• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.32 no.4B
• /
• pp.221-232
• /
• 2012

In this study, the model enhancing the safety of reservoirs and reducing the downstream flood damage by reservoirs system operation during abnormal flood was developed. Linear programming was used for the optimal reservoirs system operation during an abnormal flood and fuzzy inference system was introduced to solve the uncertainty problem which is included in hydrological factors like inflow, water level and inflow variation of reservoir operation. The linear programming model determined the optimal reservoir system operation rules and could be used in situation where water demands varies rapidly during the abnormal flood events using fuzzy control technique. In this study, the optimal reservoirs system operation for Andong and Imha reservoirs located in the upper basin of Nakdong river was performed in order that the design flood discharge at Andong city would not be exceeded for the design flood of 100 year and PMF(Probable Maximum Flood). And the model that determines the release according to the downstream flow discharge, the reservoir storage, the inflow and the inflow variation of each reservoir was developed using the optimal system operation result and fuzzy control technique. The developed model consisted of 224 fuzzy rules according to the conditions of Andong reservoir, Imha reservoir and Andong city. And the release from each reservoir could be determined when the current data are used as input data through the developed GUI.

• Proceedings of the KIEE Conference
• /
• 2004.11c
• /
• pp.325-327
• /
• 2004

ECG limb lead II signal widely used to diagnosis heart diseases and it is essential to detect ECG events (onsets, offsets and peaks of the QRS complex P wave and T wave) and extract them from ECG signal for heart diseases diagnoses. However, it is very difficult to develop standardized feature extraction formulas since ECG signals are varying on patients and disease types. In this paper, simple feature extraction method from normal and abnormal types of ECG signals is proposed. As a signal features, heart rate, PR interval, QRS interval, QT interval, interval between S wave and baseline, and T wave types are extracted. To show the validity of proposed method, Right Bundle Branch Block (RBBB), Left Bundle Branch Block (LBBB), Sinus Bradycardia, and Sinus Tachycardia data from MIT-BIH arrhythmia database are used for feature extraction and the extraction results showed higher extraction capability compare to conventional formula based extraction method.

• Proceedings of the KIEE Conference
• /
• 2011.07a
• /
• pp.252-253
• /
• 2011

Many errors are broken out when hydro power plants are operating connected to electric power system. To minimize ripple effects of accidents, a hydro power plant is separated by a circuit breaker consisting of each protection equipments. In this paper, I will analyze a cause of abnormal events of emergency stop and therefore I take measures and suggest solutions for similar cases.

• BMB Reports
• /
• v.53 no.3
• /
• pp.125-132
• /
• 2020

Transient receptor potential (TRP) channels comprise a diverse family of ion channels, the majority of which are calcium permeable and show sophisticated regulatory patterns in response to various environmental cues. Early studies led to the recognition of TRP channels as environmental and chemical sensors. Later studies revealed that TRP channels mediated the regulation of intracellular calcium. Mutations in TRP channel genes result in abnormal regulation of TRP channel function or expression, and interfere with normal spatial and temporal patterns of intracellular local Ca²⁺ distribution. The resulting dysregulation of multiple downstream effectors, depending on Ca²⁺ homeostasis, is associated with hallmarks of cancer pathophysiology, including enhanced proliferation, survival and invasion of cancer cells. These findings indicate that TRP channels affect multiple events that control cellular fate and play a key role in cancer progression. This review discusses the accumulating evidence supporting the role of TRP channels in tumorigenesis, with emphasis on prostate cancer.

• Journal of Haehwa Medicine
• /
• v.13 no.1
• /
• pp.169-181
• /
• 2004

Uterine bleeding is a physiologic monthly event occuring during the reproductive period of the nonpregnant woman. As with any other physiologic event, normal women have different menstrual patterns and at times, it is difficult to define when normality ends and abnormality begins. Dysfunctional uterine bleeding is an all-inclusive term: its diagnosis usually bepends on the exclusion of local or systemic organic causes. The term dysfunctional refers to alterations in the physiologic mechanism controlling a multitude of cyclic events in the women's reproductive function. These mechanism are primarily neuroendocrine in nature. According to oriental medicine, the Metrorrhagia(崩漏) means an abnormal bleeding of femail genetalia, and is devided to bungjung and bungha. The etiological factors of metrorrhagia are heat of blood, asthenic coldness, asthenia of chong and ren channels, deficiency of blood, deficiency of vital energy, stagnated blood, and asthenia of spleen & stomach.

• Journal of Korean Society for Quality Management
• /
• v.19 no.2
• /
• pp.96-107
• /
• 1991

At the design stage of a plant, the plausible causes and pathways of release of hazardous materials are not clearly known. Thus there exist large amount of uncertainties on the consequences resulting from the operation of a fusion plant. In order to better handle such uncertain circumstances, we utilize the Probabilistic Risk Assessment(PRA) for the safety analyses on fusion power plant. In this paper, we concentrate on the tritium release accident. We develop a simple model that describes the process and flow of tritium, by which we figure out the locations of tritium inventory and their vulnerability. We construct event tree models that lead to various levels of tritium release from abnormal initiating events. Branch parameters on the event tree are assessed from the fault tree analysis. Based on the event tree models we construct influence diagram models which are more useful for the parameter updating and analysis. We briefly discuss the parameter updating scheme, and finally develop the methodology to obtain the predictive distribution of consequences resulting from the operating a fusion power plant. We also discuss the way to utilize the results of testing on sub-systems to reduce the uncertain ties on over all system.

• Proceedings of the KSR Conference
• /
• 2009.05a
• /
• pp.959-965
• /
• 2009

To meet the demand increasing passengers in railway vehicles, railway transportation service companies are increasing the numbers of cars per train-set. Two solutions, Variable train-set formations and Multiple train-set operation, are common way to increase the transportation capability. These kind of long distance train-set can effect train-set command and control system, and sometimes the digital signals using train line from master cabin can not reach to the systems located the other extremity slave car. This is so called Voltage Drop. This phenomenon is originated from the electrical power consumption and electrical cable resistance, and cause to the equipments or cars located end of the electrical cable way, malfunction or abnormal operations. This voltage drop happens not only in train lines but also Battery Power Lines. The purpose of this investigation is to design high reliability railway vehicles by clarifying the possibility of happening these events case by case, by analyzing the reasons, and finally by finding the best solutions.

• Animal cells and systems
• /
• v.10 no.4
• /
• pp.237-241
• /
• 2006

Chemotactic behavior is essential for the survival of animals. However, the mechanism by which animals carry out chemotaxis is poorly understood. To explore the biochemical events underlying chemotaxis, we isolated C. elegans mutants that displayed abnormal chemotactic responses to cAMP, a strong attractant for C. elegans. Based on their responses to other chemoattractants, the mutant animals could be classified into five groups: (1) animals with defective chemotaxis to cAMP only; (2) animals with defective chemotaxis to both cAMP and cGMP; (3) animals with defective chemotaxis to water-soluble attractants; (4) animals with defective chemotaxis to both water-soluble and volatile attractants; and (5) animals with enhanced chemotactic responses. We expect that analyses of these mutants will help understand the molecular mechanisms underlying chemotaxis in C. elegans.

• Proceedings of the Korea Society for Simulation Conference
• /
• 2003.06a
• /
• pp.67-71
• /
• 2003

In order to manage a cluster system that consists of a number servers, management aspects such as configuration management, fault management, performance management, and user management should be considered. Especially, it is necessary to monitor performances for performance and fault management. An agent in each server collects performance counters, status changes, and events occurred in normal or abnormal states. The data collected are delivered to a collector sorter and processed in a report tool for performance analysts and management decision in the cluster system point of view, by detecting fault state and tracing out resource usage, service response, and response, and states until failed. In this paper we propose an architecture modeling of a performance report tool for proactive cluster system management. Some results on a cluster system are presented.

• BMB Reports
• /
• v.42 no.8
• /
• pp.467-474
• /
• 2009

The modification of proteins by reversible phosphorylation is a key mechanism in the regulation of various physiological functions. Abnormal protein kinase or phosphatase activity can cause disease by altering the phosphorylation of critical proteins in normal cellular and disease processes. Alzheimer' disease (AD), typically occurring in the elderly, is an irreversible, progressive brain disorder characterized by memory loss and cognitive decline. Accumulating evidence suggests that protein kinase and phosphatase activity are altered in the brain tissue of AD patients. Tau is a highly recognized phosphoprotein that undergoes hyperphosphorylation to form neurofibrillary tangles, a neuropathlogical hallmark with amyloid plaques in AD brains. This study is a brief overview of the altered protein phosphorylation pathways found in AD. Understanding the molecular mechanisms by which the activities of protein kinases and phosphatases are altered as well as the phosphorylation events in AD can potentially reveal novel insights into the role aberrant phosphorylation plays in the pathogenesis of AD, providing support for protein phosphorylation as a potential treatment strategy for AD.