• Journal of electromagnetic engineering and science
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• v.1 no.1
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• pp.67-72
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• 2001

In this paper, the plano-convex lens antenna fed by a single patch is studied for a microwave remote-traffic monitoring sensor with constraints of small size and low cost. Measurement of an AUT (Antenna Under Test) involves the considerations of a triangular groove for matched layer and metallic shielding effects. A formulation for extracting the parameters of a piano-convex lens antenna, based on geometrical optics, is introduced using Fermat`s principle of the equi-phased ray condition. Teflon ($\varepsilon_{{\gamma}}$/ =2.0) is chosen as a material of a plano-convex lens antenna for adjustment of aberrations on the lens surfaces automatically. A fabricated plano-convex lens shows 3-dB beamwidth of 7.5 degree and side-lobe level of -29 dB with an aperture distribution of the parabolic-squared taper on pedestal. This lens supports easier integration with the planar microwave circuits by using a microstrip single patch as a primary feeder of the lens antenna.feeder of the lens antenna.

• Molecules and Cells
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• v.41 no.5
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• pp.444-453
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• 2018

Aberrations in histone modifications are being studied in mixed-lineage leukemia (MLL)-AF9-driven acute myeloid leukemia (AML). In this study, we focused on the regulation of the differentiation of the MLL-AF9 type AML cell line THP-1. We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation. We revealed that the AURKA inhibitor alisertib accelerates the expression of the H3K27 demethylase KDM6B, thereby dissociating AURKA and YY1 from the KDM6B promoter region. Using Flow cytometry, we found that alisertib induces THP-1 differentiation into monocytes. Furthermore, we found that treatment with the KDM6B inhibitor GSK-J4 perturbed the PMA-mediated differentiation of THP-1 cells. Thus, we discovered the mechanism of AURKA-KDM6B signaling that controls the differentiation of THP-1 cells, which has implications for biotherapy for leukemia.

• Environmental Mutagens and Carcinogens
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• v.25 no.4
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• pp.150-156
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• 2005

Analysis of chromosome aberration (CA) and cytokinesis-block micronucleus (CBMN) assay in peripheral lymphocytes of nurses exposed to low levels of anticancer drug and Ethylene Oxide(EO) gas in a hospital were performed. The frequency of CA was increased in the exposed compared to the controls whereas no increase of the frequency of MN was found. The frequencies of chromatid type CA were 1.2, 3.91 and 9.67 per 500 cells in the controls, workers exposed to anticancer drug and workers exposed to EO, respectively. Lower frequency of CA in nurses handling anticancer drugs with safety covers compared to those without safety covers was observed, but it was not statistically significant. The frequency of CA in nurses handling anticancer drugs increased by the frequency of mixing anticancer drugs. Poisson regression analysis showed a significant association of the frequency of chromatid type CA with age, duration of wort exposure to anticancer drug and EO gas exposure, but no association of the frequency of chromosome type CA with any variables. The results suggested that there were associations between CA and the occupational exposure to low levels of anticancer drug and EO gas.

• Journal of Korean Medical Science
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• v.33 no.44
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• pp.275.1-275.15
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• 2018

Background: We compared the efficacy between trifocal and bifocal diffractive intraocular lens (IOL) implantation. Methods: Through PubMed, MEDLINE, EMBASE, and CENTRAL, we searched potentially relevant articles published from 1990 to 2018. Defocus curves, visual acuities (VAs) were measured as primary outcomes. Spectacle dependence, postoperative refraction, contrast sensitivity (CS), glare, and higher-order aberrations (HOAs) were measured as secondary outcomes. Effects were pooled using random-effects method. Results: We included 11 clinical trials, with a total of 787 eyes (395 subjects). The trifocal IOL group showed better binocular distance VA corrected with defocus levels of -0.5, -1.0, -1.5, and -2.5 diopter than the bifocal IOL group (All $P{\leq}0.004$). The trifocal IOL group showed better monocular uncorrected distance and intermediate VAs (mean difference [MD], -0.04 logarithm of the minimum angle of resolution [logMAR]; 95% confidence interval [CI], -0.07, -0.01; P = 0.006 and MD, -0.07 logMAR; 95% CI, -0.13, -0.01; P = 0.03, respectively). Postoperative refraction, glare, CS, and HOAs were not significantly different from each other. Conclusion: The overall findings indicate that trifocal diffractive IOL implantation is better than the bifocal diffractive IOL in intermediate VA, and provides similar or better in distance and near VAs without any major deterioration in the visual quality.

• Korean Journal of Optics and Photonics
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• v.12 no.5
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• pp.362-370
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• 2001

We prove that 3-D profile mapping using white light interferometry has systematic errors caused by aberrations of the optimal system. The tilt of an object invokes an offset between the object and the reference ray, which eventually makes the aberration cancel incompletely. The fringe peak of a white light interferogram is mainly affected by the aberration effect while the envelope peak remains stable. By the difference between the two peaks, it is easily confirmed how much the error existed in the fringe peak. Experimental results prove that the error caused by aberration is varied by object tilt, microscope NA, optics alignment within the range of $\pm$50nm.

• Current Optics and Photonics
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• v.1 no.1
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• pp.1-6
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• 2017

Degradation of bit-error-rate (BER), caused by atmospheric turbulence, seriously hinders the performance of coherent Free Space Optical (FSO) communication systems. An adaptive optics system proves to be effective in suppressing the atmospheric turbulence. The holographic modal wavefront sensor (HMWFS) proposed in our previous work, noted for its fast detecting rates and insensitivity to beam scintillation, is applied to the coherent FSO communication systems. In this paper, based on our previous work, we first introduce the principle of the HMWFS in brief and give the BER of the coherent FSO with homodyne detection in theory, and then analyze the improvement of BER for a coherent FSO system based on our previous simulation works. The results show that the wavefront sensor we propose is better for weak atmospheric turbulence. The most obvious advantages of HMWFS are fast detecting rates and insensitivity to beam scintillation.

• Psychiatry investigation
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• v.15 no.12
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• pp.1121-1129
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• 2018

Objective Categorical syndrome such as schizophrenia could be the complex of many continuous mental structure phenotypes including several personality development/degeneration dimensions. This is the study to search heritability and familiality of MMPI personality dimensions in the Korean schizophrenic LD (Linkage Disequilibrium) families. Methods We have recruited 204 probands (with schizophrenia) with their parents and siblings whenever possible. We have used MMPI questionnaires for measuring personality and symptomatic dimensions. Heritabilities of personality dimensions in total 543 family members were estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR). Personality dimensions in total family members were compared with those in 307 healthy unrelated controls for measuring the familialities using ANOVA analysis. Results Seven of the 10 MMPI variables were significantly heritable and were included in the subsequent analyses. The three groups (control, unaffected 1st degree relative, case) were found to be significantly different with the expected order of average group scores for all heritable dimensions. Conclusion Our results show that the aberrations in several personality dimensions could form the complexity of schizophrenic syndrome as a result of genetic-environment coactions or interactions in spite of some limitations (recruited family, phenotyping).

• The Korean Journal of Food & Health Convergence
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• v.5 no.1
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• pp.33-38
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• 2019

The purpose of previous study centered around introducing minerals into bee colonies was to observe the Varrosa destructor mites-repelling effect of minerals ("Pszczelarstwo" 6/2016). The results of research published so far confirmed the purpose of using minerals in the fight against Varrosa infestation. This publication presents partial results of the next stage of research. Using foundation enriched with studied minerals in right proportions leads to diminishing the number of Varroa destructor parasites in bee colonies. It may also contribute to increase in the amount of honey obtained from bees. Foundations with minerals were in most cases correctly filled with larvae, and the new generation of bees didn't show any morphometric or physical-motor aberrations. The effect of minerals in the foundation weakens with time, which requires adequate reaction from the beekeeper. The study showed no negative effect of mineral suspensions added directly to royal jelly of larvae in the swarm cells and worker cells on the development of bees. Additional research was carried out in August and September and led to surprising observations, which are still too early to report. It obliges us to carry out further, extended subject research on a large number of bee colonies in 2017.

• Journal of Pharmacopuncture
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• v.25 no.3
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• pp.290-300
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• 2022

Objectives: This study was conducted to evaluate the safety of SU-Eohyeol pharmacopuncture (SUEP) by assessing its potential to cause chromosomal abnormalities in Chinese hamster lung cells (CHL/IC). Methods: A dose-curve was conducted to determine the highest dose of SUEP. Doses of 10, 5, 2.5, 1.25, 0.625, and 0.313% were used, and no cytotoxicity or SUEP precipitation was observed. SUEP doses of 10, 5, and 2.5%, with positive and negative controls, were used in a chromosome aberration test. Results: In this study, the frequency of abnormal chromosomal cells in the SUEP group did not show a statistically significant difference from that of the negative control group in short-term treatments with and without metabolic activation and the continuous treatment without metabolic activation. Compared with the negative control group, the positive control group had a significantly higher frequency of cells with structural chromosomal abnormalities. This test's results satisfied all conditions for determining the results. Conclusion: SUEP did not induce chromosomal aberrations under the conditions of this study. Other toxicity evaluations, safety studies in humans, and various clinical trials are required to evaluate the safety and efficacy of SUEP.

• Current Optics and Photonics
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• v.7 no.3
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• pp.273-282
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• 2023

This paper presents a new method for redistributing effectively the first orders of each lens element to achromatize and athermalize an optical system, by introducing a novel method for adjusting the slope of an achromatic and athermal line. This line is specified by connecting the housing, equivalent single lens, and aberration-corrected point on a glass map composed of available plastic and glass materials for molding. Thus, if a specific lens is replaced with the material characterized by the chromatic and thermal powers of an aberration-corrected point, we obtain an achromatic and athermal system. First, we identify two materials that yield the minimum and maximum slopes of the line from a housing coordinate, which specifies the slope range of the line spanning the available materials on a glass map. Next, redistributing the optical first orders (optical powers and paraxial ray heights) of lens elements by moving the achromatic and athermal line into the available slope range of materials yields a good achromatic and athermal design. Applying this concept to design a mobile-phone camera lens, we efficiently obtain an achromatic and athermal system with cost-effective material selection, over the specified temperature and waveband ranges.