched sensitivity was 75.3% in men and 72.7% in women (P=ns): specificity was 84.6% in men and 67.9% in women (P < 0.025). For individual coronary artery, the sensitivity in men and women was 87.7%, 81.8% for LAD; 78%, 83.3% for RCA and 52.2%, 46.7% for LCX (P=ns): the specificity was 80%, 40% for LAD (P<0.01), 82.5%, 68.4% for RCA, 88.9%, 86.4% for LCX (P=ns). The hemodynamic parameter after intravenous dipyridamole in men and women were significantly changed; the heart rate was increased and systolic, diastolic blood pressure was decreased. Adverse effects were reported in 58.8% of men and 72.7% in women (P=ns). The incidence of chest pain and headache were higher in women. There was no significant difference in the incidences of nausea, abdominal pain, dizziness, facial flushing, dyspnea. In conclusion, dipyridamole $^{99m}Tc$-MIBI myocardial SPECT is a safe, noninvasive test for evaluation of CAD. There was no gender difference to detect CAD, but more false-positive rate in women especially in the territory of LAD.

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The Study of Permeation Characteristics for Pure Carbon Dioxide and Methane, and Gas Mixture in Cellulosic Membrane (셀룰로오스 분리막을 통한 순수 이산화탄소 메탄 및 혼합기체의 투과 특성 연구)

  • Kim, Hyun Joon;Kim, Hong Il;Kang, Yong Soo;Hong, Suk In
    • Applied Chemistry for Engineering
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    • v.7 no.4
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    • pp.605-613
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    • 1996
  • The permeation characteristics were investigated for pure carbon dioxide and methane through asymmetric cellulose acetate(CA) membrane, composite cellulose acetate membrane and asymmetric cellulose triacetate(CTA) membrane. In particular, the effect of operating pressure on the permeation performance was examined. And the permeation behavior for a mixture of carbon dioxide and methane ($CO_2/CH_4=57.6/42.4$) was also investigated and compared to the characteristics obtained from pure gases. The experiments were run at the range of partial pressure from 25 to 125 psig, and room temperature. The permeation behaviors of the CA composite and CTA membrane were similiar to those of the CA membrane. The permeation rates of pure carbon dioxide for CA, CA composite and CTA membrane were increased slightly with an increase in upstream partial pressure, while in the case of pure methane they were independent of upstream partial pressure. For a binary mixture of carbon dioxide and methane, abnormal permeation behaviors were observed due to the plasticization of carbon dioxide and the competition effect of each gas. The separation factor and permeation rate for CTA membrane were found to be higher than those for CA membrane, but the mechanical strength of CTA membrane was very poor. And the permeation rate for CA composite membrane was higher than that for CA membrane. Consequently, it can be said that the CA composite membrane is a strong candidate for the separation of $CH_4$ and $CO_2$.

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Genotoxicity Study of Litsea japonica Fruit Flesh Extract (까마귀쪽나무열매추출물의 유전독성 평가)

  • Yun, Ji-Hyun;Park, In-Jae;Park, Sung-Hwan;Choi, Goo-Hee;Kim, Hyun-Jung;Cho, Ju-Hyun
    • Journal of Food Hygiene and Safety
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    • v.33 no.3
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    • pp.207-213
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    • 2018
  • This study aimed to evaluate the genotoxicity of Litsea japonica fruit-hexane extract (LJF-HE). In order to examine the genotoxicity, we carried out bacterial reverse mutation assay, chromosome aberration assay, and a micronucleus induction (MN) test according to the OECD and the Korea Ministry of Food and Drug Safety (MFDS) toxicity test guidelines. In the bacterial reverse mutation assay, no significant increase in revertant colonies, nor bacterial toxicity, was observed in the LJF-HE treatment group, regardless of the absence or presence of metabolic activation by the S9 mixture. However, in the positive control group, revertant colony counts were shown to be more than twice that of the negative control group. The chromosome aberration test showed that the repetition rate of abnormal chromosome aberration was less than 5%, regardless of the treatment time, and with or without the S9 mixture. No significant change was observed when (p < 0.05) compared with the negative control group. The micronucleated polychromatic erythrocytes (MNPCE) repetition rate of the polychromatic erythrocytes (PCE) showed no significant changes when compared with the negative control group (p < 0.05). The PCE portion of total erythrocytes also showed no significant changes (p < 0.05). These results showed that LJF-HE had no significant genotoxic effects.

Effects of A-site Ca and B-site Zr Substitution on the Dielectric Characteristics and Microstructure of BaTiO3-CaTiO3 Composite (A-site Ca 및 B-site Zr 첨가에 의한 BaTiO3-CaTiO3복합체의 유전특성 및 미세구조에 미치는 영향)

  • 윤만순;박영민
    • Journal of the Korean Ceramic Society
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    • v.40 no.1
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    • pp.37-45
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    • 2003
  • The dielectric and sintering characteristics of composites made by substituting Ca ion to Ba-site and Zr ion to Ti site in $(Ba{1-x}Ca_x)(Ti{0.96-yZr_ySn_{0.04})O_3$ $(0.15{\leq}x{\leq}0.20,\;0.09{\leq}y{\leq}0.14)$ were investigated. As the content of Ca was more than 15 mol%, composite was formed by precipitating the second phase whose main element was $CaTiO_3$ and the fraction of the second phase was increased. The curie temperature of composites was depended on Ca concentration, $-1.7^{\circ}C$ per mol% and the maximum dielectric constant of composite was decreased by the rate of 200/mol%. The substitution of Zr ion decreased the curie temperature by the rate of $10^{\circ}C$ per mol% and the maximum dielectric constant was decreased by 217/mol% due to the increase of diffuse phase transition. The density and insulation breakdown characteristics were improved by suppressing the abnormal grain growth due to the increase of second phase. We developed the composition of Y5U (EIA standard) condenser which had high breakdown voltage and dielectric constant by controlling diffuse phase transition by the addition of Zr ion into composite.

Effect of Insect Pollinators for Chinese jujube (Zizyphus jujuba var. inermis (Bunge) Rehder) in Rain shelter house (대추 비가림하우스 내 화분매개곤충의 수분 특성 및 효과)

  • Oh, Ha Kyung;Lee, Jong Won;Kim, Chung Woo;Lee, Kyeong Hee;Lee, Seong Kyun;Kim, Sang Hee;Yoon, Hyung Joo;Lee, Kyeong Yong
    • Korean journal of applied entomology
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    • v.56 no.4
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    • pp.365-370
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    • 2017
  • The flowering season of jujube (Zizyphus jujuba var. inermis (Bunge) Rehder) is overlaps with the rainy season and the abnormal weather conditions in Korea, thereby affecting pollination, fertilization, and fruit setting. We studied the pollinating activities of Apis mellifera L. and Bombus terrestris L. in rain shelter houses and their effects on fruit setting, with the ultimate aim of stabilizing fruit setting in Z. jujuba. A. mellifera and B. terrestirs were used for pollination in jujube orchard in the rain shelter house for approximately 55 days from June 1, 2016, to July 25, 2016. The peak time of the rate of outgoing and incoming A. mellifera was recorded in the afternoon. However, the diurnal activity of B. terrestris was constant between 09:30 and 17:30 h. The rate of jujube fruit set on current shoots by A. mellifera and B. terrestirs was 10.2 and 8.9%, whereas that in plots with no pollinators was 5.5%. Therefore, using pollinator in the rain shelter house in jujube orchard is effective in promoting jujube fruit setting.

Electrochemical Behavior of Dissolved Hydrogen and Hydrogen Peroxide in Boric Acid Solution at the Elevated Temperature (붕산수용액 매질에서 용존수소와 과산화수소의 고온 전기화학 거동연구)

  • Yeon Jei-Won;Woo Seung-Kyun;Choi Young-Ku;Jung Yongju;Kim Won-Ho
    • Journal of the Korean Electrochemical Society
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    • v.7 no.1
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    • pp.21-25
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    • 2004
  • The electrochemical behaviors of dissolved hydrogen and hydrogen peroxide at a platinum disk electrode were investigated in boric acid solution by potentiostatic polarization method at the temperature of 25 and $200^{\circ}C$. The oxidation of dissolved hydrogen at $25^{\circ}C$ was kinetically controlled reaction, the rate of which depends upon the electron transfer on the electrode surface. As temperature was raised, however, the electrochemical characteristics of dissolved hydrogen were changed from a kinetically controlled reaction to a diffusion controlled one. One notable feature, with dissolved hydrogen at high temperature, is that an abnormal potential range was observed, where the oxidation rate of dissolved hydrogen rapidly decreased just before starting potential of water oxidation. We think it is caused by the deactivation of the electrode that results from the adsorption of hydroxyl ion on the surface of the platinum disk. On the contrary, a definite change with temperature was not identified in the case of the hydrogen peroxide except for the increase in current density that was due to the increasing diffusion coefcient with an increase of temperature.

Effect of Age on Glucose Metabolism of Skeletal Muscle in Rats (흰쥐에서 연령이 골격근의 당 대사에 미치는 영향)

  • Jang, Eung-Chan;Youn, Woon-Ki;Lee, Suck-Kang
    • Journal of Yeungnam Medical Science
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    • v.18 no.1
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    • pp.94-100
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    • 2001
  • Background: It is doubtful that aging causes deteriorated glucose metabolism and insulin resistance of skeletal muscle. Some researchers had different results about it. So we have studied the mechanism responsible for the abnormal glucose tolerance associated with aging in rapidly growing and matured rats. Materials and Methods: Animals were used S.D. rats. Growing rats were 7 weeks old (BW: 160-190 gm) and matured rats were 28 weeks old (BW: 420-525 gm). Results: Fasting blood glucose and plasma insulin levels were significantly elevated in matured rat compared with growing rats. And during oral glucose tolerance test the glucose level was also significantly elevated in matured rats. These results confirmed an insulin resistant state of aging. Insulin levels at 30 minutes of oral glucose tolerance test was significantly elevated in growing rat. But at 120 minutes it was maintained at higher level in matured rats than in growing rats. It suggested the possibility of increased insulin secretion by initial stimulation of beta-cells in growing rats, and increased secretion and decreased catabolic rate of insulin in matured rats. Glucose uptake rate of soleus muscle in matured rats was lower than that of growing rats, but the difference was not statistically significant. The dose(insulin)-responsive(glucose uptake) curve of soleus muscle was only slightly deviated to the right side. Conclusion: Glucose metabolism of rat skeletal muscle was worsened by aging. The data of glucose uptake experiments suggested the possibility of insulin resistance of skeletal muscle in matured rats. but the mechanism of insulin resistance of skeletal muscle need further studies.

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The effect of different bag materials on grape quality and endeavor of maturation period determination (서로 다른 봉지재료가 포도 품질 및 숙기판단 노력에 미치는 영향)

  • 남상영;강한철;김태수
    • Korean Journal of Plant Resources
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    • v.13 no.2
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    • pp.111-117
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    • 2000
  • In an attempt to select grape bag, which elevates grape quality and make easy maturation period determination, the following research was carried out at Chungbuk Institute of Agricultural Technology, Grape Experiment Station. Light transmittance rate of bag reached to 11-65% with non-woven fabric and non-dripped vinyl bags. Non-dripped vinyl perforation and white painting bag resulted in 50 and 75%, respectively. Berry weights in non-woven fabric and non-dripped vinyl bag were high than that in paper bag. Non-dripped vinyl perforation 50%, white painting bag brought into fruit cracking, shattering, and rotten fruit, making the investigation difficult. Maturation period preceded about 1-4 day with non-woven fabric and non-dripped vinyl compared with that in paper bag. Soluble solids content with non-woven fabric and non-dripped vinyl bags was high and acidity showed a reverse result. Coloring extent was developed rapidly with non-woven fabric and non-dripped vinyl than paper bag. During initial state of coloring, coloring was rapid with Maekban-Stone mixed non-woven fabric and non-dripped vinyl + non-woven fabric bag. This was rapid with non-woven fabric bag as long appropriate maturation period. Abnormal berry rate was 5.4-7.0% with paper and non-woven fabric bags but brought about as much as 16.6-100% with non-dripped vinyl and it's mixed bags. Appearance quality was the best with index 9.0 for non-woven fabric bag. Maekban-Stone mixed non-woven fabric but non-dripped vinyl performance 50% white painting bag was the least, showing index 1.0. The time consumed for maturation determination was reduced to 74-93% with non-woven fabric and non-dripped vinyl bag compared with 17.4h/10a with paper bag.

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A study on the selection of priority management watershed for the restoration of water cycle (물순환 회복을 위한 우선관리유역 선정 방안에 대한 연구)

  • Kim, Jaemoon;Baek, Jongseok;Park, Jaerock;Park, Byungwoo;Shin, Hyunsuk
    • Journal of Korea Water Resources Association
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    • v.55 no.10
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    • pp.749-759
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    • 2022
  • The paradigm of water cycle management in the watershed is changing due to the increase in abnormal climate phenomena caused by climate change and the increase in impervious area due to urbanization. Research is continuously underway based on Low Impact Development technology that can suppress water cycle distortion. In this study, factors that can reflect water cycle distortion were selected before applying LID, and the PSR index for each 148 watershed was calculated for the the Nakdonggang River basin. As of 1975, the PSR index is calculated by calculating the pressure index P, which represents the rate of change in impervious surface area to 2019, the phenomenon index S, which represents the rate of change in water cycle for each subwatershed, and the Low Impact Development area countermeasure index R. The lower PSR index value, the higher the priority management watershed, and the water cycle recovery priority management watershed was calculated in the order of 1, 2, 87, 90, 91, and 147. It is expected that the efficient application of low-impact development factors in accordance with the order of priority management of water cycle by subwatershed in the large area will contribute to the recovery of water cycle distortion.

Measurements of Void Concentration Parameters in the Drift-Flux Model (상대유량 모델내의 기포분포계수 측정에 관한 연구)

  • Yun, B.J.;Park, G.C.;Chung, C.H.
    • Nuclear Engineering and Technology
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    • v.25 no.1
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    • pp.91-101
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    • 1993
  • To predict accurately the thermal hydraulic behavior of light water reactors during normal or abnormal operation, the accurate estimation of the void distribution is required. Up to date, many techniques for predicting void fraction of two-phase flow systems have been suggested. Among these techniques, the drift-flux model is widely used because of its exact calculation ability and simplicity. However, to get more accurate prediction of void fraction using drift-flux model, slip and flow regime effects must be considered more properly In the drift-flux method, these two effects are accounted for by two drift-flux parameters ; $C_{o}$ and (equation omitted). At earlier stage, $C_{o}$ is measured in a circular tube. In this study, $C_{o}$ is experimentally determined by measuring local void fraction and vapor velocity distribution in a rectangular subchannel having 4 heating rods which simulates nuclear subchannels. The measurements are peformed with two-electrical conductivity probes which are known to be adequate for measuring local parameters. The experiments are performed at low flow rate and the system pressure less than 3 atmo spheric pressure. In this experiment, (equation omitted), is not measured, but quoted from well-known empirical correlation to formulate $C_{o}$. Finally, $C_{o}$ is expressed as a function of channel averaged void fraction. fraction.

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